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| | M446_4988 | PFAM: dTDP-4-dehydrorhamnose 35-epimerase related; KEGG: cau:Caur_1214 dTDP-4-dehydrorhamnose 3,5-epimerase. (205 aa) |
| | M446_4971 | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; KEGG: cau:Caur_1215 NAD-dependent epimerase/dehydratase. (352 aa) |
| | nadE | NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (679 aa) |
| | purC-2 | KEGG: mex:Mext_0587 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (254 aa) |
| | M446_4806 | RNA polymerase, sigma 32 subunit, RpoH; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; KEGG: mex:Mext_3881 RNA polymerase sigma factor, sigma-70 family. (293 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | M446_4793 | PFAM: aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; ferredoxin; [2Fe-2S]-binding domain protein; aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; KEGG: mex:Mext_1728 aldehyde oxidase and xanthine dehydrogenase molybdopterin binding. (925 aa) |
| | gpt | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (168 aa) |
| | M446_4788 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: xau:Xaut_0976 RNA polymerase, sigma-24 subunit, ECF subfamily. (184 aa) |
| | M446_4784 | KEGG: xau:Xaut_2315 hypothetical protein. (134 aa) |
| | M446_4693 | PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; Male sterility domain; KEGG: drm:Dred_1895 NAD-dependent epimerase/dehydratase. (317 aa) |
| | M446_4689 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: mex:Mext_0458 RNA polymerase sigma factor, sigma-70 family; Belongs to the sigma-70 factor family. ECF subfamily. (227 aa) |
| | M446_4668 | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KEGG: hne:HNE_2698 NAD-dependent epimerase/dehydratase family protein. (324 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (333 aa) |
| | M446_4590 | KEGG: mex:Mext_2645 L-aspartate oxidase; TIGRFAM: L-aspartate oxidase; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (500 aa) |
| | M446_4589 | KEGG: mex:Mext_2646 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (287 aa) |
| | M446_4552 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: mex:Mext_1376 RNA polymerase sigma factor, sigma-70 family; Belongs to the sigma-70 factor family. ECF subfamily. (193 aa) |
| | M446_4500 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: mex:Mext_4462 RNA polymerase sigma factor, sigma-70 family; Belongs to the sigma-70 factor family. ECF subfamily. (249 aa) |
| | dnaE2 | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1075 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (166 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa) |
| | pyrB | TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; KEGG: mex:Mext_3312 aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (316 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (430 aa) |
| | M446_4290 | KEGG: bpd:BURPS668_3046 hypothetical protein. (669 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (605 aa) |
| | amn | AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (493 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (205 aa) |
| | M446_4095 | PFAM: DnaB domain protein helicase domain protein; SMART: AAA ATPase; KEGG: azc:AZC_0834 DnaB helicase. (482 aa) |
| | M446_4030 | PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KR domain protein; KEGG: amr:AM1_2189 NAD-dependent epimerase/dehydratase. (406 aa) |
| | M446_4020 | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KEGG: hne:HNE_2698 NAD-dependent epimerase/dehydratase family protein. (318 aa) |
| | M446_3947 | KEGG: mex:Mext_0823 flagellar protein export ATPase FliI; TIGRFAM: ATPase, FliI/YscN family; flagellar protein export ATPase FliI; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; SMART: AAA ATPase. (451 aa) |
| | M446_3933 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: afw:Anae109_1554 RNA polymerase, sigma-24 subunit, ECF subfamily. (214 aa) |
| | M446_3801 | KEGG: syg:sync_0783 putative circadian phase modifier CpmA homolog. (222 aa) |
| | purC | PFAM: SAICAR synthetase; KEGG: rle:RL3872 putative phosphoribosylamidoimidazole-succinocarboxamide synthase. (325 aa) |
| | M446_3533 | TIGRFAM: modD protein; PFAM: Quinolinate phosphoribosyl transferase; KEGG: azc:AZC_1053 putative molybdenum utilization protein; Belongs to the NadC/ModD family. (280 aa) |
| | M446_3437 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: mms:mma_2030 RNA polymerase sigma-70 factor, ECF subfamily. (172 aa) |
| | M446_3402 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_4596 hypothetical protein. (308 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; KEGG: mex:Mext_1088 carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1157 aa) |
