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| | A0A1V6QC17 | PPM-type phosphatase domain-containing protein. (573 aa) |
| | A0A1V6QQ37 | Queuosine salvage protein; Involved in salvaging queuosine. (420 aa) |
| | NBP35 | Cytosolic Fe-S cluster assembly factor NBP35; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (342 aa) |
| | A0A1V6QPE1 | S4 RNA-binding domain-containing protein. (526 aa) |
| | A0A1V6QNU3 | Uncharacterized protein. (212 aa) |
| | A0A1V6QNQ9 | Uncharacterized protein. (96 aa) |
| | A0A1V6QND5 | tRNA_int_end_N2 domain-containing protein. (455 aa) |
| | A0A1V6QNA6 | PseudoU_synth_1 domain-containing protein. (567 aa) |
| | A0A1V6QMU9 | Threonylcarbamoyl-AMP synthase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (428 aa) |
| | A0A1V6QL75 | Uncharacterized protein. (422 aa) |
| | A0A1V6QKU6 | Aminotran_5 domain-containing protein. (503 aa) |
| | A0A1V6QKN2 | Uncharacterized protein. (398 aa) |
| | A0A1V6QK03 | PseudoU_synth_1 domain-containing protein. (610 aa) |
| | A0A1V6QJN8 | Protein kinase domain-containing protein. (272 aa) |
| | A0A1V6QIQ1 | Uncharacterized protein. (307 aa) |
| | A0A1V6QI72 | Exonuclease domain-containing protein. (706 aa) |
| | A0A1V6QHZ2 | Uncharacterized protein. (267 aa) |
| | A0A1V6QGH7 | Uncharacterized protein. (507 aa) |
| | A0A1V6QGB3 | Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (418 aa) |
| | A0A1V6QG33 | tRNA_int_endo domain-containing protein. (503 aa) |
| | TRM8 | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (345 aa) |
| | A0A1V6QF70 | Uncharacterized protein. (363 aa) |
| | A0A1V6QF51 | Uncharacterized protein. (147 aa) |
| | A0A1V6QF12 | Uncharacterized protein. (456 aa) |
| | A0A1V6QEM3 | Uncharacterized protein. (369 aa) |
| | A0A1V6QED3 | DPH-type MB domain-containing protein. (153 aa) |
| | A0A1V6QE78 | Sen15 domain-containing protein. (211 aa) |
| | A0A1V6QE15 | Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (385 aa) |
| | A0A1V6QDN2 | Uncharacterized protein. (364 aa) |
| | A0A1V6QDH2 | Uncharacterized protein; Belongs to the CGI121/TPRKB family. (198 aa) |
| | A0A1V6QDC4 | A to I editase domain-containing protein. (505 aa) |
| | A0A1V6QDA0 | Uncharacterized protein. (1459 aa) |
| | NCS2 | Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (370 aa) |
| | A0A1V6QBY1 | Uncharacterized protein. (262 aa) |
| | A0A1V6QBQ3 | Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (625 aa) |
| | uba4 | Adenylyltransferase and sulfurtransferase uba4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (496 aa) |
| | LSM3 | U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa) |
| | KAE1 | tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (364 aa) |
| | A0A1V6QBC4 | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (457 aa) |
| | A0A1V6QBB5 | GIDA_assoc domain-containing protein. (689 aa) |
| | A0A1V6QAX6 | Uncharacterized protein. (343 aa) |
| | URM1 | Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target pr [...] (114 aa) |
| | A0A1V6QAJ2 | Uncharacterized protein. (806 aa) |
| | A0A1V6QAD8 | Uncharacterized protein. (686 aa) |
| | A0A1V6QA38 | Uncharacterized protein. (298 aa) |
| | A0A1V6Q9W1 | Uncharacterized protein. (213 aa) |
| | A0A1V6Q9Q9 | THUMP domain-containing protein. (270 aa) |
| | LSM5 | U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (83 aa) |
| | A0A1V6Q7S6 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1335 aa) |
| | A0A1V6Q729 | tRNA ligase. (837 aa) |
| | A0A1V6Q6P2 | DUF3453 domain-containing protein. (744 aa) |
| | A0A1V6Q6B4 | AA_TRNA_LIGASE_II domain-containing protein. (536 aa) |
| | NAT10 | RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1038 aa) |
| | NCS6 | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (411 aa) |
| | A0A1V6Q571 | Formyl_trans_N domain-containing protein. (399 aa) |
