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| | ABR65219.1 | PFAM: protein of unknown function DUF126; KEGG: mmq:MmarC5_0709 protein of unknown function DUF126; Belongs to the UPF0107 family. (130 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (408 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (533 aa) |
| | ABR65198.1 | TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: mmq:MmarC5_0688 isopropylmalate/isohomocitrate dehydrogenase. (339 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec); Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily. (514 aa) |
| | ABR65180.1 | PFAM: aminotransferase class-III; KEGG: mmq:MmarC5_0670 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (467 aa) |
| | ABR65176.1 | TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein; KEGG: mmp:MMP0861 lysine 2,3-aminomutase. (433 aa) |
| | ABR66838.1 | TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein; KEGG: mja:MJ0634 hypothetical protein. (594 aa) |
| | ABR66821.1 | PFAM: protein of unknown function DUF161; KEGG: mmp:MMP0498 hypothetical protein. (214 aa) |
| | ABR66798.1 | Phenylacetate--CoA ligase; KEGG: mmp:MMP0715 coenzyme F390 synthetase II. (432 aa) |
| | ABR66797.1 | PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: mmp:MMP0714 indolepyruvate oxidoreductase subunit beta 2. (188 aa) |
| | ABR66785.1 | TIGRFAM: alpha-L-glutamate ligase, RimK family; PFAM: RimK domain protein ATP-grasp; KEGG: mmp:MMP0702 conserved hypothetical protein. (292 aa) |
| | leuS | TIGRFAM: leucyl-tRNA synthetase; KEGG: mmp:MMP0697 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (955 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (460 aa) |
| | sepS | O-phosphoseryl-tRNA(Cys) synthetase; Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys). (537 aa) |
| | tpiA | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (217 aa) |
| | aroA-2 | Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (272 aa) |
| | ABR66754.1 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (306 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa) |
| | ABR66733.1 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: mmp:MMP0651 acetohydroxyacid synthase small subunit. (169 aa) |
| | ABR66732.1 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: mmp:MMP0650 acetohydroxyacid synthase large subunit. (587 aa) |
| | ABR66727.1 | PFAM: Lactate/malate dehydrogenase; KEGG: mmp:MMP0645 malate dehydrogenase, MDHII (NADP+-dependent); Belongs to the LDH/MDH superfamily. (314 aa) |
| | ABR66688.1 | TIGRFAM: putative CoA-substrate-specific enzyme activase; PFAM: ATPase BadF/BadG/BcrA/BcrD type; KEGG: mmp:MMP0608 2-hydroxyglutaryl-CoA dehydratase (component A) related protein. (411 aa) |
| | ABR66678.1 | KEGG: mmp:MMP0598 archaeal phosphoglycerate mutase-related. (428 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (886 aa) |
| | ABR66660.1 | KEGG: mmp:MMP0581 hypothetical protein. (260 aa) |
| | ABR66657.1 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; KEGG: mmp:MMP0578 chorismate mutase. (96 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (289 aa) |
| | ABR66643.1 | PFAM: AMP-dependent synthetase and ligase; KEGG: mmp:MMP0566 acyl-CoA synthase. (549 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (304 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mmp:MMP0548 imidazoleglycerol-phosphate dehydratase. (190 aa) |
| | ABR66620.1 | PFAM: protein of unknown function DUF98; KEGG: mmp:MMP0543 hypothetical protein. (171 aa) |
| | ABR66618.1 | TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase subfamily IB hypothetical 1; KEGG: mmp:MMP0541 phosphoserine phosphatase. (213 aa) |
| | ABR66616.1 | TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: mmp:MMP0539 3-isopropylmalate dehydrogenase. (330 aa) |
| | ABR66595.1 | PFAM: beta-lactamase domain protein; KEGG: mmp:MMP0517 hypothetical protein. (176 aa) |
| | ABR66496.1 | PFAM: protein of unknown function DUF201; RimK domain protein ATP-grasp; KEGG: mmp:MMP0436 putative SSU ribosomal protein S6 modification protein. (316 aa) |
| | hisA | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: mmp:MMP0417 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino)imidazole-4-carboxamide isomerase. (238 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr); Belongs to the class-II aminoacyl-tRNA synthetase family. (622 aa) |
| | cofD | LPPG domain containing protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (309 aa) |
| | ABR66462.1 | PFAM: Methionine synthase vitamin-B12 independent; Cobalamin-independent synthase MetE domain protein; KEGG: mmq:MmarC5_1237 methionine synthase, vitamin-B12 independent. (312 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (892 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa) |
| | ABR66455.1 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (244 aa) |
| | ABR66452.1 | Alanine--glyoxylate transaminase; PFAM: aminotransferase class V; KEGG: mmp:MMP0391 aspartate aminotransferase. (382 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa) |
| | ABR66413.1 | PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; KEGG: mja:MJ1054 UDP-glucose dehydrogenase, putative. (441 aa) |