| | M446_3258 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (359 aa) |
| | M446_3227 | Nicotinamidase; PFAM: isochorismatase hydrolase; KEGG: mex:Mext_3904 nicotinamidase. (210 aa) |
| | M446_3211 | PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KEGG: mex:Mext_3027 NAD-dependent epimerase/dehydratase. (350 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; KEGG: mex:Mext_0615 carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (405 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (219 aa) |
| | M446_3111 | PFAM: aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; KEGG: acr:Acry_2211 carbon-monoxide dehydrogenase (acceptor). (756 aa) |
| | M446_3012 | PFAM: Oxidoreductase FAD-binding domain protein; FAD-binding 9 siderophore-interacting domain protein; KEGG: bam:Bamb_5905 oxidoreductase FAD-binding domain protein. (288 aa) |
| | pyrD | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (320 aa) |
| | M446_2997 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mca:MCA2813 4Fe-4S binding domain protein. (442 aa) |
| | purH | KEGG: mex:Mext_2566 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. (534 aa) |
| | acsA | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (649 aa) |
| | M446_2803 | PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; response regulator receiver; histidine kinase A domain protein; KEGG: sme:SMb20358 putative regulatory protein. (531 aa) |
| | M446_2796 | PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; response regulator receiver; KEGG: bja:blr2864 two-component response regulator. (447 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (378 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (165 aa) |
| | M446_2688 | PFAM: AMP-dependent synthetase and ligase; KEGG: mex:Mext_1958 AMP-dependent synthetase and ligase. (641 aa) |
| | M446_2671 | PFAM: aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; KEGG: mex:Mext_0837 aldehyde oxidase and xanthine dehydrogenase molybdopterin binding. (745 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (429 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (236 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (544 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (499 aa) |
| | M446_2594 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (495 aa) |
| | M446_2560 | PFAM: aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; KEGG: bja:blr2219 dehydrogenase. (744 aa) |
| | M446_2543 | TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase; Amidohydrolase 3; KEGG: reh:H16_A3075 D-hydantoinase. (503 aa) |
| | M446_2336 | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: mex:Mext_2030 putative ferredoxin-NAD reductase component. (321 aa) |
| | M446_2222 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; KEGG: mex:Mext_0420 riboflavin biosynthesis protein RibF; Belongs to the ribF family. (321 aa) |
| | M446_2199 | PFAM: AMP-dependent synthetase and ligase; KEGG: mex:Mext_4434 AMP-dependent synthetase and ligase. (538 aa) |
| | M446_2197 | KEGG: mex:Mext_2861 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (196 aa) |
| | M446_2182 | RNA polymerase, sigma 54 subunit, RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (518 aa) |
| | selA | L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (467 aa) |
| | M446_2078 | PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; Male sterility domain; KR domain protein; KEGG: mex:Mext_0251 NAD-dependent epimerase/dehydratase. (391 aa) |
| | M446_2071 | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KEGG: mex:Mext_0504 NAD-dependent epimerase/dehydratase. (340 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (220 aa) |
| | M446_1983 | PFAM: aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; ferredoxin; [2Fe-2S]-binding domain protein; aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; KEGG: mag:amb1483 aldehyde oxidoreductase. (912 aa) |
| | M446_1982 | PFAM: molybdopterin dehydrogenase FAD-binding; CO dehydrogenase flavoprotein domain protein; KEGG: sil:SPO0831 xanthine dehydrogenase family protein, medium subunit. (281 aa) |
| | M446_1937 | PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: azc:AZC_2105 fumarate reductase. (464 aa) |
| | M446_1829 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: mex:Mext_4462 RNA polymerase sigma factor, sigma-70 family; Belongs to the sigma-70 factor family. ECF subfamily. (246 aa) |
| | M446_1753 | KEGG: mex:Mext_4303 dihydroorotase, multifunctional complex type; TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase; Amidohydrolase 3. (446 aa) |
| | M446_1688 | PFAM: Exonuclease RNase T and DNA polymerase III; SMART: Exonuclease; KEGG: mex:Mext_0325 exonuclease RNase T and DNA polymerase III. (186 aa) |