| | A0A1V6Q502 | Uncharacterized protein; Belongs to the cytochrome P450 family. (842 aa) |
| | TRM82 | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. (476 aa) |
| | A0A1V6Q4D4 | Uncharacterized protein. (188 aa) |
| | A0A1V6Q3L7 | 2OG-FeII_Oxy_2 domain-containing protein. (370 aa) |
| | A0A1V6Q3H8 | Uncharacterized protein. (883 aa) |
| | A0A1V6Q3C1 | Uncharacterized protein. (198 aa) |
| | A0A1V6Q2Y1 | Uncharacterized protein. (338 aa) |
| | TRM5 | tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (730 aa) |
| | A0A1V6Q1R6 | Sm domain-containing protein. (92 aa) |
| | A0A1V6Q1G7 | NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (305 aa) |
| | A0A1V6Q0R7 | DUF2428 domain-containing protein. (1639 aa) |
| | A0A1V6Q0P8 | Uncharacterized protein. (534 aa) |
| | A0A1V6Q0M5 | Uncharacterized protein. (126 aa) |
| | A0A1V6Q0E7 | Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (432 aa) |
| | A0A1V6PZQ2 | Uncharacterized protein. (403 aa) |
| | A0A1V6PZE7 | TRUD domain-containing protein. (740 aa) |
| | A0A1V6PZB8 | Uncharacterized protein. (1175 aa) |
| | A0A1V6PZ07 | Uncharacterized protein. (466 aa) |
| | A0A1V6PYX3 | SAM-dependent MTase TRM10-type domain-containing protein. (406 aa) |
| | A0A1V6PYH3 | Uncharacterized protein. (387 aa) |
| | A0A1V6PYD4 | ATP_bind_3 domain-containing protein. (677 aa) |
| | A0A1V6PXI0 | TRAM domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (545 aa) |
| | A0A1V6PX86 | AA_TRNA_LIGASE_II_ALA domain-containing protein. (264 aa) |
| | A0A1V6PX48 | Uncharacterized protein. (400 aa) |
| | A0A1V6PX28 | Uncharacterized protein. (558 aa) |
| | A0A1V6PWV3 | Zn(2)-C6 fungal-type domain-containing protein. (651 aa) |
| | A0A1V6PWQ9 | Ribonuclease P protein subunit. (242 aa) |
| | A0A1V6PWM0 | ATP-grasp domain-containing protein. (608 aa) |
| | A0A1V6PWK5 | tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (318 aa) |
| | A0A1V6PWA3 | Uncharacterized protein. (191 aa) |
| | A0A1V6PVK9 | CMP/dCMP-type deaminase domain-containing protein. (200 aa) |
| | AIM41 | Altered inheritance of mitochondria protein 41. (183 aa) |
| | A0A1V6PVF5 | Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (422 aa) |
| | A0A1V6PV76 | Methyltransf_11 domain-containing protein. (228 aa) |
| | A0A1V6PV14 | Exportin-T; tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Belongs to the exportin family. (1031 aa) |
| | A0A1V6PV00 | Uncharacterized protein. (457 aa) |
| | A0A1V6PUV6 | Uncharacterized protein. (232 aa) |
| | A0A1V6PUA4 | tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (636 aa) |
| | A0A1V6PU46 | Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (703 aa) |
| | A0A1V6PU15 | Rhodanese domain-containing protein. (228 aa) |
| | A0A1V6PTV7 | tRNA-dihydrouridine(47) synthase [NAD(P)(+)]; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. (749 aa) |
| | A0A1V6PTR1 | ThiF domain-containing protein. (574 aa) |
| | A0A1V6PT50 | Uncharacterized protein. (318 aa) |
| | A0A1V6PSP1 | Uncharacterized protein. (273 aa) |
| | A0A1V6PSN7 | Uncharacterized protein. (259 aa) |
| | A0A1V6PSC8 | Uncharacterized protein. (468 aa) |
| | CFD1 | Cytosolic Fe-S cluster assembly factor CFD1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (320 aa) |
| | A0A1V6PRF8 | Uncharacterized protein. (292 aa) |
| | ALA1 | Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (958 aa) |
| | A0A1V6PQY2 | Uncharacterized protein. (236 aa) |
| | A0A1V6PQX2 | Uncharacterized protein. (558 aa) |
| | A0A1V6PQK1 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (575 aa) |
| | A0A1V6PM10 | Uncharacterized protein. (343 aa) |
| | A0A1V6PJ99 | Uncharacterized protein. (265 aa) |
| | A0A1V6PI11 | Uncharacterized protein. (282 aa) |
| | A0A1V6PGU4 | Uncharacterized protein. (229 aa) |
| | A0A1V6PD92 | Uncharacterized protein. (364 aa) |
