(33 nodes) (2023) Natural products target glycolysis in liver disease. network (Helianthus annuus)

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proteins of unknown 3D structure

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experimentally determined

Predicted Interactions

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Your Input:
	HXK1	Phosphotransferase. (494 aa)
	LDHA-2	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (350 aa)
	HKL1	Phosphotransferase. (507 aa)
	ATHXK2	Phosphotransferase. (498 aa)
	PHSL2	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (916 aa)
	HKL3	Phosphotransferase. (552 aa)
	A0A251TIN9	Putative thiamine pyrophosphate (TPP)-dependent enzyme. (605 aa)
	A0A251TK63	Putative glyoxylate carboligase. (605 aa)
	A0A251TNQ2	Phosphotransferase. (496 aa)
	A0A251TRU4	Phosphotransferase. (498 aa)
	PFK4	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (517 aa)
	PFK	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (487 aa)
	PFK3	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (536 aa)
	ENO1	Putative enolase 1. (506 aa)
	HXK2	Phosphotransferase. (493 aa)
	PHSH	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (844 aa)
	PHSL1	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (955 aa)
	A0A251URF9	Putative thiamine pyrophosphate enzyme TPP-binding protein. (596 aa)
	PDC1-2	Putative pyruvate decarboxylase 1. (605 aa)
	HXK2-2	Phosphotransferase. (492 aa)
	ENO1-2	Putative enolase 1. (489 aa)
	PFK-2	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (524 aa)
	A0A251V019	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (985 aa)
	PFK7	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (492 aa)
	ATHXK4	Phosphotransferase. (509 aa)
	PDC2-2	Putative pyruvate decarboxylase. (602 aa)
	LDHA	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (351 aa)
	PDC2	Putative pyruvate decarboxylase. (573 aa)
	A0A251RT28	Phosphotransferase. (98 aa)
	PFK5	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (518 aa)
	A0A251S4B5	Putative thiamine pyrophosphate (TPP)-dependent enzyme. (604 aa)
	PDC1	Putative pyruvate decarboxylase 1. (584 aa)
	VDAC	Putative outer plastidial membrane protein porin. (276 aa)

Your Current Organism:

Helianthus annuus

NCBI taxonomy Id: 4232
Other names: H. annuus, Helianthus annuus L., common sunflower

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A251RT28	A0A251TNQ2	A0A251RT28	A0A251TNQ2	Phosphotransferase.	Phosphotransferase.	0.607
A0A251RT28	A0A251TRU4	A0A251RT28	A0A251TRU4	Phosphotransferase.	Phosphotransferase.	0.611
A0A251RT28	A0A251V019	A0A251RT28	A0A251V019	Phosphotransferase.	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.	0.652
A0A251RT28	ATHXK2	A0A251RT28	A0A251SYJ3	Phosphotransferase.	Phosphotransferase.	0.610
A0A251RT28	ATHXK4	A0A251RT28	A0A251VHM7	Phosphotransferase.	Phosphotransferase.	0.632
A0A251RT28	HKL1	A0A251RT28	A0A251SV07	Phosphotransferase.	Phosphotransferase.	0.636
A0A251RT28	HKL3	A0A251RT28	A0A251T4K8	Phosphotransferase.	Phosphotransferase.	0.615
A0A251RT28	HXK1	A0A251RT28	A0A251SGS4	Phosphotransferase.	Phosphotransferase.	0.609
A0A251RT28	HXK2	A0A251RT28	A0A251UL92	Phosphotransferase.	Phosphotransferase.	0.616
A0A251RT28	HXK2-2	A0A251RT28	A0A251UUM1	Phosphotransferase.	Phosphotransferase.	0.609
A0A251RT28	PDC2	A0A251RT28	A0A251RR72	Phosphotransferase.	Putative pyruvate decarboxylase.	0.414
A0A251RT28	PFK	A0A251RT28	A0A251UA02	Phosphotransferase.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.	0.844
A0A251RT28	PFK-2	A0A251RT28	A0A251UZH8	Phosphotransferase.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.	0.844
A0A251RT28	PFK3	A0A251RT28	A0A251UHG5	Phosphotransferase.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.	0.844
A0A251RT28	PFK4	A0A251RT28	A0A251U6Q5	Phosphotransferase.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.	0.859
A0A251RT28	PFK5	A0A251RT28	A0A251S0T3	Phosphotransferase.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.	0.869
A0A251RT28	PFK7	A0A251RT28	A0A251V904	Phosphotransferase.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.	0.844
A0A251RT28	PHSH	A0A251RT28	A0A251UMQ2	Phosphotransferase.	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.	0.624
A0A251RT28	PHSL1	A0A251RT28	A0A251RNZ4	Phosphotransferase.	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.	0.624
A0A251RT28	PHSL2	A0A251RT28	A0A251T1W8	Phosphotransferase.	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.	0.624