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| | mettl16 | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (530 aa) |
| | naf1 | Nuclear assembly factor 1 homolog (S. cerevisiae). (608 aa) |
| | dnajb11 | DnaJ heat shock protein family (Hsp40) member B11. (360 aa) |
| | trmt2b | tRNA methyltransferase 2 homolog B; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (470 aa) |
| | elp2 | Elongator acetyltransferase complex subunit 2. (826 aa) |
| | ctu1 | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. (343 aa) |
| | virma | Vir like m6A methyltransferase associated. (1824 aa) |
| | tfb1m | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (353 aa) |
| | tyw5 | tRNA-yW synthesizing protein 5. (322 aa) |
| | nsun4 | NOP2/Sun RNA methyltransferase 4; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (380 aa) |
| | trit1 | tRNA isopentenyltransferase 1; Belongs to the IPP transferase family. (530 aa) |
| | bud23 | BUD23 rRNA methyltransferase and ribosome maturation factor. (282 aa) |
| | dkc1 | Dyskeratosis congenita 1, dyskerin. (521 aa) |
| | kti12 | KTI12 chromatin associated homolog. (275 aa) |
| | LOC108444310 | Si:ch211-225b11.4. (1862 aa) |
| | gtpbp3 | GTP binding protein 3, mitochondrial; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (552 aa) |
| | LOC108413727 | Elongator acetyltransferase complex subunit 5. (295 aa) |
| | cdkal1 | CDK5 regulatory subunit associated protein 1-like 1. (572 aa) |
| | LOC108436170 | RNA pseudouridine synthase D4. (376 aa) |
| | mettl5 | Methyltransferase like 5. (207 aa) |
| | hsd17b10 | Hydroxysteroid (17-beta) dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (260 aa) |
| | LOC108413669 | Si:ch1073-157b13.1. (709 aa) |
| | THADA | THADA armadillo repeat containing. (1924 aa) |
| | tsr3 | Probable ribosome biogenesis protein; Probable pre-rRNA processing protein involved in ribosome biogenesis. (288 aa) |
| | adarb1 | Adenosine deaminase RNA specific B1b. (699 aa) |
| | CDK5RAP1 | CDK5 regulatory subunit associated protein 1. (593 aa) |
| | apobec2 | Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2b. (278 aa) |
| | nhp2 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (151 aa) |
| | thg1l | tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. (297 aa) |
| | pus10 | Pseudouridine synthase 10. (526 aa) |
| | dus1l | Dihydrouridine synthase 1-like (S. cerevisiae). (483 aa) |
| | nsun5 | NOP2/Sun RNA methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (479 aa) |
| | thumpd3 | THUMP domain containing 3. (480 aa) |
| | alkbh5 | AlkB homolog 5, RNA demethylase. (360 aa) |
| | aars1 | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (1057 aa) |
| | LOC108416728 | Fe2OG dioxygenase domain-containing protein. (215 aa) |
| | yrdc | YrdC N(6)-threonylcarbamoyltransferase domain containing. (242 aa) |
| | mocs3 | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (459 aa) |
| | ftsj1 | Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (321 aa) |
| | trmt2a | tRNA methyltransferase 2 homolog A; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (654 aa) |
| | cunh11orf54 | Zgc:85789. (318 aa) |
| | adat1 | Adenosine deaminase tRNA specific 1. (519 aa) |
| | dtwd2 | DTW domain containing 2. (271 aa) |
| | larp7 | La ribonucleoprotein domain family, member 7. (567 aa) |
| | wdr6 | WD repeat domain 6. (1184 aa) |
| | ndufa4l2 | NDUFA4 mitochondrial complex associated like 2b. (81 aa) |
| | elp6 | Elongator acetyltransferase complex subunit 6. (268 aa) |
| | ENSPNAP00000012772 | Uncharacterized protein. (293 aa) |
| | trmt12 | tRNA methyltransferase 12 homolog. (421 aa) |
| | aicda | Activation-induced cytidine deaminase. (211 aa) |
| | dimt1 | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (306 aa) |
| | nat10 | RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1024 aa) |
| | trmt6 | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. (478 aa) |
| | mrm3 | Mitochondrial rRNA methyltransferase 3. (451 aa) |
