STRINGSTRING
Mpe_A0026 Mpe_A0026 sucD sucD sucC sucC argC argC hemE hemE Mpe_A0159 Mpe_A0159 Mpe_A0166 Mpe_A0166 Mpe_A0168 Mpe_A0168 Mpe_A0186 Mpe_A0186 Mpe_A0213 Mpe_A0213 dapB dapB Mpe_A0245 Mpe_A0245 tktA tktA gapA gapA proA proA pgk pgk pykF pykF cbbA cbbA purC purC purE purE purK purK Mpe_A0306 Mpe_A0306 Mpe_A0307 Mpe_A0307 Mpe_A0330 Mpe_A0330 Mpe_A0343 Mpe_A0343 Mpe_A0363 Mpe_A0363 Mpe_A0416 Mpe_A0416 Mpe_A0450 Mpe_A0450 Mpe_A0473 Mpe_A0473 Mpe_A0483 Mpe_A0483 purH purH argB argB Mpe_A0510 Mpe_A0510 proB proB ubiX ubiX hemA hemA Mpe_A0591 Mpe_A0591 Mpe_A0597 Mpe_A0597 Mpe_A0599 Mpe_A0599 Mpe_A0625 Mpe_A0625 Mpe_A0626 Mpe_A0626 Mpe_A0627 Mpe_A0627 Mpe_A0628 Mpe_A0628 Mpe_A0629 Mpe_A0629 plsX plsX Mpe_A0637 Mpe_A0637 Mpe_A0638 Mpe_A0638 acpP acpP Mpe_A0658 Mpe_A0658 Mpe_A0710 Mpe_A0710 gpmA gpmA gpsA gpsA panB1 panB1 Mpe_A0788 Mpe_A0788 hisG hisG hisD hisD hisC hisC hisB hisB hisH hisH hisA hisA hisF hisF hisI hisI hisE hisE Mpe_A0874 Mpe_A0874 Mpe_A0879 Mpe_A0879 Mpe_A0896 Mpe_A0896 Mpe_A0959 Mpe_A0959 Mpe_A0960 Mpe_A0960 Mpe_A0961 Mpe_A0961 Mpe_A0973 Mpe_A0973 Mpe_A0976 Mpe_A0976 Mpe_A1016 Mpe_A1016 Mpe_A1017 Mpe_A1017 Mpe_A1081 Mpe_A1081 Mpe_A1100 Mpe_A1100 argH argH Mpe_A1135 Mpe_A1135 Mpe_A1136 Mpe_A1136 thrB thrB panC panC panB2 panB2 surE surE Mpe_A1287 Mpe_A1287 Mpe_A1316 Mpe_A1316 Mpe_A1327 Mpe_A1327 Mpe_A1331 Mpe_A1331 Mpe_A1333 Mpe_A1333 purD purD hemF hemF Mpe_A1358 Mpe_A1358 Mpe_A1361 Mpe_A1361 Mpe_A1363 Mpe_A1363 argA argA Mpe_A1382 Mpe_A1382 acsA acsA ilvD ilvD tpiA tpiA aroC aroC Mpe_A1429 Mpe_A1429 Mpe_A1430 Mpe_A1430 gcvP gcvP gcvH gcvH Mpe_A1433 Mpe_A1433 Mpe_A1462 Mpe_A1462 cbbL cbbL cbbS cbbS cbbF cbbF cbbZ cbbZ Mpe_A1498 Mpe_A1498 Mpe_A1499 Mpe_A1499 Mpe_A1500 Mpe_A1500 Mpe_A1511 Mpe_A1511 Mpe_A1521 Mpe_A1521 Mpe_A1536 Mpe_A1536 Mpe_A1540 Mpe_A1540 Mpe_A1541 Mpe_A1541 Mpe_A1542 Mpe_A1542 Mpe_A1557 Mpe_A1557 Mpe_A1568 Mpe_A1568 ispD ispD ispF ispF Mpe_A1580 Mpe_A1580 gapA-2 gapA-2 Mpe_A1594 Mpe_A1594 Mpe_A1600 Mpe_A1600 Mpe_A1615 Mpe_A1615 guaB guaB purL purL Mpe_A1776 Mpe_A1776 Mpe_A1820 Mpe_A1820 Mpe_A1865 Mpe_A1865 Mpe_A1869 Mpe_A1869 Mpe_A1889 Mpe_A1889 Mpe_A1913 Mpe_A1913 Mpe_A1924 Mpe_A1924 Mpe_A1953 Mpe_A1953 dxr dxr Mpe_A1974 Mpe_A1974 Mpe_A1975 Mpe_A1975 hisZ hisZ ispG ispG ndk ndk Mpe_A2010 Mpe_A2010 Mpe_A2012 Mpe_A2012 Mpe_A2013 Mpe_A2013 miaA miaA Mpe_A2045 Mpe_A2045 Mpe_A2082 Mpe_A2082 Mpe_A2097 Mpe_A2097 leuA leuA Mpe_A2102 Mpe_A2102 ilvC ilvC Mpe_A2104 Mpe_A2104 Mpe_A2105 Mpe_A2105 Mpe_A2110 Mpe_A2110 Mpe_A2115 Mpe_A2115 Mpe_A2126 Mpe_A2126 Mpe_A2127 Mpe_A2127 Mpe_A2128 Mpe_A2128 cbbI cbbI Mpe_A2141 Mpe_A2141 Mpe_A2149 Mpe_A2149 purF purF accD accD trpA trpA trpB trpB trpF trpF asd asd leuB leuB leuD leuD leuC leuC Mpe_A2165 Mpe_A2165 Mpe_A2167 Mpe_A2167 Mpe_A2168 Mpe_A2168 Mpe_A2169 Mpe_A2169 Mpe_A2170 Mpe_A2170 mdh mdh Mpe_A2226 Mpe_A2226 ubiG ubiG serC serC Mpe_A2241 Mpe_A2241 Mpe_A2242 Mpe_A2242 cmk cmk Mpe_A2293 Mpe_A2293 Mpe_A2321 Mpe_A2321 Mpe_A2452 Mpe_A2452 accA accA Mpe_A2468 Mpe_A2468 Mpe_A2470 Mpe_A2470 adk adk Mpe_A2493 Mpe_A2493 hemH hemH Mpe_A2524 Mpe_A2524 dapA dapA Mpe_A2577 Mpe_A2577 Mpe_A2622 Mpe_A2622 dxs dxs Mpe_A2632 Mpe_A2632 purN purN Mpe_A2684 Mpe_A2684 ispH ispH Mpe_A2724 Mpe_A2724 Mpe_A2729 Mpe_A2729 ubiE ubiE argJ argJ plsY plsY cbbF-2 cbbF-2 pfp pfp Mpe_A2779 Mpe_A2779 cbbL-2 cbbL-2 cbbS-2 cbbS-2 cbbE cbbE cbbZ-2 cbbZ-2 cbbF-3 cbbF-3 cbbT cbbT cbbG cbbG cbbK cbbK cbbA-2 cbbA-2 psd psd Mpe_A2839 Mpe_A2839 Mpe_A2841 Mpe_A2841 eno eno Mpe_A2888 Mpe_A2888 Mpe_A2912 Mpe_A2912 Mpe_A2921 Mpe_A2921 Mpe_A2936 Mpe_A2936 glyA glyA Mpe_A2945 