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A0A1V6NGI5 A0A1V6NGI5 A0A1V6NGJ4 A0A1V6NGJ4 A0A1V6NK78 A0A1V6NK78 A0A1V6PBN7 A0A1V6PBN7 A0A1V6PHE0 A0A1V6PHE0 A0A1V6PHH0 A0A1V6PHH0 A0A1V6PQA7 A0A1V6PQA7 A0A1V6PR95 A0A1V6PR95 A0A1V6PRW8 A0A1V6PRW8 A0A1V6PTE7 A0A1V6PTE7 A0A1V6PTN1 A0A1V6PTN1 A0A1V6PU20 A0A1V6PU20 A0A1V6PVT4 A0A1V6PVT4 A0A1V6PWE8 A0A1V6PWE8 A0A1V6PWP8 A0A1V6PWP8 A0A1V6PWR4 A0A1V6PWR4 A0A1V6PWT8 A0A1V6PWT8 A0A1V6PXE5 A0A1V6PXE5 A0A1V6PY49 A0A1V6PY49 MCM7 MCM7 A0A1V6PYQ8 A0A1V6PYQ8 A0A1V6PZG4 A0A1V6PZG4 A0A1V6Q170 A0A1V6Q170 A0A1V6Q1Y8 A0A1V6Q1Y8 A0A1V6Q267 A0A1V6Q267 A0A1V6Q2U4 A0A1V6Q2U4 A0A1V6Q4N2 A0A1V6Q4N2 A0A1V6Q586 A0A1V6Q586 A0A1V6Q596 A0A1V6Q596 A0A1V6Q885 A0A1V6Q885 A0A1V6Q9H9 A0A1V6Q9H9 KAE1 KAE1 A0A1V6QBQ1 A0A1V6QBQ1 PIF1 PIF1 A0A1V6QBY3 A0A1V6QBY3 A0A1V6QCJ8 A0A1V6QCJ8 A0A1V6QDD8 A0A1V6QDD8 A0A1V6QDJ5 A0A1V6QDJ5 A0A1V6QDK9 A0A1V6QDK9 A0A1V6QEA5 A0A1V6QEA5 A0A1V6QEK5 A0A1V6QEK5 A0A1V6QG26 A0A1V6QG26 A0A1V6QGW4 A0A1V6QGW4 A0A1V6QIM5 A0A1V6QIM5 A0A1V6QJJ7 A0A1V6QJJ7 A0A1V6QLG2 A0A1V6QLG2 A0A1V6QMU9 A0A1V6QMU9 A0A1V6QNY1 A0A1V6QNY1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A1V6NGI5Uncharacterized protein. (90 aa)
A0A1V6NGJ4Uncharacterized protein. (86 aa)
A0A1V6NK78Uncharacterized protein. (159 aa)
A0A1V6PBN7ATP-dependent DNA helicase; Belongs to the helicase family. (280 aa)
A0A1V6PHE0Uncharacterized protein. (610 aa)
A0A1V6PHH0Uncharacterized protein. (195 aa)
A0A1V6PQA7Uncharacterized protein. (245 aa)
A0A1V6PR95Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (635 aa)
A0A1V6PRW8DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (344 aa)
A0A1V6PTE7SAP domain-containing protein. (651 aa)
A0A1V6PTN1Uncharacterized protein. (1654 aa)
A0A1V6PU20Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2411 aa)
A0A1V6PVT4Stc1 domain-containing protein. (224 aa)
A0A1V6PWE8Rif1_N domain-containing protein. (1735 aa)
A0A1V6PWP8HTH myb-type domain-containing protein. (832 aa)
A0A1V6PWR4HTH APSES-type domain-containing protein. (446 aa)
A0A1V6PWT8Uncharacterized protein. (675 aa)
A0A1V6PXE5Uncharacterized protein. (125 aa)
A0A1V6PY49Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (505 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (808 aa)
A0A1V6PYQ8Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (511 aa)
A0A1V6PZG4HD domain-containing protein. (229 aa)
A0A1V6Q170AAA_23 domain-containing protein. (1334 aa)
A0A1V6Q1Y8Uncharacterized protein. (886 aa)
A0A1V6Q267Telomere_reg-2 domain-containing protein. (969 aa)
A0A1V6Q2U4Uncharacterized protein. (1488 aa)
A0A1V6Q4N2Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (324 aa)
A0A1V6Q586Uncharacterized protein. (564 aa)
A0A1V6Q596DNA helicase; Belongs to the MCM family. (881 aa)
A0A1V6Q885ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (497 aa)
A0A1V6Q9H9Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (354 aa)
KAE1tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (364 aa)
A0A1V6QBQ1Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1219 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (716 aa)
A0A1V6QBY3Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2912 aa)
A0A1V6QCJ8CULLIN_2 domain-containing protein; Belongs to the cullin family. (875 aa)
A0A1V6QDD8Uncharacterized protein. (126 aa)
A0A1V6QDJ5DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (628 aa)
A0A1V6QDK9ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (715 aa)
A0A1V6QEA5Uncharacterized protein. (1661 aa)
A0A1V6QEK5Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (775 aa)
A0A1V6QG26DNA helicase; Belongs to the MCM family. (720 aa)
A0A1V6QGW4Uncharacterized protein. (344 aa)
A0A1V6QIM5DRMBL domain-containing protein. (836 aa)
A0A1V6QJJ7CUE domain-containing protein. (873 aa)
A0A1V6QLG2PHD-type domain-containing protein. (841 aa)
A0A1V6QMU9Threonylcarbamoyl-AMP synthase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (428 aa)
A0A1V6QNY1Telo_bind domain-containing protein. (596 aa)
Your Current Organism:
Penicillium antarcticum
NCBI taxonomy Id: 416450
Other names: CBS 100492, FRR 4989, P. antarcticum
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