| | LOC108440096 | Si:ch211-153b23.4. (888 aa) |
| | dalrd3 | DALR anticodon binding domain containing 3. (567 aa) |
| | nop2 | NOP2 nucleolar protein homolog (yeast); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (752 aa) |
| | emg1 | EMG1 N1-specific pseudouridine methyltransferase. (238 aa) |
| | ENSPNAP00000014168 | DPH-type MB domain-containing protein. (127 aa) |
| | qtrt2 | Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). (397 aa) |
| | OSGEPL1 | Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (393 aa) |
| | LOC108435111 | Si:ch211-51e12.7. (199 aa) |
| | fbl | Fibrillarin. (330 aa) |
| | alkbh8 | AlkB homolog 8, tRNA methyltransferase. (654 aa) |
| | osgep | Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (593 aa) |
| | mettl4 | Methyltransferase like 4; Belongs to the MT-A70-like family. (415 aa) |
| | ENSPNAP00000015667 | Methyltransferase like 15. (344 aa) |
| | dus4l | tRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family. (311 aa) |
| | trmt13 | tRNA methyltransferase 13 homolog. (463 aa) |
| | dus3l | tRNA-dihydrouridine(47) synthase [NAD(P)(+)]. (655 aa) |
| | trmt5 | tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (488 aa) |
| | ftsj3 | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (854 aa) |
| | ENSPNAP00000016508 | Adenosine deaminase RNA specific B1a. (659 aa) |
| | trmt61b | tRNA methyltransferase 61B. (475 aa) |
| | pus7l | Pseudouridine synthase 7 like. (651 aa) |
| | nsun3 | NOP2/Sun RNA methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (356 aa) |
| | fto | FTO alpha-ketoglutarate dependent dioxygenase. (590 aa) |
| | pusl1 | tRNA pseudouridine synthase. (289 aa) |
| | trmt1 | tRNA (guanine(26)-N(2))-dimethyltransferase. (566 aa) |
| | ENSPNAP00000018646 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (346 aa) |
| | trmo | tRNA methyltransferase O. (454 aa) |
| | ENSPNAP00000018906 | RNA binding motif protein 15B. (400 aa) |
| | lcmt2 | Leucine carboxyl methyltransferase 2. (681 aa) |
| | mettl3 | Methyltransferase like 3; Belongs to the MT-A70-like family. (610 aa) |
| | rnmt | mRNA cap guanine-N7 methyltransferase. (378 aa) |
| | ENSPNAP00000019717 | Uncharacterized protein. (88 aa) |
| | pcif1 | PDX1 C-terminal inhibiting factor 1. (725 aa) |
| | aars2 | Alanyl-tRNA synthetase 2, mitochondrial (putative); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (1013 aa) |
| | tfb2m | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (519 aa) |
| | adar | Adenosine deaminase RNA specific. (1366 aa) |
| | adad1 | Adenosine deaminase domain containing 1 (testis-specific). (559 aa) |
| | dtwd1 | DTW domain containing 1. (286 aa) |
| | adat2 | Adenosine deaminase tRNA specific 2. (200 aa) |
| | cmtr1 | Cap methyltransferase 1. (878 aa) |
| | tyw3 | tRNA-yW synthesizing protein 3 homolog (S. cerevisiae). (253 aa) |
| | trmt1l | tRNA methyltransferase 1-like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (695 aa) |
| | elp3 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (548 aa) |
| | trmu | tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase. (426 aa) |
| | dus2 | Dihydrouridine synthase 2. (535 aa) |
| | adarb2 | Adenosine deaminase RNA specific B2 (inactive). (743 aa) |
| | mettl1 | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (247 aa) |
| | rbm15 | RNA binding motif protein 15. (858 aa) |
| | a1cf | Apobec1 complementation factor. (596 aa) |
| | rbm47 | RNA binding motif protein 47. (600 aa) |
| | trmt9b | tRNA methyltransferase 9B. (421 aa) |
| | nsun6 | NOP2/Sun RNA methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (473 aa) |
| | elp4 | Elongator acetyltransferase complex subunit 4. (369 aa) |
| | henmt1 | HEN methyltransferase 1. (369 aa) |
| | LOC108428657 | Zgc:109986. (326 aa) |
| | alkbh1 | AlkB homolog 1, histone H2A dioxygenase. (374 aa) |
| | LOC108443711 | tRNA-yW synthesizing protein 1 homolog (S. cerevisiae). (728 aa) |
