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| | dnaA | Replication initiation protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (454 aa) |
| | llmg_1908 | O-methyltransferase, family 3; High confidence in function and specificity. (230 aa) |
| | recD | Exodeoxyribonuclease V alpha chain; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (833 aa) |
| | comEA | Pseudogene; Putative competence protein, contains a frameshift around position 1032; High confidence in function and specificity. (204 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1207 aa) |
| | rpoB | DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1196 aa) |
| | llmg_1986 | Conserved hypothetical protein; Putative methylated-DNA--protein-cysteine methyltransferase; High confidence in function and specificity. (101 aa) |
| | recQ | ATP-requiring DNA helicase RecQ; High confidence in function and specificity. (592 aa) |
| | uvrA | UvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (943 aa) |
| | asnS | asparaginyl-tRNA synthetase; High confidence in function and specificity. (447 aa) |
| | dinG | Probable ATP-dependent helicase dinG homolog; 3'-5' exonuclease. (791 aa) |
| | gidA | Glucose inhibited division protein A; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (625 aa) |
| | mrnC | Ribonuclease III (EC 3.1.26.3) (RNase III); Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors; Belongs to the MrnC RNase family. (139 aa) |
| | cysS | CysS protein; Cysteinyl-tRNA synthetase; High confidence in function and specificity; Belongs to the class-I aminoacyl-tRNA synthetase family. (448 aa) |
| | pnpA | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (766 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (932 aa) |
| | trmH | 23S ribosomal RNA methyltransferase, TrmH family; High confidence in function and specificity; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (242 aa) |
| | sunL | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (424 aa) |
| | ps439 | Conserved hypothetical protein; Putative restriction endonuclease. (172 aa) |
| | tnp712-8 | Transposase for insertion sequence element IS712H. (407 aa) |
| | ps416 | Single-strand binding protein ssB; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (141 aa) |
| | ps415 | Putative translation initiation factor. (123 aa) |
| | ps401 | Phage integrase family; High confidence in function and specificity; Belongs to the 'phage' integrase family. (404 aa) |
| | fmt | Methionyl tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (323 aa) |
| | priA | Primosomal protein N' (Replication factor Y); Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (781 aa) |
| | rpoZ | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (117 aa) |
| | rny | Hypothetical protein; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. (531 aa) |
| | thrS | ThrS protein; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (646 aa) |
| | llmg_2173 | Hypothetical protein. (96 aa) |
| | tnp904-6 | Transposase for insertion sequence element IS904I. (253 aa) |
| | pheT-2 | phenylalanyl-tRNA synthetase beta chain; High confidence in function and specificity; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (797 aa) |
| | pheS | phenylalanyl-tRNA synthetase alpha chain; High confidence in function and specificity; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (345 aa) |
| | llmg_2209 | tRNA-dihydrouridine synthase B (EC 1.-.-.-); Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (334 aa) |
| | aspS | AspS protein; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (590 aa) |
| | hisS | HisS protein; Histidyl-tRNA synthetase, class IIa; High confidence in function and specificity. (430 aa) |
| | recF | DNA replication and repair protein recF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (359 aa) |
| | ps501 | PF00589: Phage integrase family; Conserved hypothetical protein; Belongs to the 'phage' integrase family. (393 aa) |
| | llmg_2300 | Conserved hypothetical protein; PF00581: Rhodanese-like domain. (128 aa) |
| | dinP | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (364 aa) |
| | llmg_2306 | Conserved hypothetical protein; IPR007214: YbaK/prolyl-tRNA synthetase associated region. (163 aa) |
| | argS | ArgS protein; PF00750: tRNA synthetases class I, TIGR00456: arginyl-tRNA synthetase; High confidence in function and specificity. (564 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (483 aa) |
| | radA | Putative ATP-dependent protease; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (453 aa) |
