(40 nodes) (2020) Therapeutic Potential of Hydroxysafflor Yellow A on Cardio-Cerebrovascular Diseases. network (Helianthus annuus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HXK1	Phosphotransferase. (494 aa)
	A0A251RQ09	Putative small GTPase superfamily, P-loop containing nucleoside triphosphate hydrolase. (198 aa)
	RAC2	Putative rac-like GTP-binding protein RAC2. (197 aa)
	RAC7	Putative rac-like GTP-binding protein 7. (198 aa)
	A0A251RT28	Phosphotransferase. (98 aa)
	A0A251RY64	Putative small GTPase superfamily, P-loop containing nucleoside triphosphate hydrolase. (213 aa)
	A0A251S2B7	Putative small GTPase superfamily, P-loop containing nucleoside triphosphate hydrolase. (108 aa)
	A0A251S4C0	Putative small GTPase superfamily, P-loop containing nucleoside triphosphate hydrolase. (197 aa)
	A0A251S9G9	Putative small GTPase superfamily, P-loop containing nucleoside triphosphate hydrolase. (197 aa)
	A0A251SHJ4	Putative small GTPase superfamily, P-loop containing nucleoside triphosphate hydrolase. (197 aa)
	A0A251SMA1	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (226 aa)
	PLDP1	Phospholipase. (1102 aa)
	HKL1	Phosphotransferase. (507 aa)
	RHO1	Putative rac-like GTP-binding protein RHO1. (198 aa)
	ATHXK2	Phosphotransferase. (498 aa)
	A0A251T2N1	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (390 aa)
	HKL3	Phosphotransferase. (552 aa)
	A0A251T766	Putative small GTPase superfamily, P-loop containing nucleoside triphosphate hydrolase. (107 aa)
	A0A251T9Z7	Putative small GTPase superfamily, P-loop containing nucleoside triphosphate hydrolase. (153 aa)
	PLDP2	Phospholipase. (1071 aa)
	A0A251TLK8	Putative small GTPase superfamily, P-loop containing nucleoside triphosphate hydrolase. (198 aa)
	A0A251TNQ2	Phosphotransferase. (496 aa)
	ARAC7	Putative RHO-related protein from plants 9. (210 aa)
	A0A251TRC1	Putative small GTPase superfamily, Ran GTPase, P-loop containing nucleoside triphosphate hydrolase. (211 aa)
	A0A251TRU4	Phosphotransferase. (498 aa)
	ARAC6	Putative RAC-like 6. (197 aa)
	RAC3	Putative rac-like GTP-binding protein 3. (210 aa)
	FSD1	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (255 aa)
	PCNA2	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (364 aa)
	A0A251U844	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (212 aa)
	A0A251UCB3	Phospholipase. (1054 aa)
	HXK2	Phosphotransferase. (493 aa)
	A0A251UMT7	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (358 aa)
	HXK2-2	Phosphotransferase. (492 aa)
	ATSK41	Putative shaggy-like protein kinase 41; Belongs to the protein kinase superfamily. (425 aa)
	A0A251V9A2	Phospholipase. (1104 aa)
	ATHXK4	Phosphotransferase. (509 aa)
	RAC13	Putative rac-like GTP-binding protein RAC13. (203 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (264 aa)
	A6XIG5_HELAN	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (228 aa)

Your Current Organism:

Helianthus annuus

NCBI taxonomy Id: 4232
Other names: H. annuus, Helianthus annuus L., common sunflower

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A251RQ09	ATSK41	A0A251RQ09	A0A251V653	Putative small GTPase superfamily, P-loop containing nucleoside triphosphate hydrolase.	Putative shaggy-like protein kinase 41; Belongs to the protein kinase superfamily.	0.540
A0A251RT28	A0A251TNQ2	A0A251RT28	A0A251TNQ2	Phosphotransferase.	Phosphotransferase.	0.607
A0A251RT28	A0A251TRU4	A0A251RT28	A0A251TRU4	Phosphotransferase.	Phosphotransferase.	0.611
A0A251RT28	ATHXK2	A0A251RT28	A0A251SYJ3	Phosphotransferase.	Phosphotransferase.	0.610
A0A251RT28	ATHXK4	A0A251RT28	A0A251VHM7	Phosphotransferase.	Phosphotransferase.	0.632
A0A251RT28	HKL1	A0A251RT28	A0A251SV07	Phosphotransferase.	Phosphotransferase.	0.636
A0A251RT28	HKL3	A0A251RT28	A0A251T4K8	Phosphotransferase.	Phosphotransferase.	0.615
A0A251RT28	HXK1	A0A251RT28	A0A251SGS4	Phosphotransferase.	Phosphotransferase.	0.609
A0A251RT28	HXK2	A0A251RT28	A0A251UL92	Phosphotransferase.	Phosphotransferase.	0.616
A0A251RT28	HXK2-2	A0A251RT28	A0A251UUM1	Phosphotransferase.	Phosphotransferase.	0.609
A0A251RY64	ATSK41	A0A251RY64	A0A251V653	Putative small GTPase superfamily, P-loop containing nucleoside triphosphate hydrolase.	Putative shaggy-like protein kinase 41; Belongs to the protein kinase superfamily.	0.557
A0A251S2B7	ATSK41	A0A251S2B7	A0A251V653	Putative small GTPase superfamily, P-loop containing nucleoside triphosphate hydrolase.	Putative shaggy-like protein kinase 41; Belongs to the protein kinase superfamily.	0.540
A0A251S4C0	ATSK41	A0A251S4C0	A0A251V653	Putative small GTPase superfamily, P-loop containing nucleoside triphosphate hydrolase.	Putative shaggy-like protein kinase 41; Belongs to the protein kinase superfamily.	0.540
A0A251S9G9	ATSK41	A0A251S9G9	A0A251V653	Putative small GTPase superfamily, P-loop containing nucleoside triphosphate hydrolase.	Putative shaggy-like protein kinase 41; Belongs to the protein kinase superfamily.	0.535
A0A251SHJ4	ATSK41	A0A251SHJ4	A0A251V653	Putative small GTPase superfamily, P-loop containing nucleoside triphosphate hydrolase.	Putative shaggy-like protein kinase 41; Belongs to the protein kinase superfamily.	0.540
A0A251SMA1	A0A251U844	A0A251SMA1	A0A251U844	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.909
A0A251SMA1	A6XIG5_HELAN	A0A251SMA1	A6XIG5	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.900
A0A251T2N1	A0A251UMT7	A0A251T2N1	A0A251UMT7	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.555
A0A251T2N1	PCNA	A0A251T2N1	A0A251VNQ5	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.548
A0A251T2N1	PCNA2	A0A251T2N1	A0A251U7R5	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.554