STRINGSTRING
rpl35ae rpl35ae Hbut_0775 Hbut_0775 Hbut_0697 Hbut_0697 Hbut_0681 Hbut_0681 Hbut_0595 Hbut_0595 Hbut_0586 Hbut_0586 Hbut_0579 Hbut_0579 Hbut_0577 Hbut_0577 rpl37ae rpl37ae rpl15e rpl15e rpl24e rpl24e rps28e rps28e rps2 rps2 rps9 rps9 rps4 rps4 rbcL rbcL rps17e rps17e Hbut_0457 Hbut_0457 rps6e rps6e rps24e rps24e rps3ae rps3ae rpl12 rpl12 nep1 nep1 Hbut_0266 Hbut_0266 Hbut_0262 Hbut_0262 Hbut_0236 Hbut_0236 rpl13e rpl13e flpA flpA Hbut_0030 Hbut_0030 rpl21e rpl21e priS priS rpl44e rpl44e Hbut_1618 Hbut_1618 rpl31e rpl31e rps19e rps19e nep1-2 nep1-2 Hbut_1584 Hbut_1584 rps10 rps10 rpl30e rpl30e Hbut_1562 Hbut_1562 Hbut_1530 Hbut_1530 Hbut_1493 Hbut_1493 Hbut_1480 Hbut_1480 Hbut_1472 Hbut_1472 cobB cobB truB truB rpl34e rpl34e rps5 rps5 rpl18 rpl18 rpl19e rpl19e Hbut_1317 Hbut_1317 rpl6 rpl6 rps4e rps4e rps17 rps17 rpl29 rpl29 rps3 rps3 Hbut_1301 Hbut_1301 Hbut_1297 Hbut_1297 rps19 rps19 Hbut_1265 Hbut_1265 rad50 rad50 mre11 mre11 Hbut_1170 Hbut_1170 priL priL pdxS pdxS albA-2 albA-2 top6A top6A albA albA Hbut_0909 Hbut_0909 rfcL rfcL dnaG dnaG Hbut_0776 Hbut_0776
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpl35ae50S ribosomal protein L35Ae; Belongs to the eukaryotic ribosomal protein eL33 family. (106 aa)
Hbut_0775Universally conserved protein. (508 aa)
Hbut_0697Hypothetical protein. (151 aa)
Hbut_0681ADP-ribosylglycohydrolase. (256 aa)
Hbut_0595Cdc6-1; Involved in regulation of DNA replication. (407 aa)
Hbut_0586Universally conserved protein. (220 aa)
Hbut_057950S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. (57 aa)
Hbut_0577Predicted phosphoesterase, DHH family. (355 aa)
rpl37ae50S ribosomal protein L37Ae; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily. (88 aa)
rpl15e50S ribosomal protein L15e; Belongs to the eukaryotic ribosomal protein eL15 family. (226 aa)
rpl24e50S ribosomal protein L24e; Binds to the 23S rRNA. (61 aa)
rps28e30S ribosomal protein S28e; Belongs to the eukaryotic ribosomal protein eS28 family. (81 aa)
rps230S ribosomal protein S2P; Belongs to the universal ribosomal protein uS2 family. (216 aa)
rps930S ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family. (158 aa)
rps430S ribosomal protein S4p; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (176 aa)
rbcLRibulose bisphosphate carboxylase; Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (441 aa)
rps17e30S ribosomal protein S17e; The protein has a longer C terminal than otherwise seen in archaea; Belongs to the eukaryotic ribosomal protein eS17 family. (103 aa)
Hbut_0457RNA binding protein, Gar1-type. (116 aa)
rps6e30S ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family. (217 aa)
rps24e30S ribosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family. (122 aa)
rps3ae30S ribosomal protein S3Ae; Belongs to the eukaryotic ribosomal protein eS1 family. (215 aa)
rpl1250S ribosomal protein L12P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (127 aa)
nep1Conserved uncharacterized protein, Mra1; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. (230 aa)
Hbut_0266Predicted EndoIII-related endonuclease. (242 aa)
Hbut_0262Adenylate cyclase, class 2. (193 aa)
Hbut_0236Phosphohydrolase - HD superfamily; Has a HD domain. (539 aa)
rpl13e50S ribosomal protein L13e; Belongs to the eukaryotic ribosomal protein eL13 family. (88 aa)
flpArRNA/tRNA 2'-O-methyltransferase; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (236 aa)
Hbut_0030Ribosomal biogenesis protein - Nop56/SIK1. (413 aa)
