STRINGSTRING
adk adk Mpe_A2492 Mpe_A2492 Mpe_A2513 Mpe_A2513 pyrF pyrF Mpe_A2520 Mpe_A2520 mobA mobA Mpe_A2523 Mpe_A2523 dut dut Mpe_A2571 Mpe_A2571 Mpe_A2579 Mpe_A2579 Mpe_A2615 Mpe_A2615 Mpe_A2629 Mpe_A2629 folE2 folE2 Mpe_A3624 Mpe_A3624 dxs dxs purN purN ispH ispH gmk gmk plsY plsY psd psd Mpe_A2838 Mpe_A2838 pyrG pyrG Mpe_A2893 Mpe_A2893 Mpe_A2928 Mpe_A2928 pdxH pdxH Mpe_A2952 Mpe_A2952 Mpe_A3012 Mpe_A3012 Mpe_A3017 Mpe_A3017 Mpe_A3021 Mpe_A3021 Mpe_A3045 Mpe_A3045 Mpe_A3192 Mpe_A3192 Mpe_A3207 Mpe_A3207 Mpe_A3213 Mpe_A3213 gmhA gmhA coaD coaD prs prs ispE ispE nadK nadK Mpe_A3378 Mpe_A3378 corC corC apt apt coaX coaX amn amn Mpe_A3475 Mpe_A3475 Mpe_A3504 Mpe_A3504 purU purU Mpe_A3521 Mpe_A3521 Mpe_A0029 Mpe_A0029 moaC moaC pyrE pyrE atpB atpB atpE atpE atpF atpF atpH atpH atpA atpA atpG atpG atpD atpD atpC atpC thiL thiL Mpe_A0212 Mpe_A0212 purC purC purE purE purK purK Mpe_A0343 Mpe_A0343 Mpe_A0395 Mpe_A0395 pyrC pyrC lpxC lpxC Mpe_A0484 Mpe_A0484 purH purH coaE coaE Mpe_A3711 Mpe_A3711 glmU glmU fliI fliI plsX plsX Mpe_A0705 Mpe_A0705 pyrB pyrB Mpe_A0709 Mpe_A0709 Mpe_A0710 Mpe_A0710 gpsA gpsA Mpe_A0791 Mpe_A0791 Mpe_A0792 Mpe_A0792 Mpe_A0846 Mpe_A0846 Mpe_A1074 Mpe_A1074 Mpe_A1083 Mpe_A1083 Mpe_A1164 Mpe_A1164 Mpe_A1170 Mpe_A1170 fdhD fdhD Mpe_A1177 Mpe_A1177 carA carA carB carB Mpe_A1318 Mpe_A1318 Mpe_A1328 Mpe_A1328 Mpe_A1329 Mpe_A1329 purD purD nadD nadD acsA acsA Mpe_A1543 Mpe_A1543 Mpe_A1544 Mpe_A1544 Mpe_A1545 Mpe_A1545 Mpe_A1547 Mpe_A1547 Mpe_A1551 Mpe_A1551 Mpe_A1553 Mpe_A1553 Mpe_A1554 Mpe_A1554 ispD ispD ispF ispF thiL-2 thiL-2 Mpe_A1603 Mpe_A1603 Mpe_A1606 Mpe_A1606 thiG thiG Mpe_A1608 Mpe_A1608 thiC thiC guaB guaB guaA guaA Mpe_A1722 Mpe_A1722 Mpe_A1734 Mpe_A1734 purL purL upp upp tmk tmk Mpe_A1958 Mpe_A1958 lpxB lpxB lpxA lpxA lpxD lpxD dxr dxr Mpe_A1974 Mpe_A1974 pyrH pyrH Mpe_A1984 Mpe_A1984 purA purA ispG ispG ndk ndk Mpe_A2045 Mpe_A2045 thyA thyA Mpe_A2077 Mpe_A2077 Mpe_A2102 Mpe_A2102 Mpe_A2110 Mpe_A2110 nadE nadE folD folD pyrD pyrD purF purF accD accD Mpe_A2181 Mpe_A2181 Mpe_A2183 Mpe_A2183 cmk cmk accA accA lpxH lpxH lpxK lpxK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
Mpe_A2492Adenylate cyclase family 3-like protein; Some proteins contain HAMP domain. (313 aa)
Mpe_A2513PrpE protein ligase (putative propionyl-CoA synthetase). (631 aa)
pyrFPutative orotidine 5'-phosphate decarboxylase protein; Belongs to the OMP decarboxylase family. Type 2 subfamily. (278 aa)
Mpe_A2520Putative molybdenum cofactor biosynthesis protein A. (229 aa)
mobAMolybdenum cofactor guanylyltransferase; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (203 aa)
Mpe_A2523Molybdopterin molybdochelatase; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (433 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (149 aa)
Mpe_A2571Phosphopantothenoylcysteine decarboxylase / Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (414 aa)
Mpe_A2579Hypothetical protein. (84 aa)
Mpe_A2615DNA/pantothenate metabolism flavolike protein. (181 aa)
Mpe_A2629Putative hydrolase protein. (220 aa)
folE2GTP cyclohydrolase; Converts GTP to 7,8-dihydroneopterin triphosphate. (300 aa)
Mpe_A3624Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (457 aa)
dxs1-Deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (631 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (209 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (329 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa)
plsYAcyl-phosphate glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (210 aa)
psdPhosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (283 aa)
Mpe_A2838Molybdopterin adenylyltransferase. (204 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (555 aa)
Mpe_A2893Beta subunit of malonate decarboxylase. (291 aa)
Mpe_A2928Conserved hypothetical protein. (210 aa)
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (224 aa)
Mpe_A2952Hypothetical protein. (167 aa)
Mpe_A3012Conserved hypothetical protein. (315 aa)
Mpe_A3017Deoxynucleoside kinase. (246 aa)
Mpe_A3021Conserved hypothetical protein. (222 aa)
Mpe_A3045FMN adenylyltransferase / riboflavin kinase; Belongs to the ribF family. (349 aa)
