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| | M446_4618 | PFAM: Amidase; KEGG: pol:Bpro_1387 amidase; Belongs to the amidase family. (473 aa) |
| | atpE | H+transporting two-sector ATPase C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (75 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (251 aa) |
| | M446_6855 | TIGRFAM: malonate decarboxylase, beta subunit; KEGG: mex:Mext_0026 malonate decarboxylase, beta subunit. (306 aa) |
| | M446_6854 | TIGRFAM: malonate decarboxylase, gamma subunit; PFAM: malonate decarboxylase gamma subunit; KEGG: mex:Mext_0027 malonate decarboxylase, gamma subunit. (238 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa) |
| | M446_6763 | PFAM: protein of unknown function DUF404; protein of unknown function DUF407; KEGG: mex:Mext_2208 protein of unknown function DUF404. (479 aa) |
| | murC | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (471 aa) |
| | M446_6668 | PFAM: GumN family protein; KEGG: ret:RHE_CH03880 hypothetical protein. (340 aa) |
| | M446_6659 | Glutamate--cysteine ligase GCS2; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (380 aa) |
| | argG | PFAM: argininosuccinate synthase; KEGG: mex:Mext_2293 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (413 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (190 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (509 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (292 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (484 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (133 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (233 aa) |
| | M446_6588 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: mex:Mext_2377 glutamine synthetase, type I. (470 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (435 aa) |
| | sucD-2 | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (299 aa) |
| | sucC-2 | succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (392 aa) |
| | M446_6525 | PFAM: AMP-dependent synthetase and ligase; KEGG: bra:BRADO6291 putative 2-succinylbenzoate--CoA ligase (OSB-CoA synthetase) (o-succinylbenzoyl-CoA synthetase). (487 aa) |
| | M446_6505 | KEGG: mex:Mext_0682 ATPase, FliI/YscN family; TIGRFAM: ATPase, FliI/YscN family; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; SMART: AAA ATPase. (441 aa) |
| | M446_6497 | KEGG: mex:Mext_3229 cobalt chelatase, pCobT subunit; TIGRFAM: cobalt chelatase, pCobT subunit; PFAM: Cobalt chelatase CobT subunit; SMART: von Willebrand factor type A. (630 aa) |
| | M446_6482 | PFAM: protein of unknown function DUF1508; KEGG: mex:Mext_2572 protein of unknown function DUF1508. (61 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. (515 aa) |
| | M446_6331 | PFAM: Glutathione S-transferase domain; KEGG: mex:Mext_3449 glutathione S-transferase domain. (200 aa) |
| | thrS | TIGRFAM: threonyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); TGS domain protein; Anticodon-binding domain protein; Threonyl/alanyl tRNA synthetase SAD; KEGG: mex:Mext_2321 threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (670 aa) |
| | M446_6312 | KEGG: mex:Mext_4168 acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II-like protein. (425 aa) |
| | lysS | Lysine--tRNA ligase; PFAM: Lysyl-tRNA synthetase class 1c; KEGG: mex:Mext_2980 lysyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (567 aa) |
| | M446_6249 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (426 aa) |
| | M446_6157 | KEGG: bja:bll3081 hypothetical protein. (352 aa) |
| | M446_6124 | PFAM: argininosuccinate synthase; KEGG: ang:An12g01280 hypothetical protein Pfam: Asn_synthase Arginosuc_synth. (417 aa) |
| | purD | KEGG: mex:Mext_3871 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family. (442 aa) |
