(7 nodes) C5-Branched dibasic acid metabolism network (Lactococcus lactis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Your Input:
	aldB	AldB protein; Converts acetolactate into acetoin. (236 aa)
	ilvN	IPR004789: Acetolactate synthase, small subunit, TIGR00119: acetolactate synthase, small subunit; High confidence in function and specificity. (158 aa)
	ilvB	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity. (574 aa)
	leuD	3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (191 aa)
	leuC	LeuC protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (458 aa)
	als	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity. (554 aa)
	aldC	AldC protein; High confidence in function and specificity; Belongs to the alpha-acetolactate decarboxylase family. (221 aa)

Your Current Organism:

Lactococcus lactis

NCBI taxonomy Id: 416870
Other names: L. lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris str. MG1363, Lactococcus lactis subsp. cremoris strain MG1363

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
aldB	aldC	llmg_1275	llmg_1464	AldB protein; Converts acetolactate into acetoin.	AldC protein; High confidence in function and specificity; Belongs to the alpha-acetolactate decarboxylase family.	0.917
aldB	als	llmg_1275	llmg_1309	AldB protein; Converts acetolactate into acetoin.	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	0.988
aldB	ilvB	llmg_1275	llmg_1279	AldB protein; Converts acetolactate into acetoin.	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	0.971
aldB	ilvN	llmg_1275	llmg_1278	AldB protein; Converts acetolactate into acetoin.	IPR004789: Acetolactate synthase, small subunit, TIGR00119: acetolactate synthase, small subunit; High confidence in function and specificity.	0.938
aldC	aldB	llmg_1464	llmg_1275	AldC protein; High confidence in function and specificity; Belongs to the alpha-acetolactate decarboxylase family.	AldB protein; Converts acetolactate into acetoin.	0.917
aldC	als	llmg_1464	llmg_1309	AldC protein; High confidence in function and specificity; Belongs to the alpha-acetolactate decarboxylase family.	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	0.985
aldC	ilvB	llmg_1464	llmg_1279	AldC protein; High confidence in function and specificity; Belongs to the alpha-acetolactate decarboxylase family.	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	0.952
aldC	ilvN	llmg_1464	llmg_1278	AldC protein; High confidence in function and specificity; Belongs to the alpha-acetolactate decarboxylase family.	IPR004789: Acetolactate synthase, small subunit, TIGR00119: acetolactate synthase, small subunit; High confidence in function and specificity.	0.911
als	aldB	llmg_1309	llmg_1275	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	AldB protein; Converts acetolactate into acetoin.	0.988
als	aldC	llmg_1309	llmg_1464	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	AldC protein; High confidence in function and specificity; Belongs to the alpha-acetolactate decarboxylase family.	0.985
als	ilvB	llmg_1309	llmg_1279	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	0.924
als	ilvN	llmg_1309	llmg_1278	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	IPR004789: Acetolactate synthase, small subunit, TIGR00119: acetolactate synthase, small subunit; High confidence in function and specificity.	0.983
als	leuC	llmg_1309	llmg_1284	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	LeuC protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.419
als	leuD	llmg_1309	llmg_1282	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.	0.468
ilvB	aldB	llmg_1279	llmg_1275	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	AldB protein; Converts acetolactate into acetoin.	0.971
ilvB	aldC	llmg_1279	llmg_1464	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	AldC protein; High confidence in function and specificity; Belongs to the alpha-acetolactate decarboxylase family.	0.952
ilvB	als	llmg_1279	llmg_1309	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	0.924
ilvB	ilvN	llmg_1279	llmg_1278	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	IPR004789: Acetolactate synthase, small subunit, TIGR00119: acetolactate synthase, small subunit; High confidence in function and specificity.	0.999
ilvB	leuC	llmg_1279	llmg_1284	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	LeuC protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.832
ilvB	leuD	llmg_1279	llmg_1282	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.	0.904

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