Mpe_A2945 Mpe_A2946 Mpe_A2946 ribB ribB ribH ribH Mpe_A3000 Mpe_A3000 Mpe_A3001 Mpe_A3001 hemC hemC argD argD argF argF argG argG Mpe_A3045 Mpe_A3045 Mpe_A3053 Mpe_A3053 pgi pgi tal tal Mpe_A3102 Mpe_A3102 Mpe_A3103 Mpe_A3103 aroB aroB aroK aroK lysA lysA coq7 coq7 ilvA ilvA Mpe_A3141 Mpe_A3141 Mpe_A3170 Mpe_A3170 ctaB ctaB Mpe_A3174 Mpe_A3174 hemL hemL Mpe_A3194 Mpe_A3194 aroE aroE aroQ aroQ Mpe_A3206 Mpe_A3206 Mpe_A3207 Mpe_A3207 prs prs ispE ispE dapF dapF metK metK Mpe_A3260 Mpe_A3260 Mpe_A3261 Mpe_A3261 glyA-2 glyA-2 Mpe_A3263 Mpe_A3263 Mpe_A3318 Mpe_A3318 fumC fumC Mpe_A3338 Mpe_A3338 Mpe_A3354 Mpe_A3354 Mpe_A3367 Mpe_A3367 Mpe_A3378 Mpe_A3378 trpC trpC trpD trpD Mpe_A3462 Mpe_A3462 trpE trpE cbbE-2 cbbE-2 Mpe_A3505 Mpe_A3505 ilvE ilvE panD panD metXS metXS Mpe_A3624 Mpe_A3624 Mpe_A3638 Mpe_A3638 Mpe_A3639 Mpe_A3639 Mpe_A3640 Mpe_A3640 Mpe_A3651 Mpe_A3651 Mpe_A3664 Mpe_A3664 Mpe_A3678 Mpe_A3678 Mpe_A3682 Mpe_A3682 pckG pckG katG katG ubiA ubiA proC proC Mpe_A3748 Mpe_A3748 Mpe_A3770 Mpe_A3770 Mpe_A3771 Mpe_A3771 Mpe_A3775 Mpe_A3775 Mpe_A3790 Mpe_A3790 Mpe_A3792 Mpe_A3792
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Mpe_A0026Serine O-acetyltransferase. (322 aa)
sucDsuccinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (297 aa)
sucCsuccinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (307 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (372 aa)
Mpe_A0159Malate synthase; Belongs to the malate synthase family. (528 aa)
Mpe_A0166Methionine synthase (B12-dependent). (357 aa)
Mpe_A0168Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (923 aa)
Mpe_A0186Valine-pyruvate aminotransferase. (402 aa)
Mpe_A0213Putative 2-hydroxyacid dehydrogenase in PhoH-CsgG intergenic region. (310 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (276 aa)
Mpe_A0245Putative 2-octaprenyl-6-methoxyphenol hydroxylase oxidoreductase protein. (411 aa)
tktATransketolase; Belongs to the transketolase family. (680 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (338 aa)
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (429 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (397 aa)
pykFPyruvate kinase; Belongs to the pyruvate kinase family. (478 aa)
cbbAFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (300 aa)
purEPhosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (159 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (397 aa)
Mpe_A0306Porphobilinogen synthase; Belongs to the ALAD family. (343 aa)
Mpe_A0307Putative transmembrane protein. (142 aa)
Mpe_A0330Phosphoglycerate mutase. (233 aa)
Mpe_A0343Putative acetyl-coenzyme A synthetase. (571 aa)
Mpe_A0363Putative alcohol dehydrogenase precursor. (572 aa)
Mpe_A0416Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (399 aa)
Mpe_A0450Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (306 aa)
Mpe_A0473Quinoprotein ethanol dehydrogenase, putative. (580 aa)
Mpe_A0483Phosphatidate cytidylyltransferase. (324 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. (531 aa)
argBN-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (304 aa)
Mpe_A0510Dimethylallyltransferase; Belongs to the FPP/GGPP synthase family. (330 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (372 aa)
ubiXPutative flavoprotein; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (187 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (443 aa)
Mpe_A05912-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase. (372 aa)
Mpe_A0597Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (262 aa)
Mpe_A0599Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (506 aa)
