(69 nodes) Actin cytoskeleton network (Lomentospora prolificans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	jhhlp_003986	Uncharacterized protein. (777 aa)
	jhhlp_000085	Uncharacterized protein. (443 aa)
	jhhlp_000040	EH domain-containing protein. (544 aa)
	jhhlp_000543	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (169 aa)
	jhhlp_000542	Uncharacterized protein. (717 aa)
	jhhlp_000307	Peptidase_M3 domain-containing protein. (941 aa)
	jhhlp_000936	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1236 aa)
	jhhlp_001519	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (202 aa)
	jhhlp_001525	Uncharacterized protein. (798 aa)
	jhhlp_001258	Coronin; Belongs to the WD repeat coronin family. (631 aa)
	jhhlp_001270	Uncharacterized protein. (1257 aa)
	jhhlp_001136	Uncharacterized protein. (788 aa)
	jhhlp_003307	Uncharacterized protein. (672 aa)
	jhhlp_003312	Uncharacterized protein. (726 aa)
	jhhlp_003225	Uncharacterized protein. (451 aa)
	jhhlp_003221	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (299 aa)
	jhhlp_003148	Uncharacterized protein. (143 aa)
	jhhlp_003147	Uncharacterized protein. (448 aa)
	jhhlp_003115	Uncharacterized protein. (194 aa)
	jhhlp_002865	Uncharacterized protein. (1014 aa)
	jhhlp_002587	Uncharacterized protein. (375 aa)
	jhhlp_002522	Uncharacterized protein. (161 aa)
	jhhlp_002506	Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (343 aa)
	jhhlp_002527	Uncharacterized protein. (125 aa)
	jhhlp_002245	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (318 aa)
	jhhlp_002179	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (470 aa)
	jhhlp_002171	Uncharacterized protein; Belongs to the actin family. (463 aa)
	jhhlp_002118	Uncharacterized protein. (593 aa)
	jhhlp_002105	Uncharacterized protein. (332 aa)
	jhhlp_001984	Uncharacterized protein. (181 aa)
	jhhlp_001927	Uncharacterized protein. (898 aa)
	jhhlp_004633	Calponin-homology (CH) domain-containing protein. (709 aa)
	jhhlp_004603	Uncharacterized protein. (1514 aa)
	jhhlp_004513	Uncharacterized protein. (879 aa)
	jhhlp_004507	Uncharacterized protein. (1740 aa)
	jhhlp_004029	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2406 aa)
	jhhlp_003966	Uncharacterized protein. (385 aa)
	jhhlp_003734	Uncharacterized protein. (524 aa)
	jhhlp_003715	UDENN domain-containing protein. (744 aa)
	jhhlp_003433	TGc domain-containing protein. (629 aa)
	jhhlp_003407	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1854 aa)
	jhhlp_003408	Cytochrome b5 heme-binding domain-containing protein. (1827 aa)
	jhhlp_005174	Uncharacterized protein. (269 aa)
	jhhlp_006683	Cellulase domain-containing protein; Belongs to the glycosyl hydrolase 5 (cellulase A) family. (383 aa)
	jhhlp_006447	Uncharacterized protein. (1011 aa)
	jhhlp_006431	C2 domain-containing protein. (1032 aa)
	jhhlp_006270	Uncharacterized protein. (741 aa)
	jhhlp_006260	Uncharacterized protein. (652 aa)
	jhhlp_006100	UBR-type domain-containing protein. (493 aa)
	jhhlp_006058	Uncharacterized protein. (662 aa)
	jhhlp_005976	Uncharacterized protein. (146 aa)
	jhhlp_005978	Peptidase_M3 domain-containing protein. (783 aa)
	jhhlp_005913	ADF-H domain-containing protein. (153 aa)
	jhhlp_006896	MFS domain-containing protein. (547 aa)
	jhhlp_006882	Protein kinase domain-containing protein. (1036 aa)
	jhhlp_007375	WH2 domain-containing protein. (423 aa)
	jhhlp_007160	SAC domain-containing protein. (1427 aa)
	jhhlp_007186	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks; Belongs to the WD repeat ARPC1 family. (363 aa)
	jhhlp_007102	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (287 aa)
	jhhlp_007092	Uncharacterized protein. (438 aa)
	jhhlp_007826	STAS domain-containing protein. (786 aa)
	jhhlp_007653	Uncharacterized protein. (223 aa)
	jhhlp_007648	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (388 aa)
	jhhlp_007590	Uncharacterized protein. (353 aa)
	jhhlp_008155	Uncharacterized protein. (430 aa)
	jhhlp_008100	Uncharacterized protein. (266 aa)
	jhhlp_008713	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (704 aa)
	jhhlp_008590	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1586 aa)
	jhhlp_008428	Zn(2)-C6 fungal-type domain-containing protein. (789 aa)

