(151 nodes) Positive regulation of transcription, DNA-templated network (Puccinia graminis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PGTG_08863	Uncharacterized protein. (946 aa)
	PGTG_08860	Uncharacterized protein. (1340 aa)
	PGTG_00044	Uncharacterized protein. (229 aa)
	PGTG_00230	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (886 aa)
	PGTG_00651	Uncharacterized protein. (126 aa)
	PGTG_00665	Transcriptional adapter 2-alpha. (771 aa)
	PGTG_00153	Bromo domain-containing protein. (596 aa)
	PGTG_00731	Nuclear transcription factor Y, beta. (228 aa)
	PGTG_01955	CBFD_NFYB_HMF domain-containing protein. (142 aa)
	PGTG_01961	Helicase ATP-binding domain-containing protein. (689 aa)
	PGTG_00747	Transcriptional adapter 2-alpha. (694 aa)
	PGTG_01241	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (596 aa)
	PGTG_02507	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family. (1603 aa)
	PGTG_02767	zf-C2HC5 domain-containing protein. (527 aa)
	PGTG_02032	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (103 aa)
	PGTG_02038	TAF domain-containing protein. (562 aa)
	PGTG_02039	Uncharacterized protein. (833 aa)
	PGTG_02200	Plus3 domain-containing protein. (548 aa)
	PGTG_02205	Uncharacterized protein. (222 aa)
	PGTG_02405	Peptidase_M50 domain-containing protein. (535 aa)
	PGTG_03082	HTH APSES-type domain-containing protein. (649 aa)
	PGTG_03179	SAGA-associated factor 11. (358 aa)
	PGTG_03307	Uncharacterized protein. (153 aa)
	PGTG_03401	RING-type domain-containing protein. (730 aa)
	PGTG_03589	Usp domain-containing protein. (721 aa)
	PGTG_03730	Uncharacterized protein; Belongs to the cyclin family. (399 aa)
	PGTG_03733	Uncharacterized protein. (1596 aa)
	PGTG_03830	Uncharacterized protein. (390 aa)
	PGTG_03931	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (568 aa)
	PGTG_03958	Uncharacterized protein. (444 aa)
	PGTG_04105	26S protease subunit rpt4; Belongs to the AAA ATPase family. (393 aa)
	PGTG_04450	FACT-Spt16_Nlob domain-containing protein. (630 aa)
	PGTG_04452	FACT-Spt16_Nlob domain-containing protein. (631 aa)
	PGTG_04863	Uncharacterized protein. (153 aa)
	PGTG_04864	BP28CT domain-containing protein. (1815 aa)
	PGTG_04929	Response regulatory domain-containing protein. (687 aa)
	PGTG_05723	Uncharacterized protein. (517 aa)
	PGTG_05607	Uncharacterized protein. (979 aa)
	PGTG_05665	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (1203 aa)
	PGTG_05872	BRCT domain-containing protein. (655 aa)
	PGTG_05114	Uncharacterized protein. (192 aa)
	PGTG_05339	Uncharacterized protein. (262 aa)
	PGTG_05362	WD_REPEATS_REGION domain-containing protein. (1007 aa)
	PGTG_06430	Peptidase_M24 domain-containing protein. (1060 aa)
	PGTG_06440	BHLH domain-containing protein. (652 aa)
	PGTG_06288	Abhydrolase_3 domain-containing protein. (1021 aa)
	PGTG_06315	Med12 domain-containing protein. (1845 aa)
	PGTG_06678	Uncharacterized protein. (1089 aa)
	PGTG_06575	Uncharacterized protein. (137 aa)
	PGTG_06509	Uncharacterized protein. (902 aa)
	MED10	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (190 aa)
	PGTG_07157	MADS-box domain-containing protein. (757 aa)
	PGTG_07393	Uncharacterized protein; Belongs to the MT-A70-like family. (643 aa)
	PGTG_07418	Uncharacterized protein. (822 aa)
	PGTG_07006	PHD domain-containing protein. (1325 aa)
	PGTG_06950	TAFII28 domain-containing protein. (257 aa)
	PGTG_06951	CBFD_NFYB_HMF domain-containing protein. (140 aa)
	PGTG_07086	Uncharacterized protein. (1043 aa)
	PGTG_07796	Uncharacterized protein. (984 aa)
	PGTG_07823	Uncharacterized protein. (674 aa)
	PGTG_07736	BZIP domain-containing protein. (596 aa)
	PGTG_08023	Uncharacterized protein. (685 aa)