rpl21e50S ribosomal protein L21e; Belongs to the eukaryotic ribosomal protein eL21 family. (107 aa)
priSProbable DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer sy [...] (380 aa)
rpl44e50S ribosomal protein L44e; Binds to the 23S rRNA. (95 aa)
Hbut_1618Hypothetical protein. (215 aa)
rpl31e50S ribosomal protein L31e; Belongs to the eukaryotic ribosomal protein eL31 family. (100 aa)
rps19e30S ribosomal protein S19E; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (153 aa)
nep1-2Conserved archaeal protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. (230 aa)
Hbut_1584Predicted transcriptional regulator. (142 aa)
rps1030S ribosomal protein S10p; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rpl30e50S ribosomal protein L30e; Belongs to the eukaryotic ribosomal protein eL30 family. (112 aa)
Hbut_1562Predicted GTPase. (375 aa)
Hbut_1530Conserved archaeal protein. (97 aa)
Hbut_1493Putative MoxR ATPase. (315 aa)
Hbut_1480Ribosomal protein 10e. (151 aa)
Hbut_1472Hypothetical protein; Similar to ref:NP_148161.1. (216 aa)
cobBNAD-dependent protein deacetylases, SIR2 family; Belongs to the sirtuin family. Class III subfamily. (258 aa)
truBPredicted pseudouridine synthase; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (345 aa)
rpl34e50S ribosomal protein L34e; Belongs to the eukaryotic ribosomal protein eL34 family. (106 aa)
rps550S ribosomal protein S5p; With S4 and S12 plays an important role in translational accuracy. (213 aa)
rpl1850S ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (211 aa)
rpl19e50S ribosomal protein L19E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (153 aa)
Hbut_131750S ribosomal protein L32E. (122 aa)
rpl650S ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (186 aa)
rps4e30S ribosomal protein S4e; Belongs to the eukaryotic ribosomal protein eS4 family. (255 aa)
rps1730S ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (116 aa)
rpl2950S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (77 aa)
rps330S ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (247 aa)
Hbut_1301Conserved archaeal protein. (280 aa)
Hbut_1297Predicted ATPase. (333 aa)
rps1930S ribosomal protein S19p; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (155 aa)
Hbut_1265ATPase. (383 aa)
rad50Predicted Rad50; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. (887 aa)
mre11Predicted DNA repair exonuclease; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. (407 aa)
Hbut_1170Universally conserved protein. (444 aa)
priLConserved archaeal protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (377 aa)
pdxSPyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (335 aa)
albA-2DNA/RNA-binding protein Alba 1; Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family. (89 aa)
top6AType II DNA topoisomerase VI subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (387 aa)
albADNA/RNA-binding protein Alba 1; Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family. (98 aa)
Hbut_0909Cdc6-2; Involved in regulation of DNA replication. (411 aa)
rfcLReplication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (484 aa)
dnaGConserved archaeal protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (426 aa)
Hbut_077630S ribosomal protein S26. (96 aa)
Your Current Organism:
Hyperthermus butylicus
NCBI taxonomy Id: 415426
Other names: H. butylicus DSM 5456, Hyperthermus butylicus DSM 5456, Hyperthermus butylicus str. DSM 5456, Hyperthermus butylicus strain DSM 5456
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