Mpe_A0625dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (184 aa)
Mpe_A0626Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (294 aa)
Mpe_A0627dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (298 aa)
Mpe_A0628dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (357 aa)
Mpe_A0629Mannose-1-phosphate guanylyltransferase (GDP); Belongs to the mannose-6-phosphate isomerase type 2 family. (500 aa)
plsXPhosphate:acyl-[acyl carrier protein] acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (368 aa)
Mpe_A0637[Acyl-carrier-protein] S-malonyltransferase. (312 aa)
Mpe_A06383-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (249 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (79 aa)
Mpe_A0658Haloacid dehalogenase-like hydrolase. (222 aa)
Mpe_A0710Lyso-ornithine lipid acyltransferase. (249 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (247 aa)
gpsAGlycerol-3-phosphate dehydrogenase (NAD(P)+); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (333 aa)
panB13-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (294 aa)
Mpe_A0788Acyl-carrier-protein S-malonyltransferase-like protein. (366 aa)
hisGATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (214 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (447 aa)
hisCHistidinol phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (371 aa)
hisBImidazoleglycerol-phosphate dehydratase. (199 aa)
hisHImidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (218 aa)
hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (248 aa)
hisFImidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (129 aa)
hisEphosphoribosyl-ATP pyrophosphatase. (120 aa)
Mpe_A0874Pyruvate dehydrogenase (lipoamide); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (891 aa)
Mpe_A0879Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
Mpe_A0896Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (350 aa)
Mpe_A0959Putative glycolate oxidase (FAD-linked subunit) oxidoreductase protein. (501 aa)
Mpe_A0960FAD linked oxidase. (368 aa)
Mpe_A0961Putative glycolate oxidase (iron-sulfur subunit) protein. (411 aa)
Mpe_A0973Putative D-isomer specific 2-hydroxyacid dehydrogenase. (321 aa)
Mpe_A0976Hydroxypyruvate reductase. (429 aa)
Mpe_A1016propionyl-CoA carboxylase beta subunit. (510 aa)
Mpe_A1017propionyl-CoA carboxylase, alpha subunit. (675 aa)
Mpe_A1081Arginase; Belongs to the arginase family. (311 aa)
Mpe_A1100Conserved hypothetical protein. (262 aa)
argHArgininosuccinate lyase. (467 aa)
Mpe_A1135UDP-glucose pyrophosphorylase. (288 aa)
Mpe_A1136Phosphoglycerate dehydrogenase-related protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (374 aa)
thrBHomoserine kinase; Belongs to the pseudomonas-type ThrB family. (324 aa)
panCPantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (281 aa)
panB23-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (295 aa)
surEExopolyphosphatase / 3'-nucleotidase / 5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (257 aa)
Mpe_A1287Farnesyl-diphosphate farnesyltransferase. (287 aa)
Mpe_A1316Acyl carrier protein. (101 aa)
Mpe_A13273-oxoacyl-(ACP) reductase. (243 aa)
Mpe_A1331Conserved hypothetical protein. (344 aa)
Mpe_A1333Demethylmenaquinone methyltransferase. (258 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (430 aa)
hemFCoproporphyrinogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (306 aa)
Mpe_A1358Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (909 aa)
Mpe_A13612-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (305 aa)
Mpe_A1363Aconitase; Belongs to the aconitase/IPM isomerase family. (863 aa)