| | ABR66412.1 | TIGRFAM: putative CoA-substrate-specific enzyme activase; PFAM: ATPase BadF/BadG/BcrA/BcrD type; KEGG: mmp:MMP0349 2-hydroxyglutaryl-CoA dehydratase (component A) related protein. (242 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (663 aa) |
| | gap | TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type II; PFAM: glyceraldehyde 3-phosphate dehydrogenase; dihydrodipicolinate reductase; KEGG: mmp:MMP0325 glyceraldehyde 3-phosphate dehydrogenase. (340 aa) |
| | aroK | TIGRFAM: shikimate kinase; PFAM: GHMP kinase; GHMP kinase domain protein; KEGG: mmp:MMP0320 shikimate kinase (archaeal). (283 aa) |
| | ilvD | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: mmp:MMP0318 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (550 aa) |
| | ABR66380.1 | PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: mmp:MMP0315 indolepyruvate oxidoreductase subunit beta 1. (202 aa) |
| | ABR66379.1 | Phenylacetate--CoA ligase; KEGG: mmp:MMP0314 coenzyme F390 synthetase. (414 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (301 aa) |
| | ABR66359.1 | PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: mmp:MMP0293 hypothetical protein. (308 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (129 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily. (309 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (203 aa) |
| | glyS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). (574 aa) |
| | ABR66269.1 | PFAM: flavoprotein; KEGG: mmp:MMP0204 hypothetical protein. (176 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (272 aa) |
| | ABR66236.1 | TIGRFAM: alpha-L-glutamate ligase, RimK family; PFAM: protein of unknown function DUF201; RimK domain protein ATP-grasp; KEGG: mmp:MMP0170 gamma-F420-2:alpha-L-glutamate ligase. (285 aa) |
| | ABR66226.1 | Phenylacetate--CoA ligase; KEGG: mmp:MMP0160 coenzyme F390 synthetase. (433 aa) |
| | ABR66219.1 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; KEGG: mmp:MMP0153 2-oxosuberate synthase, first step; Belongs to the alpha-IPM synthase/homocitrate synthase family. (386 aa) |
| | ABR66214.1 | TIGRFAM: acetate--CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: mmp:MMP0148 acetyl-CoA synthetase, AMP-forming. (636 aa) |
| | ABR66210.1 | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase; PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: mmp:MMP0144 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase. (202 aa) |
| | ABR66203.1 | TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: mmp:MMP0138 formate dehydrogenase alpha subunit. (676 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (167 aa) |
| | ABR66200.1 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (404 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (287 aa) |
| | mfnA | Pyridoxal-dependent decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. (384 aa) |
| | ABR66193.1 | PFAM: cyclase family protein; KEGG: mmp:MMP0128 hypothetical protein. (189 aa) |
| | ABR66191.1 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mmp:MMP0126 biotin synthase. (341 aa) |
| | ABR66183.1 | PFAM: beta-lactamase domain protein; KEGG: mmp:MMP0118 hypothetical protein. (205 aa) |
| | cofC | Protein of unknown function DUF121; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (222 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (343 aa) |
| | ABR66177.1 | TIGRFAM: phosphonopyruvate decarboxylase-related protein; PFAM: metalloenzyme domain protein; KEGG: mmp:MMP0112 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2. (426 aa) |
| | ABR66145.1 | Glutamate synthase (NADPH); PFAM: dihydroorotate dehydrogenase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; ferredoxin-dependent glutamate synthase; KEGG: mmp:MMP0081 glutamate synthase; large subunit; archaeal subunit 2; Belongs to the glutamate synthase family. (510 aa) |
| | ABR66144.1 | PFAM: glutamine amidotransferase class-II; KEGG: mmp:MMP0080 glutamate synthase; large subunit; archaeal subunit 1. (363 aa) |
| | argG | PFAM: argininosuccinate synthase; ExsB family protein; KEGG: mmp:MMP0073 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (397 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (294 aa) |
| | hisE | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mmp:MMP0051 phosphoribosyl-ATP pyrophosphatase. (96 aa) |
| | ABR66092.1 | PFAM: CobB/CobQ domain protein glutamine amidotransferase; KEGG: mmp:MMP0028 adenosyl-cobyric acid synthase. (483 aa) |
| | ABR66081.1 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: mmp:MMP0017 hypothetical protein. (350 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: mmp:MMP0013 argininosuccinate lyase. (481 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (361 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (272 aa) |
| | ABR66058.1 | TIGRFAM: coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase-related protein; PFAM: H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase; KEGG: mmp:MMP1716 H(2)-forming methylenetetrahydromethanopterin dehydrogenase related protein. (341 aa) |
| | arfB | Creatininase; Catalyzes the hydrolysis of the formamide of 2-amino-5- formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy). (221 aa) |
| | ABR66044.1 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding protein; KEGG: mmp:MMP1702 homoserine dehydrogenase. (337 aa) |
