(80 nodes) Hedgehog signaling pathway network (Pygocentrus nattereri)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108439654	Protein kinase domain-containing protein. (403 aa)
	ENSPNAP00000008703	Growth arrest-specific 1a. (263 aa)
	mosmo	Modulator of smoothened b. (167 aa)
	sufu	Suppressor of fused homolog. (483 aa)
	LOC108429687	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (374 aa)
	ENSPNAP00000009831	Uncharacterized protein. (86 aa)
	ENSPNAP00000009911	Uncharacterized protein. (244 aa)
	lmbr1	Limb development membrane protein 1; Belongs to the LIMR family. (491 aa)
	LOC108412922	Uncharacterized protein. (167 aa)
	BCL2	BCL2 apoptosis regulator. (208 aa)
	atrn	Attractin. (1370 aa)
	gli1	GLI family zinc finger 1. (1454 aa)
	gli2	GLI family zinc finger 2a. (1450 aa)
	LOC108434652	Arrestin, beta 2b. (410 aa)
	LOC108435708	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (433 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
	csnk1a1	Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily. (372 aa)
	gpr161	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (523 aa)
	ENSPNAP00000017014	Uncharacterized protein. (307 aa)
	dhh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (444 aa)
	lmbr1l	Limb development membrane protein 1-like; Belongs to the LIMR family. (491 aa)
	prkaca	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa)
	megf8	Multiple EGF-like-domains 8. (2865 aa)
	ENSPNAP00000019759	Uncharacterized protein. (96 aa)
	LOC108438290	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
	CSNK1G1	Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (456 aa)
	ENSPNAP00000020129	Si:dkey-88l16.3. (1675 aa)
	lrp4	Low density lipoprotein receptor-related protein 4. (1853 aa)
	ENSPNAP00000020205	Uncharacterized protein. (166 aa)
	ENSPNAP00000020244	Uncharacterized protein. (302 aa)
	ENSPNAP00000020365	EGF-like domain-containing protein. (266 aa)
	atrnl1	Attractin-like 1b. (1367 aa)
	SMURF2	SMAD specific E3 ubiquitin protein ligase 2. (704 aa)
	cul3	Cullin 3b; Belongs to the cullin family. (767 aa)
	LOC108440366	Arrestin, beta 1. (418 aa)
	csnk1g2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (451 aa)
	ptch2	Patched 2. (1436 aa)
	kif3a	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (727 aa)
	LOC108436396	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (419 aa)
	LOC108430955	F-box and WD repeat domain containing 11a. (562 aa)
	LOC108431980	Casein kinase 1, epsilon; Belongs to the protein kinase superfamily. (417 aa)
	LOC108413068	Speckle type BTB/POZ protein like a. (392 aa)
	mgrn1	Mahogunin, ring finger 1b. (553 aa)
	lrp2	Low density lipoprotein receptor-related protein 2a. (4267 aa)
	spop	Speckle type BTB/POZ protein. (338 aa)
	LOC108412981	Speckle type BTB/POZ protein like b. (392 aa)
	LOC108444237	Uncharacterized protein. (1580 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (390 aa)
	LOC108434709	Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (421 aa)
	LOC108411758	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa)
	cul1	Cullin 1b; Belongs to the cullin family. (792 aa)
	hhip	Hedgehog interacting protein. (692 aa)
	boc	BOC cell adhesion associated, oncogene regulated. (1040 aa)
	LOC108428259	Cullin 3a; Belongs to the cullin family. (712 aa)
	bcl2	BCL2 apoptosis regulator. (236 aa)
	ccnd2	Cyclin D2, b; Belongs to the cyclin family. (293 aa)
	smurf1	E3 ubiquitin-protein ligase. (731 aa)
	fbxw11	F-box and WD repeat domain containing 11b. (567 aa)
	ccnd1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	csnk1g1	Casein kinase 1, gamma 1; Belongs to the protein kinase superfamily. (466 aa)
	LOC108442735	Cyclin D2, a; Belongs to the cyclin family. (401 aa)
	LOC108432078	E3 ubiquitin-protein ligase. (764 aa)
	tspan33	Tetraspanin. (280 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (829 aa)
	grk3	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (701 aa)
	arrb2	Arrestin, beta 2a. (415 aa)
	ENSPNAP00000004632	HintN domain-containing protein. (198 aa)
	LOC108431992	Mahogunin, ring finger 1a. (557 aa)
	ptch1	Patched 1. (1482 aa)
	LOC108411256	Uncharacterized protein. (1385 aa)
	ihh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa)
	evc	Uncharacterized protein. (895 aa)
	ENSPNAP00000006564	Uncharacterized protein. (69 aa)
	evc2	Uncharacterized protein. (833 aa)
	LOC108433080	Cullin 1a; Belongs to the cullin family. (777 aa)
	cdon	Cell adhesion associated, oncogene regulated. (1242 aa)
	kif7	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1359 aa)
	LOC108435268	Casein kinase 1, delta b; Belongs to the protein kinase superfamily. (425 aa)
	LOC108411205	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
	csnk1d	Casein kinase 1, delta a; Belongs to the protein kinase superfamily. (405 aa)