| | rpoA | RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (312 aa) |
| | nusG | Transcription antitermination protein nusG; Participates in transcription elongation, termination and antitermination. (185 aa) |
| | rluA | Ribosomal large subunit pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (290 aa) |
| | polC | DNA polymerase III alpha subunit; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1635 aa) |
| | proS | Pseudogene; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of [...] (616 aa) |
| | rlmH | Conserved hypothetical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (159 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. (877 aa) |
| | comX | Competence regulator ComX; Sigma factor, regulation of competence. (163 aa) |
| | llmg_2444 | PF03602:Conserved hypothetical protein 95, TIGR00095: methyltransferase, putative. (179 aa) |
| | valS | ValS protein; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (880 aa) |
| | llmg_2464 | Putative RNA methyltransferase; PF01938: TRAM domain, TIGR00479: 23S rRNA (uracil-5-)-methyltransferase RumA; Conserved hypothetical protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (513 aa) |
| | ssbB | Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (166 aa) |
| | dnaX | DNA polymerase III subunits gamma / tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (553 aa) |
| | ruvB | Holliday junction DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (333 aa) |
| | ruvA | Holliday junction DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (197 aa) |
| | mutL | DNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (656 aa) |
| | mutS-2 | DNA mismatch repair protein mutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (840 aa) |
| | tnp905-7 | Transposase for insertion sequence element IS905N; PF00872: Transposase, Mutator family; Conserved hypothetical protein. (391 aa) |
| | dnaJ | Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (379 aa) |
| | llmg_2518 | Ribosomal small subunit pseudouridine synthase A; Region start changed from 2476018 to 2476276 (258 bases); Belongs to the pseudouridine synthase RsuA family. (328 aa) |
| | trmE | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (455 aa) |
| | recG | ATP-dependent DNA helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (666 aa) |
| | ps601 | PF00589: Phage integrase family; Conserved hypothetical protein; Belongs to the 'phage' integrase family. (392 aa) |
| | ps614 | Hypothetical protein predicted by Glimmer/Critica; Similar to ps101 in L. lactis IL1403. (107 aa) |
| | rnhA | RnhA protein; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. RnhC subfamily. (292 aa) |
| | scpA | Segregation and condensation protein A; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. (242 aa) |
| | tnp905 | Transposase for insertion sequence element IS905A; Required for the transposition of the insertion element. (391 aa) |
| | recO | DNA repair protein recO; Involved in DNA repair and RecF pathway recombination. (251 aa) |
| | trpS | TrpS protein; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (341 aa) |
| | cshA | Chromosome segregation helicase; High confidence in function and specificity. (419 aa) |
| | llmg_0111 | Conserved hypothetical protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (250 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (151 aa) |
| | llmg_0121 | Conserved hypothetical protein; Putative transposase helper protein for IS904. (96 aa) |
| | tnp904 | Transposase for insertion sequence element IS904A; Integrase, catalytic region; Conserved hypothetical protein. (253 aa) |
| | rnpA | Ribonuclease P; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (117 aa) |
| | llmg_0151 | Putative Hollyday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. (143 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] (382 aa) |
| | llmg_0168 | Deoxyribonuclease; DNA/RNA non-specific endonuclease; High confidence in function and specificity. (261 aa) |
| | rlmN | Conserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (365 aa) |
| | tmcAL | Putative nucleotidyltransferase; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. (379 aa) |
| | ung | Pseudogene; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (219 aa) |
| | llmg_0281 | Anaerobic ribonucleoside-triphosphate reductase; Region start changed from 267151 to 267262 (-111 bases). (747 aa) |
| | rnj | Putative Zn-dependent hydrolase; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (561 aa) |
| | llmg_0304 | Conserved hypothetical protein; Protein of unknown function DUF1447; Belongs to the UPF0356 family. (76 aa) |