| | M446_6034 | PFAM: AMP-dependent synthetase and ligase; KEGG: mex:Mext_0876 AMP-dependent synthetase and ligase. (507 aa) |
| | M446_5994 | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily. (455 aa) |
| | M446_5903 | KEGG: mex:Mext_0137 hypothetical protein. (417 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (903 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (426 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (886 aa) |
| | M446_5781 | TIGRFAM: alpha-L-glutamate ligase, RimK family; PFAM: protein of unknown function DUF201; RimK domain protein ATP-grasp; KEGG: mex:Mext_1832 alpha-L-glutamate ligase, RimK family; Belongs to the RimK family. (305 aa) |
| | M446_5659 | PFAM: carboxyl transferase; KEGG: mex:Mext_0282 carboxyl transferase. (510 aa) |
| | M446_5648 | 5-oxoprolinase (ATP-hydrolyzing); PFAM: Hydantoinase/oxoprolinase; Hydantoinaseoxoprolinase domain protein; KEGG: oan:Oant_4581 5-oxoprolinase (ATP-hydrolyzing). (697 aa) |
| | M446_5647 | 5-oxoprolinase (ATP-hydrolyzing); PFAM: Hydantoinase B/oxoprolinase; KEGG: oan:Oant_4582 5-oxoprolinase (ATP-hydrolyzing). (582 aa) |
| | M446_5472 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. (180 aa) |
| | M446_5468 | PFAM: protein of unknown function UPF0005; KEGG: mex:Mext_2268 protein of unknown function UPF0005; Belongs to the BI1 family. (274 aa) |
| | M446_5426 | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (159 aa) |
| | M446_5425 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (451 aa) |
| | M446_5405 | PFAM: glutathionylspermidine synthase; KEGG: mex:Mext_4658 glutathionylspermidine synthase. (384 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (542 aa) |
| | M446_5364 | PFAM: AMP-dependent synthetase and ligase; KEGG: xau:Xaut_2806 AMP-dependent synthetase and ligase. (536 aa) |
| | pheS | TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; PFAM: phenylalanyl-tRNA synthetase class IIc; aminoacyl tRNA synthetase class II domain protein; KEGG: mex:Mext_1629 phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (360 aa) |
| | pheT | KEGG: mex:Mext_1630 phenylalanyl-tRNA synthetase, beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit. (808 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (225 aa) |
| | purM | KEGG: mex:Mext_2063 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. (355 aa) |
| | M446_5076 | PFAM: protein of unknown function DUF403; protein of unknown function DUF404; protein of unknown function DUF407; KEGG: mex:Mext_3416 protein of unknown function DUF404. (837 aa) |
| | M446_5062 | PFAM: IucA/IucC family protein; KEGG: oan:Oant_3257 IucA/IucC family protein. (588 aa) |
| | M446_5060 | PFAM: IucA/IucC family protein; KEGG: oan:Oant_3255 IucA/IucC family protein. (615 aa) |
| | M446_5041 | PFAM: Amidase; KEGG: mlo:mll3370 amidase. (435 aa) |
| | nadE | NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (679 aa) |
| | purC-2 | KEGG: mex:Mext_0587 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (254 aa) |
| | M446_4877 | PFAM: glutamyl-tRNA synthetase class Ic; KEGG: mex:Mext_1025 glutamyl-tRNA synthetase class Ic; Belongs to the class-I aminoacyl-tRNA synthetase family. (279 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | M446_4779 | PFAM: O-antigen polymerase; KEGG: mex:Mext_2300 O-antigen polymerase. (410 aa) |
| | M446_4697 | 5-oxoprolinase (ATP-hydrolyzing); PFAM: Hydantoinase/oxoprolinase; Hydantoinaseoxoprolinase domain protein; KEGG: rpd:RPD_2368 5-oxoprolinase (ATP-hydrolyzing). (692 aa) |
| | M446_4696 | 5-oxoprolinase (ATP-hydrolyzing); PFAM: Hydantoinase B/oxoprolinase; KEGG: rpd:RPD_2367 5-oxoprolinase (ATP-hydrolyzing). (548 aa) |
| | M446_4572 | Glutamate--ammonia ligase; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: xau:Xaut_1141 glutamate--ammonia ligase. (345 aa) |