| | qtrt1 | Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (400 aa) |
| | mettl14 | Methyltransferase like 14; Belongs to the MT-A70-like family. (453 aa) |
| | LOC108412444 | Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a. (264 aa) |
| | ENSPNAP00000025433 | tRNA methyltransferase 10C, mitochondrial RNase P subunit. (312 aa) |
| | pus7 | Pseudouridine synthase 7. (701 aa) |
| | zc3h13 | Zinc finger CCCH-type containing 13. (1811 aa) |
| | zcchc4 | Zinc finger, CCHC domain containing 4. (486 aa) |
| | trmt11 | tRNA methyltransferase 11 homolog. (469 aa) |
| | LOC108413726 | Elongator complex protein 5-like. (295 aa) |
| | gtpbp6 | GTP binding protein 6 (putative). (550 aa) |
| | elp1 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1307 aa) |
| | rrnad1 | Ribosomal RNA adenine dimethylase domain containing 1. (621 aa) |
| | ankrd16 | Ankyrin repeat domain 16. (372 aa) |
| | trmt61a | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. (304 aa) |
| | tprkb | Tp53rk binding protein; Belongs to the CGI121/TPRKB family. (175 aa) |
| | trub1 | TruB pseudouridine (psi) synthase family member 1. (269 aa) |
| | ENSPNAP00000037078 | Uncharacterized protein. (184 aa) |
| | LOC108438797 | Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase. (476 aa) |
| | trmt112 | tRNA methyltransferase subunit 11-2. (123 aa) |
| | nsun2 | NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (673 aa) |
| | pus1 | Pseudouridine synthase 1. (422 aa) |
| | LOC108415084 | Uncharacterized protein. (1279 aa) |
| | thumpd1 | THUMP domain containing 1. (301 aa) |
| | ENSPNAP00000034741 | YrdC-like domain-containing protein. (220 aa) |
| | trdmt1 | tRNA aspartic acid methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (356 aa) |
| | mto1 | Mitochondrial tRNA translation optimization 1. (699 aa) |
| | bcdin3d | BCDIN3 domain containing. (253 aa) |
| | thumpd2 | THUMP domain containing 2. (442 aa) |
| | mettl6 | Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (290 aa) |
| | ENSPNAP00000033904 | NOP10 ribonucleoprotein homolog (yeast). (64 aa) |
| | tgs1 | LYN proto-oncogene, Src family tyrosine kinase. (817 aa) |
| | wtap | WT1 associated protein. (429 aa) |
| | mrm2 | Mitochondrial rRNA methyltransferase 2. (242 aa) |
| | ctu2 | Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. (503 aa) |
| | mtfmt | Mitochondrial methionyl-tRNA formyltransferase. (388 aa) |
| | ENSPNAP00000032734 | RING-type domain-containing protein. (485 aa) |
| | trmt10b | tRNA methyltransferase 10B. (304 aa) |
| | LOC108419324 | Zgc:136858. (720 aa) |
| | mettl8 | Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (389 aa) |
| | gar1 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (247 aa) |
| | adad2 | Adenosine deaminase domain containing 2. (518 aa) |
| | ENSPNAP00000031933 | Si:ch211-153b23.3. (875 aa) |
| | ENSPNAP00000031896 | SpoU_methylase domain-containing protein. (139 aa) |
| | trmt10a | tRNA methyltransferase 10A. (341 aa) |
| | trmt44 | tRNA methyltransferase 44 homolog. (602 aa) |
| | trub2 | TruB pseudouridine (psi) synthase family member 2. (350 aa) |
| | urm1 | Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically [...] (135 aa) |
| | cunh9orf64 | Queuosine salvage protein; Involved in salvaging queuosine. (339 aa) |
| | alkbh3 | AlkB homolog 3, alpha-ketoglutarate-dependent dioxygenase. (282 aa) |
| | wdr4 | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. (425 aa) |
| | LOC108413617 | Methylphosphate capping enzyme. (782 aa) |
| | lyrm9 | LYR motif containing 9; Belongs to the complex I LYR family. (78 aa) |
| | LOC108439641-2 | Cap methyltransferase 2. (745 aa) |
| | fdxacb1 | Ferredoxin-fold anticodon binding domain containing 1. (582 aa) |
| | pus3 | Pseudouridylate synthase 3. (479 aa) |
| | mrm1 | Mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae). (406 aa) |
| | LOC108431328 | Mitochondrial rRNA methyltransferase 3b. (436 aa) |
| | rpusd1 | RNA pseudouridine synthase domain containing 1. (295 aa) |