argAN-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily. (446 aa)
Mpe_A1382Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (633 aa)
ilvDDihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (560 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (368 aa)
Mpe_A1429L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (463 aa)
Mpe_A1430L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (350 aa)
gcvPGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (1003 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (124 aa)
Mpe_A1433Aminomethyltransferase. (381 aa)
Mpe_A1462Conserved hypothetical protein. (159 aa)
cbbLRibulose-1,5-bisphosphate carboxylase/oxygenase large subunit; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site; Belongs to the RuBisCO large chain family. Type I subfamily. (488 aa)
cbbSRibulose 1,5-bisphosphate carboxylase small subunit. (147 aa)
cbbFD-fructose 1,6-bisphosphatase. (351 aa)
cbbZPhosphoglycolate phosphatase. (231 aa)
Mpe_A1498uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (262 aa)
Mpe_A1499Sulfate adenylyltransferase subunit 1. (427 aa)
Mpe_A1500Sulfate adenylyltransferase subunit 2. (319 aa)
Mpe_A1511Putative 2-hydroxyacid dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (330 aa)
Mpe_A1521Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (784 aa)
Mpe_A1536Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
Mpe_A1540Aminotransferase. (409 aa)
Mpe_A1541Homoserine dehydrogenase. (438 aa)
Mpe_A1542L-threonine synthase. (470 aa)
Mpe_A1557Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (564 aa)
Mpe_A1568Phosphoserine phosphatase. (241 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (237 aa)
ispF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (162 aa)
Mpe_A1580Putative catalase; Has an organic peroxide-dependent peroxidase activity. Belongs to the catalase family. (338 aa)
gapA-2Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (347 aa)
Mpe_A1594Glucose dehydrogenase. (651 aa)
Mpe_A1600Acetoin dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase. (371 aa)
Mpe_A1615Cystathionine beta-lyase. (399 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1336 aa)
Mpe_A1776Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
Mpe_A1820Putative D-3-phosphoglycerate dehydrogenase oxidoreductase protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (365 aa)
Mpe_A1865Asparaginase. (315 aa)
Mpe_A1869acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
Mpe_A1889Isocitrate lyase. (438 aa)
Mpe_A1913Glutaminase-(asparagin-)ase; Belongs to the asparaginase 1 family. (363 aa)
Mpe_A1924Enoyl-[acyl-carrier-protein] reductase (NADH). (261 aa)
Mpe_A1953Putative acyl-CoA dehydrogenase family protein. (415 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (392 aa)
Mpe_A1974Putative phosphatidate cytidylyltransferase membrane protein; Belongs to the CDS family. (279 aa)
Mpe_A1975Undecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (258 aa)
hisZATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (387 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (432 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa)
Mpe_A2010Dihydrolipoamide dehydrogenase. (475 aa)
Mpe_A20122-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (426 aa)
Mpe_A20132-oxoglutarate dehydrogenase E1 component. (952 aa)
miaAtRNA isopentenyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (327 aa)
Mpe_A2045CDP-diacylglycerol-serine o-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (216 aa)
Mpe_A2082N-acetylglucosamine kinase. (318 aa)
