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| | glyS | KEGG: mex:Mext_3096 glycyl-tRNA synthetase, beta subunit; TIGRFAM: glycyl-tRNA synthetase, beta subunit. (704 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (737 aa) |
| | M446_0171 | PFAM: AMP-dependent synthetase and ligase; phosphopantetheine-binding; KEGG: gsu:GSU1103 acyl-CoA synthetase. (630 aa) |
| | M446_0200 | PFAM: AMP-dependent synthetase and ligase; KEGG: mex:Mext_3653 AMP-dependent synthetase and ligase. (566 aa) |
| | M446_0237 | PFAM: AMP-dependent synthetase and ligase; KEGG: reh:H16_B1239 long-chain-fatty-acid--CoA ligase. (602 aa) |
| | murF | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (485 aa) |
| | murE | UDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (488 aa) |
| | glnE | (Glutamate--ammonia-ligase) adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...] (976 aa) |
| | tilS | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (344 aa) |
| | M446_0378 | Lysine--tRNA ligase; PFAM: tRNA synthetase class II (D K and N); KEGG: mlo:mlr8260 lysyl-tRNA synthetase. (350 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (430 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (228 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (80 aa) |
| | cysS | KEGG: mex:Mext_4745 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: tRNA synthetase class I (M); Cysteinyl-tRNA synthetase class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family. (460 aa) |
| | M446_0475 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: mex:Mext_4444 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (441 aa) |
| | M446_0628 | PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mex:Mext_3237 ATP dependent DNA ligase. (568 aa) |
| | gltX1 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (474 aa) |
| | M446_0875 | PFAM: AMP-dependent synthetase and ligase; KEGG: mex:Mext_0346 AMP-dependent synthetase and ligase. (517 aa) |
| | ddl | D-alanine--D-alanine ligase; Cell wall formation. (382 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (518 aa) |
| | gshB | KEGG: mex:Mext_0939 glutathione synthetase; TIGRFAM: glutathione synthetase; PFAM: glutathione synthetase domain protein; glutathione synthetase ATP-binding; RimK domain protein ATP-grasp; Belongs to the prokaryotic GSH synthase family. (317 aa) |
| | M446_1294 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: mex:Mext_0779 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (252 aa) |
| | M446_1304 | PFAM: AMP-dependent synthetase and ligase; KEGG: rpc:RPC_0851 AMP-dependent synthetase and ligase. (513 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (288 aa) |
| | leuS | TIGRFAM: leucyl-tRNA synthetase; KEGG: mex:Mext_1579 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (871 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (460 aa) |
| | ligA | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (827 aa) |
| | M446_1699 | PFAM: AMP-dependent synthetase and ligase; KEGG: olu:OSTLU_37273 predicted protein. (1433 aa) |
| | M446_1755 | PFAM: YbaK/prolyl-tRNA synthetase associated region; KEGG: pap:PSPA7_4026 hypothetical protein. (156 aa) |
| | sucC | succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (398 aa) |
| | sucD | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa) |
| | M446_2199 | PFAM: AMP-dependent synthetase and ligase; KEGG: mex:Mext_4434 AMP-dependent synthetase and ligase. (538 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). (989 aa) |
| | M446_2243 | Glutamate--cysteine ligase GCS2; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (377 aa) |
| | M446_2308 | PFAM: AMP-dependent synthetase and ligase; KEGG: bbt:BBta_5715 putative long-chain-fatty-acid-CoA ligase. (657 aa) |
| | M446_2311 | KEGG: bbt:BBta_5720 putative phenylacetate-CoA ligase. (410 aa) |
| | M446_2317 | Propionyl-CoA carboxylase; PFAM: carboxyl transferase; KEGG: mmr:Mmar10_1734 propionyl-CoA carboxylase. (535 aa) |
| | M446_2319 | PFAM: AMP-dependent synthetase and ligase; KEGG: rpb:RPB_0580 AMP-dependent synthetase and ligase. (565 aa) |
| | M446_2438 | KEGG: mex:Mext_1439 cobaltochelatase, CobN subunit; TIGRFAM: cobaltochelatase, CobN subunit; PFAM: CobN/magnesium chelatase. (1099 aa) |
| | cobB | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (447 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (604 aa) |
