(66 nodes) Sterol biosynthetic process network (Penicillium antarcticum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1V6Q889	Uncharacterized protein. (368 aa)
	A0A1V6Q6B1	Uncharacterized protein; Belongs to the cytochrome P450 family. (534 aa)
	A0A1V6Q6H1	Uncharacterized protein. (279 aa)
	A0A1V6Q901	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (403 aa)
	A0A1V6Q9F3	PH domain-containing protein. (1369 aa)
	A0A1V6QA31	Uncharacterized protein. (296 aa)
	A0A1V6QA34	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (348 aa)
	A0A1V6QAJ4	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (348 aa)
	A0A1V6QAY2	FAD-binding FR-type domain-containing protein. (385 aa)
	A0A1V6QB97	Uncharacterized protein. (470 aa)
	A0A1V6QBA5	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (350 aa)
	A0A1V6QBK5	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (478 aa)
	A0A1V6QCW7	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (458 aa)
	A0A1V6QD53	3Beta_HSD domain-containing protein. (510 aa)
	A0A1V6QD83	Uncharacterized protein. (495 aa)
	A0A1V6QDK4	3-hydroxy-3-methylglutaryl coenzyme A reductase. (1129 aa)
	A0A1V6QDK6	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (310 aa)
	A0A1V6QE16	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450. (708 aa)
	A0A1V6QE51	Uncharacterized protein; Belongs to the cytochrome P450 family. (531 aa)
	A0A1V6QET3	Uncharacterized protein. (439 aa)
	A0A1V6QGI1	Uncharacterized protein. (125 aa)
	A0A1V6QHC8	Uncharacterized protein. (285 aa)
	A0A1V6QHE3	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (346 aa)
	A0A1V6QHJ6	Uncharacterized protein; Belongs to the cytochrome P450 family. (523 aa)
	A0A1V6QHK3	Uncharacterized protein. (344 aa)
	A0A1V6QHV9	3Beta_HSD domain-containing protein. (412 aa)
	A0A1V6QIB3	Uncharacterized protein. (363 aa)
	A0A1V6QIK0	Uncharacterized protein. (324 aa)
	A0A1V6QIP7	Glyco_transf_28 domain-containing protein. (957 aa)
	A0A1V6QKA9	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (326 aa)
	A0A1V6QKE5	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (324 aa)
	A0A1V6QKT1	Glyco_transf_28 domain-containing protein. (721 aa)
	A0A1V6QL27	Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. (377 aa)
	A0A1V6QMD5	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (84 aa)
	cprA	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (695 aa)
	A0A1V6QP62	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (352 aa)
	A0A1V6QP63	Uncharacterized protein. (452 aa)
	A0A1V6QP69	AlcB domain-containing protein. (431 aa)
	A0A1V6QPE9	Uncharacterized protein. (289 aa)
	A0A1V6QPI6	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (352 aa)
	A0A1V6PPY9	Uncharacterized protein. (444 aa)
	A0A1V6PM85	Uncharacterized protein. (371 aa)
	A0A1V6PQ25	Uncharacterized protein. (1993 aa)
	A0A1V6PQB2	AlcB domain-containing protein. (442 aa)
	A0A1V6Q690	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (455 aa)
	A0A1V6Q5S5	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (318 aa)
	A0A1V6Q5A8	Uncharacterized protein. (238 aa)
	A0A1V6Q4A5	Uncharacterized protein; Belongs to the cytochrome P450 family. (514 aa)
	A0A1V6Q305	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (138 aa)
	A0A1V6Q1P5	Uncharacterized protein. (472 aa)
	A0A1V6Q0V7	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (522 aa)
	A0A1V6Q0L5	Uncharacterized protein. (580 aa)
	A0A1V6PZH0	Uncharacterized protein. (2082 aa)
	A0A1V6PXV1	AlcB domain-containing protein. (440 aa)
	A0A1V6PXR5	Uncharacterized protein. (295 aa)
	A0A1V6PXN8	Uncharacterized protein. (272 aa)
	A0A1V6PXF9	Glyco_transf_28 domain-containing protein. (890 aa)
	A0A1V6PU77	Uncharacterized protein. (135 aa)
	A0A1V6PU19	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (298 aa)
	A0A1V6PTF7	Uncharacterized protein. (474 aa)
	A0A1V6PSV5	Uncharacterized protein. (461 aa)
	A0A1V6PSD0	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (261 aa)
	A0A1V6PS37	FAD-binding PCMH-type domain-containing protein. (529 aa)
	A0A1V6PRS2	Uncharacterized protein. (551 aa)
	A0A1V6PR32	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
	A0A1V6PQF0	Uncharacterized protein. (230 aa)