| | M446_4550 | PFAM: protein of unknown function UPF0005; KEGG: rle:pRL110005 putative transmembrane protein; Belongs to the BI1 family. (236 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro); Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily. (444 aa) |
| | M446_4404 | TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin/lipoate A/B protein ligase; KEGG: mex:Mext_1071 biotin--acetyl-CoA-carboxylase ligase. (264 aa) |
| | gatC | glutamyl-tRNA(Gln) amidotransferase, C subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (95 aa) |
| | gatA | glutamyl-tRNA(Gln) amidotransferase, A subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (497 aa) |
| | gatB | glutamyl-tRNA(Gln) amidotransferase, B subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (490 aa) |
| | M446_4318 | PFAM: AMP-dependent synthetase and ligase; KEGG: mex:Mext_4606 AMP-dependent synthetase and ligase. (592 aa) |
| | M446_4234 | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: mex:Mext_1632 UBA/ThiF-type NAD/FAD binding protein. (263 aa) |
| | M446_4026 | PFAM: O-antigen polymerase; KEGG: sma:SAV5357 hypothetical protein. (499 aa) |
| | M446_3947 | KEGG: mex:Mext_0823 flagellar protein export ATPase FliI; TIGRFAM: ATPase, FliI/YscN family; flagellar protein export ATPase FliI; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; SMART: AAA ATPase. (451 aa) |
| | M446_3920 | KEGG: mex:Mext_0137 hypothetical protein. (418 aa) |
| | M446_3855 | PFAM: AMP-dependent synthetase and ligase; KEGG: rsq:Rsph17025_2837 AMP-dependent synthetase and ligase. (550 aa) |
| | M446_3811 | PFAM: carboxyl transferase; KEGG: mex:Mext_0282 carboxyl transferase. (510 aa) |
| | M446_3732 | PFAM: von Willebrand factor type A; KEGG: mex:Mext_3009 von Willebrand factor type A. (581 aa) |
| | M446_3731 | Magnesium chelatase ATPase subunit I; Involved in bacteriochlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX. (368 aa) |
| | M446_3720 | KEGG: mex:Mext_4814 magnesium chelatase, H subunit; TIGRFAM: magnesium chelatase, H subunit; PFAM: CobN/magnesium chelatase. (1244 aa) |
| | M446_3691 | TIGRFAM: allophanate hydrolase; PFAM: Amidase; KEGG: rle:pRL90294 putative UreA amidolyase. (599 aa) |
| | purC | PFAM: SAICAR synthetase; KEGG: rle:RL3872 putative phosphoribosylamidoimidazole-succinocarboxamide synthase. (325 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (347 aa) |
| | M446_3406 | KEGG: sfu:Sfum_3332 coenzyme F390 synthetase-like. (478 aa) |
| | M446_3402 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_4596 hypothetical protein. (308 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; KEGG: mex:Mext_1088 carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1157 aa) |
| | fhs | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: mex:Mext_0414 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (558 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; KEGG: mex:Mext_0615 carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (405 aa) |
| | M446_3209 | GatB/YqeY; KEGG: mex:Mext_0614 GatB/YqeY. (152 aa) |
| | M446_3080 | KEGG: mex:Mext_0382 hypothetical protein. (251 aa) |
| | M446_3072 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: mex:Mext_2363 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (202 aa) |
| | acsA | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (649 aa) |
| | M446_2902 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: mex:Mext_0779 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (203 aa) |
| | M446_2876 | PFAM: AMP-dependent synthetase and ligase; KEGG: nmu:Nmul_A1417 AMP-dependent synthetase and ligase. (612 aa) |
| | glyS | KEGG: mex:Mext_3096 glycyl-tRNA synthetase, beta subunit; TIGRFAM: glycyl-tRNA synthetase, beta subunit. (704 aa) |
