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| | M446_0004 | KEGG: mex:Mext_0006 ATP-dependent DNA helicase RecQ; TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; Helicase superfamily 1 and 2 ATP-binding; SMART: DEAD-like helicases. (615 aa) |
| | M446_0010 | KEGG: mex:Mext_0017 hypothetical protein. (293 aa) |
| | M446_0035 | PFAM: glycosyl transferase family 4; KEGG: mex:Mext_2033 glycosyl transferase family 4. (334 aa) |
| | M446_0135 | PFAM: cytochrome c biogenesis protein transmembrane region; Thioredoxin domain; KEGG: rpc:RPC_4907 cytochrome c biogenesis protein, transmembrane region. (596 aa) |
| | M446_0209 | Mg chelatase, subunit ChlI; KEGG: rpc:RPC_0317 Mg chelatase-related protein; TIGRFAM: Mg chelatase, subunit ChlI; PFAM: magnesium chelatase ChlI subunit; ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase. (512 aa) |
| | uppP | Undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (267 aa) |
| | mraY | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (361 aa) |
| | murF | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (485 aa) |
| | murE | UDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (488 aa) |
| | minC | Septum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. (231 aa) |
| | M446_0296 | PFAM: NADH:ubiquinone oxidoreductase 17.2 kD subunit; KEGG: mex:Mext_1101 NADH:ubiquinone oxidoreductase 17.2 kD subunit. (138 aa) |
| | M446_0462 | PFAM: Asp/Glu/hydantoin racemase; KEGG: rme:Rmet_3887 Asp/Glu racemase. (243 aa) |
| | M446_0475 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: mex:Mext_4444 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (441 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (730 aa) |
| | M446_0489 | TIGRFAM: double-strand break repair helicase AddA; PFAM: UvrD/REP helicase; KEGG: mex:Mext_4440 double-strand break repair helicase AddA; Belongs to the helicase family. UvrD subfamily. (1157 aa) |
| | mfd | DEAD/DEAH box helicase domain protein; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1098 aa) |
| | M446_0523 | TIGRFAM: arsenical resistance protein ArsH; PFAM: NADPH-dependent FMN reductase; KEGG: mex:Mext_3863 arsenical resistance protein ArsH. (247 aa) |
| | frr | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (187 aa) |
| | bamA | Outer membrane protein assembly complex, YaeT protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (829 aa) |
| | M446_0687 | PFAM: flagellar FlbT family protein; KEGG: mex:Mext_1248 flagellar FlbT family protein. (152 aa) |
| | rlpA | Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (124 aa) |
| | ruvA | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (205 aa) |
| | M446_0863 | KEGG: mex:Mext_2337 hypothetical protein. (86 aa) |
| | M446_0894 | PFAM: flagellar FlaF family protein; KEGG: mex:Mext_1612 flagellar FlaF family protein. (121 aa) |
| | M446_0905 | Non-specific serine/threonine protein kinase; KEGG: hch:HCH_06999 superfamily II DNA/RNA helicase, SNF2 family; PFAM: SNF2-related protein; helicase domain protein; zinc finger SWIM domain protein; SMART: DEAD-like helicases. (1120 aa) |
| | ddl | D-alanine--D-alanine ligase; Cell wall formation. (382 aa) |
| | M446_0926 | PFAM: SWIB/MDM2 domain protein; KEGG: mex:Mext_3127 SWIB/MDM2 domain protein. (120 aa) |
| | M446_1084 | PFAM: UvrD/REP helicase; KEGG: mex:Mext_0322 UvrD/REP helicase. (789 aa) |
| | ruvB | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (348 aa) |
| | M446_1272 | PFAM: helicase domain protein; type III restriction protein res subunit; SMART: DEAD-like helicases; KEGG: scl:sce5529 putative SNF2/RAD54 family helicase. (476 aa) |
| | M446_1305 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: acr:Acry_0672 enoyl-CoA hydratase/isomerase. (263 aa) |
| | M446_1338 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: rxy:Rxyl_1762 enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (250 aa) |
