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murB murB fadB fadB aroE aroE tdh tdh Ssed_0106 Ssed_0106 Ssed_0112 Ssed_0112 Ssed_0286 Ssed_0286 leuB leuB Ssed_0538 Ssed_0538 Ssed_0671 Ssed_0671 Ssed_0783 Ssed_0783 Ssed_0825 Ssed_0825 Ssed_0919 Ssed_0919 arnA arnA mdh mdh pdxA pdxA Ssed_0972 Ssed_0972 Ssed_1175 Ssed_1175 Ssed_1258 Ssed_1258 Ssed_1273 Ssed_1273 Ssed_1461 Ssed_1461 Ssed_1478 Ssed_1478 Ssed_1513 Ssed_1513 fadJ fadJ pdxB pdxB Ssed_1883 Ssed_1883 zwf zwf Ssed_2349 Ssed_2349 Ssed_2423 Ssed_2423 Ssed_2530 Ssed_2530 hisD hisD Ssed_2733 Ssed_2733 Ssed_2973 Ssed_2973 Ssed_3011 Ssed_3011 guaB guaB gpsA gpsA dxr dxr Ssed_3224 Ssed_3224 Ssed_3318 Ssed_3318 Ssed_3445 Ssed_3445 maeA maeA Ssed_3947 Ssed_3947 Ssed_4040 Ssed_4040 Ssed_4166 Ssed_4166 Ssed_4227 Ssed_4227 Ssed_4231 Ssed_4231
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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murBUDP-N-acetylmuramate dehydrogenase; Cell wall formation. (344 aa)
fadBFatty oxidation complex, alpha subunit FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (716 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (271 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa)
Ssed_0106dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (289 aa)
Ssed_0112Glycerol dehydrogenase-like protein; KEGG: chy:CHY_2583 putative glycerol-1-phosphate dehydrogenase. (356 aa)
Ssed_0286KEGG: spc:Sputcn32_0377 iron-containing alcohol dehydrogenase. (385 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (364 aa)
Ssed_0538KEGG: slo:Shew_0383 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)). (415 aa)
Ssed_0671Hypothetical protein; KEGG: rrs:RoseRS_2460 NAD/NADP octopine/nopaline dehydrogenase. (392 aa)
Ssed_0783KEGG: slo:Shew_0553 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (308 aa)
Ssed_0825KEGG: slo:Shew_0787 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (329 aa)
Ssed_0919KEGG: vpa:VP0236 nucleotide sugar dehydrogenase. (388 aa)
arnABifunctional polymyxin resistance ArnA protein (polymyxin resistanceprotein PmrI); Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic aci [...] (660 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. (311 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (328 aa)
Ssed_0972KEGG: slo:Shew_0887 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (323 aa)
Ssed_1175Aspartate kinase., Homoserine dehydrogenase; KEGG: slo:Shew_1079 aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. (821 aa)
Ssed_1258KEGG: slo:Shew_1166 iron-containing alcohol dehydrogenase. (382 aa)
Ssed_1273Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (374 aa)
Ssed_1461Phosphogluconate dehydrogenase (decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (517 aa)
Ssed_1478KEGG: shn:Shewana3_2766 3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (308 aa)
Ssed_1513KEGG: ppr:PBPRA1465 steroid dehydrogenase. (365 aa)
fadJFatty acid oxidation complex, alpha subunit FadJ; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (715 aa)
pdxBD-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (387 aa)
Ssed_1883KEGG: shm:Shewmr7_1681 isocitrate dehydrogenase, NADP-dependent; Belongs to the monomeric-type IDH family. (741 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (490 aa)
Ssed_2349KEGG: sfr:Sfri_1898 iron-containing alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (866 aa)
Ssed_2423KEGG: slo:Shew_1857 iron-containing alcohol dehydrogenase. (356 aa)
Ssed_2530KEGG: hch:HCH_06318 alcohol dehydrogenase, class IV. (388 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (439 aa)
Ssed_2733KEGG: vpa:VP1425 putative alcohol dehydrogenase. (410 aa)
Ssed_2973KEGG: saz:Sama_2260 UDP-glucose/GDP-mannose dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (423 aa)
Ssed_3011dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (303 aa)
guaBMalate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa)
gpsAKEGG: slo:Shew_3803 glycerol-3-phosphate dehydrogenase (NAD(P)(+)); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (338 aa)
dxr1-deoxy-D-xylulose-5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (395 aa)
Ssed_32243-alpha,7-alpha, 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoAhydratase; KEGG: drm:Dred_0577 MaoC domain protein dehydratase. (283 aa)
Ssed_3318KEGG: slo:Shew_2760 isocitrate dehydrogenase (NAD(+)). (335 aa)
Ssed_34452-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (310 aa)
maeAKEGG: slo:Shew_2962 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); Belongs to the malic enzymes family. (562 aa)
Ssed_3947KEGG: slo:Shew_3196 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (411 aa)
Ssed_4040Aspartate kinase., Homoserine dehydrogenase; KEGG: slo:Shew_0521 aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. (795 aa)
Ssed_4166Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (493 aa)
Ssed_4227KEGG: sfr:Sfri_3427 alcohol dehydrogenase GroES domain protein; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (376 aa)
Ssed_4231KEGG: son:SO_A0164 iron-containing alcohol dehydrogenase. (383 aa)
Your Current Organism:
Shewanella sediminis
NCBI taxonomy Id: 425104
Other names: S. sediminis HAW-EB3, Shewanella sediminis HAW-EB3, Shewanella sediminis str. HAW-EB3, Shewanella sediminis strain HAW-EB3
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