| | glyQ | KEGG: mex:Mext_3099 glycyl-tRNA synthetase, alpha subunit; TIGRFAM: glycyl-tRNA synthetase, alpha subunit; PFAM: glycyl-tRNA synthetase alpha subunit. (313 aa) |
| | M446_2733 | PFAM: AMP-dependent synthetase and ligase; KEGG: rpe:RPE_4352 AMP-dependent synthetase and ligase. (542 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (378 aa) |
| | M446_2689 | PFAM: AMP-dependent synthetase and ligase; KEGG: mex:Mext_4171 AMP-dependent synthetase and ligase. (543 aa) |
| | M446_2688 | PFAM: AMP-dependent synthetase and ligase; KEGG: mex:Mext_1958 AMP-dependent synthetase and ligase. (641 aa) |
| | M446_2680 | KEGG: mex:Mext_4868 asparagine synthase family amidotransferase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing); asparagine synthase family amidotransferase; PFAM: glutamine amidotransferase class-II; asparagine synthase. (590 aa) |
| | M446_2679 | KEGG: rru:Rru_A1988 GCN5-related N-acetyltransferase; TIGRFAM: GNAT-family acetyltransferase TIGR03103; PFAM: GCN5-related N-acetyltransferase; RimK domain protein ATP-grasp. (571 aa) |
| | M446_2648 | KEGG: mex:Mext_1781 hypothetical protein. (419 aa) |
| | hisS | KEGG: mex:Mext_1555 histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein. (532 aa) |
| | M446_2646 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). (378 aa) |
| | gltX2 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (447 aa) |
| | argS | KEGG: mex:Mext_3396 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. (586 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (604 aa) |
| | cobB | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (447 aa) |
| | M446_2438 | KEGG: mex:Mext_1439 cobaltochelatase, CobN subunit; TIGRFAM: cobaltochelatase, CobN subunit; PFAM: CobN/magnesium chelatase. (1099 aa) |
| | M446_2319 | PFAM: AMP-dependent synthetase and ligase; KEGG: rpb:RPB_0580 AMP-dependent synthetase and ligase. (565 aa) |
| | M446_2317 | Propionyl-CoA carboxylase; PFAM: carboxyl transferase; KEGG: mmr:Mmar10_1734 propionyl-CoA carboxylase. (535 aa) |
| | M446_2316 | PFAM: biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: pla:Plav_2788 carbamoyl-phosphate synthase L chain ATP-binding. (662 aa) |
| | M446_2311 | KEGG: bbt:BBta_5720 putative phenylacetate-CoA ligase. (410 aa) |
| | M446_2308 | PFAM: AMP-dependent synthetase and ligase; KEGG: bbt:BBta_5715 putative long-chain-fatty-acid-CoA ligase. (657 aa) |
| | M446_2243 | Glutamate--cysteine ligase GCS2; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (377 aa) |
| | M446_2241 | PFAM: protein of unknown function DUF540; KEGG: mex:Mext_0573 protein of unknown function DUF540. (238 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). (989 aa) |
| | M446_2199 | PFAM: AMP-dependent synthetase and ligase; KEGG: mex:Mext_4434 AMP-dependent synthetase and ligase. (538 aa) |
| | sucD | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa) |
| | sucC | succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (398 aa) |
| | M446_2142 | KEGG: mex:Mext_1692 hypothetical protein. (141 aa) |
| | M446_2141 | TIGRFAM: amidohydrolase, AtzE family; PFAM: Amidase; KEGG: mex:Mext_1693 amidohydrolase, AtzE family. (461 aa) |
| | M446_1981 | 5-oxoprolinase (ATP-hydrolyzing); PFAM: Hydantoinase B/oxoprolinase; KEGG: mlo:mlr4788 N-methylhydantoinase B. (562 aa) |
| | M446_1980 | 5-oxoprolinase (ATP-hydrolyzing); PFAM: Hydantoinase/oxoprolinase; Hydantoinaseoxoprolinase domain protein; KEGG: mlo:mlr4786 N-methylhydantoinase A (mikimopine-lactam hydrogenase). (693 aa) |
| | M446_1935 | 5-oxoprolinase (ATP-hydrolyzing); PFAM: Hydantoinase/oxoprolinase; Hydantoinaseoxoprolinase domain protein; KEGG: azc:AZC_2117 hydantoin utilization protein A. (690 aa) |
| | M446_1934 | 5-oxoprolinase (ATP-hydrolyzing); PFAM: Hydantoinase B/oxoprolinase; KEGG: azc:AZC_2116 hydantoin utilization protein B. (561 aa) |
