(54 nodes) Nuclear receptor coactivator activity network (Pygocentrus nattereri)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	carm1	Coactivator-associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (586 aa)
	LOC108413382	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
	LOC108427740	High mobility group AT-hook 1a. (101 aa)
	ncoa2	Nuclear receptor coactivator. (1494 aa)
	elk1	ETS transcription factor ELK1. (527 aa)
	ccar1	Cell division cycle and apoptosis regulator 1. (1243 aa)
	LOC108437159	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
	LOC108433665	High mobility group AT-hook 1b. (94 aa)
	LOC108434864	RNA binding motif protein 4.3. (354 aa)
	ENSPNAP00000007743	Uncharacterized protein. (78 aa)
	LOC108442460	Zgc:123278. (177 aa)
	wdr77	WD_REPEATS_REGION domain-containing protein. (260 aa)
	LOC108443181	Zinc finger, MIZ-type containing 1a. (1105 aa)
	LOC108413183	Zinc finger, MIZ-type containing 1b. (1025 aa)
	ENSPNAP00000003083	Phorbol-ester/DAG-type domain-containing protein. (56 aa)
	LOC108440922	Actinin, alpha 1. (892 aa)
	LOC108437096	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (881 aa)
	LOC108436428	Uncharacterized protein. (742 aa)
	LOC108436109	Nuclear receptor coactivator 3. (1488 aa)
	LOC108440266	Actinin alpha 3b. (897 aa)
	LOC108442650	Tumor susceptibility 101b. (403 aa)
	LOC108428729	Uncharacterized protein. (1047 aa)
	prkca	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (677 aa)
	ncoa1	Nuclear receptor coactivator 1. (1370 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1731 aa)
	LOC108428880	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (498 aa)
	ENSPNAP00000018869	S1-like domain-containing protein. (223 aa)
	ENSPNAP00000017806	EFhand_Ca_insen domain-containing protein. (97 aa)
	ncoa6	Nuclear receptor coactivator 6. (2363 aa)
	LOC108417963	Peroxisome proliferator-activated receptor gamma, coactivator 1 beta. (838 aa)
	ENSPNAP00000017297	Pkinase_C domain-containing protein. (72 aa)
	LOC108433346	Actinin, alpha 2b. (894 aa)
	bud31	BUD31 homolog. (144 aa)
	zmiz2	Zinc finger, MIZ-type containing 2. (908 aa)
	ENSPNAP00000015569	Coiled-coil domain containing 62. (239 aa)
	actn4	Actinin, alpha 4. (760 aa)
	LOC108436848	Bromodomain containing 8. (814 aa)
	LOC108437900	Uncharacterized protein. (885 aa)
	LOC108421584	PPARG related coactivator 1. (1318 aa)
	LOC108428045	Actinin alpha 3a. (897 aa)
	tsg101	Tumor susceptibility 101a. (390 aa)
	prkcb	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
	tmf1	TATA element modulatory factor 1. (1143 aa)
	psmc3ip	PSMC3 interacting protein. (213 aa)
	helz2	Helicase with zinc finger 2, transcriptional coactivator. (2530 aa)
	LOC108437484	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (695 aa)
	LOC108434615	Si:dkey-19b23.10. (755 aa)
	sra1	Steroid receptor RNA activator 1. (284 aa)
	cnot9	CCR4-NOT transcription complex subunit 9. (297 aa)
	LOC108412756	Si:dkey-93h22.8. (1106 aa)
	slc30a9	Solute carrier family 30 member 9. (579 aa)
	dcaf6	Ddb1 and cul4 associated factor 6. (967 aa)
	ncoa3	Uncharacterized protein. (1518 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (847 aa)

Your Current Organism:

Pygocentrus nattereri

NCBI taxonomy Id: 42514
Other names: P. nattereri, Serrasalmus nattereri, red piranha, red-bellied piranha

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPNAP00000003083	elk1	ENSPNAP00000003083	ENSPNAP00000035006	Phorbol-ester/DAG-type domain-containing protein.	ETS transcription factor ELK1.	0.536
ENSPNAP00000017297	elk1	ENSPNAP00000017297	ENSPNAP00000035006	Pkinase_C domain-containing protein.	ETS transcription factor ELK1.	0.536
ENSPNAP00000017806	LOC108440922	ENSPNAP00000017806	ENSPNAP00000003451	EFhand_Ca_insen domain-containing protein.	Actinin, alpha 1.	0.859
ENSPNAP00000017806	actn4	ENSPNAP00000017806	ENSPNAP00000014454	EFhand_Ca_insen domain-containing protein.	Actinin, alpha 4.	0.434
LOC108412756	bud31	ENSPNAP00000034058	ENSPNAP00000016651	Si:dkey-93h22.8.	BUD31 homolog.	0.956
LOC108413382	elk1	ENSPNAP00000034360	ENSPNAP00000035006	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	ETS transcription factor ELK1.	0.536
LOC108413382	prkca	ENSPNAP00000034360	ENSPNAP00000022436	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.801
LOC108421584	bud31	ENSPNAP00000009383	ENSPNAP00000016651	PPARG related coactivator 1.	BUD31 homolog.	0.956
LOC108428880	LOC108436109	ENSPNAP00000019796	ENSPNAP00000027057	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor coactivator 3.	0.794
LOC108428880	helz2	ENSPNAP00000019796	ENSPNAP00000030210	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Helicase with zinc finger 2, transcriptional coactivator.	0.726
LOC108428880	med1	ENSPNAP00000019796	ENSPNAP00000020836	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.837
LOC108428880	ncoa1	ENSPNAP00000019796	ENSPNAP00000021213	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor coactivator 1.	0.794
LOC108428880	ncoa2	ENSPNAP00000019796	ENSPNAP00000034954	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor coactivator.	0.794
LOC108428880	ncoa3	ENSPNAP00000019796	ENSPNAP00000034146	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Uncharacterized protein.	0.794
LOC108428880	ncoa6	ENSPNAP00000019796	ENSPNAP00000017693	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor coactivator 6.	0.621
LOC108436109	LOC108428880	ENSPNAP00000027057	ENSPNAP00000019796	Nuclear receptor coactivator 3.	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.794
LOC108436109	carm1	ENSPNAP00000027057	ENSPNAP00000034357	Nuclear receptor coactivator 3.	Coactivator-associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.794
LOC108436109	helz2	ENSPNAP00000027057	ENSPNAP00000030210	Nuclear receptor coactivator 3.	Helicase with zinc finger 2, transcriptional coactivator.	0.638
LOC108436109	med1	ENSPNAP00000027057	ENSPNAP00000020836	Nuclear receptor coactivator 3.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.769
LOC108436109	ncoa6	ENSPNAP00000027057	ENSPNAP00000017693	Nuclear receptor coactivator 3.	Nuclear receptor coactivator 6.	0.649