(13 nodes) Pantothenate and CoA biosynthesis network (Lactococcus lactis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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Your Input:
	dfpA	Putative DNA/pantothenate metabolism flavoprotein; Putative phosphopantothenoylcysteine decarboxylase; High confidence in function and specificity. (178 aa)
	dfpB	Putative phosphopantothenate--cysteine ligase; (Phosphopantothenoylcysteine synthetase) (PPC synthetase); High confidence in function and specificity. (231 aa)
	coaE	CoaE protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (219 aa)
	coaA	Pantothenate kinase; High confidence in function and specificity. (306 aa)
	panE	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (312 aa)
	ilvE	PF01063: Aminotransferase class IV, TIGR01123: branched-chain amino acid aminotransferase; High confidence in function and specificity. (340 aa)
	ilvC	IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (340 aa)
	ilvN	IPR004789: Acetolactate synthase, small subunit, TIGR00119: acetolactate synthase, small subunit; High confidence in function and specificity. (158 aa)
	ilvB	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity. (574 aa)
	ilvD	PF00920: Dehydratase family, TIGR00110: dihydroxy-acid dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family. (570 aa)
	als	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity. (554 aa)
	acpS	Holo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (119 aa)
	kdtB	Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (166 aa)

Your Current Organism:

Lactococcus lactis

NCBI taxonomy Id: 416870
Other names: L. lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris str. MG1363, Lactococcus lactis subsp. cremoris strain MG1363

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
acpS	coaE	llmg_1705	llmg_0630	Holo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family.	CoaE protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.	0.905
als	ilvB	llmg_1309	llmg_1279	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	0.924
als	ilvC	llmg_1309	llmg_1277	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.980
als	ilvD	llmg_1309	llmg_1280	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	PF00920: Dehydratase family, TIGR00110: dihydroxy-acid dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family.	0.908
als	ilvE	llmg_1309	llmg_1181	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	PF01063: Aminotransferase class IV, TIGR01123: branched-chain amino acid aminotransferase; High confidence in function and specificity.	0.663
als	ilvN	llmg_1309	llmg_1278	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	IPR004789: Acetolactate synthase, small subunit, TIGR00119: acetolactate synthase, small subunit; High confidence in function and specificity.	0.983
coaA	dfpA	llmg_1058	llmg_0543	Pantothenate kinase; High confidence in function and specificity.	Putative DNA/pantothenate metabolism flavoprotein; Putative phosphopantothenoylcysteine decarboxylase; High confidence in function and specificity.	0.914
coaA	dfpB	llmg_1058	llmg_0544	Pantothenate kinase; High confidence in function and specificity.	Putative phosphopantothenate--cysteine ligase; (Phosphopantothenoylcysteine synthetase) (PPC synthetase); High confidence in function and specificity.	0.916
coaA	kdtB	llmg_1058	llmg_2443	Pantothenate kinase; High confidence in function and specificity.	Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.	0.926
coaE	acpS	llmg_0630	llmg_1705	CoaE protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.	Holo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family.	0.905
coaE	kdtB	llmg_0630	llmg_2443	CoaE protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.	Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.	0.994
dfpA	coaA	llmg_0543	llmg_1058	Putative DNA/pantothenate metabolism flavoprotein; Putative phosphopantothenoylcysteine decarboxylase; High confidence in function and specificity.	Pantothenate kinase; High confidence in function and specificity.	0.914
dfpA	dfpB	llmg_0543	llmg_0544	Putative DNA/pantothenate metabolism flavoprotein; Putative phosphopantothenoylcysteine decarboxylase; High confidence in function and specificity.	Putative phosphopantothenate--cysteine ligase; (Phosphopantothenoylcysteine synthetase) (PPC synthetase); High confidence in function and specificity.	0.999
dfpA	kdtB	llmg_0543	llmg_2443	Putative DNA/pantothenate metabolism flavoprotein; Putative phosphopantothenoylcysteine decarboxylase; High confidence in function and specificity.	Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.	0.928
dfpB	coaA	llmg_0544	llmg_1058	Putative phosphopantothenate--cysteine ligase; (Phosphopantothenoylcysteine synthetase) (PPC synthetase); High confidence in function and specificity.	Pantothenate kinase; High confidence in function and specificity.	0.916
dfpB	dfpA	llmg_0544	llmg_0543	Putative phosphopantothenate--cysteine ligase; (Phosphopantothenoylcysteine synthetase) (PPC synthetase); High confidence in function and specificity.	Putative DNA/pantothenate metabolism flavoprotein; Putative phosphopantothenoylcysteine decarboxylase; High confidence in function and specificity.	0.999
ilvB	als	llmg_1279	llmg_1309	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	0.924
ilvB	ilvC	llmg_1279	llmg_1277	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.998
ilvB	ilvD	llmg_1279	llmg_1280	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	PF00920: Dehydratase family, TIGR00110: dihydroxy-acid dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family.	0.997
ilvB	ilvE	llmg_1279	llmg_1181	Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity.	PF01063: Aminotransferase class IV, TIGR01123: branched-chain amino acid aminotransferase; High confidence in function and specificity.	0.695

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