| | llmg_0306 | Putative O-sialoglycoprotein endopeptidase; Family membership. (241 aa) |
| | gcp | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (341 aa) |
| | llmg_0333 | Conserved hypothetical protein; YbaK/prolyl-tRNA synthetase associated region, PF04073.3: YbaK_EbsC: ybaK/ebsC protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (158 aa) |
| | recR | Recombination protein recR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (198 aa) |
| | rheA | ATP-dependent RNA helicase; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily. (551 aa) |
| | fpg | Fpg protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (272 aa) |
| | recA | Recombination protein A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (387 aa) |
| | rluE | Ribosomal large subunit pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (293 aa) |
| | lysS | lysyl-tRNA synthetase; High confidence in function and specificity; Belongs to the class-II aminoacyl-tRNA synthetase family. (494 aa) |
| | thiI | Thiamine biosynthesis protein thiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (406 aa) |
| | tyrS | Tyrosine-tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (419 aa) |
| | ssbA | Helix-destabilizing protein, Nucleic acid-binding OB-fold; High confidence in function and specificity. (129 aa) |
| | vicX | Ribonuclease Z (tRNA 3 endonuclease)., Beta-lactamase-like, Metallo-beta-lactamase superfamily; High confidence in function and specificity. (270 aa) |
| | holB | holB: DNA polymerase III, delta prime subunit; High confidence in function and specificity. (286 aa) |
| | llmg_0418 | Conserved hypothetical protein; Involved in initiation control of chromosome replication. Belongs to the YabA family. (108 aa) |
| | rsmI | Conserved hypothetical protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (291 aa) |
| | rheB | ATP-dependent RNA helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. (446 aa) |
| | ligA | DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (686 aa) |
| | llmg_0459 | Conserved hypothetical protein; Uncharacterised P-loop hydrolase UPF0079. (148 aa) |
| | truA | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (253 aa) |
| | dnaE | DNA polymerase III alpha subunit; High confidence in function and specificity. (1070 aa) |
| | ogt | Methylated-DNA--protein-cysteine methyltransferase; High confidence in function and specificity. (169 aa) |
| | adaA | methylphosphotriester-DNA alkyltransferase; High confidence in function and specificity. (182 aa) |
| | recU | Putative recombination protein U; Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation; Belongs to the RecU family. (213 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (637 aa) |
| | rpoD | RNA polymerase sigma factor rpoD (Sigma-42); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (447 aa) |
| | uvrB | UvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] (692 aa) |
| | tnp981 | Transposase for insertion sequence element IS981A; Integrase core domain; High confidence in function and specificity. (279 aa) |
| | ymbI-2 | Conserved hypothetical protein; Putative transposase helper protein for IS981. (86 aa) |
| | tnp905-2 | Transposase for insertion sequence element IS905B; Required for the transposition of the insertion element. (391 aa) |
| | tdk | Tdk protein; High confidence in function and specificity. (189 aa) |
| | spoU | 23S rRNA (guanosine-2'-O-)-methyltransferase, rRNA_methyl_3: RNA methyltransferase, TrmH family, group 3; High confidence in function and specificity; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (252 aa) |
| | miaA | tRNA isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (294 aa) |
| | ps201 | Phage integrase; DNA breaking-rejoining enzyme, catalytic core, site-specific recombinase, phage integrase family; High confidence in function and specificity; Belongs to the 'phage' integrase family. (338 aa) |
| | rnz | Ribonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (307 aa) |
| | recJ | Single strand DNA-specific exonuclease; DHH family; High confidence in function and specificity. (742 aa) |
| | rpoE | DNA-directed RNA polymerase delta chain; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family. (188 aa) |
| | tnp1077-2 | Pseudogene; Transposase for insertion sequence IS1077B (fragment), Integrase, catalytic region; High confidence in function and specificity. (96 aa) |
| | tnp904-7 | Transposase for insertion sequence element IS904B; Region start changed from 601339 to 601417 (-78 bases). (253 aa) |
