STRINGSTRING
Ssed_0104 Ssed_0104 Ssed_0159 Ssed_0159 Ssed_0188 Ssed_0188 ftsE ftsE Ssed_0221 Ssed_0221 mraZ mraZ rsmH rsmH ftsL ftsL ftsI ftsI murE murE murF murF mraY mraY murD murD ftsW ftsW murG murG murC murC ftsQ ftsQ ftsA ftsA ftsZ ftsZ lpxC lpxC Ssed_0435 Ssed_0435 Ssed_0532 Ssed_0532 Ssed_0558 Ssed_0558 Ssed_0559 Ssed_0559 Ssed_0666 Ssed_0666 Ssed_0667 Ssed_0667 Ssed_0727 Ssed_0727 lptA lptA lptC lptC Ssed_0730 Ssed_0730 Ssed_0731 Ssed_0731 Ssed_0733 Ssed_0733 Ssed_0734 Ssed_0734 Ssed_0735 Ssed_0735 Ssed_0736 Ssed_0736 Ssed_0737 Ssed_0737 Ssed_0738 Ssed_0738 murA murA Ssed_0764 Ssed_0764 Ssed_0794 Ssed_0794 lptD lptD Ssed_1015 Ssed_1015 Ssed_1016 Ssed_1016 anmK anmK Ssed_1103 Ssed_1103 murJ murJ lspA lspA Ssed_1196 Ssed_1196 Ssed_1259 Ssed_1259 ftsB ftsB pcm1 pcm1 Ssed_1297 Ssed_1297 bamE bamE Ssed_1434 Ssed_1434 bamB bamB Ssed_1441 Ssed_1441 lpxH lpxH Ssed_1590 Ssed_1590 Ssed_1783 Ssed_1783 Ssed_1812 Ssed_1812 ddl ddl Ssed_1988 Ssed_1988 Ssed_2291 Ssed_2291 kdsB kdsB bamC bamC lpxM lpxM Ssed_2675 Ssed_2675 Ssed_2824 Ssed_2824 lpxK lpxK msbA msbA Ssed_2828 Ssed_2828 Ssed_3037 Ssed_3037 lpxB lpxB lpxA lpxA fabZ fabZ lpxD lpxD Ssed_3152 Ssed_3152 bamA bamA Ssed_3154 Ssed_3154 Ssed_3156 Ssed_3156 uppS uppS frr frr pyrH pyrH kdsA kdsA lptE lptE mrdA mrdA mrdB mrdB Ssed_3487 Ssed_3487 rlpA rlpA Ssed_3489 Ssed_3489 Ssed_3490 Ssed_3490 lipB lipB lipA lipA bamD bamD hldE hldE lpxL lpxL Ssed_3894 Ssed_3894 mpl mpl Ssed_4215 Ssed_4215 Ssed_4221 Ssed_4221 gmhA gmhA Ssed_4271 Ssed_4271 Ssed_4465 Ssed_4465 Ssed_4466 Ssed_4466 Ssed_4471 Ssed_4471 Ssed_4472 Ssed_4472 Ssed_4473 Ssed_4473 Ssed_4502 Ssed_4502
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ssed_0104three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (422 aa)
Ssed_0159KEGG: slo:Shew_3650 lytic transglycosylase, catalytic. (245 aa)
Ssed_0188KEGG: slo:Shew_0115 hypothetical protein. (98 aa)
ftsECell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. (230 aa)
Ssed_0221Protein of unknown function DUF214; Part of the ABC transporter FtsEX involved in cellular division; Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. (321 aa)
mraZKEGG: slo:Shew_3462 MraZ protein; Belongs to the MraZ family. (152 aa)
rsmHS-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (314 aa)
ftsLCell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (104 aa)
ftsIPeptidoglycan glycosyltransferase; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (578 aa)
murEUDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. (493 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl- D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (455 aa)
mraYPhospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (443 aa)
ftsWCell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (410 aa)
murGUndecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (365 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (489 aa)
ftsQPolypeptide-transport-associated domain protein, FtsQ-type; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. (254 aa)
ftsACell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (411 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (391 aa)
lpxCUDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (306 aa)
Ssed_0435Patatin; KEGG: slo:Shew_3427 patatin. (751 aa)
Ssed_0532KEGG: slo:Shew_0377 sporulation domain protein. (188 aa)
Ssed_0558KEGG: slo:Shew_0403 cell shape determining protein, MreB/Mrl family. (349 aa)
Ssed_0559Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape. (298 aa)