| | argS | KEGG: mex:Mext_3396 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. (586 aa) |
| | gltX2 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (447 aa) |
| | M446_2646 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_1498 tRNA synthetase class II (G H P and S). (378 aa) |
| | hisS | KEGG: mex:Mext_1555 histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein. (532 aa) |
| | M446_2679 | KEGG: rru:Rru_A1988 GCN5-related N-acetyltransferase; TIGRFAM: GNAT-family acetyltransferase TIGR03103; PFAM: GCN5-related N-acetyltransferase; RimK domain protein ATP-grasp. (571 aa) |
| | M446_2680 | KEGG: mex:Mext_4868 asparagine synthase family amidotransferase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing); asparagine synthase family amidotransferase; PFAM: glutamine amidotransferase class-II; asparagine synthase. (590 aa) |
| | M446_2688 | PFAM: AMP-dependent synthetase and ligase; KEGG: mex:Mext_1958 AMP-dependent synthetase and ligase. (641 aa) |
| | M446_2689 | PFAM: AMP-dependent synthetase and ligase; KEGG: mex:Mext_4171 AMP-dependent synthetase and ligase. (543 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (378 aa) |
| | M446_2733 | PFAM: AMP-dependent synthetase and ligase; KEGG: rpe:RPE_4352 AMP-dependent synthetase and ligase. (542 aa) |
| | glyQ | KEGG: mex:Mext_3099 glycyl-tRNA synthetase, alpha subunit; TIGRFAM: glycyl-tRNA synthetase, alpha subunit; PFAM: glycyl-tRNA synthetase alpha subunit. (313 aa) |
| | M446_2875 | PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; phosphopantetheine-binding; KEGG: pol:Bpro_3393 AMP-dependent synthetase and ligase. (958 aa) |
| | M446_2876 | PFAM: AMP-dependent synthetase and ligase; KEGG: nmu:Nmul_A1417 AMP-dependent synthetase and ligase. (612 aa) |
| | M446_2902 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: mex:Mext_0779 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (203 aa) |
| | acsA | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (649 aa) |
| | M446_3072 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: mex:Mext_2363 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (202 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; KEGG: mex:Mext_0615 carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (405 aa) |
| | fhs | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: mex:Mext_0414 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (558 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; KEGG: mex:Mext_1088 carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1157 aa) |
| | M446_3402 | PFAM: tRNA synthetase class II (G H P and S); KEGG: mex:Mext_4596 hypothetical protein. (308 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (347 aa) |
| | purC | PFAM: SAICAR synthetase; KEGG: rle:RL3872 putative phosphoribosylamidoimidazole-succinocarboxamide synthase. (325 aa) |
| | M446_3720 | KEGG: mex:Mext_4814 magnesium chelatase, H subunit; TIGRFAM: magnesium chelatase, H subunit; PFAM: CobN/magnesium chelatase. (1244 aa) |
| | M446_3731 | Magnesium chelatase ATPase subunit I; Involved in bacteriochlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX. (368 aa) |
| | M446_3855 | PFAM: AMP-dependent synthetase and ligase; KEGG: rsq:Rsph17025_2837 AMP-dependent synthetase and ligase. (550 aa) |
| | M446_4318 | PFAM: AMP-dependent synthetase and ligase; KEGG: mex:Mext_4606 AMP-dependent synthetase and ligase. (592 aa) |
| | gatB | glutamyl-tRNA(Gln) amidotransferase, B subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (490 aa) |
| | gatA | glutamyl-tRNA(Gln) amidotransferase, A subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (497 aa) |
| | gatC | glutamyl-tRNA(Gln) amidotransferase, C subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (95 aa) |
| | M446_4404 | TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin/lipoate A/B protein ligase; KEGG: mex:Mext_1071 biotin--acetyl-CoA-carboxylase ligase. (264 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro); Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily. (444 aa) |
| | M446_4572 | Glutamate--ammonia ligase; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: xau:Xaut_1141 glutamate--ammonia ligase. (345 aa) |
| | M446_4578 | PFAM: AMP-dependent synthetase and ligase; phospholipid/glycerol acyltransferase; major facilitator superfamily MFS_1; KEGG: mex:Mext_1501 AMP-dependent synthetase and ligase. (1139 aa) |