Your Current Organism:

Lomentospora prolificans

NCBI taxonomy Id: 41688
Other names: CBS 467.74, IMI 188615, L. prolificans, MUCL 18141, Scedosporium inflatum, Scedosporium prolificans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
jhhlp_000040	jhhlp_002171	A0A2N3NLH6	A0A2N3ND95	EH domain-containing protein.	Uncharacterized protein; Belongs to the actin family.	0.417
jhhlp_000040	jhhlp_006447	A0A2N3NLH6	A0A2N3N5W7	EH domain-containing protein.	Uncharacterized protein.	0.798
jhhlp_000040	jhhlp_006882	A0A2N3NLH6	A0A2N3N308	EH domain-containing protein.	Protein kinase domain-containing protein.	0.712
jhhlp_000040	jhhlp_007160	A0A2N3NLH6	A0A2N3N1Y2	EH domain-containing protein.	SAC domain-containing protein.	0.532
jhhlp_000040	jhhlp_007648	A0A2N3NLH6	A0A2N3N067	EH domain-containing protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.405
jhhlp_000085	jhhlp_002171	A0A2N3NLK7	A0A2N3ND95	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.417
jhhlp_000085	jhhlp_006447	A0A2N3NLK7	A0A2N3N5W7	Uncharacterized protein.	Uncharacterized protein.	0.798
jhhlp_000085	jhhlp_006882	A0A2N3NLK7	A0A2N3N308	Uncharacterized protein.	Protein kinase domain-containing protein.	0.712
jhhlp_000085	jhhlp_007160	A0A2N3NLK7	A0A2N3N1Y2	Uncharacterized protein.	SAC domain-containing protein.	0.473
jhhlp_000085	jhhlp_007648	A0A2N3NLK7	A0A2N3N067	Uncharacterized protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.405
jhhlp_000307	jhhlp_005976	A0A2N3NKG8	A0A2N3N4M8	Peptidase_M3 domain-containing protein.	Uncharacterized protein.	0.493
jhhlp_000542	jhhlp_000936	A0A2N3NL88	A0A2N3NJY4	Uncharacterized protein.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.444
jhhlp_000542	jhhlp_001519	A0A2N3NL88	A0A2N3NIG6	Uncharacterized protein.	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.	0.986
jhhlp_000542	jhhlp_001525	A0A2N3NL88	A0A2N3NIE8	Uncharacterized protein.	Uncharacterized protein.	0.806
jhhlp_000542	jhhlp_002171	A0A2N3NL88	A0A2N3ND95	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.983
jhhlp_000542	jhhlp_002245	A0A2N3NL88	A0A2N3NDJ6	Uncharacterized protein.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.986
jhhlp_000542	jhhlp_002587	A0A2N3NL88	A0A2N3NEE7	Uncharacterized protein.	Uncharacterized protein.	0.881
jhhlp_000542	jhhlp_004029	A0A2N3NL88	A0A2N3NAG4	Uncharacterized protein.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.481
jhhlp_000542	jhhlp_005913	A0A2N3NL88	A0A2N3N4F3	Uncharacterized protein.	ADF-H domain-containing protein.	0.547
jhhlp_000542	jhhlp_007102	A0A2N3NL88	A0A2N3N1N9	Uncharacterized protein.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.625