Ssed_0666Hypothetical protein; KEGG: cac:CAC2107 contains cell adhesion domain. (110 aa)
Ssed_0667Hypothetical protein. (407 aa)
Ssed_0727KEGG: slo:Shew_3310 ABC transporter-related protein. (243 aa)
lptAOstA family protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (217 aa)
lptCProtein of unknown function DUF1239; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. (185 aa)
Ssed_07303-deoxy-manno-octulosonate-8-phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (183 aa)
Ssed_0731Arabinose-5-phosphate isomerase; KEGG: slo:Shew_3306 KpsF/GutQ family protein. (325 aa)
Ssed_0733KEGG: slo:Shew_3304 ABC transporter-related protein. (267 aa)
Ssed_0734KEGG: slo:Shew_3303 protein of unknown function DUF140. (260 aa)
Ssed_0735KEGG: slo:Shew_3302 mammalian cell entry related domain protein. (156 aa)
Ssed_0736KEGG: shw:Sputw3181_3449 toluene tolerance family protein. (220 aa)
Ssed_0737KEGG: shw:Sputw3181_3448 SpoIIAA family protein. (100 aa)
Ssed_0738KEGG: slo:Shew_3299 BolA family protein; Belongs to the BolA/IbaG family. (96 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa)
Ssed_0764KEGG: slo:Shew_3276 hypothetical protein. (450 aa)
Ssed_0794KEGG: slo:Shew_0563 N-acetylmuramoyl-L-alanine amidase. (440 aa)
lptDOrganic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. (774 aa)
Ssed_1015KEGG: slo:Shew_0940 permease YjgP/YjgQ family protein. (370 aa)
Ssed_1016KEGG: slo:Shew_0941 permease YjgP/YjgQ family protein. (352 aa)
anmKConserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (369 aa)
Ssed_1103Peptidase M23B; KEGG: slo:Shew_1021 peptidase M23B. (475 aa)
murJIntegral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (519 aa)
lspASignal peptidase II; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. (176 aa)
Ssed_1196KEGG: slo:Shew_1101 peptidylprolyl isomerase, FKBP-type. (140 aa)
Ssed_1259KEGG: slo:Shew_0238 porin, gram-negative type. (386 aa)
ftsBSeptum formation initiator; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (99 aa)
pcm1Protein-L-isoaspartate(D-aspartate) O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (211 aa)
Ssed_1297Peptidase M23B; KEGG: slo:Shew_1212 peptidase M23B. (304 aa)
bamESmpA/OmlA domain protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (171 aa)
Ssed_1434KEGG: slo:Shew_1292 tetratricopeptide TPR_4. (206 aa)
bamBPyrrolo-quinoline quinone; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (395 aa)
Ssed_1441KEGG: shw:Sputw3181_1493 lipoprotein, putative. (127 aa)
lpxHUDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (242 aa)
Ssed_1590Peptidase M23B; KEGG: slo:Shew_2455 peptidase M23B. (424 aa)
Ssed_1783KEGG: slo:Shew_2357 D,D-heptose 1,7-bisphosphate phosphatase. (183 aa)
Ssed_1812Peptidase M23B; KEGG: slo:Shew_1474 peptidase M23B. (282 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation. (333 aa)
Ssed_1988KEGG: slo:Shew_2115 lytic transglycosylase, catalytic. (519 aa)
Ssed_2291Serine-type D-Ala-D-Ala carboxypeptidase; KEGG: spc:Sputcn32_2034 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase. (485 aa)
kdsB3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO8N (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in the Shewanella genus. Belongs to the KdsB family. (245 aa)
bamCNlpBDapX family lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (373 aa)
lpxMLipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (311 aa)
Ssed_2675KEGG: slo:Shew_2141 lytic murein transglycosylase. (377 aa)
Ssed_2824KEGG: slo:Shew_1640 protein of unknown function DUF343; Belongs to the UPF0434 family. (60 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (337 aa)
