(29 nodes) Pyruvate metabolism network (Lactococcus lactis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	pdhD	Pyruvate dehydrogenase complex E3 component; lipoamide_DH: dihydrolipoamide dehydrogenase; High confidence in function and specificity. (472 aa)
	pdhC	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, PDHac_trf_long: pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; High confidence in function and specificity. (530 aa)
	pdhB	Pyruvate dehydrogenase E1 component beta subunit; 1-deoxy-D-xylulose-5-phosphate synthase (DXP synthase); High confidence in function and specificity. (326 aa)
	pdhA	[EC:1.2.4.1], Pyruvate dehydrogenase E1 component alpha subunit type II, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A) (Fragment)., Dehydrogenase, E1 component, Dehydrogenase E1 component; High confidence in function and specificity. (374 aa)
	llmg_0184	Lactoylglutathione lyase, Methylglyoxalase; Aldoketomutase; Glyoxalase I, Ketone-aldehyde mutase; High confidence in function and specificity. (126 aa)
	llmg_0352	Aldo/keto reductase family; Family membership. (272 aa)
	ldhB	L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (314 aa)
	nifJ	NifJ protein; Pyruvate:ferredoxin (flavodoxin) oxidoreductase, Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, pyruv_ox_red: pyruvate:ferredoxin (flavodoxin) oxidoreductase; High confidence in function and specificity. (1223 aa)
	llmg_0475	Malate/lactate dehydrogenase; Similar to ldhB; Specificity unclear; Belongs to the LDH/MDH superfamily. (304 aa)
	llmg_0510	Putative Zn-dependent hydrolase of metallo-beta-lactamase superfamily; Metallo-beta-lactamase superfamily; Family membership. (210 aa)
	llmg_0568	Putative acylphosphate phosphohydrolase; High confidence in function and specificity. (97 aa)
	fadD	Long-chain acyl-CoA synthetase; Acetyl-coenzyme A synthetase; High confidence in function and specificity. (507 aa)
	pfl	Pyruvate formate-lyase; High confidence in function and specificity. (787 aa)
	pycA	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1137 aa)
	pta	Phosphate acetyltransferase; High confidence in function and specificity. (326 aa)
	thiL	ThiL protein; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family. (386 aa)
	pyk	Pyk protein; High confidence in function and specificity; Belongs to the pyruvate kinase family. (502 aa)
	ldh	L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (325 aa)
	ldhX	L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (323 aa)
	frdC	Fumarate reductase flavoprotein subunit; High confidence in function and specificity; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (502 aa)
	mleS	Malolactic enzyme; High confidence in function and specificity. (540 aa)
	accA	AccA protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (264 aa)
	accD	acetyl-CoA carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (288 aa)
	accC	acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (455 aa)
	accB	acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (155 aa)
	ackA2	AckA2 protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (395 aa)
	ackA1	AckA1 protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (395 aa)
	poxL	Pyruvate oxidase; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity. (575 aa)
	adhE	PF00465.7: Iron-containing alcohol dehydrogenase; High confidence in function and specificity; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (903 aa)

Your Current Organism:

Lactococcus lactis

NCBI taxonomy Id: 416870
Other names: L. lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris str. MG1363, Lactococcus lactis subsp. cremoris strain MG1363

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
accA	accB	llmg_1777	llmg_1782	AccA protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.	acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	0.996
accA	accC	llmg_1777	llmg_1779	AccA protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.	acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	0.993
accA	accD	llmg_1777	llmg_1778	AccA protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.	acetyl-CoA carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family.	0.999
accA	adhE	llmg_1777	llmg_2432	AccA protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.	PF00465.7: Iron-containing alcohol dehydrogenase; High confidence in function and specificity; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.	0.901
accA	fadD	llmg_1777	llmg_0627	AccA protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.	Long-chain acyl-CoA synthetase; Acetyl-coenzyme A synthetase; High confidence in function and specificity.	0.912
accA	frdC	llmg_1777	llmg_1441	AccA protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.	Fumarate reductase flavoprotein subunit; High confidence in function and specificity; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.	0.803
accA	nifJ	llmg_1777	llmg_0447	AccA protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.	NifJ protein; Pyruvate:ferredoxin (flavodoxin) oxidoreductase, Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, pyruv_ox_red: pyruvate:ferredoxin (flavodoxin) oxidoreductase; High confidence in function and specificity.	0.901
accA	pdhC	llmg_1777	llmg_0072	AccA protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, PDHac_trf_long: pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; High confidence in function and specificity.	0.903
accA	pfl	llmg_1777	llmg_0629	AccA protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.	Pyruvate formate-lyase; High confidence in function and specificity.	0.900
accA	pta	llmg_1777	llmg_0763	AccA protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.	Phosphate acetyltransferase; High confidence in function and specificity.	0.910
accA	pycA	llmg_1777	llmg_0634	AccA protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.897
accA	thiL	llmg_1777	llmg_0930	AccA protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.	ThiL protein; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.	0.908
accB	accA	llmg_1782	llmg_1777	acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	AccA protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.	0.996
accB	accC	llmg_1782	llmg_1779	acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	0.999
accB	accD	llmg_1782	llmg_1778	acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	acetyl-CoA carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family.	0.999
accB	adhE	llmg_1782	llmg_2432	acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	PF00465.7: Iron-containing alcohol dehydrogenase; High confidence in function and specificity; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.	0.937
accB	fadD	llmg_1782	llmg_0627	acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	Long-chain acyl-CoA synthetase; Acetyl-coenzyme A synthetase; High confidence in function and specificity.	0.924
accB	frdC	llmg_1782	llmg_1441	acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	Fumarate reductase flavoprotein subunit; High confidence in function and specificity; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.	0.809
accB	nifJ	llmg_1782	llmg_0447	acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	NifJ protein; Pyruvate:ferredoxin (flavodoxin) oxidoreductase, Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, pyruv_ox_red: pyruvate:ferredoxin (flavodoxin) oxidoreductase; High confidence in function and specificity.	0.938
accB	pdhC	llmg_1782	llmg_0072	acetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, PDHac_trf_long: pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; High confidence in function and specificity.	0.925

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