Mpe_A3192Hydroxymethylpyrimidine kinase. (319 aa)
Mpe_A3207Putative biotin carboxylase protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa)
Mpe_A3213Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (403 aa)
gmhAPhosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (200 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (166 aa)
prsRibose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (321 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (287 aa)
nadKNAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (301 aa)
Mpe_A33781-acyl-sn-glycerol-3-phosphate acyltransferase. (254 aa)
corCTransport protein; Mg2+/Co2+ efflux. (306 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (196 aa)
coaXTranscriptional regulator, Bvg acessory factor; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (254 aa)
amnAMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (517 aa)
Mpe_A3475Conserved hypothetical protein. (342 aa)
Mpe_A3504NUDIX domain family protein. (192 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (295 aa)
Mpe_A3521Conserved hypothetical protein. (89 aa)
Mpe_A0029PhnB protein. (140 aa)
moaCGTP cyclohydrolase subunit MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (171 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (234 aa)
atpBF0-ATP synthase, a subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (290 aa)
atpEF0-ATP synthase, c subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (82 aa)
atpFATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (156 aa)
atpHPutative ATP synthase delta chain protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (177 aa)
atpASodium-transporting two-sector ATPase; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (517 aa)
atpGSodium-transporting two-sector ATPase; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (291 aa)
atpDSodium-transporting two-sector ATPase; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (471 aa)
atpCPutative ATP synthase epsilon chain protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. (138 aa)
thiLThiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (323 aa)
Mpe_A0212Competence/damage-inducible protein CinA C-terminal domain; Belongs to the CinA family. (168 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (300 aa)
purEPhosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (159 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (397 aa)
Mpe_A0343Putative acetyl-coenzyme A synthetase. (571 aa)
Mpe_A0395PrpE protein ligase (putative propionyl-CoA synthetase). (631 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa)
lpxCUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (311 aa)
Mpe_A0484Acyltransferase, putative. (208 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. (531 aa)
coaEDephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (207 aa)
Mpe_A3711Formate dehydrogenase B chain. (133 aa)
glmUGlucosamine-1-phosphate N-acetyltransferase / UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the t [...] (460 aa)
fliIFlagellar biosynthesis ATPase. (487 aa)
plsXPhosphate:acyl-[acyl carrier protein] acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (368 aa)
Mpe_A0705Conserved hypothetical protein; Belongs to the UPF0301 (AlgH) family. (200 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (320 aa)
Mpe_A0709Dihydroorotase. (439 aa)
Mpe_A0710Lyso-ornithine lipid acyltransferase. (249 aa)
gpsAGlycerol-3-phosphate dehydrogenase (NAD(P)+); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (333 aa)
Mpe_A0791Malonate decarboxylase gamma subunit. (239 aa)
Mpe_A0792Beta subunit of malonate decarboxylase. (311 aa)
Mpe_A08464-hydroxythreonine-4-phosphate dehydrogenase; Belongs to the PdxA family. (337 aa)
Mpe_A1074GTP cyclohydrolase. (243 aa)
Mpe_A1083Putative molybdopterin biosynthesis protein. (254 aa)
Mpe_A1164Conserved hypothetical protein. (166 aa)
Mpe_A1170Formate dehydrogenase large subunit precursor; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (988 aa)
fdhDPutative fdhD protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (299 aa)
Mpe_A1177dCTP deaminase. (120 aa)
carACarbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (383 aa)
carBCarbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1090 aa)
Mpe_A1318Putative CoA ligase (AMP forming). (466 aa)
Mpe_A1328Glycosyl transferase, family 2. (257 aa)
Mpe_A1329Acyltransferase, putative. (248 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (430 aa)
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (212 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (633 aa)
Mpe_A1543Putative molybdopterin-guanine dinucleotide biosynthesis protein. (207 aa)
Mpe_A1544Putative molybdopterin biosynthesis moea protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (404 aa)
Mpe_A1545Molybdopterin synthase subunit MoaD. (84 aa)
Mpe_A1547Molybdopterin synthase subunit MoaE. (165 aa)
Mpe_A1551L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (530 aa)
Mpe_A1553Nicotinate-nucleotide pyrophosphorylase (carboxylating); Belongs to the NadC/ModD family. (290 aa)
Mpe_A1554Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (371 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (237 aa)
ispF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (162 aa)
thiL-2Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (319 aa)
Mpe_A1603Acetoin catabolism protein X; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (351 aa)
Mpe_A1606Phosphomethylpyrimidine kinase / thiamine-phosphate pyrophosphorylase. (532 aa)
thiGThiamine biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (293 aa)
Mpe_A1608Sulfur transfer protein; Involved in thiamine biosynthesis. (77 aa)
thiCThiamin biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (628 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (534 aa)
Mpe_A1722Conserved hypothetical protein. (332 aa)
Mpe_A1734ATPase-like protein. (977 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1336 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
tmkThymidylate kinase / thymidylate synthase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (215 aa)
Mpe_A1958CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (188 aa)
lpxBlipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (376 aa)
lpxAacyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (274 aa)
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (365 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (392 aa)
Mpe_A1974Putative phosphatidate cytidylyltransferase membrane protein; Belongs to the CDS family. (279 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (236 aa)
Mpe_A1984Putative transferase. (173 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (444 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (432 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa)
Mpe_A2045CDP-diacylglycerol-serine o-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (216 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (283 aa)
Mpe_A2077Conserved hypothetical protein. (269 aa)
Mpe_A2102CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (313 aa)
Mpe_A2110Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (126 aa)
nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (559 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa)
pyrDDihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (344 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (509 aa)
accDAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa)
Mpe_A2181Hypothetical protein. (269 aa)
Mpe_A2183Conserved hypothetical protein. (318 aa)
cmk3-phosphoshikimate 1-carboxyvinyltransferase / cytidylate kinase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. (674 aa)
accAAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (323 aa)
lpxHUDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (283 aa)
lpxKlipid-A-disaccharide synthase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (358 aa)
Your Current Organism:
Methylibium petroleiphilum
NCBI taxonomy Id: 420662
Other names: M. petroleiphilum PM1, MTBE-degrading bacterium PM1, Methylibium petroleiphilum PM1, Methylibium petroleiphilum str. PM1, Methylibium petroleiphilum strain PM1, Rubrivivax gelatinosus PM1
Server load: low (14%) [HD]