node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
als | icd | llmg_1309 | llmg_0637 | Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity. | Isocitrate dehydrogenase; High confidence in function and specificity. | 0.417 |
als | ilvB | llmg_1309 | llmg_1279 | Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity. | Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity. | 0.924 |
als | ilvC | llmg_1309 | llmg_1277 | Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity. | IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.980 |
als | ilvD | llmg_1309 | llmg_1280 | Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity. | PF00920: Dehydratase family, TIGR00110: dihydroxy-acid dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family. | 0.908 |
als | ilvE | llmg_1309 | llmg_1181 | Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity. | PF01063: Aminotransferase class IV, TIGR01123: branched-chain amino acid aminotransferase; High confidence in function and specificity. | 0.663 |
als | ilvN | llmg_1309 | llmg_1278 | Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity. | IPR004789: Acetolactate synthase, small subunit, TIGR00119: acetolactate synthase, small subunit; High confidence in function and specificity. | 0.983 |
als | leuC | llmg_1309 | llmg_1284 | Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity. | LeuC protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.419 |
als | leuD | llmg_1309 | llmg_1282 | Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.468 |
als | thrA | llmg_1309 | llmg_1820 | Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity. | Aspartate kinase; High confidence in function and specificity; Belongs to the aspartokinase family. | 0.455 |
argB | argC | llmg_1755 | llmg_1758 | ArgB protein; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. | 0.999 |
argB | argD | llmg_1755 | llmg_1756 | ArgB protein; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | Acetylornithine aminotransferase; High confidence in function and specificity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. | 0.998 |
argB | argJ | llmg_1755 | llmg_1757 | ArgB protein; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | Ornithine acetyltransferase / amino-acid acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | 0.999 |
argB | leuC | llmg_1755 | llmg_1284 | ArgB protein; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | LeuC protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.450 |
argC | argB | llmg_1758 | llmg_1755 | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. | ArgB protein; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | 0.999 |
argC | argD | llmg_1758 | llmg_1756 | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. | Acetylornithine aminotransferase; High confidence in function and specificity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. | 0.998 |
argC | argE | llmg_1758 | llmg_0536 | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. | Acetylornithine deacetylase; High confidence in function and specificity. | 0.445 |
argC | argJ | llmg_1758 | llmg_1757 | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. | Ornithine acetyltransferase / amino-acid acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | 0.994 |
argC | asd | llmg_1758 | llmg_0871 | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. | Asd protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.520 |
argD | argB | llmg_1756 | llmg_1755 | Acetylornithine aminotransferase; High confidence in function and specificity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. | ArgB protein; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | 0.998 |
argD | argC | llmg_1756 | llmg_1758 | Acetylornithine aminotransferase; High confidence in function and specificity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. | 0.998 |