| | xerD | Integrase-recombinase; DNA breaking-rejoining enzyme, catalytic core, Phage integrase family; Conserved hypothetical protein; Belongs to the 'phage' integrase family. (311 aa) |
| | tnp981-2 | Pseudogene; Transposase for insertion sequence element IS-LL6A (fragment), contains several frameshifts, the first at position 182. (279 aa) |
| | llmg_0622 | Conserved hypothetical protein; Putative transposase helper protein for IS981. (86 aa) |
| | tnp981-3 | Transposase for insertion sequence element IS981C; Integrase, catalytic region; High confidence in function and specificity. (279 aa) |
| | llmg_0648 | Conserved hypothetical protein; Putative transposase helper protein for IS981; Family membership. (86 aa) |
| | llmg_0652 | Transposase for insertion sequence element IS904C; Region start changed from 648046 to 647968 (-78 bases). (253 aa) |
| | llmg_0653 | Conserved hypothetical protein; Putative transposase helper protein for insertion sequence element IS904. (50 aa) |
| | tnpIS-LL6 | Transposase for insertion sequence element IS-LL6B; Integrase, catalytic region; High confidence in function and specificity. (206 aa) |
| | llmg_0655 | Transposase; Contains Homeodomain-like region; Family membership. (91 aa) |
| | hsdR | Type I restriction-modification system restriction subunit; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1058 aa) |
| | hsdM | Putative type I site-specific deoxyribonuclease; Type I restriction modification system, M subunit; Specificity unclear. (545 aa) |
| | hsdS | Probable specificity determinant HsdS; Type I restriction modification DNA specificity subunit; Specificity unclear. (416 aa) |
| | tnp1297 | Transposase for insertion sequence element IS1297; High confidence in function and specificity. (226 aa) |
| | tnp712-2 | Transposase for insertion sequence element IS712B; Integrase, catalytic region; Specificity unclear. (407 aa) |
| | tnp1675 | Transposase DDE domain; Specificity unclear. (439 aa) |
| | tnpR | DNA-invertase/resolvase; High confidence in function and specificity. (184 aa) |
| | tnp981-5 | Transposase for insertion sequence element IS981F; Integrase, catalytic region; High confidence in function and specificity. (279 aa) |
| | tnp946 | Transposase for insertion sequence element IS946; Integrase, catalytic region, also known as iso-ISS1; High confidence in function and specificity. (226 aa) |
| | llmg_0720 | Conserved hypothetical protein; Putative transposase helper protein for IS981. (86 aa) |
| | tnp981-6 | Transposase for insertion sequence element IS981G; Integrase, catalytic region; High confidence in function and specificity. (279 aa) |
| | serS | SerS protein; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (423 aa) |
| | holA | Putative DNA polymerase III, delta subunit; High confidence in function and specificity. (334 aa) |
| | llmg_0771 | Putative N6-adenine-specific DNA methylase; Family membership; Belongs to the methyltransferase superfamily. (384 aa) |
| | mutS | DNA mismatch repair protein mutS; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (776 aa) |
| | ps301 | PF00589: Phage integrase family; High confidence in function and specificity; Belongs to the 'phage' integrase family. (377 aa) |
| | ps314 | Conserved hypothetical protein; PF07211: Protein of unknown function DUF1417. (172 aa) |
| | ps320 | Conserved hypothetical protein; Putative holliday junction resolvase, PF05866: Endodeoxyribonuclease RusA; High confidence in function and specificity. (161 aa) |
| | tnp712-4 | Transposase for insertion sequence element IS712D; PF00665: Integrase core domain; Conserved hypothetical protein. (407 aa) |
| | rnj-2 | Metallo-beta-lactamase superfamily protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (570 aa) |
| | pyrR | Pyrimidine operon attenuation protein / uracil phosphoribosyltransferase; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines, probably by binding to specific sites on pyr mRNA. This probably disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. (173 aa) |
| | ymbI | Conserved hypothetical protein; Putative helper protein for IS981. (86 aa) |
| | tnp981-7 | Transposase for insertion sequence element IS981H; Integrase, catalytic region; High confidence in function and specificity. (279 aa) |
| | rimM | 16S rRNA processing protein rimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (171 aa) |
| | trmD | tRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (251 aa) |
| | papL | poly(A) polymerase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (402 aa) |