Mpe_A2097Putative ferredoxin. (449 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (513 aa)
Mpe_A2102CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (313 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
Mpe_A2104Acetolactate synthase, small subunit. (163 aa)
Mpe_A2105Acetolactate synthase, large subunit. (591 aa)
Mpe_A2110Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (126 aa)
Mpe_A2115Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (411 aa)
Mpe_A2126Dihydrolipoamide dehydrogenase. (595 aa)
Mpe_A2127Dihydrolipoamide S-succinyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (543 aa)
Mpe_A2128Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (909 aa)
cbbIRibose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (219 aa)
Mpe_A2141Phosphomannomutase. (463 aa)
Mpe_A2149glutamyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (350 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (509 aa)
accDAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa)
trpATryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (272 aa)
trpBTryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (412 aa)
trpFPhosphoribosylanthranilate isomerase; Belongs to the TrpF family. (213 aa)
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (375 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (216 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (479 aa)
Mpe_A2165Citrate synthase; Belongs to the citrate synthase family. (437 aa)
Mpe_A2167Succinate dehydrogenase subunit B; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (234 aa)
Mpe_A2168Succinate dehydrogenase subunit A; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (596 aa)
Mpe_A2169Succinate dehydrogenase subunit D. (120 aa)
Mpe_A2170Succinate dehydrogenase subunit C. (146 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
Mpe_A22262-dehydropantoate 2-reductase. (336 aa)
ubiG3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (253 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (366 aa)
Mpe_A2241Prephenate dehydratase / chorismate mutase. (370 aa)
Mpe_A2242Prephenate dehydrogenase. (294 aa)
cmk3-phosphoshikimate 1-carboxyvinyltransferase / cytidylate kinase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. (674 aa)
Mpe_A2293Aromatic amino acid aminotransferase. (396 aa)
Mpe_A2321uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (259 aa)
Mpe_A2452Aspartate kinase; Belongs to the aspartokinase family. (453 aa)
accAAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (323 aa)
Mpe_A2468Isocitrate dehydrogenase (NADP). (417 aa)
Mpe_A2470Coproporphyrinogen III oxidase, anaerobic; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (476 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
Mpe_A2493Hydrolase. (235 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (363 aa)
Mpe_A2524Dihydrolipoamide dehydrogenase. (481 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa)
Mpe_A2577Aldehyde dehydrogenase. (477 aa)
Mpe_A2622HisA/HisF family protein, putative; Belongs to the HisA/HisF family. (273 aa)
dxs1-Deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (631 aa)
Mpe_A2632Farnesyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. (297 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (209 aa)
Mpe_A2684Tryptophan repressor binding protein. (195 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (329 aa)
Mpe_A2724Asparagine synthase (glutamine-hydrolyzing). (621 aa)
Mpe_A2729Mannose-1-phosphate guanylyltransferase (GDP); Belongs to the mannose-6-phosphate isomerase type 2 family. (481 aa)