| | secB | Protein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (168 aa) |
| | M446_1375 | PFAM: MltA domain protein; 3D domain protein; KEGG: mex:Mext_1561 MltA domain protein. (404 aa) |
| | M446_1405 | KEGG: mex:Mext_1588 hypothetical protein. (178 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (460 aa) |
| | M446_1724 | TIGRFAM: CRISPR-associated protein Cas5 family; CRISPR-associated protein Cas5; KEGG: gdi:GDI0063 hypothetical protein. (218 aa) |
| | M446_1726 | TIGRFAM: CRISPR-associated protein, CT1132 family; CRISPR-associated protein, Csd2 family; PFAM: CRISPR-associated protein TM1801; KEGG: rru:Rru_A0831 CRISPR-associated TM1801 family protein. (359 aa) |
| | cas2 | CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (96 aa) |
| | M446_1773 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: rpd:RPD_1475 enoyl-CoA hydratase/isomerase. (263 aa) |
| | M446_2027 | PFAM: Fimbrial assembly family protein; KEGG: xau:Xaut_2114 fimbrial assembly family protein. (353 aa) |
| | M446_2118 | KEGG: mex:Mext_2706 hypothetical protein. (99 aa) |
| | ureE | UreE urease accessory domain protein; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family. (163 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (290 aa) |
| | M446_2257 | Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: beta-lactamase; peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Sporulation domain protein; KEGG: mex:Mext_4800 serine-type D-Ala-D-Ala carboxypeptidase; Belongs to the peptidase S11 family. (503 aa) |
| | M446_2264 | TIGRFAM: small GTP-binding protein; GTP-binding protein TypA; PFAM: elongation factor G domain protein; protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; KEGG: mex:Mext_1265 GTP-binding protein TypA. (607 aa) |
| | ctaG | Cytochrome c oxidase assembly protein CtaG/Cox11; Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I; Belongs to the COX11/CtaG family. (206 aa) |
| | M446_2357 | TIGRFAM: CRISPR-associated protein Cas2; KEGG: gdi:GDI0058 hypothetical protein. (94 aa) |
| | M446_2371 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mex:Mext_3610 enoyl-CoA hydratase/isomerase. (254 aa) |
| | M446_2386 | PFAM: peptidase A24A prepilin type IV; KEGG: mex:Mext_2478 peptidase A24A prepilin type IV. (168 aa) |
| | M446_2397 | PFAM: Lytic transglycosylase catalytic; KEGG: mex:Mext_3465 lytic transglycosylase catalytic. (375 aa) |
| | M446_2414 | KEGG: rpd:RPD_2731 hypothetical protein. (152 aa) |
| | M446_2468 | TIGRFAM: iron-sulfur cluster assembly accessory protein; PFAM: HesB/YadR/YfhF-family protein; KEGG: mex:Mext_3392 iron-sulfur cluster assembly accessory protein; Belongs to the HesB/IscA family. (108 aa) |
| | M446_2554 | KEGG: mex:Mext_1569 hypothetical protein. (407 aa) |
| | M446_2594 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (495 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (429 aa) |
| | M446_2709 | PFAM: cell wall hydrolase SleB; KEGG: mex:Mext_2889 cell wall hydrolase SleB. (446 aa) |
| | rlpA-2 | Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (121 aa) |
| | M446_2935 | Hypothetical protein. (56 aa) |
| | fliP | Flagellar biosynthetic protein FliP; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (262 aa) |
| | M446_3101 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: mex:Mext_3167 riboflavin synthase, alpha subunit. (211 aa) |
| | mltG | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (454 aa) |
| | uppP-2 | Undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (296 aa) |
| | flhB | Flagellar biosynthetic protein FlhB; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (354 aa) |
| | M446_3373 | PFAM: glycosyl transferase family 2; chitin synthase; KEGG: nis:NIS_0181 glucosaminyltransferase. (483 aa) |
