STRINGSTRING
APL_0257 APL_0257 norM norM macA macA APL_0586 APL_0586 acrB acrB macB macB APL_0836 APL_0836 APL_0837 APL_0837 APL_0838 APL_0838 APL_0839 APL_0839 APL_0840 APL_0840 APL_1607 APL_1607 macA-2 macA-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APL_0257Probable outer membrane protein. (464 aa)
norMPutative multidrug resistance protein NorM. (463 aa)
macAProbable macrolide-specific efflux protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (393 aa)
APL_0586Putative RND efflux membrane fusion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (401 aa)
acrBAcriflavine resistance protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1039 aa)
macBPutative macrolide-specific ABC-type efflux carrier; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (640 aa)
APL_0836Putative transcriptional regulator. (184 aa)
APL_0837Hypothetical protein. (353 aa)
APL_0838Hypothetical ABC transporter ATP-binding protein. (913 aa)
APL_0839Predicted inner membrane transport permease. (374 aa)
APL_0840Predicted outer membrane protein; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. (464 aa)
APL_1607Putative drug resistance protein. (109 aa)
macA-2Probable macrolide-specific efflux protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (258 aa)
Your Current Organism:
Actinobacillus pleuropneumoniae
NCBI taxonomy Id: 416269
Other names: A. pleuropneumoniae serovar 5b str. L20, Actinobacillus pleuropneumoniae L20, Actinobacillus pleuropneumoniae serovar 5b str. L20, Actinobacillus pleuropneumoniae serovar 5b strain L20
Server load: low (14%) [HD]