STRINGSTRING
M446_6067 M446_6067 tig tig murD murD ftsZ ftsZ ftsA ftsA ftsQ ftsQ murB murB murC murC murG murG M446_6868 M446_6868 smc smc xerD xerD M446_2194 M446_2194 ftsE ftsE M446_2484 M446_2484 M446_2587 M446_2587 murA murA xerC xerC tolB tolB minE-2 minE-2 minC-2 minC-2 M446_3885 M446_3885 M446_4267 M446_4267 M446_4844 M446_4844 engB engB M446_5222 M446_5222 M446_5399 M446_5399 M446_5680 M446_5680 M446_5895 M446_5895 M446_5999 M446_5999 M446_0628 M446_0628 M446_0475 M446_0475 minE minE minC minC cpoB cpoB pal pal murE murE murF murF mraY mraY M446_0035 M446_0035
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
M446_6067KEGG: mex:Mext_4468 hypothetical protein. (3296 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (485 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (460 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (616 aa)
ftsACell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (441 aa)
ftsQPolypeptide-transport-associated domain protein FtsQ-type; Essential cell division protein; Belongs to the FtsQ/DivIB family. FtsQ subfamily. (324 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (304 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (471 aa)
murGUndecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (372 aa)
M446_6868KEGG: mex:Mext_3785 chromosome segregation ATPase-like protein. (390 aa)
smcChromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1144 aa)
xerDTyrosine recombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (309 aa)
M446_2194PFAM: protein of unknown function DUF214; KEGG: mex:Mext_2864 protein of unknown function DUF214. (316 aa)
ftsECell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. (232 aa)
M446_2484Segregation and condensation protein B; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (218 aa)
M446_2587PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase; KEGG: mex:Mext_1477 PpiC-type peptidyl-prolyl cis-trans isomerase. (295 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (429 aa)
xerCIntegrase family protein; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (320 aa)
tolBTol-Pal system beta propeller repeat protein TolB; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (442 aa)
minE-2Cell division topological specificity factor MinE; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. (94 aa)
minC-2Septum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. (238 aa)
M446_3885KEGG: mex:Mext_3785 chromosome segregation ATPase-like protein. (390 aa)
M446_4267KEGG: noc:Noc_1209 hypothetical protein. (463 aa)
M446_4844KEGG: mex:Mext_1790 hypothetical protein. (305 aa)
engBGTP-binding protein HSR1-related; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (216 aa)
M446_5222Hypothetical protein. (133 aa)
M446_5399PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase; KEGG: mex:Mext_4667 PpiC-type peptidyl-prolyl cis-trans isomerase. (632 aa)
M446_5680PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase; KEGG: azc:AZC_1429 putative peptidyl-prolyl cis-trans isomerase. (277 aa)
M446_5895PFAM: Septum formation initiator; KEGG: mex:Mext_2785 septum formation initiator. (103 aa)
M446_5999Protein of unknown function DUF710; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. (127 aa)
M446_0628PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mex:Mext_3237 ATP dependent DNA ligase. (568 aa)
M446_0475TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: mex:Mext_4444 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (441 aa)
minECell division topological specificity factor MinE; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. (89 aa)
minCSeptum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. (231 aa)
cpoBTol-pal system protein YbgF; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (313 aa)
palPeptidoglycan-associated lipoprotein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (168 aa)
murEUDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (488 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (485 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (361 aa)
M446_0035PFAM: glycosyl transferase family 4; KEGG: mex:Mext_2033 glycosyl transferase family 4. (334 aa)
Your Current Organism:
Methylobacterium sp. 446
NCBI taxonomy Id: 426117
Other names: M. sp. 4-46, Methylobacterium sp. 4-46
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.