	PGTG_07306	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1108 aa)
	PGTG_08031	Uncharacterized protein. (842 aa)
	MED6	Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (265 aa)
	PGTG_07541	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (122 aa)
	PGTG_08996	Uncharacterized protein. (960 aa)
	PGTG_12647	Uncharacterized protein. (670 aa)
	PGTG_13224	Uncharacterized protein. (301 aa)
	PGTG_13127	Uncharacterized protein. (456 aa)
	PGTG_13078	GATA-binding protein. (632 aa)
	KAE1	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (373 aa)
	PGTG_13006	Uncharacterized protein. (118 aa)
	SUS1	Transcription and mRNA export factor SUS1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex required for deubiquitination of [...] (159 aa)
	PGTG_12382	Uncharacterized protein. (325 aa)
	PGTG_12372	Hist_deacetyl domain-containing protein. (720 aa)
	PGTG_12312	Serine/threonine protein kinase. (314 aa)
	PGTG_12288	Prefoldin, alpha subunit. (153 aa)
	PGTG_11387	Uncharacterized protein. (371 aa)
	PGTG_11384	Fork-head domain-containing protein. (1413 aa)
	PGTG_11380	Transcription factor. (146 aa)
	PGTG_11504	Uncharacterized protein. (373 aa)
	PGTG_11248	Uncharacterized protein. (378 aa)
	PGTG_10429	CMGC/CDK/CDK9 protein kinase. (1315 aa)
	PGTG_10885	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (460 aa)
	PGTG_10130	CID domain-containing protein. (330 aa)
	PGTG_10082	Uncharacterized protein. (87 aa)
	PGTG_10610	Uncharacterized protein. (695 aa)
	PGTG_09722	BHLH domain-containing protein. (583 aa)
	PGTG_09509	26S protease regulatory subunit 8; Belongs to the AAA ATPase family. (407 aa)
	PGTG_09285	BHLH domain-containing protein. (425 aa)
	PGTG_08738	Uncharacterized protein. (1402 aa)
	PGTG_08554	CDC73_C domain-containing protein. (489 aa)
	PGTG_08516	Homeobox domain-containing protein. (566 aa)
	PGTG_09035	BZIP domain-containing protein. (433 aa)
	PGTG_09016	Uncharacterized protein. (1114 aa)
	PGTG_09876	Uncharacterized protein. (325 aa)
	PGTG_08983	CBFD_NFYB_HMF domain-containing protein. (478 aa)
	PGTG_08868	Uncharacterized protein; Belongs to the cyclin family. (438 aa)
	PGTG_22340	CID domain-containing protein. (328 aa)
	PGTG_22438	MADS-box domain-containing protein. (508 aa)
	PGTG_22042	Peptidase_M24 domain-containing protein. (254 aa)
	PGTG_20773	CMGC/CDK/CRK7 protein kinase. (1259 aa)
	PGTG_20734	26S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (416 aa)
	PGTG_20579	IPT/TIG domain-containing protein. (1520 aa)
	PGTG_19573	Uncharacterized protein. (741 aa)
	PGTG_19531	Uncharacterized protein. (519 aa)
	PGTG_19542	AAA domain-containing protein. (1381 aa)
	PGTG_19477	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (540 aa)
	PGTG_19495	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (802 aa)
	PGTG_19329	PLK/PLK1 protein kinase. (1042 aa)
	PGTG_19324	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. (110 aa)
	PGTG_19181	Uncharacterized protein. (518 aa)
	PGTG_19163	Peptidyl-prolyl cis-trans isomerase. (170 aa)
	PGTG_18855	Uncharacterized protein. (1112 aa)
	PGTG_18976	Uncharacterized protein. (375 aa)
	PGTG_18356	Uncharacterized protein. (221 aa)
	PGTG_17985	BRCT domain-containing protein. (1233 aa)
	PGTG_18154	Uncharacterized protein. (449 aa)
	PGTG_17651	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (724 aa)
	PGTG_17149	WD_REPEATS_REGION domain-containing protein. (558 aa)
	PGTG_16421	CID domain-containing protein. (330 aa)
	PGTG_16409	Uncharacterized protein. (178 aa)
	PGTG_16387	Adenosinetriphosphatase. (1125 aa)
	PGTG_16948	Uncharacterized protein. (788 aa)
	PGTG_16928	JmjC domain-containing protein. (470 aa)