| | M446_1622 | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (274 aa) |
| | kdsB | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (264 aa) |
| | M446_1569 | PFAM: phosphate acetyl/butaryl transferase; KEGG: mex:Mext_0052 phosphate butyryltransferase. (324 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | M446_1564 | PFAM: protein of unknown function DUF344; KEGG: mex:Mext_1138 protein of unknown function DUF344. (279 aa) |
| | M446_1550 | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KEGG: nwi:Nwi_0898 NAD-dependent epimerase/dehydratase. (357 aa) |
| | M446_1528 | PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; response regulator receiver; KEGG: bja:blr2288 two-component hybrid sensor and regulator. (350 aa) |
| | M446_1507 | KEGG: aae:aq_1855 DNA polymerase III gamma subunit; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase. (699 aa) |
| | M446_1416 | PFAM: protein of unknown function DUF344; KEGG: bja:bll2813 hypothetical protein. (305 aa) |
| | M446_1406 | TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: mex:Mext_1587 DNA polymerase III, delta subunit. (342 aa) |
| | M446_1400 | PFAM: Exonuclease RNase T and DNA polymerase III; SMART: Exonuclease; KEGG: bov:BOV_A0588 putative exonuclease. (222 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (436 aa) |
| | M446_1353 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: bbt:BBta_3387 putative RNA polymerase ECF-type sigma factor. (260 aa) |
| | M446_1301 | PFAM: aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; cyclase/dehydrase; aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; carbon monoxide dehydrogenase subunit G; KEGG: bja:blr3533 putative carbon monoxide dehydrogenase large chain. (988 aa) |
| | M446_1277 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: mex:Mext_0458 RNA polymerase sigma factor, sigma-70 family; Belongs to the sigma-70 factor family. ECF subfamily. (260 aa) |
| | M446_1224 | RecA-family ATPase-like protein; KEGG: nar:Saro_2712 hypothetical protein. (719 aa) |
| | M446_1212 | Hypothetical protein; KEGG: xau:Xaut_2298 tetratricopeptide TPR_2 repeat protein. (274 aa) |
| | M446_1167 | PFAM: Primase 1; Bifunctional DNA primase/polymerase; KEGG: cth:Cthe_1986 phage / plasmid primase, P4 family. (289 aa) |
| | M446_1166 | TIGRFAM: phage/plasmid primase, P4 family; PFAM: primase P4; KEGG: xau:Xaut_3437 phage/plasmid primase, P4 family. (467 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (204 aa) |
| | dnaQ | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (238 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (497 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (518 aa) |
| | M446_0921 | PFAM: Forkhead-associated protein; adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: afw:Anae109_3652 putative adenylate/guanylate cyclase. (306 aa) |
| | M446_0875 | PFAM: AMP-dependent synthetase and ligase; KEGG: mex:Mext_0346 AMP-dependent synthetase and ligase. (517 aa) |
| | M446_0810 | PFAM: protein of unknown function DUF927; KEGG: gdi:GDI3600 hypothetical protein. (930 aa) |
| | adk-2 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (205 aa) |
| | M446_0746 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: mex:Mext_0458 RNA polymerase sigma factor, sigma-70 family; Belongs to the sigma-70 factor family. ECF subfamily. (237 aa) |
| | M446_0722 | Adenylate/guanylate cyclase with Chase sensor; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; CHASE2 domain protein; KEGG: ret:RHE_CH02180 putative adenylate cyclase protein. (613 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (1016 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (240 aa) |
| | M446_0628 | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mex:Mext_3237 ATP dependent DNA ligase. (568 aa) |
| | M446_0623 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: mex:Mext_0458 RNA polymerase sigma factor, sigma-70 family; Belongs to the sigma-70 factor family. ECF subfamily. (250 aa) |
| | M446_0550 | PFAM: aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; KEGG: mex:Mext_1289 carbon-monoxide dehydrogenase (acceptor). (790 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (730 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (303 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (80 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (228 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (430 aa) |
| | nusG | NusG antitermination factor; Participates in transcription elongation, termination and antitermination. (177 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1374 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1400 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (199 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (339 aa) |
