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M446_0035 M446_0035 uppP uppP mraY mraY murF murF murE murE M446_0475 M446_0475 rlpA rlpA ddl ddl M446_1375 M446_1375 murD murD murI murI M446_2257 M446_2257 M446_2397 M446_2397 murA murA M446_2709 M446_2709 rlpA-2 rlpA-2 mltG mltG uppP-2 uppP-2 rlpA-3 rlpA-3 murJ murJ glmU glmU M446_6089 M446_6089 M446_6175 M446_6175 rlpA-4 rlpA-4 M446_6277 M446_6277 rlpA-5 rlpA-5 M446_6593 M446_6593 mtgA mtgA murB murB murC murC murG murG
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
M446_0035PFAM: glycosyl transferase family 4; KEGG: mex:Mext_2033 glycosyl transferase family 4. (334 aa)
uppPUndecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (267 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (361 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (485 aa)
murEUDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (488 aa)
M446_0475TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: mex:Mext_4444 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (441 aa)
rlpARare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (124 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation. (382 aa)
M446_1375PFAM: MltA domain protein; 3D domain protein; KEGG: mex:Mext_1561 MltA domain protein. (404 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (460 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (290 aa)
M446_2257Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: beta-lactamase; peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Sporulation domain protein; KEGG: mex:Mext_4800 serine-type D-Ala-D-Ala carboxypeptidase; Belongs to the peptidase S11 family. (503 aa)
M446_2397PFAM: Lytic transglycosylase catalytic; KEGG: mex:Mext_3465 lytic transglycosylase catalytic. (375 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (429 aa)
M446_2709PFAM: cell wall hydrolase SleB; KEGG: mex:Mext_2889 cell wall hydrolase SleB. (446 aa)
rlpA-2Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (121 aa)
mltGAminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (454 aa)
uppP-2Undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (296 aa)
rlpA-3Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (121 aa)
murJIntegral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (509 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (451 aa)
M446_6089PFAM: virulence factor MVIN family protein; KEGG: bra:BRADO7074 putative virulence factor MviN-like protein. (554 aa)
M446_6175PFAM: cell wall hydrolase SleB; KEGG: mex:Mext_2798 cell wall hydrolase SleB. (226 aa)
rlpA-4Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (394 aa)
M446_6277Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: mex:Mext_2917 serine-type D-Ala-D-Ala carboxypeptidase; Belongs to the peptidase S11 family. (402 aa)
rlpA-5Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (135 aa)
M446_6593Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: beta-lactamase; peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; KEGG: mex:Mext_1220 serine-type D-Ala-D-Ala carboxypeptidase; Belongs to the peptidase S11 family. (506 aa)
mtgAMonofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (256 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (304 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (471 aa)
murGUndecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (372 aa)
Your Current Organism:
Methylobacterium sp. 446
NCBI taxonomy Id: 426117
Other names: M. sp. 4-46, Methylobacterium sp. 4-46
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