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cbbA cbbA Mpe_A0330 Mpe_A0330 Mpe_A0337 Mpe_A0337 Mpe_A0338 Mpe_A0338 Mpe_A0343 Mpe_A0343 gpmA gpmA Mpe_A0938 Mpe_A0938 Mpe_A0939 Mpe_A0939 Mpe_A0976 Mpe_A0976 Mpe_A1136 Mpe_A1136 Mpe_A1170 Mpe_A1170 Mpe_A1171 Mpe_A1171 Mpe_A1173 Mpe_A1173 acsA acsA cbbF cbbF Mpe_A1521 Mpe_A1521 Mpe_A1568 Mpe_A1568 Mpe_A1820 Mpe_A1820 Mpe_A1891 Mpe_A1891 Mpe_A1892 Mpe_A1892 Mpe_A1893 Mpe_A1893 mdh mdh serC serC Mpe_A2607 Mpe_A2607 mch mch Mpe_A2612 Mpe_A2612 Mpe_A2618 Mpe_A2618 Mpe_A2619 Mpe_A2619 Mpe_A2620 Mpe_A2620 Mpe_A2621 Mpe_A2621 Mpe_A2623 Mpe_A2623 Mpe_A2624 Mpe_A2624 ffsA ffsA Mpe_A2626 Mpe_A2626 Mpe_A2627 Mpe_A2627 Mpe_A2653 Mpe_A2653 cbbF-2 cbbF-2 pfp pfp cbbF-3 cbbF-3 cbbA-2 cbbA-2 eno eno glyA glyA ppc ppc Mpe_A3254 Mpe_A3254 Mpe_A3255 Mpe_A3255 sucD-2 sucD-2 sucC-2 sucC-2 Mpe_A3259 Mpe_A3259 Mpe_A3260 Mpe_A3260 Mpe_A3261 Mpe_A3261 glyA-2 glyA-2 Mpe_A3263 Mpe_A3263 Mpe_A3273 Mpe_A3273 Mpe_A3274 Mpe_A3274 Mpe_A3275 Mpe_A3275 Mpe_A3276 Mpe_A3276 Mpe_A3393 Mpe_A3393 Mpe_A3708 Mpe_A3708 Mpe_A3709 Mpe_A3709 Mpe_A3710 Mpe_A3710 Mpe_A3712 Mpe_A3712
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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cbbAFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
Mpe_A0330Phosphoglycerate mutase. (233 aa)
Mpe_A0337Formate dehydrogenase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (955 aa)
Mpe_A0338NADH dehydrogenase (quinone). (573 aa)
Mpe_A0343Putative acetyl-coenzyme A synthetase. (571 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (247 aa)
Mpe_A0938Hypothetical protein. (168 aa)
Mpe_A0939Conserved hypothetical protein. (166 aa)
Mpe_A0976Hydroxypyruvate reductase. (429 aa)
Mpe_A1136Phosphoglycerate dehydrogenase-related protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (374 aa)
Mpe_A1170Formate dehydrogenase large subunit precursor; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (988 aa)
Mpe_A1171Formate dehydrogenase iron-sulfur subunit. (210 aa)
Mpe_A1173Formate dehydrogenase gamma subunit. (388 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (633 aa)
cbbFD-fructose 1,6-bisphosphatase. (351 aa)
Mpe_A1521Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (784 aa)
Mpe_A1568Phosphoserine phosphatase. (241 aa)
Mpe_A1820Putative D-3-phosphoglycerate dehydrogenase oxidoreductase protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (365 aa)
Mpe_A1891MxaL protein, putative. (353 aa)
Mpe_A1892MxaK protein, putative. (179 aa)
Mpe_A1893MxaC protein, putative. (353 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (366 aa)
Mpe_A2607Methylene tetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase, putative. (300 aa)
mchMethenyltetrahydromethanopterin cyclohydrolase; Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family. (350 aa)
Mpe_A2612Formaldehyde-activating enzyme. (169 aa)
Mpe_A2618Conserved hypothetical protein. (227 aa)
Mpe_A2619Uncharacterized kinase. (202 aa)
Mpe_A2620S-layer protein, putative. (352 aa)
Mpe_A2621Conserved hypothetical protein. (319 aa)
Mpe_A2623Formylmethanofuran dehydrogenase, subunit B. (423 aa)
Mpe_A2624Formylmethanofuran dehydrogenase, subunit A. (561 aa)
ffsAFormylmethanofuran-tetrahydromethanopterin formyltransferase; Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT); Belongs to the FTR family. (307 aa)
Mpe_A2626Formylmethanofuran dehydrogenase, subunit C. (269 aa)
Mpe_A2627Putative formaldehyde-activating enzyme. (177 aa)
Mpe_A2653Amine dehydrogenase; Belongs to the aromatic amine dehydrogenase light chain family. (184 aa)
cbbF-2D-fructose 1,6-bisphosphatase. (336 aa)
pfpPyrophosphate-dependent phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (420 aa)
cbbF-3D-fructose 1,6-bisphosphatase. (357 aa)
cbbA-2Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (345 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (433 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (421 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (934 aa)
Mpe_A3254Citryl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. (327 aa)
Mpe_A3255Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (920 aa)
sucD-2succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa)
sucC-2succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa)
Mpe_A3259Methylenetetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase. (286 aa)
Mpe_A3260Putative 2-hydroxyacid dehydrogenase family protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (320 aa)
Mpe_A3261Serine-glyoxylate aminotransferase. (415 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (454 aa)
Mpe_A3263Glycerate 2-kinase. (420 aa)
Mpe_A3273MxaL protein, putative. (309 aa)
Mpe_A3274Hypothetical protein. (196 aa)
Mpe_A3275MxaC protein, putative. (342 aa)
Mpe_A3276Hypothetical protein. (323 aa)
Mpe_A3393Putative methanol dehydrogenase protein, large subunit. (606 aa)
Mpe_A3708NAD-dependent formate dehydrogenase gamma subunit. (161 aa)
Mpe_A3709NADH dehydrogenase (quinone). (520 aa)
Mpe_A3710NAD-dependent formate dehydrogenase alpha subunit. (977 aa)
Mpe_A3712Formate dehydrogenase delta subunit. (74 aa)
Your Current Organism:
Methylibium petroleiphilum
NCBI taxonomy Id: 420662
Other names: M. petroleiphilum PM1, MTBE-degrading bacterium PM1, Methylibium petroleiphilum PM1, Methylibium petroleiphilum str. PM1, Methylibium petroleiphilum strain PM1, Rubrivivax gelatinosus PM1
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