STRINGSTRING
A0A1V6Q1S4 A0A1V6Q1S4 A0A1V6Q0B8 A0A1V6Q0B8 A0A1V6Q4R6 A0A1V6Q4R6 A0A1V6Q5T8 A0A1V6Q5T8 A0A1V6Q5Y7 A0A1V6Q5Y7 EFM4 EFM4 A0A1V6QF13 A0A1V6QF13 TRM8 TRM8 A0A1V6QI91 A0A1V6QI91 A0A1V6PVF5 A0A1V6PVF5 A0A1V6QJT3 A0A1V6QJT3 A0A1V6QJW3 A0A1V6QJW3 A0A1V6QKG8 A0A1V6QKG8 EFM7 EFM7 A0A1V6Q705 A0A1V6Q705 EFM6 EFM6 A0A1V6Q913 A0A1V6Q913 A0A1V6QAJ3 A0A1V6QAJ3 A0A1V6PQK1 A0A1V6PQK1 A0A1V6PQV1 A0A1V6PQV1 A0A1V6PXI0 A0A1V6PXI0 A0A1V6PXD1 A0A1V6PXD1 A0A1V6PWS5 A0A1V6PWS5 A0A1V6PWK3 A0A1V6PWK3 COQ5 COQ5 A0A1V6QBM1 A0A1V6QBM1 A0A1V6PS26 A0A1V6PS26 A0A1V6PSB4 A0A1V6PSB4 A0A1V6PSQ1 A0A1V6PSQ1 A0A1V6PTW5 A0A1V6PTW5 A0A1V6PU46 A0A1V6PU46 A0A1V6PUN6 A0A1V6PUN6 A0A1V6PUY1 A0A1V6PUY1 A0A1V6PV21 A0A1V6PV21 A0A1V6PZF5 A0A1V6PZF5 A0A1V6PY49 A0A1V6PY49 SPB1 SPB1 COQ3 COQ3 A0A1V6QL27 A0A1V6QL27 A0A1V6QMM5 A0A1V6QMM5 A0A1V6QMU7 A0A1V6QMU7 A0A1V6QQ33 A0A1V6QQ33 A0A1V6Q3J5 A0A1V6Q3J5 A0A1V6Q4F7 A0A1V6Q4F7 A0A1V6QBQ3 A0A1V6QBQ3 A0A1V6QDT5 A0A1V6QDT5 A0A1V6Q2C7 A0A1V6Q2C7 TRM5 TRM5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A1V6Q1S4Methyltransf_2 domain-containing protein. (396 aa)
A0A1V6Q0B8Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. (1200 aa)
A0A1V6Q4R6Methyltransf_2 domain-containing protein. (386 aa)
A0A1V6Q5T8Methyltransf_2 domain-containing protein. (396 aa)
A0A1V6Q5Y7Phosphatidyl-N-methylethanolamine N-methyltransferase; Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC). (201 aa)
EFM4Protein-lysine N-methyltransferase EFM4; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family. (333 aa)
A0A1V6QF13rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (383 aa)
TRM8tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (345 aa)
A0A1V6QI91Protein-L-isoaspartate O-methyltransferase. (239 aa)
A0A1V6PVF5Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (422 aa)
A0A1V6QJT3Methyltransf_2 domain-containing protein. (398 aa)
A0A1V6QJW3Methyltransf_2 domain-containing protein. (426 aa)
A0A1V6QKG8Uncharacterized protein. (549 aa)
EFM7Protein N-terminal and lysine N-methyltransferase EFM7; S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono-and dimethylation of 'Lys-3'. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family. (267 aa)
A0A1V6Q705Methyltransf_2 domain-containing protein. (389 aa)
EFM6Protein-lysine N-methyltransferase EFM6; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha. Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily. (238 aa)
A0A1V6Q913Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (541 aa)
A0A1V6QAJ3Bin3-type SAM domain-containing protein. (140 aa)
A0A1V6PQK1Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (575 aa)
A0A1V6PQV1Methyltransf_2 domain-containing protein. (415 aa)
A0A1V6PXI0TRAM domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (545 aa)
A0A1V6PXD12-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. (435 aa)
A0A1V6PWS5Protein arginine N-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. (853 aa)
A0A1V6PWK3Methyltransf_2 domain-containing protein. (386 aa)
COQ52-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (310 aa)
A0A1V6QBM1Uncharacterized protein. (237 aa)
A0A1V6PS26FtsJ domain-containing protein. (270 aa)
A0A1V6PSB4SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (750 aa)
A0A1V6PSQ1Ribosomal RNA-processing protein 8; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Belongs to the methyltransferase superfamily. RRP8 family. (508 aa)
A0A1V6PTW5Methyltransf_2 domain-containing protein. (386 aa)
A0A1V6PU46Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (703 aa)
A0A1V6PUN625S rRNA adenine-N(1) methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA; Belongs to the BMT2 family. (283 aa)
A0A1V6PUY1Uncharacterized protein; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (899 aa)
A0A1V6PV21Uncharacterized protein. (822 aa)
A0A1V6PZF5SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (574 aa)
A0A1V6PY49Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (505 aa)
SPB1AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (811 aa)
COQ3Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (353 aa)
A0A1V6QL27Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. (377 aa)
A0A1V6QMM5Phosphatidylethanolamine N-methyltransferase; Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME); Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family. (974 aa)
A0A1V6QMU7Methyltransf_2 domain-containing protein. (443 aa)
A0A1V6QQ33SET domain-containing protein. (667 aa)
A0A1V6Q3J5mRNA cap guanine-N7 methyltransferase. (535 aa)
A0A1V6Q4F7Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (349 aa)
A0A1V6QBQ3Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (625 aa)
A0A1V6QDT52-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2; Belongs to the DPH1/DPH2 family. DPH2 subfamily. (567 aa)
A0A1V6Q2C7Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (416 aa)
TRM5tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (730 aa)
Your Current Organism:
Penicillium antarcticum
NCBI taxonomy Id: 416450
Other names: CBS 100492, FRR 4989, P. antarcticum
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.