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mtlD mtlD gnd gnd uxuB uxuB gpsA gpsA panE panE ilvC ilvC ugd ugd tyrA tyrA proC proC gntZ gntZ ywjF ywjF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mtlDMannitol-1-phosphate 5-dehydrogenase; High confidence in function and specificity. (388 aa)
gnd6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (472 aa)
uxuBFructuronate reductase; High confidence in function and specificity. (544 aa)
gpsAGpsA protein; High confidence in function and specificity; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (342 aa)
panE2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (312 aa)
ilvCIlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (340 aa)
ugdUDP-glucose 6-dehydrogenase; High confidence in function and specificity. (389 aa)
tyrATyrA protein; Predicted prephenate dehydrogenase, feedback inhibition-sensitive, Prephenate dehydrogenase; High confidence in function and specificity; Belongs to the prephenate/arogenate dehydrogenase family. (354 aa)
proCPyrroline carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (263 aa)
gntZGntZ protein; PF03446: NAD binding domain of 6-phosphogluconate dehydrogenase, TIGR00872: gnd_rel: 6-phosphogluconate dehydrogenase (decarboxylating); High confidence in function and specificity. (301 aa)
ywjFPutative 3-hydroxyisobutyrate dehydrogenase; TIGR01505: 2-hydroxy-3-oxopropionate reductase; Conserved hypothetical protein. (293 aa)
Your Current Organism:
Lactococcus lactis
NCBI taxonomy Id: 416870
Other names: L. lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris str. MG1363, Lactococcus lactis subsp. cremoris strain MG1363
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