	PGTG_17299	Uncharacterized protein. (449 aa)
	PGTG_16563	Uncharacterized protein. (765 aa)
	PGTG_16516	Uncharacterized protein. (998 aa)
	PGTG_16512	Histone chaperone ASF1. (225 aa)
	PGTG_16228	PITH domain-containing protein. (239 aa)
	PGTG_15394	Uncharacterized protein. (311 aa)
	PGTG_15728	Uncharacterized protein. (433 aa)
	PGTG_15320	CMGC/CDK/CDK7 protein kinase; Belongs to the protein kinase superfamily. (367 aa)
	PGTG_15303	Uncharacterized protein; Belongs to the actin family. (778 aa)
	PGTG_15512	Uncharacterized protein. (720 aa)
	PGTG_15035	PITH domain-containing protein. (214 aa)
	PGTG_14141	Uncharacterized protein. (419 aa)
	PGTG_14098	Uncharacterized protein. (125 aa)
	PGTG_14055	TPR_REGION domain-containing protein. (1907 aa)
	PGTG_14428	Amino_oxidase domain-containing protein. (598 aa)
	PGTG_14349	Uncharacterized protein. (199 aa)
	PGTG_13494	Uncharacterized protein. (735 aa)
	PGTG_13964	BHLH domain-containing protein. (626 aa)
	PGTG_13889	Uncharacterized protein. (976 aa)
	PGTG_13876	CBFD_NFYB_HMF domain-containing protein. (478 aa)
	PGTG_13705	Uncharacterized protein. (648 aa)
	PGTG_13704	SAGA-associated factor 73. (575 aa)
	PGTG_13324	Uncharacterized protein. (148 aa)
	PGTG_13323	Uncharacterized protein. (627 aa)
	PGTG_12692	SGF29 C-terminal domain-containing protein. (354 aa)

Your Current Organism:

Puccinia graminis

NCBI taxonomy Id: 418459
Other names: P. graminis f. sp. tritici CRL 75-36-700-3, Puccinia graminis f. sp. tritici CRL 75-36-700-3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MED10	MED6	E3K9C7	E3KD59	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.999
MED10	PGTG_00230	E3K9C7	E3JQ96	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.892
MED10	PGTG_02038	E3K9C7	E3JX02	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	TAF domain-containing protein.	0.511
MED10	PGTG_02205	E3K9C7	E3JXG9	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.435
MED10	PGTG_02767	E3K9C7	E3JWA1	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	zf-C2HC5 domain-containing protein.	0.958
MED10	PGTG_06315	E3K9C7	E3K7R1	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Med12 domain-containing protein.	0.516
MED10	PGTG_06575	E3K9C7	E3K8N8	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.914
MED10	PGTG_06950	E3K9C7	E3KAK5	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	TAFII28 domain-containing protein.	0.514
MED10	PGTG_07006	E3K9C7	E3KA94	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	PHD domain-containing protein.	0.504
MED10	PGTG_07541	E3K9C7	E3KDD5	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.	0.936
MED10	PGTG_08868	E3K9C7	E3KED9	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein; Belongs to the cyclin family.	0.958
MED10	PGTG_15320	E3K9C7	E3KYT2	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	CMGC/CDK/CDK7 protein kinase; Belongs to the protein kinase superfamily.	0.512
MED10	PGTG_15394	E3K9C7	E3KZL3	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.867
MED10	PGTG_17651	E3K9C7	E3L4X2	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	0.921
MED10	PGTG_18976	E3K9C7	E3L8T8	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.995
MED6	MED10	E3KD59	E3K9C7	Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.999
MED6	PGTG_00230	E3KD59	E3JQ96	Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.778
MED6	PGTG_02038	E3KD59	E3JX02	Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	TAF domain-containing protein.	0.519
MED6	PGTG_02205	E3KD59	E3JXG9	Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.574
MED6	PGTG_06315	E3KD59	E3K7R1	Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Med12 domain-containing protein.	0.653