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rpoD rpoD llmg_0576 llmg_0576 dnaG dnaG rpoE rpoE greA greA ctsR ctsR trmA trmA flpB flpB malR malR spxA spxA llmg_0503 llmg_0503 adaA adaA llmg_0484 llmg_0484 treR treR llrC llrC rlrD rlrD rlrG rlrG fhuR fhuR llmg_0248 llmg_0248 llmg_0242 llmg_0242 codY codY llmg_0161 llmg_0161 tetR tetR llmg_0141 llmg_0141 tnp1077 tnp1077 llrF llrF ccpA ccpA rbsR rbsR kdgR kdgR pyrR pyrR llrA llrA glnB glnB cmhR cmhR llmg_0956 llmg_0956 llmg_0962 llmg_0962 llmg_0996 llmg_0996 xylR xylR busR busR rgrB rgrB llrB llrB llmg_1151 llmg_1151 rdrB rdrB llmg_1324 llmg_1324 rex rex llrE llrE llmg_1554 llmg_1554 flpA flpA fruR fruR hrcA hrcA llrD llrD llmg_1660 llmg_1660 mleR mleR ahrC ahrC nusA nusA nrdR nrdR rmaA rmaA rliC rliC nusB nusB llrG llrG birA1 birA1 rpoC rpoC rpoB rpoB codZ codZ rlrB rlrB rpoZ rpoZ llmg_2297 llmg_2297 argR argR llmg_2334 llmg_2334 rpoA rpoA nusG nusG zitR zitR rcfB rcfB llmg_2517 llmg_2517 llmg_2542 llmg_2542 purR purR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpoDRNA polymerase sigma factor rpoD (Sigma-42); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (447 aa)
llmg_0576Pseudogene; Putative transport protein, Major facilitator superfamily, Contains a stopcodon at position 303; Conserved hypothetical protein. (209 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (637 aa)
rpoEDNA-directed RNA polymerase delta chain; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family. (188 aa)
greATranscription elongation factor greA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (156 aa)
ctsRTranscriptional regulator ctsR; Firmicute transcriptional repressor of class III stress genes; High confidence in function and specificity; Belongs to the CtsR family. (151 aa)
trmARegulatory protein spx; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity). Belongs to the ArsC family. Spx subfamily. (132 aa)
flpBTranscriptional regulator FNR like protein B; Cyclic nucleotide-binding domain; Conserved hypothetical protein. (229 aa)
malRPutative maltose operon transcriptional repressor, LacI family; High confidence in function and specificity. (324 aa)
spxAConserved hypothetical protein; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily. (133 aa)
llmg_0503Transcriptional regulator, LytR family; PF04397.5: LytTr DNA-binding domain; Conserved hypothetical protein. (152 aa)
adaAmethylphosphotriester-DNA alkyltransferase; High confidence in function and specificity. (182 aa)
llmg_0484Transcriptional regulator, LacI family; Function unclear. (329 aa)
treRTrehalose operon transcriptional repressor; GntR family transcriptional regulator; Conserved hypothetical protein. (238 aa)
llrCTwo-component system regulator; Response regulator receiver domain, PhoB: Phosphate regulon transcriptional regulatory protein phoB; Conserved hypothetical protein. (233 aa)
rlrDTranscriptional regulator, LysR family; High confidence in function and specificity; Belongs to the LysR transcriptional regulatory family. (273 aa)
rlrGTranscriptional regulator, LysR family; High confidence in function and specificity; Belongs to the LysR transcriptional regulatory family. (272 aa)
fhuRHTH-type transcriptional regulator fhuR; Also known as transcriptional activator of metCcysK operon cmbR; High confidence in function and specificity; Belongs to the LysR transcriptional regulatory family. (301 aa)
llmg_0248Transcriptional regulator, TetR family; Function unclear. (181 aa)
llmg_0242Conserved hypothetical protein; PF01709.9: Protein of unknown function DUF28. (238 aa)
codYTranscriptional regulator; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. (262 aa)
llmg_0161Putative HTH-type transcriptional regulator; Homeodomain-like, Bacterial regulatory proteins, tetR family; Conserved hypothetical protein. (182 aa)
tetRHomeodomain-like, Bacterial regulatory proteins, tetR family. (181 aa)
llmg_0141Putative Transcriptional regulator; Tetracyclin repressor-like, C-terminal; Conserved hypothetical protein. (191 aa)
tnp1077Pseudogene; Transposase for insertion sequence IS1077A (fragment), Integrase, catalytic region; High confidence in function and specificity. (193 aa)
llrFTwo-component system regulator llrF; Response regulator receiver domain; High confidence in function and specificity. (222 aa)
ccpACatabolite control protein A; High confidence in function and specificity. (332 aa)
rbsRRibose operon repressor; High confidence in function and specificity. (327 aa)
kdgRBacterial regulatory proteins, gntR family; High confidence in function and specificity. (226 aa)
pyrRPyrimidine operon attenuation protein / uracil phosphoribosyltransferase; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines, probably by binding to specific sites on pyr mRNA. This probably disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. (173 aa)
llrATwo-component system regulator llrA; Contains response regulator receiver domain; High confidence in function and specificity. (230 aa)
glnBNitrogen regulatory protein P-II; High confidence in function and specificity; Belongs to the P(II) protein family. (113 aa)
