STRINGSTRING
pdhD pdhD pdhC pdhC pdhB pdhB pdhA pdhA llmg_0117 llmg_0117 llmg_0177 llmg_0177 pgk pgk hadL hadL dhaK dhaK fbp fbp dapD dapD pmg pmg ldhB ldhB nifJ nifJ llmg_0475 llmg_0475 llmg_0508 llmg_0508 gapA gapA xylH xylH glyA glyA serC serC serA serA serB serB llmg_0568 llmg_0568 gnd gnd enoA enoA fadD fadD pfl pfl pycA pycA gltA gltA citB citB icd icd pta pta kdgA kdgA llmg_0866 llmg_0866 llmg_0867 llmg_0867 tkt tkt asd asd dapA dapA thiL thiL dapB dapB llmg_0955 llmg_0955 rpe2 rpe2 rpiB rpiB llmg_0970 llmg_0970 pfk pfk pyk pyk ldh ldh gadB gadB gltB gltB gltD gltD lysA lysA metF metF thrB thrB hom hom nagD nagD tpiA tpiA ldhX ldhX frdC frdC fruA fruA fhs fhs llmg_1633 llmg_1633 mleS mleS llmg_1652 llmg_1652 folD folD pepV pepV prsA prsA argD argD cysK cysK accA accA accD accD accC accC accB accB thrA thrA llmg_1825 llmg_1825 llmg_1894 llmg_1894 adhA adhA cysE cysE prsB prsB fbaA fbaA rpe rpe pcaC pcaC galM galM ackA2 ackA2 ackA1 ackA1 glk glk arcC2 arcC2 arcC1 arcC1 thrC thrC llmg_2431 llmg_2431 adhE adhE pgiA pgiA gntK gntK gntZ gntZ glnA glnA zwf zwf rpiA rpiA gapB gapB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pdhDPyruvate dehydrogenase complex E3 component; lipoamide_DH: dihydrolipoamide dehydrogenase; High confidence in function and specificity. (472 aa)
pdhCDihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, PDHac_trf_long: pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; High confidence in function and specificity. (530 aa)
pdhBPyruvate dehydrogenase E1 component beta subunit; 1-deoxy-D-xylulose-5-phosphate synthase (DXP synthase); High confidence in function and specificity. (326 aa)
pdhA[EC:1.2.4.1], Pyruvate dehydrogenase E1 component alpha subunit type II, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A) (Fragment)., Dehydrogenase, E1 component, Dehydrogenase E1 component; High confidence in function and specificity. (374 aa)
llmg_0117Hypothetical protein; Putative hydrolase (HAD superfamily) (PFAM), Haloacid dehalogenase-like hydrolase; Conserved hypothetical protein. (207 aa)
llmg_0177Amidase; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases, Similar to GatA; High confidence in function and specificity; Belongs to the amidase family. (499 aa)
pgkPhosphoglycerate kinase; High confidence in function and specificity; Belongs to the phosphoglycerate kinase family. (398 aa)
hadL(S)-2-haloacid dehalogenase (Halocarboxylic acid halidohydrolase), Haloacid dehalogenase, type II; High confidence in function and specificity. (224 aa)
dhaKDihydroxyacetone kinase DhaK; High confidence in function and specificity. (328 aa)
fbpFructose-bisphosphatase; High confidence in function and specificity. (640 aa)
dapD2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (256 aa)
pmgPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (233 aa)
ldhBL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (314 aa)
nifJNifJ protein; Pyruvate:ferredoxin (flavodoxin) oxidoreductase, Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, pyruv_ox_red: pyruvate:ferredoxin (flavodoxin) oxidoreductase; High confidence in function and specificity. (1223 aa)
llmg_0475Malate/lactate dehydrogenase; Similar to ldhB; Specificity unclear; Belongs to the LDH/MDH superfamily. (304 aa)
llmg_0508Cysteine synthase; Unnamed protein product; Region start changed from 500979 to 500913 (-66 bases); Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase, type I; High confidence in function and specificity; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (337 aa)
xylH[EC:5.3.2.-], 4-oxalocrotonate tautomerase, Tautomerase enzyme; Conserved hypothetical protein. (61 aa)
glyAGlyA protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (365 aa)
serAD-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; High confidence in function and specificity. (398 aa)
serBSerB protein; High confidence in function and specificity. (220 aa)
llmg_0568Putative acylphosphate phosphohydrolase; High confidence in function and specificity. (97 aa)
gnd6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (472 aa)
enoAEnoA protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (433 aa)