| | llmg_0981 | Conserved hypothetical protein; Putative transposase helper protein for IS904. (96 aa) |
| | tnp904-2 | Pseudogene; Transposase for insertion sequence element IS904D, contains a frameshift at position 230; Conserved hypothetical protein. (193 aa) |
| | tnp1216 | Transposase for insertion sequence-like element IS1216; Integrase, catalytic region; High confidence in function and specificity. (226 aa) |
| | rsmC | Ribosomal RNA small subunit methyltransferase C; High confidence in function and specificity. (198 aa) |
| | llmg_1073 | Transposase for insertion sequence element IS904E (fragment); Integrase, catalytic region, 30 aa from the C-terminus are missing, possibly inactive; High confidence in function and specificity. (238 aa) |
| | tnp712-5 | Transposase for insertion sequence element IS712E; Integrase, catalytic region; Specificity unclear. (407 aa) |
| | queH | Conserved hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (241 aa) |
| | rluC | Ribosomal large subunit pseudouridine synthase; High confidence in function and specificity; Belongs to the pseudouridine synthase RsuA family. (177 aa) |
| | gidB | Glucose-inhibited division protein; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (238 aa) |
| | sbcD | Nuclease SbcCD subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (390 aa) |
| | tnp905-4 | Transposase for insertion sequence element IS905F; High confidence in function and specificity. (391 aa) |
| | tnp981-8 | Transposase for insertion sequence element IS981I; High confidence in function and specificity. (279 aa) |
| | llmg_1145 | Conserved hypothetical protein; Putative transposase helper protein for IS981. (86 aa) |
| | rnhB | RnhB protein; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (257 aa) |
| | xerD2 | Tyrosine recombinase xerD2; Putative tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site. Belongs to the 'phage' integrase family. XerD-like subfamily. (238 aa) |
| | ps101 | Phage integrase; DNA breaking-rejoining enzyme, catalytic core, Tyrosine recombinase xerD; Conserved hypothetical protein; Belongs to the 'phage' integrase family. (394 aa) |
| | scpB | Segregation and condensation protein B; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (188 aa) |
| | rluB | PF00849: RNA pseudouridylate synthase; High confidence in function and specificity; Belongs to the pseudouridine synthase RsuA family. (257 aa) |
| | tnp1077-5 | Pseudogene; Transposase for insertion sequence element IS1077E (fragment), PF00665: Integrase core domain; Conserved hypothetical protein. (193 aa) |
| | llmg_1232 | Conserved hypothetical protein; Putative transposase helper protein for IS904. (96 aa) |
| | tnp981-9 | Transposase for insertion element IS981J; PF00665: Integrase core domain; High confidence in function and specificity. (279 aa) |
| | llmg_1234 | Conserved hypothetical protein; Putative transposase helper protein for IS981. (86 aa) |
| | llmg_1249 | Conserved hypothetical protein; Putative pyridine nucleotide-disulphide oxidoreductase, PF00070: Pyridine nucleotide-disulphide oxidoreductase. (553 aa) |
| | tnp712-6 | Transposase for insertion sequence element IS712F; PF00665: Integrase core domain; Conserved hypothetical protein. (407 aa) |
| | llmg_1264 | Putative transposase helper protein for IS981. (86 aa) |
| | tnp981-10 | Transposase for insertion sequence element IS981J. (204 aa) |
| | ceo2 | Pseudogene; N5-carboxyethyl-ornithine synthase, PF01262: Alanine dehydrogenase/PNT, C-terminal domain, possible pseudogene; High confidence in function and specificity; Belongs to the 'phage' integrase family. (351 aa) |
| | xerS | Tyrosine recombinase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. Binds an atypical recombination dif site (difSL). Binds preferentially to the left arm and cooperatively to the right arm of difSL ; Belongs to the 'phage' integrase family. XerS subfamily. (356 aa) |
| | gidC | GidC protein; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. (448 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (708 aa) |
| | leuA | Pseudogene; 2-isopropylmalate synthase, Contains a frameshift around position 558, PF00682: HMGL-like, TIGR02090: isopropylmalate/citramalate/homocitrate synthases; High confidence in function and specificity; Belongs to the UPF0176 family. (319 aa) |
| | vacB2 | Putative exoribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (667 aa) |
