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ABR65198.1 ABR65198.1 argJ argJ dapF dapF dapB dapB aroE aroE hisG hisG hisD hisD trpA trpA trpB trpB trpF trpF ABR65317.1 ABR65317.1 trpE trpE trpD trpD ABR65320.1 ABR65320.1 ABR65329.1 ABR65329.1 cimA cimA ABR65386.1 ABR65386.1 ABR65395.1 ABR65395.1 argD argD leuC leuC ABR65488.1 ABR65488.1 lysA lysA aroA aroA hisC hisC aroC aroC asd asd aroD aroD ABR65708.1 ABR65708.1 ABR65710.1 ABR65710.1 leuC-2 leuC-2 ABR65827.1 ABR65827.1 ABR65842.1 ABR65842.1 ABR65843.1 ABR65843.1 ABR66044.1 ABR66044.1 hisF hisF aroB aroB argH argH hisE hisE argB argB argG argG argC argC ilvE ilvE ABR66200.1 ABR66200.1 leuD leuD ABR66207.1 ABR66207.1 ABR66219.1 ABR66219.1 hisH hisH hisI hisI thrB thrB ilvD ilvD aroK aroK leuD-2 leuD-2 hisA hisA ABR66616.1 ABR66616.1 ABR66618.1 ABR66618.1 hisB hisB dapA dapA ABR66657.1 ABR66657.1 ABR66694.1 ABR66694.1 ABR66732.1 ABR66732.1 ABR66733.1 ABR66733.1 ilvC ilvC aroA-2 aroA-2
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query proteins and first shell of interactors
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second shell of interactors
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a 3D structure is known or predicted
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ABR65198.1TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: mmq:MmarC5_0688 isopropylmalate/isohomocitrate dehydrogenase. (339 aa)
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (408 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (277 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (270 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (280 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (288 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (424 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate; Belongs to the TrpA family. (259 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa)
trpFPFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: mmp:MMP1004 N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (208 aa)
ABR65317.1TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: mmp:MMP1005 anthranilate synthase component II. (196 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (439 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (321 aa)
ABR65320.1PFAM: Indole-3-glycerol phosphate synthase; KEGG: mmp:MMP1008 indole-3-glycerol-phosphate synthase. (229 aa)
ABR65329.1TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; KEGG: mmp:MMP1017 aspartate kinase; Belongs to the aspartokinase family. (468 aa)
cimAIsopropylmalate/citramalate/homocitrate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (492 aa)
ABR65386.1TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (514 aa)
ABR65395.1PFAM: aminotransferase class I and II; KEGG: mmp:MMP1072 aminotransferase (subgroup I) similar to aromatic aminotransferase. (375 aa)
argDTIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; KEGG: mmp:MMP1101 aminotransferase (subgroup II) similar to acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (395 aa)
leuCHomoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (424 aa)
ABR65488.1TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: mmq:MmarC5_0416 CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (204 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (436 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (429 aa)
hisCTIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class V; aminotransferase class I and II; KEGG: mmp:MMP1216 histidinol-phosphate aminotransferase. (371 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (373 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (348 aa)
aroD3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (218 aa)
ABR65708.1PFAM: aminotransferase class I and II; KEGG: mmp:MMP1396 aminotransferase (subgroup I). (434 aa)
ABR65710.1TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: mmp:MMP1398 succinyl-diaminopimelate desuccinylase. (415 aa)
leuC-2Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (418 aa)
ABR65827.1PFAM: Prephenate dehydrogenase; 6-phosphogluconate dehydrogenase NAD-binding protein; KEGG: mmp:MMP1514 prephenate dehydrogenase. (443 aa)
ABR65842.1PFAM: aminotransferase class I and II; KEGG: mmp:MMP1527 aspartate aminotransferase. (416 aa)
ABR65843.1PFAM: prephenate dehydratase; KEGG: mmp:MMP1528 prephenate dehydratase. (269 aa)
ABR66044.1PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding protein; KEGG: mmp:MMP1702 homoserine dehydrogenase. (337 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (272 aa)
aroB3-dehydroquinate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (361 aa)
argHTIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: mmp:MMP0013 argininosuccinate lyase. (481 aa)
hisEPFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mmp:MMP0051 phosphoribosyl-ATP pyrophosphatase. (96 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (294 aa)
argGPFAM: argininosuccinate synthase; ExsB family protein; KEGG: mmp:MMP0073 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (397 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (343 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (287 aa)
ABR66200.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (404 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (167 aa)
ABR66207.1PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0142 thiamine pyrophosphate dependent enzyme related to acetolactate synthase. (501 aa)
ABR66219.1TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; KEGG: mmp:MMP0153 2-oxosuberate synthase, first step; Belongs to the alpha-IPM synthase/homocitrate synthase family. (386 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (203 aa)
hisIPhosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (129 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (301 aa)
ilvDTIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: mmp:MMP0318 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (550 aa)
aroKTIGRFAM: shikimate kinase; PFAM: GHMP kinase; GHMP kinase domain protein; KEGG: mmp:MMP0320 shikimate kinase (archaeal). (283 aa)
leuD-23-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa)
hisATIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. (238 aa)
ABR66616.1TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: mmp:MMP0539 3-isopropylmalate dehydrogenase. (330 aa)
ABR66618.1TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase subfamily IB hypothetical 1; KEGG: mmp:MMP0541 phosphoserine phosphatase. (213 aa)
hisBPFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmp:MMP0548 imidazoleglycerol-phosphate dehydratase. (190 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (289 aa)
ABR66657.1TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; KEGG: mmp:MMP0578 chorismate mutase. (96 aa)
ABR66694.1PFAM: alpha-acetolactate decarboxylase; KEGG: mmp:MMP0613 alpha-acetolactate decarboxylase. (266 aa)
ABR66732.1TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0650 acetohydroxyacid synthase large subunit. (587 aa)
ABR66733.1TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: mmp:MMP0651 acetohydroxyacid synthase small subunit. (169 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa)
aroA-2Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (272 aa)
Your Current Organism:
Methanococcus maripaludis C7
NCBI taxonomy Id: 426368
Other names: M. maripaludis C7, Methanococcus maripaludis str. C7, Methanococcus maripaludis strain C7
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