STRINGSTRING
M446_3022 M446_3022 M446_0013 M446_0013 M446_0035 M446_0035 M446_0133 M446_0133 uppP uppP mraY mraY murF murF murE murE M446_0387 M446_0387 M446_0405 M446_0405 M446_0475 M446_0475 ddl ddl M446_1046 M446_1046 M446_1115 M446_1115 M446_1401 M446_1401 murD murD M446_1842 M446_1842 murI murI M446_2257 M446_2257 murA murA M446_2711 M446_2711 M446_2959 M446_2959 M446_3106 M446_3106 M446_3150 M446_3150 mltG mltG uppP-2 uppP-2 M446_3650 M446_3650 M446_3785 M446_3785 M446_4263 M446_4263 M446_4450 M446_4450 M446_4451 M446_4451 M446_4662 M446_4662 M446_4794 M446_4794 murJ murJ M446_5308 M446_5308 M446_5338 M446_5338 glmU glmU M446_5843 M446_5843 M446_5913 M446_5913 M446_5998 M446_5998 M446_6089 M446_6089 M446_6277 M446_6277 M446_6334 M446_6334 M446_6593 M446_6593 M446_6604 M446_6604 mtgA mtgA murB murB murC murC murG murG M446_6778 M446_6778
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
M446_3022PFAM: glycosyl transferase family 51; KEGG: mex:Mext_4776 penicillin-binding protein, 1A family. (681 aa)
M446_0013PFAM: Peptidoglycan-binding domain 1 protein; ErfK/YbiS/YcfS/YnhG family protein; KEGG: mex:Mext_0411 ErfK/YbiS/YcfS/YnhG family protein. (337 aa)
M446_0035PFAM: glycosyl transferase family 4; KEGG: mex:Mext_2033 glycosyl transferase family 4. (334 aa)
M446_0133PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: rpc:RPC_4909 ErfK/YbiS/YcfS/YnhG. (295 aa)
uppPUndecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (267 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (361 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (485 aa)
murEUDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (488 aa)
M446_0387PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: bja:blr4219 hypothetical protein. (194 aa)
M446_0405TIGRFAM: penicillin-binding protein 1C; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase; Penicillin-binding domain protein; KEGG: mex:Mext_1396 penicillin-binding protein 1C. (699 aa)
M446_0475TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: mex:Mext_4444 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (441 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation. (382 aa)
M446_1046KEGG: mex:Mext_0706 penicillin-binding protein, 1A family; TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase. (810 aa)
M446_1115KEGG: mex:Mext_0928 penicillin-binding protein, 1A family; TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase. (743 aa)
M446_1401KEGG: mex:Mext_1577 hypothetical protein. (177 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (460 aa)
M446_1842PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: mex:Mext_0164 ErfK/YbiS/YcfS/YnhG family protein. (183 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (290 aa)
M446_2257Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: beta-lactamase; peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Sporulation domain protein; KEGG: mex:Mext_4800 serine-type D-Ala-D-Ala carboxypeptidase; Belongs to the peptidase S11 family. (503 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (429 aa)
M446_2711PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: mex:Mext_2893 ErfK/YbiS/YcfS/YnhG family protein. (219 aa)
M446_2959PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: mex:Mext_2002 ErfK/YbiS/YcfS/YnhG family protein. (168 aa)
M446_3106PFAM: Peptidoglycan-binding domain 1 protein; ErfK/YbiS/YcfS/YnhG family protein; KEGG: mex:Mext_1377 peptidoglycan-binding domain 1 protein. (426 aa)
M446_3150PFAM: Peptidoglycan-binding domain 1 protein; KEGG: mex:Mext_2752 peptidoglycan-binding domain 1 protein. (654 aa)
mltGAminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (454 aa)
uppP-2Undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (296 aa)
M446_3650PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: mex:Mext_2880 ErfK/YbiS/YcfS/YnhG family protein. (267 aa)
M446_3785PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase; KEGG: pla:Plav_0008 penicillin-binding protein, 1A family. (636 aa)
M446_4263PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: mex:Mext_3587 ErfK/YbiS/YcfS/YnhG family protein. (236 aa)
M446_4450PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: mex:Mext_3329 ErfK/YbiS/YcfS/YnhG family protein. (190 aa)
M446_4451PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: mex:Mext_2558 ErfK/YbiS/YcfS/YnhG family protein. (214 aa)
M446_4662PFAM: Peptidoglycan-binding domain 1 protein; KEGG: mex:Mext_4769 peptidoglycan-binding domain 1 protein. (545 aa)
M446_4794PFAM: protein of unknown function DUF949; KEGG: mex:Mext_4733 protein of unknown function DUF949. (518 aa)
murJIntegral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (509 aa)
M446_5308PFAM: protein of unknown function DUF949; KEGG: mex:Mext_4457 protein of unknown function DUF949. (415 aa)
M446_5338PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase; KEGG: mex:Mext_1245 glycosyl transferase family 51. (1037 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (451 aa)
M446_5843KEGG: mex:Mext_3662 penicillin-binding protein, 1A family; TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase. (808 aa)
M446_5913PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: mex:Mext_2795 ErfK/YbiS/YcfS/YnhG family protein. (209 aa)
M446_5998PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: mex:Mext_2647 ErfK/YbiS/YcfS/YnhG family protein. (212 aa)
M446_6089PFAM: virulence factor MVIN family protein; KEGG: bra:BRADO7074 putative virulence factor MviN-like protein. (554 aa)
M446_6277Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: mex:Mext_2917 serine-type D-Ala-D-Ala carboxypeptidase; Belongs to the peptidase S11 family. (402 aa)
M446_6334PFAM: MltA-interacting MipA family protein; KEGG: rpc:RPC_0793 MltA-interacting MipA. (289 aa)
M446_6593Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: beta-lactamase; peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; KEGG: mex:Mext_1220 serine-type D-Ala-D-Ala carboxypeptidase; Belongs to the peptidase S11 family. (506 aa)
M446_6604PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: mex:Mext_0302 ErfK/YbiS/YcfS/YnhG family protein. (271 aa)
mtgAMonofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (256 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (304 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (471 aa)
murGUndecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (372 aa)
M446_6778KEGG: mex:Mext_4776 penicillin-binding protein, 1A family; TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase. (714 aa)
Your Current Organism:
Methylobacterium sp. 446
NCBI taxonomy Id: 426117
Other names: M. sp. 4-46, Methylobacterium sp. 4-46
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