(47 nodes) RNA polymerase II, holoenzyme network (Penicillium antarcticum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1V6Q210	DUF3591 domain-containing protein. (1373 aa)
	A0A1V6QL76	Uncharacterized protein. (72 aa)
	A0A1V6QL06	Acyl_transf_3 domain-containing protein. (456 aa)
	A0A1V6QJZ4	Uncharacterized protein. (366 aa)
	A0A1V6QIA4	Uncharacterized protein. (364 aa)
	A0A1V6QHV5	Uncharacterized protein. (1253 aa)
	A0A1V6QHU0	Uncharacterized protein. (169 aa)
	A0A1V6QHK1	TAFII55_N domain-containing protein. (475 aa)
	A0A1V6QHJ1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (403 aa)
	A0A1V6QHF5	BTP domain-containing protein. (215 aa)
	A0A1V6QGK4	CYCLIN domain-containing protein; Belongs to the cyclin family. (428 aa)
	A0A1V6QGF9	TAF domain-containing protein. (441 aa)
	A0A1V6QGD2	TAFII28 domain-containing protein. (383 aa)
	A0A1V6QG86	Uncharacterized protein. (821 aa)
	A0A1V6QFW3	Uncharacterized protein. (641 aa)
	A0A1V6QE75	Uncharacterized protein. (77 aa)
	A0A1V6QD22	Uncharacterized protein. (315 aa)
	A0A1V6QPC5	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (127 aa)
	A0A1V6QN31	HTH TFE/IIEalpha-type domain-containing protein. (444 aa)
	A0A1V6QN00	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (111 aa)
	A0A1V6QNM9	Uncharacterized protein. (353 aa)
	A0A1V6PRB1	CDC73_C domain-containing protein. (468 aa)
	A0A1V6PRV9	VWFA domain-containing protein. (410 aa)
	A0A1V6PSG1	Uncharacterized protein. (370 aa)
	A0A1V6PTW9	Uncharacterized protein. (683 aa)
	A0A1V6PUI5	Uncharacterized protein. (1188 aa)
	A0A1V6PUY6	TFIID_20kDa domain-containing protein. (621 aa)
	A0A1V6PWX4	RPOLD domain-containing protein. (334 aa)
	A0A1V6PWX7	Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (234 aa)
	A0A1V6PX20	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (143 aa)
	A0A1V6PXF2	CID domain-containing protein. (418 aa)
	A0A1V6PYG3	Uncharacterized protein. (381 aa)
	A0A1V6PZQ0	Plus3 domain-containing protein. (607 aa)
	A0A1V6PZQ3	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (293 aa)
	A0A1V6Q059	Uncharacterized protein. (106 aa)
	A0A1V6Q0D7	RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (482 aa)
	A0A1V6Q0U8	Uncharacterized protein. (848 aa)
	A0A1V6Q193	Uncharacterized protein. (74 aa)
	A0A1V6Q1H2	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1254 aa)
	A0A1V6Q4S0	Uncharacterized protein. (155 aa)
	A0A1V6Q4U4	RING-type domain-containing protein. (370 aa)
	A0A1V6Q688	Uncharacterized protein. (313 aa)
	A0A1V6Q6N1	RNA_pol_L_2 domain-containing protein. (170 aa)
	A0A1V6Q6T2	Uncharacterized protein. (259 aa)
	A0A1V6Q758	Uncharacterized protein. (454 aa)
	A0A1V6Q8U3	DUF4211 domain-containing protein. (685 aa)
	A0A1V6QCM1	Uncharacterized protein. (586 aa)

Your Current Organism:

Penicillium antarcticum

NCBI taxonomy Id: 416450
Other names: CBS 100492, FRR 4989, P. antarcticum

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1V6PRB1	A0A1V6PUI5	CDC73_C domain-containing protein.	Uncharacterized protein.	0.999
A0A1V6PRB1	A0A1V6PWX4	CDC73_C domain-containing protein.	RPOLD domain-containing protein.	0.935
A0A1V6PRB1	A0A1V6PX20	CDC73_C domain-containing protein.	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	0.940
A0A1V6PRB1	A0A1V6PZQ0	CDC73_C domain-containing protein.	Plus3 domain-containing protein.	0.994
A0A1V6PRB1	A0A1V6Q193	CDC73_C domain-containing protein.	Uncharacterized protein.	0.920
A0A1V6PRB1	A0A1V6Q1H2	CDC73_C domain-containing protein.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.942
A0A1V6PRB1	A0A1V6Q4S0	CDC73_C domain-containing protein.	Uncharacterized protein.	0.933
A0A1V6PRB1	A0A1V6Q6N1	CDC73_C domain-containing protein.	RNA_pol_L_2 domain-containing protein.	0.930
A0A1V6PRB1	A0A1V6Q758	CDC73_C domain-containing protein.	Uncharacterized protein.	0.999
A0A1V6PRB1	A0A1V6QCM1	CDC73_C domain-containing protein.	Uncharacterized protein.	0.999
A0A1V6PRB1	A0A1V6QE75	CDC73_C domain-containing protein.	Uncharacterized protein.	0.918
A0A1V6PRB1	A0A1V6QHU0	CDC73_C domain-containing protein.	Uncharacterized protein.	0.936
A0A1V6PRB1	A0A1V6QIA4	CDC73_C domain-containing protein.	Uncharacterized protein.	0.470
A0A1V6PRB1	A0A1V6QPC5	CDC73_C domain-containing protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	0.937
A0A1V6PRV9	A0A1V6PSG1	VWFA domain-containing protein.	Uncharacterized protein.	0.978
A0A1V6PRV9	A0A1V6PTW9	VWFA domain-containing protein.	Uncharacterized protein.	0.975
A0A1V6PRV9	A0A1V6PUY6	VWFA domain-containing protein.	TFIID_20kDa domain-containing protein.	0.895
A0A1V6PRV9	A0A1V6PWX4	VWFA domain-containing protein.	RPOLD domain-containing protein.	0.971
A0A1V6PRV9	A0A1V6PWX7	VWFA domain-containing protein.	Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...]	0.854
A0A1V6PRV9	A0A1V6PX20	VWFA domain-containing protein.	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	0.973