fadDLong-chain acyl-CoA synthetase; Acetyl-coenzyme A synthetase; High confidence in function and specificity. (507 aa)
pflPyruvate formate-lyase; High confidence in function and specificity. (787 aa)
pycAPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1137 aa)
gltAGltA protein; cit_synth_II: 2-methylcitrate synthase/citrate synthase II; High confidence in function and specificity; Belongs to the citrate synthase family. (441 aa)
citBAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (848 aa)
icdIsocitrate dehydrogenase; High confidence in function and specificity. (412 aa)
ptaPhosphate acetyltransferase; High confidence in function and specificity. (326 aa)
kdgAPseudogene; 2-keto-3-deoxygluconate kinase; High confidence in function and specificity. (213 aa)
llmg_0866PTS system, unknown pentitol phosphotransferase enzyme IIB component; High confidence in function and specificity. (99 aa)
llmg_0867PTS system, unknown pentitol phosphotransferase enzyme IIC component. (466 aa)
tktTkt protein; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (658 aa)
asdAsd protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (361 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa)
thiLThiL protein; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family. (386 aa)
dapBDapB protein; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (260 aa)
llmg_0955PF00107.12: Zinc-containing alcohol dehydrogenase superfamily; High confidence in function and specificity. (348 aa)
rpe2Ribulose-phosphate 3-epimerase; High confidence in function and specificity. (216 aa)
rpiBRibose 5-phosphate isomerase B; High confidence in function and specificity. (149 aa)
llmg_0970Carboxymuconolactone decarboxylase family protein; Family membership. (104 aa)
pfkPfk protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (340 aa)
pykPyk protein; High confidence in function and specificity; Belongs to the pyruvate kinase family. (502 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (325 aa)
gadBGlutamate decarboxylase; Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance; Belongs to the group II decarboxylase family. (466 aa)
gltBGlutamate synthase, large subunit; PF01645: Conserved region in glutamate synthase; High confidence in function and specificity. (1489 aa)
gltDTIGR01317: glutamate synthases, NADH/NADPH, small subunit; High confidence in function and specificity. (479 aa)
lysALysA protein; PF00278: Pyridoxal-dependent decarboxylase, C-terminal sheet domain, TIGR01048: diaminopimelate decarboxylase; High confidence in function and specificity. (419 aa)
metFMetF protein; PF02219: Methylenetetrahydrofolate reductase, TIGR00676: 5,10-methylenetetrahydrofolate reductase; High confidence in function and specificity; Belongs to the methylenetetrahydrofolate reductase family. (285 aa)
thrBThrB protein; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (296 aa)
homHom protein; High confidence in function and specificity. (428 aa)
nagDPutative N-acetylglucosamine catabolic protein; Putative phosphatases involved in N-acetyl-glucosamine catabolism, TIGR01457: HAD-SF-IIA-hyp2: HAD-superfamily subfamily IIA hydrolase; High confidence in function and specificity. (257 aa)
tpiATpiA protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa)
ldhXL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (323 aa)
frdCFumarate reductase flavoprotein subunit; High confidence in function and specificity; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (502 aa)
fruAPseudogene; Transposase for insertion sequence IS1077F (fragment); High confidence in function and specificity. (634 aa)
fhsFormate--tetrahydrofolate ligase; High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. (555 aa)
llmg_1633Conserved hypothetical protein; Similar to predicted ring-cleavage extradiol dioxygenase; Family membership. (281 aa)
mleSMalolactic enzyme; High confidence in function and specificity. (540 aa)
llmg_1652Conserved hypothetical protein; Similar to predicted ring-cleavage extradiol dioxygenases. (277 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa)
pepVDipeptidase; High confidence in function and specificity. (472 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa)
