(6 nodes) MCM OB domain network (Malassezia globosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MGL_2638	DNA helicase; Belongs to the MCM family. (714 aa)
	MGL_2123	DNA helicase; Belongs to the MCM family. (790 aa)
	MGL_0500	DNA helicase; Belongs to the MCM family. (930 aa)
	MGL_0327	DNA helicase; Belongs to the MCM family. (861 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (696 aa)
	MGL_2135	MCM domain-containing protein; Belongs to the MCM family. (596 aa)

Your Current Organism:

Malassezia globosa

NCBI taxonomy Id: 425265
Other names: M. globosa CBS 7966, Malassezia globosa CBS 7966

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCM7	MGL_0327	A8QD61	A8PSW4	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	MGL_0500	A8QD61	A8PTY8	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	MGL_2123	A8QD61	A8Q142	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	MGL_2135	A8QD61	A8Q250	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	MCM domain-containing protein; Belongs to the MCM family.	0.999
MCM7	MGL_2638	A8QD61	A8Q4U1	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.990
MGL_0327	MCM7	A8PSW4	A8QD61	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
MGL_0327	MGL_0500	A8PSW4	A8PTY8	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
MGL_0327	MGL_2123	A8PSW4	A8Q142	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
MGL_0327	MGL_2135	A8PSW4	A8Q250	DNA helicase; Belongs to the MCM family.	MCM domain-containing protein; Belongs to the MCM family.	0.999
MGL_0327	MGL_2638	A8PSW4	A8Q4U1	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.992
MGL_0500	MCM7	A8PTY8	A8QD61	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
MGL_0500	MGL_0327	A8PTY8	A8PSW4	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
MGL_0500	MGL_2123	A8PTY8	A8Q142	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
MGL_0500	MGL_2135	A8PTY8	A8Q250	DNA helicase; Belongs to the MCM family.	MCM domain-containing protein; Belongs to the MCM family.	0.999
MGL_0500	MGL_2638	A8PTY8	A8Q4U1	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.989
MGL_2123	MCM7	A8Q142	A8QD61	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
MGL_2123	MGL_0327	A8Q142	A8PSW4	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
MGL_2123	MGL_0500	A8Q142	A8PTY8	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
MGL_2123	MGL_2135	A8Q142	A8Q250	DNA helicase; Belongs to the MCM family.	MCM domain-containing protein; Belongs to the MCM family.	0.999
MGL_2123	MGL_2638	A8Q142	A8Q4U1	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.992