STRINGSTRING
murF murF murE murE M446_0475 M446_0475 ddl ddl gshB gshB panC panC murD murD M446_2243 M446_2243 purC purC purC-2 purC-2 M446_5060 M446_5060 M446_5062 M446_5062 M446_5076 M446_5076 M446_5781 M446_5781 M446_5994 M446_5994 M446_6157 M446_6157 M446_6249 M446_6249 M446_6659 M446_6659 murC murC M446_6763 M446_6763
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (485 aa)
murEUDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (488 aa)
M446_0475TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: mex:Mext_4444 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (441 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation. (382 aa)
gshBKEGG: mex:Mext_0939 glutathione synthetase; TIGRFAM: glutathione synthetase; PFAM: glutathione synthetase domain protein; glutathione synthetase ATP-binding; RimK domain protein ATP-grasp; Belongs to the prokaryotic GSH synthase family. (317 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (288 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (460 aa)
M446_2243Glutamate--cysteine ligase GCS2; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (377 aa)
purCPFAM: SAICAR synthetase; KEGG: rle:RL3872 putative phosphoribosylamidoimidazole-succinocarboxamide synthase. (325 aa)
purC-2KEGG: mex:Mext_0587 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (254 aa)
M446_5060PFAM: IucA/IucC family protein; KEGG: oan:Oant_3255 IucA/IucC family protein. (615 aa)
M446_5062PFAM: IucA/IucC family protein; KEGG: oan:Oant_3257 IucA/IucC family protein. (588 aa)
M446_5076PFAM: protein of unknown function DUF403; protein of unknown function DUF404; protein of unknown function DUF407; KEGG: mex:Mext_3416 protein of unknown function DUF404. (837 aa)
M446_5781TIGRFAM: alpha-L-glutamate ligase, RimK family; PFAM: protein of unknown function DUF201; RimK domain protein ATP-grasp; KEGG: mex:Mext_1832 alpha-L-glutamate ligase, RimK family; Belongs to the RimK family. (305 aa)
M446_5994Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily. (455 aa)
M446_6157KEGG: bja:bll3081 hypothetical protein. (352 aa)
M446_6249Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (426 aa)
M446_6659Glutamate--cysteine ligase GCS2; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (380 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (471 aa)
M446_6763PFAM: protein of unknown function DUF404; protein of unknown function DUF407; KEGG: mex:Mext_2208 protein of unknown function DUF404. (479 aa)
Your Current Organism:
Methylobacterium sp. 446
NCBI taxonomy Id: 426117
Other names: M. sp. 4-46, Methylobacterium sp. 4-46
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