argDAcetylornithine aminotransferase; High confidence in function and specificity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (377 aa)
cysKO-acetylserine sulfhydrylase; Cysteine synthase; High confidence in function and specificity; Belongs to the cysteine synthase/cystathionine beta- synthase family. (306 aa)
accAAccA protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (264 aa)
accDacetyl-CoA carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (288 aa)
accCacetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (455 aa)
accBacetyl-CoA carboxylase biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (155 aa)
thrAAspartate kinase; High confidence in function and specificity; Belongs to the aspartokinase family. (450 aa)
llmg_1825Conserved hypothetical protein; PF01368.8: Phosphoesterase, RecJ-like, PF02272.6: Phosphoesterase, DHHA1. (307 aa)
llmg_1894Similar to phosphoglycerate/bisphosphoglycerate mutases; High confidence in function and specificity. (193 aa)
adhAZinc-containing alcohol dehydrogenase superfamily; High confidence in function and specificity. (340 aa)
cysESerine O-acetyltransferase; High confidence in function and specificity. (199 aa)
prsBRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (321 aa)
fbaAPseudogene; Transposase for insertion sequence element IS905M, contains a stop codon at position 606; Conserved hypothetical protein. (298 aa)
rpeRibulose-phosphate 3-epimerase; High confidence in function and specificity; Belongs to the ribulose-phosphate 3-epimerase family. (220 aa)
pcaCCarboxymuconolactone decarboxylase family; High confidence in function and specificity. (122 aa)
galMAldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (339 aa)
ackA2AckA2 protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (395 aa)
ackA1AckA1 protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (395 aa)
glkGlucokinase; PF00480: ROK family, TIGR00744: ROK family protein (putative glucokinase); High confidence in function and specificity. (323 aa)
arcC2ArcC2 protein; Aspartate/glutamate/uridylate kinase, PF00696: Amino acid kinase family, TIGR00746: carbamate kinase; High confidence in function and specificity; Belongs to the carbamate kinase family. (314 aa)
arcC1ArcC1 protein; PF00696: Amino acid kinase family, TIGR00746: carbamate kinase; High confidence in function and specificity; Belongs to the carbamate kinase family. (314 aa)
thrCThrC protein; TIGR00260: threonine synthase; High confidence in function and specificity. (496 aa)
llmg_2431Conserved hypothetical protein; 3-carboxymuconate cyclase; Belongs to the cycloisomerase 2 family. (341 aa)
adhEPF00465.7: Iron-containing alcohol dehydrogenase; High confidence in function and specificity; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (903 aa)
pgiAPgiA protein; PF00342: Phosphoglucose isomerase; High confidence in function and specificity; Belongs to the GPI family. (448 aa)
gntKGluconate kinase; PF00370: FGGY family of carbohydrate kinases, N-terminal domain, TIGR01314: gntK_FGGY: gluconate kinase; High confidence in function and specificity; Belongs to the FGGY kinase family. (502 aa)
gntZGntZ protein; PF03446: NAD binding domain of 6-phosphogluconate dehydrogenase, TIGR00872: gnd_rel: 6-phosphogluconate dehydrogenase (decarboxylating); High confidence in function and specificity. (301 aa)
glnAGlnA protein; PF00120: Glutamine synthetase, catalytic domain, TIGR00653: glutamine synthetase, type I; High confidence in function and specificity. (446 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (503 aa)
rpiARibose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (224 aa)
gapBTIGR01534: Glyceraldehyde-3-phosphate dehydrogenase, type I, PF02800: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; High confidence in function and specificity; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
Your Current Organism:
Lactococcus lactis
NCBI taxonomy Id: 416870
Other names: L. lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris str. MG1363, Lactococcus lactis subsp. cremoris strain MG1363
Server load: medium (48%) [HD]