22 items (Seriola dumerili) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	msh3	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1191 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (743 aa)
	pms2	PMS1 homolog 2, mismatch repair system component. (865 aa)
	pold4	Si:dkey-28b4.7. (108 aa)
	msh6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1357 aa)
	rpa2	Replication protein A2. (278 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (439 aa)
	ENSSDUP00000016000	RPA_C domain-containing protein. (250 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
	rpa3	Replication protein A3. (122 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa)
	ssbp1	Single-stranded DNA binding protein 1. (147 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (680 aa)
	pold1	DNA polymerase. (1121 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	lig1	DNA ligase. (616 aa)
	exo1	Exonuclease 1. (797 aa)
	rfc1	Replication factor C subunit 1. (1181 aa)
	rfc4	Replication factor C (activator 1) 4. (359 aa)
	rfc2	Replication factor C (activator 1) 2. (387 aa)

Your Current Organism:

Seriola dumerili

NCBI taxonomy Id: 41447
Other names: S. dumerili, greater amberjack

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSDUP00000016000	RPA1	ENSSDUP00000016000	ENSSDUP00000022462	RPA_C domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.988
ENSSDUP00000016000	exo1	ENSSDUP00000016000	ENSSDUP00000030437	RPA_C domain-containing protein.	Exonuclease 1.	0.683
ENSSDUP00000016000	lig1	ENSSDUP00000016000	ENSSDUP00000029187	RPA_C domain-containing protein.	DNA ligase.	0.724
ENSSDUP00000016000	mlh1	ENSSDUP00000016000	ENSSDUP00000006795	RPA_C domain-containing protein.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.512
ENSSDUP00000016000	msh2	ENSSDUP00000016000	ENSSDUP00000021950	RPA_C domain-containing protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.719
ENSSDUP00000016000	msh3	ENSSDUP00000016000	ENSSDUP00000004507	RPA_C domain-containing protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.454
ENSSDUP00000016000	msh6	ENSSDUP00000016000	ENSSDUP00000008815	RPA_C domain-containing protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.814
ENSSDUP00000016000	pcna	ENSSDUP00000016000	ENSSDUP00000004184	RPA_C domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.868
ENSSDUP00000016000	pms2	ENSSDUP00000016000	ENSSDUP00000006805	RPA_C domain-containing protein.	PMS1 homolog 2, mismatch repair system component.	0.498
ENSSDUP00000016000	pold1	ENSSDUP00000016000	ENSSDUP00000023525	RPA_C domain-containing protein.	DNA polymerase.	0.706
ENSSDUP00000016000	rfc1	ENSSDUP00000016000	ENSSDUP00000031244	RPA_C domain-containing protein.	Replication factor C subunit 1.	0.706
ENSSDUP00000016000	rfc2	ENSSDUP00000016000	ENSSDUP00000032108	RPA_C domain-containing protein.	Replication factor C (activator 1) 2.	0.844
ENSSDUP00000016000	rfc3	ENSSDUP00000016000	ENSSDUP00000019982	RPA_C domain-containing protein.	Replication factor C (activator 1) 3.	0.795
ENSSDUP00000016000	rfc4	ENSSDUP00000016000	ENSSDUP00000031399	RPA_C domain-containing protein.	Replication factor C (activator 1) 4.	0.787
ENSSDUP00000016000	rfc5	ENSSDUP00000016000	ENSSDUP00000023741	RPA_C domain-containing protein.	Replication factor C (activator 1) 5.	0.741
ENSSDUP00000016000	rpa1	ENSSDUP00000016000	ENSSDUP00000016384	RPA_C domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.988
ENSSDUP00000016000	rpa2	ENSSDUP00000016000	ENSSDUP00000013262	RPA_C domain-containing protein.	Replication protein A2.	0.904
ENSSDUP00000016000	rpa3	ENSSDUP00000016000	ENSSDUP00000017919	RPA_C domain-containing protein.	Replication protein A3.	0.994
RPA1	ENSSDUP00000016000	ENSSDUP00000022462	ENSSDUP00000016000	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	RPA_C domain-containing protein.	0.988
RPA1	exo1	ENSSDUP00000022462	ENSSDUP00000030437	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Exonuclease 1.	0.839