STRINGSTRING
MCM7 MCM7 A0A1V6PAI4 A0A1V6PAI4 A0A1V6PHE0 A0A1V6PHE0 A0A1V6PQA7 A0A1V6PQA7 A0A1V6PR95 A0A1V6PR95 A0A1V6PS21 A0A1V6PS21 A0A1V6PTE7 A0A1V6PTE7 A0A1V6PTN1 A0A1V6PTN1 A0A1V6PVT4 A0A1V6PVT4 A0A1V6PWE8 A0A1V6PWE8 A0A1V6PWP8 A0A1V6PWP8 A0A1V6PWT8 A0A1V6PWT8 A0A1V6PXE5 A0A1V6PXE5 A0A1V6PY49 A0A1V6PY49 A0A1V6PYQ8 A0A1V6PYQ8 A0A1V6Q1V3 A0A1V6Q1V3 A0A1V6Q1Y8 A0A1V6Q1Y8 A0A1V6Q318 A0A1V6Q318 A0A1V6Q596 A0A1V6Q596 A0A1V6Q9B2 A0A1V6Q9B2 A0A1V6Q9H9 A0A1V6Q9H9 LSM3 LSM3 A0A1V6QBL9 A0A1V6QBL9 A0A1V6QBQ1 A0A1V6QBQ1 A0A1V6QBY3 A0A1V6QBY3 A0A1V6QCJ8 A0A1V6QCJ8 A0A1V6QDH2 A0A1V6QDH2 A0A1V6QDK9 A0A1V6QDK9 A0A1V6QEA5 A0A1V6QEA5 A0A1V6QEM2 A0A1V6QEM2 A0A1V6QG26 A0A1V6QG26 A0A1V6QJ23 A0A1V6QJ23 A0A1V6QJN8 A0A1V6QJN8 A0A1V6QLG2 A0A1V6QLG2 A0A1V6QMN4 A0A1V6QMN4 A0A1V6QNY1 A0A1V6QNY1 A0A1V6QP59 A0A1V6QP59 A0A1V6QPN6 A0A1V6QPN6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (808 aa)
A0A1V6PAI4Piwi domain-containing protein. (699 aa)
A0A1V6PHE0Uncharacterized protein. (610 aa)
A0A1V6PQA7Uncharacterized protein. (245 aa)
A0A1V6PR95Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (635 aa)
A0A1V6PS21Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (744 aa)
A0A1V6PTE7SAP domain-containing protein. (651 aa)
A0A1V6PTN1Uncharacterized protein. (1654 aa)
A0A1V6PVT4Stc1 domain-containing protein. (224 aa)
A0A1V6PWE8Rif1_N domain-containing protein. (1735 aa)
A0A1V6PWP8HTH myb-type domain-containing protein. (832 aa)
A0A1V6PWT8Uncharacterized protein. (675 aa)
A0A1V6PXE5Uncharacterized protein. (125 aa)
A0A1V6PY49Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (505 aa)
A0A1V6PYQ8Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (511 aa)
A0A1V6Q1V3RNA-dependent RNA polymerase. (1382 aa)
A0A1V6Q1Y8Uncharacterized protein. (886 aa)
A0A1V6Q318Chromo domain-containing protein. (232 aa)
A0A1V6Q596DNA helicase; Belongs to the MCM family. (881 aa)
A0A1V6Q9B2Uncharacterized protein; Belongs to the argonaute family. (1073 aa)
A0A1V6Q9H9Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (354 aa)
LSM3U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
A0A1V6QBL9Uncharacterized protein. (1132 aa)
A0A1V6QBQ1Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1219 aa)
A0A1V6QBY3Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2912 aa)
A0A1V6QCJ8CULLIN_2 domain-containing protein; Belongs to the cullin family. (875 aa)
A0A1V6QDH2Uncharacterized protein; Belongs to the CGI121/TPRKB family. (198 aa)
A0A1V6QDK9ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (715 aa)
A0A1V6QEA5Uncharacterized protein. (1661 aa)
A0A1V6QEM2Deacetylase sirtuin-type domain-containing protein. (484 aa)
A0A1V6QG26DNA helicase; Belongs to the MCM family. (720 aa)
A0A1V6QJ23Piwi domain-containing protein. (1052 aa)
A0A1V6QJN8Protein kinase domain-containing protein. (272 aa)
A0A1V6QLG2PHD-type domain-containing protein. (841 aa)
A0A1V6QMN4Uncharacterized protein. (1424 aa)
A0A1V6QNY1Telo_bind domain-containing protein. (596 aa)
A0A1V6QP59Uncharacterized protein. (982 aa)
A0A1V6QPN6RPA_C domain-containing protein. (279 aa)
Your Current Organism:
Penicillium antarcticum
NCBI taxonomy Id: 416450
Other names: CBS 100492, FRR 4989, P. antarcticum
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.