| | M446_3394 | Scaffold protein Nfu/NifU; PFAM: nitrogen-fixing NifU domain protein; Scaffold protein Nfu/NifU; KEGG: mex:Mext_3198 scaffold protein Nfu/NifU. (187 aa) |
| | M446_3481 | PFAM: Mandelate racemase/muconate lactonizing protein; KEGG: rsh:Rsph17029_3030 mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein. (387 aa) |
| | M446_3537 | KEGG: mlo:mlr5908 nitrogenase molybdenum-cofactor synthesis protein NifE; TIGRFAM: nitrogenase MoFe cofactor biosynthesis protein NifE; PFAM: oxidoreductase/nitrogenase component 1; Belongs to the NifD/NifK/NifE/NifN family. (503 aa) |
| | M446_3538 | KEGG: mlo:mlr5909 nitrogenase molybdenum-iron protein beta chain, NifN; TIGRFAM: nitrogenase molybdenum-iron cofactor biosynthesis protein NifN; PFAM: oxidoreductase/nitrogenase component 1; Belongs to the NifD/NifK/NifE/NifN family. (460 aa) |
| | M446_3582 | Fe-S cluster assembly protein NifU; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins. (329 aa) |
| | M446_3583 | TIGRFAM: iron-sulfur cluster assembly accessory protein; PFAM: HesB/YadR/YfhF-family protein; KEGG: mlo:mll5942 hypothetical protein; Belongs to the HesB/IscA family. (106 aa) |
| | M446_3658 | TIGRFAM: periplasmic protein thiol--disulphide oxidoreductase DsbE; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein; Thioredoxin domain; KEGG: mex:Mext_2614 periplasmic protein thiol--disulphide oxidoreductase DsbE. (196 aa) |
| | M446_3659 | Heme exporter protein CcmD; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family. (48 aa) |
| | ccmC | Heme exporter protein CcmC; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. (254 aa) |
| | M446_3662 | Heme exporter protein CcmB; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family. (222 aa) |
| | ccmA | Heme exporter protein CcmA; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (212 aa) |
| | M446_3677 | Flagella basal body P-ring formation protein FlgA; Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P- ring assembly; Belongs to the FlgA family. (176 aa) |
| | M446_3679 | KEGG: mex:Mext_0624 conserved hypothetical proteinn. (177 aa) |
| | minC-2 | Septum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. (238 aa) |
| | ruvB-2 | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (359 aa) |
| | M446_3794 | PFAM: protein of unknown function DUF1022; KEGG: mex:Mext_1091 protein of unknown function DUF1022. (324 aa) |
| | M446_3830 | PFAM: glycosyl transferase family 2; chitin synthase; KEGG: bja:blr2027 chitin synthase. (415 aa) |
| | M446_3885 | KEGG: mex:Mext_3785 chromosome segregation ATPase-like protein. (390 aa) |
| | M446_3947 | KEGG: mex:Mext_0823 flagellar protein export ATPase FliI; TIGRFAM: ATPase, FliI/YscN family; flagellar protein export ATPase FliI; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; SMART: AAA ATPase. (451 aa) |
| | flhA | Flagellar biosynthesis protein FlhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (708 aa) |
| | M446_3980 | Conserved hypothetical protein; KEGG: xau:Xaut_1087 AAA ATPase. (728 aa) |
| | M446_4095 | PFAM: DnaB domain protein helicase domain protein; SMART: AAA ATPase; KEGG: azc:AZC_0834 DnaB helicase. (482 aa) |
| | prfC | Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (539 aa) |
| | M446_4185 | TIGRFAM: flagellar hook-associated protein FlgK; PFAM: protein of unknown function DUF1078 domain protein; KEGG: mex:Mext_0951 flagellar hook-associated protein FlgK. (623 aa) |
| | M446_4189 | KEGG: mex:Mext_3042 hypothetical protein. (116 aa) |
| | M446_4191 | KEGG: mex:Mext_3040 hypothetical protein. (138 aa) |
| | M446_4196 | TIGRFAM: flagella basal body P-ring formation protein FlgA; PFAM: SAF domain protein; KEGG: mex:Mext_3046 flagella basal body P-ring formation protein FlgA. (347 aa) |
| | M446_4202 | KEGG: mex:Mext_3052 hypothetical protein. (310 aa) |