| | M446_0294 | PFAM: aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; KEGG: bra:BRADO2884 putative xanthine dehydrogenase, molybdenum binding subunit. (739 aa) |
| | M446_0034 | PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; NmrA family protein; Male sterility domain; KEGG: mex:Mext_2034 NAD-dependent epimerase/dehydratase. (318 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (196 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (137 aa) |
| | M446_0006 | PFAM: BolA family protein; KEGG: mex:Mext_0012 BolA family protein; Belongs to the BolA/IbaG family. (78 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (737 aa) |
| | M446_0002 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (373 aa) |
| | M446_6952 | PFAM: molybdopterin binding domain; KEGG: mex:Mext_0374 molybdopterin binding domain. (250 aa) |
| | atpF1 | H+transporting two-sector ATPase B/B' subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (161 aa) |
| | atpF2 | H+transporting two-sector ATPase B/B' subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). (187 aa) |
| | atpE | H+transporting two-sector ATPase C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (75 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (251 aa) |
| | M446_6918 | KEGG: jan:Jann_2898 hypothetical protein. (681 aa) |
| | M446_6886 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: mex:Mext_0458 RNA polymerase sigma factor, sigma-70 family; Belongs to the sigma-70 factor family. ECF subfamily. (227 aa) |
| | M446_6855 | TIGRFAM: malonate decarboxylase, beta subunit; KEGG: mex:Mext_0026 malonate decarboxylase, beta subunit. (306 aa) |
| | rpoH | RNA polymerase, sigma 32 subunit, RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (296 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa) |
| | M446_6842 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mex:Mext_0996 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (435 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (156 aa) |
| | mtnP | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (291 aa) |
| | coaA | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: mex:Mext_2554 pantothenate kinase. (335 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (627 aa) |
| | rpoD | RNA polymerase, sigma 70 subunit, RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (666 aa) |
| | M446_6772 | PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: mex:Mext_0606 adenylyl cyclase class-3/4/guanylyl cyclase. (416 aa) |
| | M446_6692 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: mex:Mext_4462 RNA polymerase sigma factor, sigma-70 family; Belongs to the sigma-70 factor family. ECF subfamily. (240 aa) |
| | dinB | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (435 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (190 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (509 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (292 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (484 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (133 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (233 aa) |
| | M446_6595 | TIGRFAM: queuosine biosynthesis protein QueD; PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: mex:Mext_1225 queuosine biosynthesis protein QueD. (118 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (210 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (435 aa) |
| | cmk | KEGG: mex:Mext_2129 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. (210 aa) |
| | apaG | PFAM: ApaG domain protein; KEGG: mex:Mext_0370 ApaG domain protein. (130 aa) |
| | M446_6505 | KEGG: mex:Mext_0682 ATPase, FliI/YscN family; TIGRFAM: ATPase, FliI/YscN family; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; SMART: AAA ATPase. (441 aa) |
| | M446_6494 | PFAM: BolA family protein; KEGG: mex:Mext_3232 BolA family protein; Belongs to the BolA/IbaG family. (96 aa) |
| | M446_6449 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: mex:Mext_0458 RNA polymerase sigma factor, sigma-70 family; Belongs to the sigma-70 factor family. ECF subfamily. (239 aa) |
| | M446_6435 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: nha:Nham_0213 sigma-24 (FecI-like); Belongs to the sigma-70 factor family. ECF subfamily. (225 aa) |
| | M446_6351 | TIGRFAM: hopanoid-associated sugar epimerase; PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KR domain protein; KEGG: mex:Mext_1940 hopanoid-associated sugar epimerase. (345 aa) |
| | M446_6279 | KEGG: mex:Mext_4190 DNA-directed DNA polymerase. (347 aa) |
