STRINGSTRING
hom hom ldhX ldhX ribD ribD ugd ugd mleS mleS butA butA butB butB fabG1 fabG1 aroE aroE adhA adhA llmg_2205 llmg_2205 adhE adhE gntZ gntZ zwf zwf ywjF ywjF mtlD mtlD cbr cbr dltE dltE rmlD rmlD guaB guaB dar dar ldhB ldhB llmg_0475 llmg_0475 serA serA gnd gnd icd icd uxuB uxuB mvaA mvaA llmg_0945 llmg_0945 llmg_0955 llmg_0955 gpsA gpsA ldh ldh panE panE ilvC ilvC hisD hisD murB murB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
homHom protein; High confidence in function and specificity. (428 aa)
ldhXL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (323 aa)
ribDRiboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (362 aa)
ugdUDP-glucose 6-dehydrogenase; High confidence in function and specificity. (389 aa)
mleSMalolactic enzyme; High confidence in function and specificity. (540 aa)
butAAcetoin reductase; High confidence in function and specificity. (253 aa)
butB2,3-butanediol dehydrogenase; High confidence in function and specificity. (326 aa)
fabG13-oxoacyl-[acyl-carrier protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (243 aa)
aroEAroE protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (286 aa)
adhAZinc-containing alcohol dehydrogenase superfamily; High confidence in function and specificity. (340 aa)
llmg_2205Conserved hypothetical protein; Bacterial bifunctional deaminase-reductase, C-terminal. (173 aa)
adhEPF00465.7: Iron-containing alcohol dehydrogenase; High confidence in function and specificity; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (903 aa)
gntZGntZ protein; PF03446: NAD binding domain of 6-phosphogluconate dehydrogenase, TIGR00872: gnd_rel: 6-phosphogluconate dehydrogenase (decarboxylating); High confidence in function and specificity. (301 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (503 aa)
ywjFPutative 3-hydroxyisobutyrate dehydrogenase; TIGR01505: 2-hydroxy-3-oxopropionate reductase; Conserved hypothetical protein. (293 aa)
mtlDMannitol-1-phosphate 5-dehydrogenase; High confidence in function and specificity. (388 aa)
cbrCarbonyl reductase cbr; 3-oxoacyl-[acyl-carrier-protein] reductase, Short-chain dehydrogenase/reductase SDR, Fatty acid biosynthesis pathway; High confidence in function and specificity. (261 aa)
dltEOxidoreductase dltE; 3-oxoacyl-[acyl-carrier-protein] reductase, Short-chain dehydrogenase/reductase SDR, Fatty acid biosynthesis pathway; High confidence in function and specificity; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
rmlDdTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (299 aa)
guaBInositol-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (493 aa)
darAcetoin(diacetyl)reductase; High confidence in function and specificity. (256 aa)
ldhBL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (314 aa)
llmg_0475Malate/lactate dehydrogenase; Similar to ldhB; Specificity unclear; Belongs to the LDH/MDH superfamily. (304 aa)
serAD-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; High confidence in function and specificity. (398 aa)
gnd6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (472 aa)
icdIsocitrate dehydrogenase; High confidence in function and specificity. (412 aa)
uxuBFructuronate reductase; High confidence in function and specificity. (544 aa)
mvaAMvaA protein; High confidence in function and specificity; Belongs to the HMG-CoA reductase family. (410 aa)
llmg_0945Putative glycerol dehydrogenase; High confidence in function and specificity. (359 aa)
llmg_0955PF00107.12: Zinc-containing alcohol dehydrogenase superfamily; High confidence in function and specificity. (348 aa)
gpsAGpsA protein; High confidence in function and specificity; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (342 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (325 aa)
panE2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (312 aa)
ilvCIlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (340 aa)
hisDHisD protein; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa)
murBMurB protein; Cell wall formation. (299 aa)
Your Current Organism:
Lactococcus lactis
NCBI taxonomy Id: 416870
Other names: L. lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris str. MG1363, Lactococcus lactis subsp. cremoris strain MG1363
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