node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
gnd | gntZ | llmg_0586 | llmg_2469 | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. | GntZ protein; PF03446: NAD binding domain of 6-phosphogluconate dehydrogenase, TIGR00872: gnd_rel: 6-phosphogluconate dehydrogenase (decarboxylating); High confidence in function and specificity. | 0.912 |
gntZ | gnd | llmg_2469 | llmg_0586 | GntZ protein; PF03446: NAD binding domain of 6-phosphogluconate dehydrogenase, TIGR00872: gnd_rel: 6-phosphogluconate dehydrogenase (decarboxylating); High confidence in function and specificity. | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. | 0.912 |
gpsA | proC | llmg_1114 | llmg_2077 | GpsA protein; High confidence in function and specificity; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | Pyrroline carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.766 |
gpsA | tyrA | llmg_1114 | llmg_1927 | GpsA protein; High confidence in function and specificity; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | TyrA protein; Predicted prephenate dehydrogenase, feedback inhibition-sensitive, Prephenate dehydrogenase; High confidence in function and specificity; Belongs to the prephenate/arogenate dehydrogenase family. | 0.659 |
ilvC | panE | llmg_1277 | llmg_1131 | IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.600 |
ilvC | proC | llmg_1277 | llmg_2077 | IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Pyrroline carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.429 |
panE | ilvC | llmg_1131 | llmg_1277 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.600 |
proC | gpsA | llmg_2077 | llmg_1114 | Pyrroline carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | GpsA protein; High confidence in function and specificity; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.766 |
proC | ilvC | llmg_2077 | llmg_1277 | Pyrroline carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.429 |
proC | tyrA | llmg_2077 | llmg_1927 | Pyrroline carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | TyrA protein; Predicted prephenate dehydrogenase, feedback inhibition-sensitive, Prephenate dehydrogenase; High confidence in function and specificity; Belongs to the prephenate/arogenate dehydrogenase family. | 0.466 |
tyrA | gpsA | llmg_1927 | llmg_1114 | TyrA protein; Predicted prephenate dehydrogenase, feedback inhibition-sensitive, Prephenate dehydrogenase; High confidence in function and specificity; Belongs to the prephenate/arogenate dehydrogenase family. | GpsA protein; High confidence in function and specificity; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.659 |
tyrA | proC | llmg_1927 | llmg_2077 | TyrA protein; Predicted prephenate dehydrogenase, feedback inhibition-sensitive, Prephenate dehydrogenase; High confidence in function and specificity; Belongs to the prephenate/arogenate dehydrogenase family. | Pyrroline carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.466 |