(36 nodes) DNA conformation change network (Malassezia globosa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	MGL_3633	UvrD-like helicase ATP-binding domain-containing protein. (966 aa)
	MGL_0432	AAA_23 domain-containing protein. (78 aa)
	MGL_0431	Uncharacterized protein. (1164 aa)
	MGL_0413	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1376 aa)
	MGL_0346	Helicase ATP-binding domain-containing protein. (837 aa)
	MGL_0327	DNA helicase; Belongs to the MCM family. (861 aa)
	MGL_0109	Uncharacterized protein. (229 aa)
	MGL_0066	AAA domain-containing protein. (446 aa)
	MGL_3593	Helicase ATP-binding domain-containing protein. (492 aa)
	MGL_3636	Uncharacterized protein. (233 aa)
	MGL_3637	Uncharacterized protein. (869 aa)
	MGL_3729	Ku domain-containing protein. (539 aa)
	MGL_3884	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (841 aa)
	MGL_4019	Uncharacterized protein. (815 aa)
	MGL_4067	Uncharacterized protein. (221 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (696 aa)
	MGL_4130	Uncharacterized protein. (120 aa)
	MGL_0500	DNA helicase; Belongs to the MCM family. (930 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (546 aa)
	MGL_2941	Helicase ATP-binding domain-containing protein. (891 aa)
	MGL_2931	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (567 aa)
	MGL_0736	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. (433 aa)
	MGL_2701	Uncharacterized protein. (1004 aa)
	MGL_2639	MCM_lid domain-containing protein. (142 aa)
	MGL_2638	DNA helicase; Belongs to the MCM family. (714 aa)
	MGL_2478	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (694 aa)
	MGL_2379	Uncharacterized protein. (876 aa)
	MGL_2317	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. (485 aa)
	MGL_2135	MCM domain-containing protein; Belongs to the MCM family. (596 aa)
	MGL_2123	DNA helicase; Belongs to the MCM family. (790 aa)
	MGL_2000	Uncharacterized protein. (1627 aa)
	MGL_1621	Ku domain-containing protein. (453 aa)
	MGL_1612	TOPEUc domain-containing protein. (877 aa)
	MGL_1398	Uncharacterized protein. (713 aa)
	MGL_1256	Uncharacterized protein. (1210 aa)
	MGL_1157	AAA domain-containing protein. (721 aa)

Your Current Organism:

Malassezia globosa

NCBI taxonomy Id: 425265
Other names: M. globosa CBS 7966, Malassezia globosa CBS 7966

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCM7	MGL_0327	A8QD61	A8PSW4	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	MGL_0413	A8QD61	A8PTE9	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.583
MCM7	MGL_0500	A8QD61	A8PTY8	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	MGL_1612	A8QD61	A8PY85	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	TOPEUc domain-containing protein.	0.612
MCM7	MGL_2123	A8QD61	A8Q142	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	MGL_2135	A8QD61	A8Q250	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	MCM domain-containing protein; Belongs to the MCM family.	0.999
MCM7	MGL_2638	A8QD61	A8Q4U1	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.990
MCM7	MGL_2639	A8QD61	A8Q4U3	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	MCM_lid domain-containing protein.	0.989
MCM7	MGL_2931	A8QD61	A8Q6D5	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.747
MCM7	MGL_4067	A8QD61	A8QCZ9	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Uncharacterized protein.	0.993
MCM7	MGL_4130	A8QD61	A8QD62	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Uncharacterized protein.	0.974
MGL_0066	MGL_1256	A8PRJ4	A8PWY0	AAA domain-containing protein.	Uncharacterized protein.	0.496
MGL_0066	MGL_3884	A8PRJ4	A8QB58	AAA domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.578
MGL_0066	PIF1	A8PRJ4	A8PUE9	AAA domain-containing protein.	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	0.541
MGL_0109	MGL_2941	A8PRR2	A8Q6E5	Uncharacterized protein.	Helicase ATP-binding domain-containing protein.	0.665
MGL_0327	MCM7	A8PSW4	A8QD61	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
MGL_0327	MGL_0413	A8PSW4	A8PTE9	DNA helicase; Belongs to the MCM family.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.625
MGL_0327	MGL_0500	A8PSW4	A8PTY8	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
MGL_0327	MGL_1256	A8PSW4	A8PWY0	DNA helicase; Belongs to the MCM family.	Uncharacterized protein.	0.407
MGL_0327	MGL_2123	A8PSW4	A8Q142	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999