ubiEDemethylmenaquinone methyltransferase / 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (243 aa)
argJGlutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (409 aa)
plsYAcyl-phosphate glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (210 aa)
cbbF-2D-fructose 1,6-bisphosphatase. (336 aa)
pfpPyrophosphate-dependent phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (420 aa)
Mpe_A2779Geranylgeranyl reductase. (330 aa)
cbbL-2Ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site; Belongs to the RuBisCO large chain family. Type I subfamily. (521 aa)
cbbS-2Ribulose 1,5-bisphosphate carboxylase small subunit. (139 aa)
cbbERibulose-5-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (234 aa)
cbbZ-2Phosphoglycolate phosphatase. (230 aa)
cbbF-3D-fructose 1,6-bisphosphatase. (357 aa)
cbbTTransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (692 aa)
cbbGGlyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (339 aa)
cbbKPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (393 aa)
cbbA-2Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (345 aa)
psdPhosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (283 aa)
Mpe_A2839Serine O-acetyltransferase. (256 aa)
Mpe_A2841Inositol-1(or 4)-monophosphatase. (330 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (433 aa)
Mpe_A2888Tryptophan repressor binding protein XF1133. (184 aa)
Mpe_A2912Ste24 endopeptidase. (422 aa)
Mpe_A2921Dehydrogenase. (261 aa)
Mpe_A29363-octaprenyl-4hydroxybenzoate decarboxylase; Belongs to the UbiD family. (525 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (421 aa)
Mpe_A2945Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (377 aa)
Mpe_A2946Riboflavin synthase alpha chain. (205 aa)
ribBGTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (364 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (160 aa)
Mpe_A3000Putative uroporphyrin-III methylase. (340 aa)
Mpe_A3001uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (275 aa)
hemCHydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (317 aa)
argDAcetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (410 aa)
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (320 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (446 aa)
Mpe_A3045FMN adenylyltransferase / riboflavin kinase; Belongs to the ribF family. (349 aa)
Mpe_A3053Oxidoreductase. (260 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (545 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (316 aa)
Mpe_A3102Glutamate synthase (NADH) small subunit. (488 aa)
Mpe_A3103Glutamate synthase (NADH) large subunit. (1579 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (370 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (184 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (424 aa)
coq7Putative ubiquinone biosynthesis monooxygenase Coq7; Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6- methoxy-1,4-benzoquinol during ubiquinone biosynthesis. (212 aa)
ilvAL-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (526 aa)
Mpe_A31415-nucleotidase, putative. (298 aa)
Mpe_A3170glutaryl-CoA dehydrogenase. (422 aa)
ctaBPutative protoheme ix farnesyltransferase (heme O synthase) transmembrane protein; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (311 aa)
Mpe_A3174Putative heme O oxygenase (cytochrome aa3-controlling) transmembrane protein. (391 aa)
hemLGlutamate-1-semialdehyde 2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (436 aa)
Mpe_A3194Aldose 1-epimerase; Belongs to the glucose-6-phosphate 1-epimerase family. (276 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (294 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (148 aa)
