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| | araT | Aromatic amino acid aminotransferase, biosynthesis of phenylalanine and tyrosine; High confidence in function and specificity. (391 aa) |
| | aroF | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (345 aa) |
| | argG | ArgG protein; Argininosuccinate synthase, Citrulline--aspartate ligase; High confidence in function and specificity; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (398 aa) |
| | argH | ArgH protein; Argininosuccinate lyase, (Arginosuccinase) (ASAL); High confidence in function and specificity. (459 aa) |
| | aspC | Aspartate aminotransferase, Transaminase A (ASPAT), Aminotransferase, class I and II; High confidence in function and specificity. (404 aa) |
| | pgk | Phosphoglycerate kinase; High confidence in function and specificity; Belongs to the phosphoglycerate kinase family. (398 aa) |
| | luxS | S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (158 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (256 aa) |
| | hipO1 | Putative hippurate hydrolase; Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate. (376 aa) |
| | pmg | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (233 aa) |
| | asnB | Asparagine synthetase B; High confidence in function and specificity. (530 aa) |
| | llmg_0508 | Cysteine synthase; Unnamed protein product; Region start changed from 500979 to 500913 (-66 bases); Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa) |
| | gapA | Glyceraldehyde-3-phosphate dehydrogenase, type I; High confidence in function and specificity; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (337 aa) |
| | argE | Acetylornithine deacetylase; High confidence in function and specificity. (373 aa) |
| | glyA | GlyA protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (365 aa) |
| | serA | D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; High confidence in function and specificity. (398 aa) |
| | serB | SerB protein; High confidence in function and specificity. (220 aa) |
| | enoA | EnoA protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (433 aa) |
| | pycA | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1137 aa) |
| | gltA | GltA protein; cit_synth_II: 2-methylcitrate synthase/citrate synthase II; High confidence in function and specificity; Belongs to the citrate synthase family. (441 aa) |
| | citB | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (848 aa) |
| | icd | Isocitrate dehydrogenase; High confidence in function and specificity. (412 aa) |
| | aroD | Putative 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (229 aa) |
| | tkt | Tkt protein; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (658 aa) |
| | asd | Asd protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (361 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa) |
| | proB | ProB protein; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (268 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (414 aa) |
| | dapB | DapB protein; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (260 aa) |
| | rpe2 | Ribulose-phosphate 3-epimerase; High confidence in function and specificity. (216 aa) |
| | rpiB | Ribose 5-phosphate isomerase B; High confidence in function and specificity. (149 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (456 aa) |
| | trpG | Anthranilate synthase component II; High confidence in function and specificity. (193 aa) |
| | trpD | TrpD protein; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (335 aa) |
| | trpC | TrpC protein; High confidence in function and specificity; Belongs to the TrpC family. (264 aa) |
| | trpF | N-(5'-phosphoribosyl)-anthranilate isomerase; High confidence in function and specificity; Belongs to the TrpF family. (352 aa) |
| | trpB | TrpB protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (401 aa) |
| | trpA | TrpA protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (253 aa) |
| | pfk | Pfk protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (340 aa) |
| | pyk | Pyk protein; High confidence in function and specificity; Belongs to the pyruvate kinase family. (502 aa) |
| | ocd | PF02423: Ornithine cyclodeaminase/mu-crystallin family; High confidence in function and specificity. (318 aa) |
| | ilvE | PF01063: Aminotransferase class IV, TIGR01123: branched-chain amino acid aminotransferase; High confidence in function and specificity. (340 aa) |
| | gltB | Glutamate synthase, large subunit; PF01645: Conserved region in glutamate synthase; High confidence in function and specificity. (1489 aa) |
| | gltD | TIGR01317: glutamate synthases, NADH/NADPH, small subunit; High confidence in function and specificity. (479 aa) |
| | lysA | LysA protein; PF00278: Pyridoxal-dependent decarboxylase, C-terminal sheet domain, TIGR01048: diaminopimelate decarboxylase; High confidence in function and specificity. (419 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (757 aa) |
| | aroH | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (340 aa) |
| | ilvA | IlvA protein; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (416 aa) |
| | ilvC | IlvC protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (340 aa) |
| | ilvN | IPR004789: Acetolactate synthase, small subunit, TIGR00119: acetolactate synthase, small subunit; High confidence in function and specificity. (158 aa) |
| | ilvB | Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity. (574 aa) |
| | ilvD | PF00920: Dehydratase family, TIGR00110: dihydroxy-acid dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family. (570 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (191 aa) |
| | leuC | LeuC protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (458 aa) |
| | hisK | Histidinol-phosphatase; IPR010140: Histidinol phosphate phosphatase, HisJ, TIGR01856: histidinol phosphate phosphatase HisJ family; High confidence in function and specificity; Belongs to the PHP hydrolase family. HisK subfamily. (261 aa) |
| | hisI | EC:3.6.1.31, PF01503: Phosphoribosyl-ATP pyrophosphohydrolase, PF01502: Phosphoribosyl-AMP cyclohydrolase; High confidence in function and specificity; In the N-terminal section; belongs to the PRA-CH family. (212 aa) |