Your Current Organism:

Pygocentrus nattereri

NCBI taxonomy Id: 42514
Other names: P. nattereri, Serrasalmus nattereri, red piranha, red-bellied piranha

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSNK1G1	LOC108411205	ENSPNAP00000019795	ENSPNAP00000008140	Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	0.823
CSNK1G1	LOC108429687	ENSPNAP00000019795	ENSPNAP00000009275	Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.718
CSNK1G1	csnk1a1	ENSPNAP00000019795	ENSPNAP00000016642	Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily.	Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily.	0.679
CSNK1G1	grk3	ENSPNAP00000019795	ENSPNAP00000002739	Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.822
CSNK1G1	prkaca	ENSPNAP00000019795	ENSPNAP00000018227	Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily.	0.718
CSNK1G1	prkacb	ENSPNAP00000019795	ENSPNAP00000029617	Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.813
CSNK1G1	smo	ENSPNAP00000019795	ENSPNAP00000002034	Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.843
ENSPNAP00000004632	ENSPNAP00000006564	ENSPNAP00000004632	ENSPNAP00000006564	HintN domain-containing protein.	Uncharacterized protein.	0.642
ENSPNAP00000004632	ENSPNAP00000008703	ENSPNAP00000004632	ENSPNAP00000008703	HintN domain-containing protein.	Growth arrest-specific 1a.	0.854
ENSPNAP00000004632	ENSPNAP00000009911	ENSPNAP00000004632	ENSPNAP00000009911	HintN domain-containing protein.	Uncharacterized protein.	0.761
ENSPNAP00000004632	ENSPNAP00000017014	ENSPNAP00000004632	ENSPNAP00000017014	HintN domain-containing protein.	Uncharacterized protein.	0.842
ENSPNAP00000004632	LOC108411758	ENSPNAP00000004632	ENSPNAP00000030770	HintN domain-containing protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.773
ENSPNAP00000004632	LOC108435708	ENSPNAP00000004632	ENSPNAP00000013314	HintN domain-containing protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.615
ENSPNAP00000004632	boc	ENSPNAP00000004632	ENSPNAP00000032635	HintN domain-containing protein.	BOC cell adhesion associated, oncogene regulated.	0.890
ENSPNAP00000004632	cdon	ENSPNAP00000004632	ENSPNAP00000006952	HintN domain-containing protein.	Cell adhesion associated, oncogene regulated.	0.890
ENSPNAP00000004632	hhip	ENSPNAP00000004632	ENSPNAP00000031576	HintN domain-containing protein.	Hedgehog interacting protein.	0.927
ENSPNAP00000004632	lrp2	ENSPNAP00000004632	ENSPNAP00000027150	HintN domain-containing protein.	Low density lipoprotein receptor-related protein 2a.	0.642
ENSPNAP00000004632	ptch1	ENSPNAP00000004632	ENSPNAP00000005161	HintN domain-containing protein.	Patched 1.	0.932
ENSPNAP00000004632	ptch2	ENSPNAP00000004632	ENSPNAP00000025297	HintN domain-containing protein.	Patched 2.	0.939
ENSPNAP00000004632	smo	ENSPNAP00000004632	ENSPNAP00000002034	HintN domain-containing protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.752