Mpe_A3206Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (152 aa)
Mpe_A3207Putative biotin carboxylase protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa)
prsRibose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (321 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (287 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (296 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (393 aa)
Mpe_A3260Putative 2-hydroxyacid dehydrogenase family protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (320 aa)
Mpe_A3261Serine-glyoxylate aminotransferase. (415 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (454 aa)
Mpe_A3263Glycerate 2-kinase. (420 aa)
Mpe_A3318NAD(P)H dehydrogenase (quinone). (237 aa)
fumCFumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (469 aa)
Mpe_A3338aromatic-L-amino-acid decarboxylase. (492 aa)
Mpe_A3354hydroxymethylglutaryl-CoA lyase. (307 aa)
Mpe_A3367Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
Mpe_A33781-acyl-sn-glycerol-3-phosphate acyltransferase. (254 aa)
trpCIndole-3-glycerol phosphate synthase; Belongs to the TrpC family. (267 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (344 aa)
Mpe_A3462Anthranilate synthase, component II. (189 aa)
trpEAnthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (491 aa)
cbbE-2Ribulose-5-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (229 aa)
Mpe_A3505Putative phospholipase A1 precursor (PldA); Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Belongs to the phospholipase A1 family. (360 aa)
ilvEBranched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa)
panDL-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (120 aa)
metXSHomoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (387 aa)
Mpe_A3624Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (457 aa)
Mpe_A3638Putative glycolate oxidase (FAD-linked subunit) oxidoreductase protein. (504 aa)
Mpe_A3639FAD linked oxidase. (376 aa)
Mpe_A3640Putative glycolate oxidase (iron-sulfur subunit) protein. (413 aa)
Mpe_A3651Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (567 aa)
Mpe_A3664Putative glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (526 aa)
Mpe_A3678Putative enoyl-CoA hydratase/isomerase. (240 aa)
Mpe_A3682Aromatic amino acid aminotransferase. (425 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (625 aa)
katGCatalase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (715 aa)
ubiA4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (307 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (273 aa)
Mpe_A3748L-proline dehydrogenase. (527 aa)
Mpe_A3770L-threonine ammonia-lyase. (412 aa)
Mpe_A37713-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (374 aa)
Mpe_A3775Conserved hypothetical protein. (184 aa)
Mpe_A3790Alpha,alpha-trehalose-phosphate synthase (UDP-forming); Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-alpha-D- glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose- 6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor; Belongs to the glycosyltransferase 20 family. (463 aa)
Mpe_A3792Trehalose-phosphatase; Removes the phosphate from trehalose 6-phosphate to produce free trehalose. (254 aa)
Your Current Organism:
Methylibium petroleiphilum
NCBI taxonomy Id: 420662
Other names: M. petroleiphilum PM1, MTBE-degrading bacterium PM1, Methylibium petroleiphilum PM1, Methylibium petroleiphilum str. PM1, Methylibium petroleiphilum strain PM1, Rubrivivax gelatinosus PM1
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