| | hisF | Imidazoleglycerol-phosphate synthase cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (259 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; [EC:5.3.1.16], subunit hisF) (IGPS subunit hisF)., Ribulose-phosphate binding barrel, Histidine biosynthesis protein, TIGR00007: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; High confidence in function and specificity. (246 aa) |
| | hisH | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (202 aa) |
| | hisB | HisB protein; PF00475: Imidazoleglycerol-phosphate dehydratase; High confidence in function and specificity. (199 aa) |
| | hisD | HisD protein; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa) |
| | hisG | HisG protein; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (208 aa) |
| | hisZ | HisZ protein; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (318 aa) |
| | hisC | PF00155: Aminotransferase class I and II, TIGR01141: histidinol-phosphate aminotransferase; High confidence in function and specificity; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa) |
| | als | Acetolactate synthase large subunit; PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, TIGR00118: acetolactate synthase, large subunit, biosynthetic type; High confidence in function and specificity. (554 aa) |
| | thrB | ThrB protein; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (296 aa) |
| | hom | Hom protein; High confidence in function and specificity. (428 aa) |
| | tpiA | TpiA protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa) |
| | pepV | Dipeptidase; High confidence in function and specificity. (472 aa) |
| | sdaA | L-serine dehydratase alpha subunit; High confidence in function and specificity; Belongs to the iron-sulfur dependent L-serine dehydratase family. (287 aa) |
| | sdaB | L-serine dehydratase beta subunit; High confidence in function and specificity; Belongs to the iron-sulfur dependent L-serine dehydratase family. (223 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa) |
| | argF | ArgF protein; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (333 aa) |
| | argB | ArgB protein; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (283 aa) |
| | argD | Acetylornithine aminotransferase; High confidence in function and specificity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (377 aa) |
| | argJ | Ornithine acetyltransferase / amino-acid acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (396 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (340 aa) |
| | cysK | O-acetylserine sulfhydrylase; Cysteine synthase; High confidence in function and specificity; Belongs to the cysteine synthase/cystathionine beta- synthase family. (306 aa) |
| | metC | Cystathionine beta-lyase; The enzymatic degradation of amino acids in cheese is believed to generate aroma compounds and therefore to be essential for flavor development. Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine but is also able to catalyze an alpha, gamma elimination. With methionine as a substrate, it produces volatile sulfur compounds which are important for flavor formation in Gouda cheese; Belongs to the trans-sulfuration enzymes family. (380 aa) |
| | thrA | Aspartate kinase; High confidence in function and specificity; Belongs to the aspartokinase family. (450 aa) |
| | metE2 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; High confidence in function and specificity. (369 aa) |
| | llmg_1894 | Similar to phosphoglycerate/bisphosphoglycerate mutases; High confidence in function and specificity. (193 aa) |
| | pheA | PheA protein; High confidence in function and specificity. (279 aa) |
| | aroK | AroK protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (162 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (430 aa) |
| | tyrA | TyrA protein; Predicted prephenate dehydrogenase, feedback inhibition-sensitive, Prephenate dehydrogenase; High confidence in function and specificity; Belongs to the prephenate/arogenate dehydrogenase family. (354 aa) |
| | aroC | AroC protein; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (388 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (356 aa) |
| | aroE | AroE protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (286 aa) |
| | cysE | Serine O-acetyltransferase; High confidence in function and specificity. (199 aa) |
| | prsB | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (321 aa) |
| | pfs | 5'-methylthioadenosine nucleosidase / S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (226 aa) |
| | proC | Pyrroline carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (263 aa) |
| | metK | MetK protein; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (399 aa) |
| | fbaA | Pseudogene; Transposase for insertion sequence element IS905M, contains a stop codon at position 606; Conserved hypothetical protein. (298 aa) |
| | metB1 | Pseudogene. (362 aa) |
| | metA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (319 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; High confidence in function and specificity; Belongs to the ribulose-phosphate 3-epimerase family. (220 aa) |
| | arcB | ArcB protein; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (354 aa) |
| | thrC | ThrC protein; TIGR00260: threonine synthase; High confidence in function and specificity. (496 aa) |
| | llmg_2481 | PF01817: Chorismate mutase type II, TIGR01805: CM_mono_grmpos: chorismate mutase; Family membership. (90 aa) |
| | glnA | GlnA protein; PF00120: Glutamine synthetase, catalytic domain, TIGR00653: glutamine synthetase, type I; High confidence in function and specificity. (446 aa) |
| | asnH | Asparagine synthetase (glutamine-hydrolyzing), PF00733: Asparagine synthase; High confidence in function and specificity. (625 aa) |
| | rpiA | Ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (224 aa) |
| | gapB | TIGR01534: Glyceraldehyde-3-phosphate dehydrogenase, type I, PF02800: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; High confidence in function and specificity; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa) |