| | M446_4204 | PFAM: TOPRIM domain protein; DNA topoisomerase type IA central domain protein; SMART: DNA topoisomerase I ATP-binding; DNA topoisomerase I DNA-binding; Toprim sub domain protein; KEGG: pen:PSEEN2193 DNA topoisomerase III. (809 aa) |
| | rsfS | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (121 aa) |
| | M446_4258 | PFAM: Class I peptide chain release factor; KEGG: mex:Mext_3233 class I peptide chain release factor. (141 aa) |
| | M446_4267 | KEGG: noc:Noc_1209 hypothetical protein. (463 aa) |
| | M446_4270 | KEGG: azc:AZC_3687 hypothetical protein. (129 aa) |
| | M446_4315 | Putative CheA signal transduction histidine kinase; KEGG: mmu:100042292 similar to CG10953-PA. (263 aa) |
| | parC | DNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (748 aa) |
| | M446_4331 | FeS assembly scaffold SufA; TIGRFAM: iron-sulfur cluster assembly accessory protein; FeS assembly scaffold SufA; PFAM: HesB/YadR/YfhF-family protein; KEGG: mex:Mext_3982 FeS assembly scaffold SufA; Belongs to the HesB/IscA family. (126 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (913 aa) |
| | parE | DNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (682 aa) |
| | ureE-2 | UreE urease accessory domain protein; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family. (215 aa) |
| | M446_4425 | Hypothetical protein; KEGG: bra:BRADO1923 conserved hypothetical protein; putative signal peptide; putative calcium-binding protein. (139 aa) |
| | M446_4430 | Cytochrome C biogenesis protein; Possible subunit of a heme lyase. (152 aa) |
| | M446_4431 | TIGRFAM: cytochrome c-type biogenesis protein CcmF; PFAM: cytochrome c assembly protein; KEGG: mex:Mext_1406 cytochrome c assembly protein. (660 aa) |
| | ccmE | CcmE/CycJ protein; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (163 aa) |
| | M446_4433 | TIGRFAM: cytochrome c-type biogenesis protein CcmI; KEGG: mex:Mext_1408 cytochrome c-type biogenesis protein CcmI. (420 aa) |
| | M446_4443 | PFAM: Fe-S metabolism associated SufE; KEGG: bbt:BBta_5927 SufE protein probably involved in Fe-S center assembly. (140 aa) |
| | gyrA | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (914 aa) |
| | M446_4535 | KEGG: mex:Mext_0734 hypothetical protein. (699 aa) |
| | M446_4606 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: azc:AZC_0802 enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (257 aa) |
| | M446_4614 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mex:Mext_4436 enoyl-CoA hydratase/isomerase. (260 aa) |
| | prfA | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (359 aa) |
| | M446_4844 | KEGG: mex:Mext_1790 hypothetical protein. (305 aa) |
| | rlpA-3 | Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (121 aa) |
| | M446_4934 | PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: mex:Mext_0892 ABC transporter related. (256 aa) |
| | M446_5045 | KEGG: mex:Mext_1974 putative DNA topoisomerase I. (389 aa) |
| | engB | GTP-binding protein HSR1-related; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (216 aa) |
| | lptD | Organic solvent tolerance protein; Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane; Belongs to the LptD family. (886 aa) |
| | M446_5105 | TIGRFAM: FeS assembly SUF system protein; PFAM: protein of unknown function DUF59; KEGG: mex:Mext_3981 FeS assembly SUF system protein. (117 aa) |
| | M446_5107 | TIGRFAM: FeS assembly protein SufD; PFAM: SufBD protein; KEGG: mex:Mext_3979 FeS assembly protein SufD. (439 aa) |
| | M446_5108 | KEGG: mex:Mext_3978 FeS assembly ATPase SufC; TIGRFAM: FeS assembly ATPase SufC; PFAM: ABC transporter related; SMART: AAA ATPase. (250 aa) |
| | M446_5109 | TIGRFAM: FeS assembly protein SufB; PFAM: SufBD protein; KEGG: mex:Mext_3977 FeS assembly protein SufB. (489 aa) |
| | M446_5114 | SMART: AAA ATPase; KEGG: rpc:RPC_1184 ATPase. (1076 aa) |