msbAABC transporter, ATP-binding protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (604 aa)
Ssed_2828KEGG: slo:Shew_1636 hypothetical protein. (159 aa)
Ssed_3037Surface lipoprotein-like protein; KEGG: slo:Shew_1395 VacJ family lipoprotein. (321 aa)
lpxBLipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (380 aa)
lpxAAcyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (255 aa)
fabZBeta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (153 aa)
lpxDUDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (341 aa)
Ssed_3152KEGG: slo:Shew_2626 outer membrane chaperone Skp (OmpH); Belongs to the skp family. (164 aa)
bamASurface antigen (D15); Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (827 aa)
Ssed_3154KEGG: slo:Shew_2628 putative membrane-associated zinc metalloprotease. (461 aa)
Ssed_3156KEGG: shm:Shewmr7_2703 phosphatidate cytidylyltransferase; Belongs to the CDS family. (285 aa)
uppSDi-trans, poly-cis-decaprenylcistransferase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (264 aa)
frrRibosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (245 aa)
kdsAKEGG: sbl:Sbal_0703 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. (282 aa)
lptERare lipoprotein B; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. (164 aa)
mrdAPeptidoglycan glycosyltransferase; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (618 aa)
mrdBRod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (368 aa)
Ssed_3487KEGG: shn:Shewana3_0993 lytic murein transglycosylase B. (339 aa)
rlpARare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (265 aa)
Ssed_3489KEGG: slo:Shew_2939 serine-type D-Ala-D-Ala carboxypeptidase; Belongs to the peptidase S11 family. (395 aa)
Ssed_3490KEGG: shw:Sputw3181_1029 protein of unknown function DUF493; Belongs to the UPF0250 family. (88 aa)
lipBLipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (219 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa)
bamDPutative lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (282 aa)
hldERfaE bifunctional protein; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family. (476 aa)
lpxLLipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (308 aa)
Ssed_3894Peptidoglycan glycosyltransferase; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (787 aa)
mplUDP-N-acetylmuramate; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (487 aa)
Ssed_4215KEGG: slo:Shew_0238 porin, gram-negative type. (352 aa)
Ssed_4221KEGG: slo:Shew_0230 hypothetical protein. (517 aa)
gmhAPhosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (197 aa)
Ssed_4271Peptidoglycan glycosyltransferase; KEGG: slo:Shew_0207 penicillin-binding protein, 1A family. (843 aa)
Ssed_4465NLP/P60 protein; KEGG: shn:Shewana3_0063 NLP/P60 protein. (150 aa)
Ssed_4466KEGG: son:SO0054 conserved hypothetical protein TIGR00275. (394 aa)
Ssed_4471Peptidase M23B; KEGG: slo:Shew_3807 peptidase M23B. (377 aa)
Ssed_4472C-terminal processing peptidase; KEGG: slo:Shew_3808 carboxyl-terminal protease; Belongs to the peptidase S41A family. (401 aa)
Ssed_4473KEGG: slo:Shew_3809 protein of unknown function DUF610, YibQ. (253 aa)
Ssed_4502Hypothetical protein; KEGG: cps:CPS_2413 SEC-C motif domain protein. (309 aa)
Your Current Organism:
Shewanella sediminis
NCBI taxonomy Id: 425104
Other names: S. sediminis HAW-EB3, Shewanella sediminis HAW-EB3, Shewanella sediminis str. HAW-EB3, Shewanella sediminis strain HAW-EB3
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.