(61 nodes) Nucleic acid-binding, OB-fold network (Lomentospora prolificans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	jhhlp_002956	AA_TRNA_LIGASE_II domain-containing protein. (554 aa)
	jhhlp_000779	AA_TRNA_LIGASE_II domain-containing protein. (917 aa)
	jhhlp_000925	AA_TRNA_LIGASE_II domain-containing protein. (653 aa)
	jhhlp_001209	Uncharacterized protein. (190 aa)
	jhhlp_003365	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
	jhhlp_003323	Zf-primase domain-containing protein. (782 aa)
	jhhlp_003351	DNA helicase; Belongs to the MCM family. (893 aa)
	jhhlp_003242	Lysine--tRNA ligase. (618 aa)
	jhhlp_001053	AA_TRNA_LIGASE_II domain-containing protein. (662 aa)
	jhhlp_000440	Uncharacterized protein; Belongs to the universal ribosomal protein uS12 family. (141 aa)
	jhhlp_000026	DNA ligase. (991 aa)
	jhhlp_000030	Uncharacterized protein. (1800 aa)
	jhhlp_003237	Stn1 domain-containing protein. (455 aa)
	jhhlp_002995	AAA domain-containing protein; Belongs to the AAA ATPase family. (421 aa)
	jhhlp_002835	AAA domain-containing protein; Belongs to the AAA ATPase family. (446 aa)
	jhhlp_002601	Telo_bind domain-containing protein. (1517 aa)
	jhhlp_002546	S1 domain-containing protein. (247 aa)
	jhhlp_002337	AAA domain-containing protein; Belongs to the AAA ATPase family. (392 aa)
	jhhlp_002167	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (568 aa)
	jhhlp_002064	DNA ligase. (872 aa)
	jhhlp_002069	Uncharacterized protein. (544 aa)
	jhhlp_004605	Uncharacterized protein. (385 aa)
	jhhlp_004589	Ribosomal_L2_C domain-containing protein. (254 aa)
	jhhlp_004475	Ribosomal_S17_N domain-containing protein; Belongs to the universal ribosomal protein uS17 family. (177 aa)
	jhhlp_004132	Uncharacterized protein. (339 aa)
	jhhlp_004027	eIF-5a domain-containing protein. (448 aa)
	jhhlp_004069	S1-like domain-containing protein; Belongs to the eIF-1A family. (157 aa)
	jhhlp_004000	AA_TRNA_LIGASE_II domain-containing protein. (592 aa)
	jhhlp_003916	Uncharacterized protein. (182 aa)
	jhhlp_003912	S1-like domain-containing protein. (136 aa)
	jhhlp_003802	Uncharacterized protein. (244 aa)
	jhhlp_003748	Uncharacterized protein. (1171 aa)
	jhhlp_003755	tRNA-binding domain-containing protein. (384 aa)
	jhhlp_003659	S1 motif domain-containing protein. (350 aa)
	jhhlp_003596	RPA_C domain-containing protein. (283 aa)
	jhhlp_003469	Eukaryotic translation initiation factor 5A. (162 aa)
	jhhlp_005122	Uncharacterized protein. (215 aa)
	jhhlp_006622	DNA helicase; Belongs to the MCM family. (721 aa)
	jhhlp_006570	RNB domain-containing protein. (1348 aa)
	jhhlp_006581	DNA_LIGASE_A3 domain-containing protein. (1054 aa)
	jhhlp_006478	Ribosomal_L2_C domain-containing protein. (394 aa)
	jhhlp_006215	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (607 aa)
	jhhlp_006112	ECR1_N domain-containing protein. (341 aa)
	jhhlp_006101	DNA helicase; Belongs to the MCM family. (865 aa)
	jhhlp_005873	Uncharacterized protein. (127 aa)
	jhhlp_005779	DNA ligase. (852 aa)
	jhhlp_005661	Uncharacterized protein. (131 aa)
	jhhlp_006755	AAA domain-containing protein; Belongs to the AAA ATPase family. (495 aa)
	jhhlp_007403	AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
	jhhlp_007319	Uncharacterized protein. (226 aa)
	jhhlp_007166	S1 motif domain-containing protein; Belongs to the RNR ribonuclease family. (982 aa)
	jhhlp_007144	RNB domain-containing protein. (998 aa)
	jhhlp_007093	Uncharacterized protein. (85 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (814 aa)
	jhhlp_007697	DNA helicase; Belongs to the MCM family. (1122 aa)
	jhhlp_007574	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family. (1417 aa)
	jhhlp_008135	Uncharacterized protein. (379 aa)
	jhhlp_008132	Uncharacterized protein. (371 aa)
	jhhlp_008064	AAA domain-containing protein; Belongs to the AAA ATPase family. (424 aa)
	jhhlp_008622	Uncharacterized protein. (682 aa)
	jhhlp_001335	DNA helicase; Belongs to the MCM family. (1021 aa)

Your Current Organism:

Lomentospora prolificans

NCBI taxonomy Id: 41688
Other names: CBS 467.74, IMI 188615, L. prolificans, MUCL 18141, Scedosporium inflatum, Scedosporium prolificans

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCM7	jhhlp_000026	A0A2N3N1K1	A0A2N3NLC3	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA ligase.	0.449
MCM7	jhhlp_001335	A0A2N3N1K1	A0A2N3NHV1	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	jhhlp_002064	A0A2N3N1K1	A0A2N3ND25	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA ligase.	0.745
MCM7	jhhlp_003237	A0A2N3N1K1	A0A2N3NGB2	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Stn1 domain-containing protein.	0.784
MCM7	jhhlp_003323	A0A2N3N1K1	A0A2N3NGK9	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Zf-primase domain-containing protein.	0.998
MCM7	jhhlp_003351	A0A2N3N1K1	A0A2N3NGJ5	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	jhhlp_003596	A0A2N3N1K1	A0A2N3N961	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	RPA_C domain-containing protein.	0.868
MCM7	jhhlp_005779	A0A2N3N1K1	A0A2N3N425	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA ligase.	0.745
MCM7	jhhlp_006101	A0A2N3N1K1	A0A2N3N4Z3	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	jhhlp_006215	A0A2N3N1K1	A0A2N3N597	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.857
MCM7	jhhlp_006581	A0A2N3N1K1	A0A2N3N6A2	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA_LIGASE_A3 domain-containing protein.	0.449
MCM7	jhhlp_006622	A0A2N3N1K1	A0A2N3N6D5	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	jhhlp_007697	A0A2N3N1K1	A0A2N3N0A8	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
jhhlp_000026	MCM7	A0A2N3NLC3	A0A2N3N1K1	DNA ligase.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.449
jhhlp_000026	jhhlp_002064	A0A2N3NLC3	A0A2N3ND25	DNA ligase.	DNA ligase.	0.580
jhhlp_000026	jhhlp_003237	A0A2N3NLC3	A0A2N3NGB2	DNA ligase.	Stn1 domain-containing protein.	0.675
jhhlp_000026	jhhlp_003365	A0A2N3NLC3	A0A2N3NGM3	DNA ligase.	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	0.627
jhhlp_000026	jhhlp_003596	A0A2N3NLC3	A0A2N3N961	DNA ligase.	RPA_C domain-containing protein.	0.684
jhhlp_000026	jhhlp_005779	A0A2N3NLC3	A0A2N3N425	DNA ligase.	DNA ligase.	0.589
jhhlp_000026	jhhlp_006101	A0A2N3NLC3	A0A2N3N4Z3	DNA ligase.	DNA helicase; Belongs to the MCM family.	0.408