| | M446_5119 | PFAM: flagellar hook-length control protein; KEGG: mex:Mext_4095 flagellar hook-length control protein. (446 aa) |
| | M446_5120 | Flagellar hook capping protein; Required for flagellar hook formation. May act as a scaffolding protein. (233 aa) |
| | M446_5138 | KEGG: mlo:mlr2941 flagellar biosynthesis repressor FlbT. (139 aa) |
| | M446_5150 | TIGRFAM: flagellar biosynthetic protein FlhB; PFAM: type III secretion exporter; KEGG: mex:Mext_2603 flagellar biosynthetic protein FlhB. (353 aa) |
| | M446_5151 | Flagellar biosynthetic protein FliR; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (252 aa) |
| | fliQ | Flagellar biosynthetic protein FliQ; Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family. (88 aa) |
| | M446_5156 | KEGG: mex:Mext_2609 hypothetical protein. (462 aa) |
| | fliP-2 | Flagellar biosynthetic protein FliP; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (283 aa) |
| | M446_5222 | Hypothetical protein. (133 aa) |
| | M446_5273 | PFAM: OstA family protein; KEGG: mex:Mext_2499 OstA family protein. (285 aa) |
| | murJ | Integral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (509 aa) |
| | M446_5306 | KEGG: mex:Mext_3299 hypothetical protein. (268 aa) |
| | rplT | Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (125 aa) |
| | gyrB | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (808 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (451 aa) |
| | M446_5532 | Hypothetical protein; KEGG: rru:Rru_A2278 transposase IS66. (193 aa) |
| | M446_5557 | KEGG: smd:Smed_6421 hypothetical protein. (279 aa) |
| | M446_5673 | PFAM: protein of unknown function DUF59; KEGG: bpd:BURPS668_2681 phenylacetic acid degradation protein PaaD. (130 aa) |
| | M446_5682 | TIGRFAM: nitrate reductase molybdenum cofactor assembly chaperone; PFAM: Nitrate reductase delta subunit; KEGG: pde:Pden_4234 nitrate reductase molybdenum cofactor assembly chaperone. (248 aa) |
| | M446_5744 | PFAM: protein of unknown function DUF87; KEGG: rpd:RPD_2094 protein of unknown function DUF87. (590 aa) |
| | M446_5801 | KEGG: mex:Mext_4369 hypothetical protein. (138 aa) |
| | prfB | Peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (321 aa) |
| | M446_5955 | Hypothetical protein. (191 aa) |
| | M446_5982 | MRP protein-like protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (374 aa) |
| | M446_5989 | Redoxin domain protein; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein; KEGG: mex:Mext_3288 redoxin domain protein. (217 aa) |
| | M446_5999 | Protein of unknown function DUF710; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. (127 aa) |
| | M446_6067 | KEGG: mex:Mext_4468 hypothetical protein. (3296 aa) |
| | M446_6089 | PFAM: virulence factor MVIN family protein; KEGG: bra:BRADO7074 putative virulence factor MviN-like protein. (554 aa) |
| | M446_6120 | PFAM: protein of unknown function DUF59; KEGG: bmn:BMA10247_1695 hypothetical protein. (136 aa) |
| | M446_6121 | KEGG: mag:amb1262 hypothetical protein. (381 aa) |
| | M446_6148 | PFAM: aminotransferase class V; KEGG: bja:blr3095 probable aminotransferase. (416 aa) |
| | M446_6175 | PFAM: cell wall hydrolase SleB; KEGG: mex:Mext_2798 cell wall hydrolase SleB. (226 aa) |
| | M446_6226 | PFAM: SmpA/OmlA domain protein; KEGG: mex:Mext_2050 SmpA/OmlA domain protein. (154 aa) |
| | M446_6246 | AAA ATPase; KEGG: xau:Xaut_2283 AAA ATPase. (520 aa) |
| | M446_6267 | KEGG: pla:Plav_0682 hypothetical protein. (301 aa) |
| | rlpA-4 | Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (394 aa) |
| | M446_6277 | Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: mex:Mext_2917 serine-type D-Ala-D-Ala carboxypeptidase; Belongs to the peptidase S11 family. (402 aa) |
| | mfd-2 | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1203 aa) |