| | M446_4608 | PFAM: YbaK/prolyl-tRNA synthetase associated region; KEGG: rle:RL4572 hypothetical protein. (172 aa) |
| | M446_4877 | PFAM: glutamyl-tRNA synthetase class Ic; KEGG: mex:Mext_1025 glutamyl-tRNA synthetase class Ic; Belongs to the class-I aminoacyl-tRNA synthetase family. (279 aa) |
| | purC-2 | KEGG: mex:Mext_0587 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (254 aa) |
| | nadE | NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (679 aa) |
| | purM | KEGG: mex:Mext_2063 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. (355 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (225 aa) |
| | lipB | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (235 aa) |
| | pheT | KEGG: mex:Mext_1630 phenylalanyl-tRNA synthetase, beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit. (808 aa) |
| | pheS | TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; PFAM: phenylalanyl-tRNA synthetase class IIc; aminoacyl tRNA synthetase class II domain protein; KEGG: mex:Mext_1629 phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (360 aa) |
| | M446_5364 | PFAM: AMP-dependent synthetase and ligase; KEGG: xau:Xaut_2806 AMP-dependent synthetase and ligase. (536 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (542 aa) |
| | M446_5425 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (451 aa) |
| | M446_5472 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. (180 aa) |
| | M446_5781 | TIGRFAM: alpha-L-glutamate ligase, RimK family; PFAM: protein of unknown function DUF201; RimK domain protein ATP-grasp; KEGG: mex:Mext_1832 alpha-L-glutamate ligase, RimK family; Belongs to the RimK family. (305 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (886 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (426 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (903 aa) |
| | M446_5994 | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily. (455 aa) |
| | M446_6034 | PFAM: AMP-dependent synthetase and ligase; KEGG: mex:Mext_0876 AMP-dependent synthetase and ligase. (507 aa) |
| | purD | KEGG: mex:Mext_3871 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family. (442 aa) |
| | M446_6079 | PFAM: AMP-dependent synthetase and ligase; KEGG: scl:sce8262 non-ribosomal peptide synthetase. (555 aa) |
| | M446_6124 | PFAM: argininosuccinate synthase; KEGG: ang:An12g01280 hypothetical protein Pfam: Asn_synthase Arginosuc_synth. (417 aa) |
| | M446_6249 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (426 aa) |
| | lysS | Lysine--tRNA ligase; PFAM: Lysyl-tRNA synthetase class 1c; KEGG: mex:Mext_2980 lysyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (567 aa) |
| | M446_6312 | KEGG: mex:Mext_4168 acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II-like protein. (425 aa) |
| | thrS | TIGRFAM: threonyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); TGS domain protein; Anticodon-binding domain protein; Threonyl/alanyl tRNA synthetase SAD; KEGG: mex:Mext_2321 threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (670 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. (515 aa) |
| | M446_6496 | KEGG: mex:Mext_3230 cobalt chelatase, pCobS small subunit; TIGRFAM: cobalt chelatase, pCobS small subunit; PFAM: ATPase associated with various cellular activities AAA_5. (327 aa) |
| | M446_6497 | KEGG: mex:Mext_3229 cobalt chelatase, pCobT subunit; TIGRFAM: cobalt chelatase, pCobT subunit; PFAM: Cobalt chelatase CobT subunit; SMART: von Willebrand factor type A. (630 aa) |
| | M446_6525 | PFAM: AMP-dependent synthetase and ligase; KEGG: bra:BRADO6291 putative 2-succinylbenzoate--CoA ligase (OSB-CoA synthetase) (o-succinylbenzoyl-CoA synthetase). (487 aa) |
| | sucC-2 | succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (392 aa) |
| | sucD-2 | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (299 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (435 aa) |
| | M446_6588 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: mex:Mext_2377 glutamine synthetase, type I. (470 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (233 aa) |
| | argG | PFAM: argininosuccinate synthase; KEGG: mex:Mext_2293 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (413 aa) |
| | M446_6659 | Glutamate--cysteine ligase GCS2; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (380 aa) |
| | murC | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (471 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa) |