Your Current Organism:

Penicillium antarcticum

NCBI taxonomy Id: 416450
Other names: CBS 100492, FRR 4989, P. antarcticum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1V6PM85	A0A1V6PRS2	A0A1V6PM85	A0A1V6PRS2	Uncharacterized protein.	Uncharacterized protein.	0.834
A0A1V6PM85	A0A1V6PS37	A0A1V6PM85	A0A1V6PS37	Uncharacterized protein.	FAD-binding PCMH-type domain-containing protein.	0.926
A0A1V6PM85	A0A1V6PSD0	A0A1V6PM85	A0A1V6PSD0	Uncharacterized protein.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.774
A0A1V6PM85	A0A1V6PTF7	A0A1V6PM85	A0A1V6PTF7	Uncharacterized protein.	Uncharacterized protein.	0.959
A0A1V6PM85	A0A1V6PU19	A0A1V6PM85	A0A1V6PU19	Uncharacterized protein.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.806
A0A1V6PM85	A0A1V6PU77	A0A1V6PM85	A0A1V6PU77	Uncharacterized protein.	Uncharacterized protein.	0.938
A0A1V6PM85	A0A1V6Q4A5	A0A1V6PM85	A0A1V6Q4A5	Uncharacterized protein.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.949
A0A1V6PM85	A0A1V6Q5A8	A0A1V6PM85	A0A1V6Q5A8	Uncharacterized protein.	Uncharacterized protein.	0.955
A0A1V6PM85	A0A1V6Q6B1	A0A1V6PM85	A0A1V6Q6B1	Uncharacterized protein.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.714
A0A1V6PM85	A0A1V6Q901	A0A1V6PM85	A0A1V6Q901	Uncharacterized protein.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.429
A0A1V6PM85	A0A1V6QA34	A0A1V6PM85	A0A1V6QA34	Uncharacterized protein.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.662
A0A1V6PM85	A0A1V6QAJ4	A0A1V6PM85	A0A1V6QAJ4	Uncharacterized protein.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.662
A0A1V6PM85	A0A1V6QB97	A0A1V6PM85	A0A1V6QB97	Uncharacterized protein.	Uncharacterized protein.	0.834
A0A1V6PM85	A0A1V6QBA5	A0A1V6PM85	A0A1V6QBA5	Uncharacterized protein.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.995
A0A1V6PM85	A0A1V6QCW7	A0A1V6PM85	A0A1V6QCW7	Uncharacterized protein.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.665
A0A1V6PM85	A0A1V6QD53	A0A1V6PM85	A0A1V6QD53	Uncharacterized protein.	3Beta_HSD domain-containing protein.	0.833
A0A1V6PM85	A0A1V6QDK4	A0A1V6PM85	A0A1V6QDK4	Uncharacterized protein.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.403
A0A1V6PM85	A0A1V6QDK6	A0A1V6PM85	A0A1V6QDK6	Uncharacterized protein.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.984
A0A1V6PM85	A0A1V6QE51	A0A1V6PM85	A0A1V6QE51	Uncharacterized protein.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.714
A0A1V6PM85	A0A1V6QET3	A0A1V6PM85	A0A1V6QET3	Uncharacterized protein.	Uncharacterized protein.	0.955