cmhRPutative HTH-type transcriptional regulator cmhR; Probable metCcysK operon transcriptional activator; Conserved hypothetical protein; Belongs to the LysR transcriptional regulatory family. (317 aa)
llmg_0956Transcriptional regulator, LacI family; Function unclear. (332 aa)
llmg_0962Transcriptional regulator, araC family; Function unclear. (386 aa)
llmg_0996Pseudogene; Predicted MDR-type permease, Major facilitator superfamily, missing N-terminal end (frameshift); Conserved hypothetical protein. (208 aa)
xylRXylose operon regulator. (310 aa)
busRTranscriptional repressor BusR, GntR family; Repressor of the osmoprotectant uptake system; High confidence in function and specificity. (206 aa)
rgrBTranscriptional regulator, Gntr family; High confidence in function and specificity. (235 aa)
llrBTwo-component system regulator llrB; Response regulator receiver domain; High confidence in function and specificity. (236 aa)
llmg_1151Conserved hypothetical protein; Transcriptional regulator, PF00392: Bacterial regulatory proteins, GntR family. (470 aa)
rdrBPF00455: Bacterial regulatory proteins, deoR family; Conserved hypothetical protein. (253 aa)
llmg_1324Transcriptional regulator, araC family; Pseudogene, PF00165: Bacterial regulatory helix-turn-helix proteins, AraC type; Conserved hypothetical protein. (151 aa)
rexRedox-sensing transcriptional repressor rex; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (216 aa)
llrETwo-component system regulator llrE; Response regulator receiver domain; High confidence in function and specificity. (228 aa)
llmg_1554Transcriptional regulator, TetR family; Homeodomain-like; Family membership. (216 aa)
flpAFNR like protein A; Cyclic nucleotide-binding domain; High confidence in function and specificity. (229 aa)
fruRTranscriptional regulator of the fructose operon; Bacterial regulatory proteins, deoR family; High confidence in function and specificity. (233 aa)
hrcAHeat-inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (347 aa)
llrDTwo-component system regulator llrD; Response regulator receiver domain; High confidence in function and specificity. (209 aa)
llmg_1660Transcriptional regulator, TetR family; Family membership. (177 aa)
mleRPseudogene; Transposase for insertion sequence element IS905J, contains a frameshift at position 401; Conserved hypothetical protein; Belongs to the LysR transcriptional regulatory family. (295 aa)
ahrCArginine transcriptional regulator; Regulates arginine biosynthesis genes. (148 aa)
nusATranscription elongation factor nusA; Participates in both transcription termination and antitermination. (382 aa)
nrdRPutative regulatory protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (148 aa)
rmaATranscriptional regulator, MarR family; High confidence in function and specificity. (160 aa)
rliCTranscriptional regulator, LacI family; High confidence in function and specificity. (329 aa)
nusBPseudogene; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (325 aa)
llrGResponse regulator; Conserved hypothetical protein. (223 aa)
birA1biotin--[acetyl-CoA-carboxylase] ligase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (323 aa)
rpoCDNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1207 aa)
rpoBDNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1196 aa)
codZTranscriptional repressor, CodY family; High confidence in function and specificity. (199 aa)
rlrBHTH type transcriptional regulator, LysR family; Conserved hypothetical protein. (292 aa)
rpoZDNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (117 aa)
llmg_2297Hypothetical protein predicted by Glimmer/Critica; PF04397: LytTr DNA-binding region. (242 aa)
argRArginine repressor; Regulates arginine biosynthesis genes. (152 aa)
llmg_2334Hypothetical protein; PF00126: Bacterial regulatory helix-turn-helix protein, lysR family; Conserved hypothetical protein; ORF3. (283 aa)
rpoARNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (312 aa)
nusGTranscription antitermination protein nusG; Participates in transcription elongation, termination and antitermination. (185 aa)
zitRTranscriptional regulator of the zit operon; Zinc-responsive regulator that represses expression of the zit operon in the presence of zinc. Acts by binding two palindromic operator sites overlapping the -35 and -10 boxes of the zit promoter. Could be a sensitive sensor of intracellular zinc to efficiently respond to zinc variations in the environment. (145 aa)
rcfBTranscriptional regulator; IPR000595: cNMP_binding, CRP/FNR family of transcription regulators; Family membership. (227 aa)
llmg_2517Conserved hypothetical protein; Region start changed from 2474583 to 2474592 (-9 bases). (204 aa)
llmg_2542Putative HTH-type transcriptional regulator; Region start changed from 2497709 to 2497655 (-54 bases). (157 aa)
purRPur operon repressor; Controls the transcription of the pur operon for purine biosynthetic genes. (271 aa)
Your Current Organism:
Lactococcus lactis
NCBI taxonomy Id: 416870
Other names: L. lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris str. MG1363, Lactococcus lactis subsp. cremoris strain MG1363
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