| | llmg_1315 | TIGR00479: 23S rRNA (uracil-5-)-methyltransferase RumA, PF05958: tRNA (Uracil-5-)-methyltransferase, PF01938: TRAM domain; Conserved hypothetical protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (456 aa) |
| | tnp905-5 | Transposase for insertion sequence element IS905H; PF00872: Transposase, Mutator family; High confidence in function and specificity. (391 aa) |
| | tnp905-6 | Transposase for insertion sequence element IS905I; PF00872: Transposase, Mutator family; High confidence in function and specificity. (391 aa) |
| | spoU-2 | Putative rRNA methyltransferase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. (196 aa) |
| | llmg_1361 | Putative tyrosine recombinase; ORF45; XerC-like, PF00589: Phage integrase family, TIGR02224: tyrosine recombinase XerC; Belongs to the 'phage' integrase family. (357 aa) |
| | tnp981-11 | Transposase for insertion sequence element IS981K; High confidence in function and specificity. (279 aa) |
| | llmg_1368 | Putative transposase helper protein for IS981; ORF39. (86 aa) |
| | matR | Maturase; Multifunctional protein that promotes group II intron splicing and mobility by acting both on RNA and DNA. It has three activities: reverse transcriptase (RT) for intron duplication, maturase to promote splicing, and DNA endonuclease for site-specific cleavage of recipient alleles. The intron-encoded protein promotes splicing by facilitating the formation of the catalytically active structure of the intron RNA. After splicing, the protein remains bound to the excised intron lariat RNA, forming ribonucleoprotein particles, and cleaving the antisense strand of the recipient DNA [...] (599 aa) |
| | ltrE | LtrE protein; Putative DNA topoisomerase, IPR000380: DNA topoisomerase I; High confidence in function and specificity. (216 aa) |
| | llmg_1379 | Predicted Zn peptidase. (394 aa) |
| | llmg_1400 | Hypothetical protein; ORF9; PF00226: DnaJ domain. (99 aa) |
| | truB | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (330 aa) |
| | tnp981-12 | Transposase for insertion sequence element IS981L; Integrase, catalytic region; High confidence in function and specificity. (279 aa) |
| | llmg_1438 | Conserved hypothetical protein; Putative transposase helper protein for IS981. (86 aa) |
| | pcrA | ATP-dependent DNA helicase; High confidence in function and specificity. (758 aa) |
| | gyrA | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (836 aa) |
| | glyS | glycyl-tRNA synthetase beta chain; High confidence in function and specificity. (673 aa) |
| | glyQ | glycyl-tRNA synthetase alpha chain; High confidence in function and specificity. (317 aa) |
| | ybeY | Conserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (162 aa) |
| | llmg_1500 | Similar to SAM-dependent methyltransferases; Conserved hypothetical protein. (229 aa) |
| | nth | Putative endonuclease III (DNA repair); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (218 aa) |
| | rluD | Ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (301 aa) |
| | parC | Topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. (824 aa) |
| | dnaQ | DNA polymerase III, epsilon chain; High confidence in function and specificity. (277 aa) |
| | parE | DNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily. (644 aa) |
| | nrdE | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (722 aa) |
| | nrdF | Ribonucleoside-diphosphate reductase beta chain; High confidence in function and specificity. (325 aa) |
| | whiA | Conserved hypothetical protein; Involved in cell division and chromosome segregation. (305 aa) |
| | llmg_1564 | Conserved hypothetical protein; Putative transposase helper protein for IS904; High confidence in function and specificity. (96 aa) |
| | tnp904-3 | Transposase for insertion sequence IS904F; Integrase, catalytic region; High confidence in function and specificity. (253 aa) |
| | llmg_1566 | Hypothetical protein predicted by Glimmer/Critica; High confidence in function and specificity. (193 aa) |
| | llmg_1584 | Endonuclease/exonuclease/phosphatase family protein; Family membership. (352 aa) |
| | vacB1 | Putative exoribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (819 aa) |
| | gyrB | Topoisomerase IV subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (651 aa) |
| | tnp981-13 | Transposase for insertion sequence element IS981M; Integrase, catalytic region; High confidence in function and specificity. (279 aa) |
| | llmg_1655 | Conserved hypothetical protein; Putative transposase helper protein for IS981; High confidence in function and specificity. (86 aa) |