| | tmk | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (226 aa) |
| | M446_6268 | PFAM: protein of unknown function DUF179; KEGG: mex:Mext_2596 protein of unknown function DUF179; Belongs to the UPF0301 (AlgH) family. (210 aa) |
| | M446_6249 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (426 aa) |
| | M446_6186 | KEGG: mex:Mext_4306 metal-dependent phosphohydrolase HD sub domain. (225 aa) |
| | M446_6099 | PFAM: phosphate acetyl/butaryl transferase; MaoC domain protein dehydratase; KEGG: sil:SPO0115 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase. (482 aa) |
| | ackA-2 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (389 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | purD | KEGG: mex:Mext_3871 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family. (442 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (181 aa) |
| | M446_5992 | KEGG: mex:Mext_1048 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; DNA polymerase III alpha subunit; SMART: phosphoesterase PHP domain protein. (1168 aa) |
| | M446_5983 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: rsh:Rsph17029_2674 RNA polymerase, sigma-24 subunit, ECF subfamily. (200 aa) |
| | M446_5952 | NusG antitermination factor; PFAM: NGN domain protein; KEGG: mex:Mext_3997 transcription termination/antitermination factor NusG. (225 aa) |
| | M446_5939 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: azc:AZC_0389 RNA polymerase ECF-type sigma factor. (307 aa) |
| | M446_5926 | PFAM: CinA domain protein; KEGG: mex:Mext_2816 CinA domain protein; Belongs to the CinA family. (166 aa) |
| | M446_5897 | Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (497 aa) |
| | queF | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (150 aa) |
| | M446_5885 | PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; SMART: AAA ATPase; KEGG: sme:SMa1591 putative adenylate cyclase. (1065 aa) |
| | M446_5837 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (297 aa) |
| | M446_5835 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (184 aa) |
| | M446_5771 | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; KEGG: rso:RSc3335 hypothetical protein. (338 aa) |
| | M446_5699 | PFAM: aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; KEGG: xau:Xaut_0648 aldehyde oxidase and xanthine dehydrogenase molybdopterin binding. (799 aa) |
| | M446_5637 | Dihydropyrimidinase; PFAM: amidohydrolase; KEGG: sfu:Sfum_2145 allantoinase. (495 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (378 aa) |
| | queA | S-adenosylmethionine--tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (362 aa) |
| | M446_5506 | KEGG: mex:Mext_3888 RNA polymerase sigma factor, sigma-70 family. (88 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (451 aa) |
| | M446_5450 | KEGG: mex:Mext_1058 4-diphosphocytidyl-2C-methyl-D-erythritol synthase. (201 aa) |
| | M446_5442 | PFAM: aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; KEGG: azc:AZC_2938 carbon-monoxide dehydrogenase large subunit. (789 aa) |
| | M446_5425 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (451 aa) |
| | M446_5406 | PFAM: DNA polymerase III chi subunit HolC; KEGG: mex:Mext_4656 DNA polymerase III chi subunit HolC. (150 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (542 aa) |
| | M446_5390 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: mes:Meso_3107 RNA polymerase, sigma-24 subunit, ECF subfamily. (181 aa) |
| | nadK | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (256 aa) |
| | M446_5330 | PFAM: protein of unknown function DUF344; KEGG: mex:Mext_4290 protein of unknown function DUF344. (318 aa) |
| | M446_5293 | PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; response regulator receiver; KEGG: bja:blr2864 two-component response regulator. (421 aa) |
| | M446_5269 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: mex:Mext_4462 RNA polymerase sigma factor, sigma-70 family; Belongs to the sigma-70 factor family. ECF subfamily. (243 aa) |
| | M446_5192 | KEGG: mex:Mext_3028 nucleotide sugar dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase NAD-binding; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase. (440 aa) |
| | M446_5188 | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KEGG: azc:AZC_0053 GDP-6-deoxy-D-lyxo-4-hexulose reductase. (322 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (218 aa) |
| | purM | KEGG: mex:Mext_2063 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. (355 aa) |
| | M446_5053 | RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70 region 4 type 2; KEGG: pol:Bpro_4793 sigma-24 (FecI-like); Belongs to the sigma-70 factor family. ECF subfamily. (189 aa) |
| | M446_5036 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (162 aa) |