| | ABR66032.1 | TIGRFAM: hisA/hisF family protein; PFAM: histidine biosynthesis protein; KEGG: mmp:MMP1690 similar to phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (222 aa) |
| | glmS | Glucosamine--fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (599 aa) |
| | ABR66002.1 | PFAM: protein of unknown function DUF521; KEGG: mmp:MMP1663 hypothetical protein. (401 aa) |
| | pyrB | TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; KEGG: mmp:MMP1659 aspartate carbamoyltransferase; catalytic subunit. (302 aa) |
| | pdxT | SNO glutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (187 aa) |
| | ABR65932.1 | Putative translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (321 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn). (438 aa) |
| | hisS | TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; KEGG: mmp:MMP1614 histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (418 aa) |
| | ABR65921.1 | TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; PFAM: flavoprotein; DNA/pantothenate metabolism flavoprotein domain protein; KEGG: mmp:MMP1606 flavoprotein:DNA/pantothenate metabolism flavoprotein. (396 aa) |
| | ABR65920.1 | TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; KEGG: mmp:MMP1605 pyruvate kinase; Belongs to the pyruvate kinase family. (447 aa) |
| | ABR65917.1 | Protein of unknown function DUF39; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; protein of unknown function DUF39; KEGG: mmp:MMP1603 ferredoxin. (388 aa) |
| | ABR65914.1 | TIGRFAM: alpha-L-glutamate ligase, RimK family; PFAM: protein of unknown function DUF201; RimK domain protein ATP-grasp; KEGG: mmp:MMP1600 ribosomal protein S6 modification enzyme (glutaminyl transferase) related. (269 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). (357 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; KEGG: mmp:MMP1589 carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (366 aa) |
| | ABR65902.1 | TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; KEGG: mmp:MMP1588 D-3-phosphoglycerate dehydrogenase. (523 aa) |
| | pdaD | TIGRFAM: arginine decarboxylase, pyruvoyl-dependent; PFAM: Pyruvoyl-dependent arginine decarboxylase; KEGG: mmp:MMP1582 pyruvoyl-dependent arginine decarboxylase, PvlArgDC, alpha and beta subunits; Belongs to the PdaD family. (164 aa) |
| | bioW | 6-carboxyhexanoate--CoA ligase; Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP. (244 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (186 aa) |
| | pgk | PFAM: phosphoglycerate kinase; KEGG: mmp:MMP1532 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (414 aa) |
| | ABR65843.1 | PFAM: prephenate dehydratase; KEGG: mmp:MMP1528 prephenate dehydratase. (269 aa) |
| | ABR65842.1 | PFAM: aminotransferase class I and II; KEGG: mmp:MMP1527 aspartate aminotransferase. (416 aa) |
| | ABR65827.1 | PFAM: Prephenate dehydrogenase; 6-phosphogluconate dehydrogenase NAD-binding protein; KEGG: mmp:MMP1514 prephenate dehydrogenase. (443 aa) |
| | ABR65826.1 | TIGRFAM: alanine dehydrogenase; PFAM: alanine dehydrogenase/PNT domain protein; KEGG: mmp:MMP1513 alanine dehydrogenase. (373 aa) |
| | ABR65825.1 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (373 aa) |
| | ABR65818.1 | TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: mmp:MMP1507 pyruvate oxidoreductase (synthase) subunit gamma. (176 aa) |
| | ABR65817.1 | TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mmp:MMP1506 pyruvate oxidoreductase (synthase) subunit delta. (85 aa) |
| | ABR65816.1 | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: mmp:MMP1505 pyruvate oxidoreductase (synthase) subunit alpha. (387 aa) |
| | ABR65815.1 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: mmp:MMP1504 pyruvate oxidoreductase (synthase) subunit beta. (298 aa) |
| | pheS | TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; PFAM: phenylalanyl-tRNA synthetase class IIc; KEGG: mmp:MMP1496 phenylalanyl-tRNA synthetase alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. (501 aa) |
| | nadK | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (566 aa) |
| | ABR65798.1 | Aldehyde dehydrogenase; Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate. (465 aa) |
| | leuC-2 | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (418 aa) |
| | cbiA | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (447 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1034 aa) |
| | ABR65780.1 | Protein of unknown function DUF1063; Catalyzes the cleavage of L-cysteine to form 2-aminoprop-2- enoate and sulfide. The former then spontaneously hydrolyzes to pyruvate and NH(3). May be responsible for the production of sulfide required for the biosynthesis of iron-sulfur centers in this archaea. (397 aa) |
| | guaAA | GMP synthase, small subunit; Catalyzes the synthesis of GMP from XMP. (189 aa) |
| | apgM | Phosphonopyruvate decarboxylase-related protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (406 aa) |
| | ABR65710.1 | TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: mmp:MMP1398 succinyl-diaminopimelate desuccinylase. (415 aa) |
| | aroD | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (218 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (348 aa) |