| | xerD-2 | Putative integrase/recombinase; Similar to phage integrase family proteins; High confidence in function and specificity; Belongs to the 'phage' integrase family. (324 aa) |
| | mraW | S-adenosyl-methyltransferase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (317 aa) |
| | recN | DNA repair protein recN; May be involved in recombinational repair of damaged DNA. (555 aa) |
| | xseB | Pseudogene; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (79 aa) |
| | xseA | Exodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (417 aa) |
| | llmg_1714 | Conserved hypothetical protein; Putative transposase helper protein for IS981; Specificity unclear. (86 aa) |
| | llmg_1715 | Conserved hypothetical protein; Putative transposase helper protein for IS904. (96 aa) |
| | tnp904-4 | Transposase for insertion sequence IS904G; Integrase, catalytic region; High confidence in function and specificity. (253 aa) |
| | mutY | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (386 aa) |
| | uvrC | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (669 aa) |
| | trmU | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (384 aa) |
| | leuS | LeuS protein; High confidence in function and specificity; Belongs to the class-I aminoacyl-tRNA synthetase family. (829 aa) |
| | smc | Chromosome segregation protein smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1174 aa) |
| | rnc | Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (231 aa) |
| | metS | MetS protein; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. (662 aa) |
| | exoA | 3'-exo-deoxyribonuclease; Exodeoxyribonuclease A; High confidence in function and specificity. (285 aa) |
| | noxC | NADH oxidase; High confidence in function and specificity. (547 aa) |
| | llmg_1771 | Putative rhodanese-related sulfurtransferase; Contains rhodanese-like domain; Conserved hypothetical protein. (102 aa) |
| | llmg_1772 | Putative rhodanese-related sulfurtransferase; Contains Rhodanese-like domain; Conserved hypothetical protein. (125 aa) |
| | rbfA | Ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (119 aa) |
| | nusA | Transcription elongation factor nusA; Participates in both transcription termination and antitermination. (382 aa) |
| | trmB | tRNA (guanine-N7-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (217 aa) |
| | dnaC | DnaC protein; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (455 aa) |
| | tnp981-15 | Transposase for insertion sequence element IS981O; Integrase, catalytic region; High confidence in function and specificity. (279 aa) |
| | llmg_1841 | Conserved hypothetical protein; Putative transposase helper protein for IS981. (86 aa) |
| | llmg_1842 | Hypothetical protein predicted by Glimmer/Critica; SSF56349: DNA breaking-rejoining enzyme, catalytic core, fragment. (34 aa) |
| | tadA | Conserved hypothetical protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (155 aa) |
| | nusB | Pseudogene; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (325 aa) |
| | ksgA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (294 aa) |
| | rnmV | Conserved hypothetical protein; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step. (186 aa) |
| | tatD | TatD-related deoxyribonuclease, TIGR00010: hydrolase, TatD family; High confidence in function and specificity. (257 aa) |
| | intTn5276 | IntTn5276 protein; DNA breaking-rejoining enzyme, catalytic core; Conserved hypothetical protein; Belongs to the 'phage' integrase family. (379 aa) |
| | alaS | AlaS protein; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (872 aa) |
| | tnp712 | Transposase for insertion sequence element IS712A. (407 aa) |
| | ps130 | Conserved hypothetical protein. (107 aa) |
| | mesJ | Cell cycle protein mesJ; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (422 aa) |
| | mfd | Transcription-repair coupling factor (TRCF); Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1180 aa) |
| | rexA | ATP-dependent nuclease subunit A; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the L.lactis chi site (5'-GCGCGTG-3'), which stimulates homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has 3'->5' exonuclease activity and probably also performs the helicase function. Belongs to the helicase family. AddA subfamily. (1203 aa) |
| | rexB | ATP-dependent nuclease subunit B; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the L.lactis chi site (5'-GCGCGTG-3'), which stimulates homologous recombination. This subunit has 5'->3' exonuclease activity. (1099 aa) |
| | dnaN | Beta subunit of DNA polymerase III; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation [...] (380 aa) |
