STRINGSTRING
iscA iscA ABX20273.1 ABX20273.1 iscS iscS ABX24442.1 ABX24442.1 ABX24099.1 ABX24099.1 nfuA nfuA cyaY cyaY ABX23388.1 ABX23388.1 erpA erpA ABX22234.1 ABX22234.1 ABX21504.1 ABX21504.1 ABX20278.1 ABX20278.1 ABX20667.1 ABX20667.1 ABX21444.1 ABX21444.1 sufE sufE ABX21501.1 ABX21501.1 ABX21502.1 ABX21502.1 ABX21503.1 ABX21503.1 hscA hscA hscB hscB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
iscAHypothetical protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. (107 aa)
ABX20273.1Hypothetical protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (128 aa)
iscSHypothetical protein; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate; Belongs to the class-V pyridoxal-phosphate-dependent aminotransfer [...] (404 aa)
ABX24442.1Hypothetical protein; KEGG: stm:STM2984 1.8e-205 csdA; putative selenocysteine lyase; COG: COG0520 Selenocysteine lyase; Psort location: Cytoplasmic, score:8.96. (401 aa)
ABX24099.1Hypothetical protein; COG: COG5007 Predicted transcriptional regulator, BolA superfamily; Belongs to the BolA/IbaG family. (97 aa)
nfuAHypothetical protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. (191 aa)
cyaYHypothetical protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. (106 aa)
ABX23388.1Hypothetical protein; KEGG: stm:STM4084 1.3e-129 fpr; ferredoxin-NADP reductase K00528; COG: COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. (248 aa)
erpAHypothetical protein; Required for insertion of 4Fe-4S clusters for at least IspG. (114 aa)
ABX22234.1Hypothetical protein; KEGG: dre:562769 9.7e-06 LOC562769; similar to Serine/threonine-protein kinase 10 (Lymphocyte-oriented kinase) K08837; COG: COG1076 DnaJ-domain-containing proteins 1; Psort location: Cytoplasmic, score:8.96. (391 aa)
ABX21504.1Hypothetical protein; COG: COG0316 Uncharacterized conserved protein; Belongs to the HesB/IscA family. (122 aa)
ABX20278.1COG: COG2975 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score:8.96. (66 aa)
ABX20667.1Hypothetical protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (369 aa)
ABX21444.1Hypothetical protein; KEGG: ama:AM1083 1.2e-07 grxC1; glutaredoxin 3 K03676; COG: COG0278 Glutaredoxin-related protein; Belongs to the glutaredoxin family. Monothiol subfamily. (115 aa)
sufEHypothetical protein; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process; Belongs to the SufE family. (138 aa)
ABX21501.1Hypothetical protein; COG: COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component. (421 aa)
ABX21502.1Hypothetical protein; KEGG: noc:Noc_2489 4.1e-87 sufC; FeS assembly ATPase SufC K09013; COG: COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. (248 aa)
ABX21503.1Hypothetical protein; COG: COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component. (495 aa)
hscAHypothetical protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. (616 aa)
hscBHypothetical protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (171 aa)
Your Current Organism:
Salmonella enterica arizonae
NCBI taxonomy Id: 41514
Other names: S. enterica subsp. arizonae serovar 62:z4,z23:-, Salmonella enterica IIIa 62:z4,z23:-, Salmonella enterica serovar IIIa 62:z4,z23:-, Salmonella enterica subsp. arizonae serovar 62:z4,z23:-
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