| | ABR65671.1 | PFAM: CBS domain containing protein; protein of unknown function DUF39; KEGG: mmp:MMP1359 hypothetical protein. (513 aa) |
| | ABR65670.1 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mmp:MMP1358 ferredoxin. (132 aa) |
| | ABR65656.1 | KEGG: mmp:MMP1343 hypothetical protein. (266 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (317 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (373 aa) |
| | ABR65641.1 | Enolase; KEGG: mmp:MMP1328 enolase. (311 aa) |
| | lysS | TIGRFAM: lysyl-tRNA synthetase; PFAM: Lysyl-tRNA synthetase class 1c; KEGG: mmp:MMP1318 lysyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (533 aa) |
| | ABR65628.1 | PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: mmp:MMP1315 2-oxoglutarate oxidoreductase gamma subunit. (177 aa) |
| | ABR65611.1 | TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: mmp:MMP1298 formate dehydrogenase alpha subunit. (674 aa) |
| | pfkC | ADP-specific phosphofructokinase; Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor. (463 aa) |
| | pgi | PFAM: phosphoglucose isomerase (PGI); KEGG: mmp:MMP1295 glucose-6-phosphate isomerase; Belongs to the GPI family. (437 aa) |
| | ABR65588.1 | PFAM: AMP-dependent synthetase and ligase; KEGG: mmp:MMP1274 acetyl-CoA synthetase, AMP-forming-related. (559 aa) |
| | gatD | glutamyl-tRNA(Gln) amidotransferase, subunit D; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (418 aa) |
| | pheT | TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; PFAM: tRNA synthetase B5; KEGG: mmp:MMP1255 phenylalanyl-tRNA synthetase beta subunit. (554 aa) |
| | ABR65557.1 | TIGRFAM: quinolinate synthetase complex, A subunit; PFAM: Quinolinate synthetase A; KEGG: mmp:MMP1242 quinolinate synthetase A. (305 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (327 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class V; aminotransferase class I and II; KEGG: mmp:MMP1216 histidinol-phosphate aminotransferase. (371 aa) |
| | cobQ | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (492 aa) |
| | ABR65528.1 | PFAM: Thiolase; KEGG: mmp:MMP1212 acetyl-CoA acyltransferase. (392 aa) |
| | ABR65522.1 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: mmp:MMP1206 glutamine synthetase. (446 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (429 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (436 aa) |
| | leuC | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (424 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (459 aa) |
| | argD | TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; KEGG: mmp:MMP1101 aminotransferase (subgroup II) similar to acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (395 aa) |
| | ABR65415.1 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (758 aa) |
| | ABR65386.1 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mmp:MMP1063 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (514 aa) |
| | cysS | TIGRFAM: cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia DALR; tRNA synthetase class I (M); Cysteinyl-tRNA synthetase class Ia; KEGG: mmp:MMP1060 cysteinyl-tRNA synthetase. (476 aa) |
| | argS | TIGRFAM: arginyl-tRNA synthetase; KEGG: mmp:MMP1026 arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (566 aa) |
| | cimA | Isopropylmalate/citramalate/homocitrate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (492 aa) |
| | ABR65329.1 | TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; KEGG: mmp:MMP1017 aspartate kinase; Belongs to the aspartokinase family. (468 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; RimK domain protein ATP-grasp; KEGG: mmp:MMP1013 carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1081 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (555 aa) |
| | ABR65320.1 | PFAM: Indole-3-glycerol phosphate synthase; KEGG: mmp:MMP1008 indole-3-glycerol-phosphate synthase. (229 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (321 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (439 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: mmp:MMP1004 N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (208 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate; Belongs to the TrpA family. (259 aa) |
| | dtdA | Protein of unknown function DUF516; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo. (254 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (424 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (288 aa) |
| | ABR65256.1 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; HAD superfamily (subfamily IA) hydrolase, TIGR02253; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: mmq:MmarC5_0746 HAD superfamily (subfamily IA) hydrolase, TIGR02253. (225 aa) |
| | cofE | F420-dependent oxidoreductase, putative; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives. (248 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (280 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (270 aa) |
| | ABR65235.1 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase class-II; asparagine synthase; KEGG: mmq:MmarC5_0725 asparagine synthase (glutamine-hydrolyzing). (513 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (277 aa) |
| | selD | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (356 aa) |