| | M446_1755 | PFAM: YbaK/prolyl-tRNA synthetase associated region; KEGG: pap:PSPA7_4026 hypothetical protein. (156 aa) |
| | M446_1699 | PFAM: AMP-dependent synthetase and ligase; KEGG: olu:OSTLU_37273 predicted protein. (1433 aa) |
| | ligA | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (827 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (460 aa) |
| | leuS | TIGRFAM: leucyl-tRNA synthetase; KEGG: mex:Mext_1579 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (871 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (288 aa) |
| | M446_1386 | PFAM: von Willebrand factor type A; KEGG: mex:Mext_0865 von Willebrand factor type A. (329 aa) |
| | M446_1304 | PFAM: AMP-dependent synthetase and ligase; KEGG: rpc:RPC_0851 AMP-dependent synthetase and ligase. (513 aa) |
| | M446_1294 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: mex:Mext_0779 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (252 aa) |
| | M446_1205 | KEGG: bxe:Bxe_A2139 hypothetical TPR domain protein. (304 aa) |
| | M446_1204 | PFAM: von Willebrand factor type A; KEGG: rba:RB9502 hypothetical protein. (342 aa) |
| | gshB | KEGG: mex:Mext_0939 glutathione synthetase; TIGRFAM: glutathione synthetase; PFAM: glutathione synthetase domain protein; glutathione synthetase ATP-binding; RimK domain protein ATP-grasp; Belongs to the prokaryotic GSH synthase family. (317 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (518 aa) |
| | ddl | D-alanine--D-alanine ligase; Cell wall formation. (382 aa) |
| | M446_0875 | PFAM: AMP-dependent synthetase and ligase; KEGG: mex:Mext_0346 AMP-dependent synthetase and ligase. (517 aa) |
| | gltX1 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (474 aa) |
| | M446_0628 | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mex:Mext_3237 ATP dependent DNA ligase. (568 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (303 aa) |
| | M446_0475 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: mex:Mext_4444 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (441 aa) |
| | cysS | KEGG: mex:Mext_4745 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: tRNA synthetase class I (M); Cysteinyl-tRNA synthetase class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family. (460 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (80 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (228 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (430 aa) |
| | M446_0385 | Carbamoyl-phosphate synthase L chain ATP-binding; PFAM: biotin/lipoyl attachment domain-containing protein; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; RimK domain protein ATP-grasp; KEGG: mex:Mext_2996 carbamoyl-phosphate synthase L chain ATP-binding. (671 aa) |
| | M446_0378 | Lysine--tRNA ligase; PFAM: tRNA synthetase class II (D K and N); KEGG: mlo:mlr8260 lysyl-tRNA synthetase. (350 aa) |
| | M446_0302 | Hypothetical protein. (79 aa) |
| | tilS | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (344 aa) |
| | murE | UDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (488 aa) |
| | murF | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (485 aa) |
| | M446_0237 | PFAM: AMP-dependent synthetase and ligase; KEGG: reh:H16_B1239 long-chain-fatty-acid--CoA ligase. (602 aa) |
| | M446_0200 | PFAM: AMP-dependent synthetase and ligase; KEGG: mex:Mext_3653 AMP-dependent synthetase and ligase. (566 aa) |
| | M446_0171 | PFAM: AMP-dependent synthetase and ligase; phosphopantetheine-binding; KEGG: gsu:GSU1103 acyl-CoA synthetase. (630 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (737 aa) |
| | atpF2 | H+transporting two-sector ATPase B/B' subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). (187 aa) |
| | atpF1 | H+transporting two-sector ATPase B/B' subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (161 aa) |