| | M446_6310 | PFAM: helicase domain protein; nucleic acid binding OB-fold tRNA/helicase-type; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: mex:Mext_4161 DEAD/DEAH box helicase domain protein. (704 aa) |
| | M446_6321 | KEGG: mex:Mext_2266 nitrogen-fixing NifU domain protein. (150 aa) |
| | M446_6322 | Protein of unknown function DUF37; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. (101 aa) |
| | M446_6337 | KEGG: mex:Mext_3453 toluene tolerance family protein. (224 aa) |
| | M446_6370 | PFAM: ATP12 ATPase; KEGG: mex:Mext_0281 ATP12 ATPase. (262 aa) |
| | M446_6372 | PFAM: LemA family protein; KEGG: mex:Mext_2020 LemA family protein. (246 aa) |
| | rlpA-5 | Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (135 aa) |
| | M446_6407 | Hypothetical protein. (539 aa) |
| | M446_6440 | KEGG: azc:AZC_0855 hypothetical protein. (641 aa) |
| | M446_6501 | KEGG: mex:Mext_0679 hypothetical protein. (208 aa) |
| | M446_6505 | KEGG: mex:Mext_0682 ATPase, FliI/YscN family; TIGRFAM: ATPase, FliI/YscN family; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; SMART: AAA ATPase. (441 aa) |
| | M446_6507 | TIGRFAM: flagellar hook-associated protein FlgK; PFAM: protein of unknown function DUF1078 domain protein; KEGG: mex:Mext_0684 flagellar hook-associated protein FlgK. (483 aa) |
| | M446_6509 | PFAM: flagellar FlaF family protein; KEGG: mex:Mext_0686 flagellar FlaF family protein. (115 aa) |
| | flbT | Flagellar FlbT family protein; Has a post-transcriptional repressor function in flagellum biogenesis. Associates with the 5'-UTR of fljK mRNA and promotes its degradation. (151 aa) |
| | M446_6511 | PFAM: flagellar hook capping protein; KEGG: mex:Mext_0688 flagellar hook capping protein. (142 aa) |
| | fliQ-2 | Export protein FliQ family 3; Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family. (88 aa) |
| | flhA-2 | Flagellar biosynthesis protein FlhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (693 aa) |
| | M446_6516 | KEGG: mex:Mext_0691 putative flagellar biosynthetic protein. (256 aa) |
| | M446_6518 | KEGG: mex:Mext_0693 hypothetical protein. (153 aa) |
| | M446_6519 | KEGG: mex:Mext_0694 hypothetical protein. (107 aa) |
| | M446_6572 | KEGG: ddi:DDBDRAFT_0219802 hypothetical protein. (358 aa) |
| | M446_6593 | Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: beta-lactamase; peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; KEGG: mex:Mext_1220 serine-type D-Ala-D-Ala carboxypeptidase; Belongs to the peptidase S11 family. (506 aa) |
| | M446_6628 | PFAM: cytochrome c biogenesis protein transmembrane region; KEGG: mex:Mext_4281 thiol:disulfide interchange protein, putative. (734 aa) |
| | mtgA | Monofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (256 aa) |
| | M446_6683 | PFAM: Domain of unknown function DUF1849; KEGG: mex:Mext_4720 domain of unknown function DUF1849. (285 aa) |
| | bamD | Putative lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (298 aa) |
| | ftsZ | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (616 aa) |
| | ftsQ | Polypeptide-transport-associated domain protein FtsQ-type; Essential cell division protein; Belongs to the FtsQ/DivIB family. FtsQ subfamily. (324 aa) |
| | murB | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (304 aa) |
| | murC | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (471 aa) |
| | murG | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (372 aa) |
| | M446_6725 | Conserved hypothetical protein; KEGG: xau:Xaut_1087 AAA ATPase. (759 aa) |
| | M446_6737 | PFAM: CHRD domain containing protein; KEGG: nha:Nham_1308 CHRD. (147 aa) |
| | M446_6833 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: mex:Mext_4237 enoyl-CoA hydratase/isomerase. (353 aa) |
| | M446_6868 | KEGG: mex:Mext_3785 chromosome segregation ATPase-like protein. (390 aa) |
| | smc | Chromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1144 aa) |
