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aspC aspC argE argE gltA gltA citB citB icd icd asd asd ilvE ilvE ilvC ilvC ilvN ilvN ilvB ilvB ilvD ilvD leuD leuD leuC leuC als als argB argB argD argD argJ argJ argC argC thrA thrA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
aspCAspartate aminotransferase, Transaminase A (ASPAT), Aminotransferase, class I and II; High confidence in function and specificity. (404 aa)
argEAcetylornithine deacetylase; High confidence in function and specificity. (373 aa)
gltAGltA protein; cit_synth_II: 2-methylcitrate synthase/citrate synthase II; High confidence in function and specificity; Belongs to the citrate synthase family. (441 aa)
citBAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (848 aa)
icdIsocitrate dehydrogenase; High confidence in function and specificity. (412 aa)
asdAsd protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (361 aa)
ilvEPF01063: Aminotransferase class IV, TIGR01123: branched-chain amino acid aminotransferase; High confidence in function and specificity. (340 aa)
ilvCIlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (340 aa)
ilvNIPR004789: Acetolactate synthase, small subunit, TIGR00119: acetolactate synthase, small subunit; High confidence in function and specificity. (158 aa)
ilvBAcetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity. (574 aa)
ilvDPF00920: Dehydratase family, TIGR00110: dihydroxy-acid dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family. (570 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (191 aa)
leuCLeuC protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (458 aa)
alsAcetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity. (554 aa)
argBArgB protein; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (283 aa)
argDAcetylornithine aminotransferase; High confidence in function and specificity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (377 aa)
argJOrnithine acetyltransferase / amino-acid acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (396 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (340 aa)
thrAAspartate kinase; High confidence in function and specificity; Belongs to the aspartokinase family. (450 aa)
Your Current Organism:
Lactococcus lactis
NCBI taxonomy Id: 416870
Other names: L. lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris MG1363, Lactococcus lactis subsp. cremoris str. MG1363, Lactococcus lactis subsp. cremoris strain MG1363
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