(18 nodes) RNA polymerase II, core complex, and Cdc73/Paf1 complex network (Fusarium nygamai)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPB2	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1270 aa)
	FNYG_13418	RPOL4c domain-containing protein. (158 aa)
	FNYG_12622	Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. (1047 aa)
	FNYG_12050	RNA_pol_L_2 domain-containing protein. (143 aa)
	FNYG_11912	Uncharacterized protein. (72 aa)
	FNYG_11724	Uncharacterized protein. (172 aa)
	FNYG_11553	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (564 aa)
	FNYG_10407	CDC73_C domain-containing protein. (409 aa)
	FNYG_10249	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. (123 aa)
	FNYG_09524	Uncharacterized protein. (1032 aa)
	FNYG_09211	Uncharacterized protein. (406 aa)
	FNYG_08396	Uncharacterized protein. (475 aa)
	FNYG_07569	RPOLD domain-containing protein. (340 aa)
	FNYG_06955	Plus3 domain-containing protein. (596 aa)
	FNYG_06458	Uncharacterized protein. (1214 aa)
	FNYG_04460	RPOL9 domain-containing protein. (186 aa)
	FNYG_03648	Uncharacterized protein. (308 aa)
	RPB1	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1744 aa)

Your Current Organism:

Fusarium nygamai

NCBI taxonomy Id: 42673
Other names: ATCC 58555, BBA 69862, CBS 749.97, DAOM 225148, F. nygamai, Gibberella nygamai, IMI 375354, NRRL 13448

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FNYG_03648	FNYG_04460	A0A2K0WM29	A0A2K0WJ16	Uncharacterized protein.	RPOL9 domain-containing protein.	0.994
FNYG_03648	FNYG_06458	A0A2K0WM29	A0A2K0WD71	Uncharacterized protein.	Uncharacterized protein.	0.814
FNYG_03648	FNYG_06955	A0A2K0WM29	A0A2K0WBF4	Uncharacterized protein.	Plus3 domain-containing protein.	0.920
FNYG_03648	FNYG_07569	A0A2K0WM29	A0A2K0WA69	Uncharacterized protein.	RPOLD domain-containing protein.	0.993
FNYG_03648	FNYG_08396	A0A2K0WM29	A0A2K0W828	Uncharacterized protein.	Uncharacterized protein.	0.915
FNYG_03648	FNYG_09211	A0A2K0WM29	A0A2K0W4Y2	Uncharacterized protein.	Uncharacterized protein.	0.941
FNYG_03648	FNYG_09524	A0A2K0WM29	A0A2K0W4L9	Uncharacterized protein.	Uncharacterized protein.	0.932
FNYG_03648	FNYG_10249	A0A2K0WM29	A0A2K0W2B3	Uncharacterized protein.	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.985
FNYG_03648	FNYG_10407	A0A2K0WM29	A0A2K0W253	Uncharacterized protein.	CDC73_C domain-containing protein.	0.952
FNYG_03648	FNYG_11553	A0A2K0WM29	A0A2K0VYG3	Uncharacterized protein.	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	0.927
FNYG_03648	FNYG_11724	A0A2K0WM29	A0A2K0VY33	Uncharacterized protein.	Uncharacterized protein.	0.987
FNYG_03648	FNYG_11912	A0A2K0WM29	A0A2K0VXN5	Uncharacterized protein.	Uncharacterized protein.	0.990
FNYG_03648	FNYG_12050	A0A2K0WM29	A0A2K0VX56	Uncharacterized protein.	RNA_pol_L_2 domain-containing protein.	0.990
FNYG_03648	FNYG_12622	A0A2K0WM29	A0A2K0VVF1	Uncharacterized protein.	Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.987
FNYG_03648	FNYG_13418	A0A2K0WM29	A0A2K0VTC8	Uncharacterized protein.	RPOL4c domain-containing protein.	0.991
FNYG_03648	RPB1	A0A2K0WM29	A0A2K0WM34	Uncharacterized protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.991
FNYG_03648	RPB2	A0A2K0WM29	A0A2K0UTM4	Uncharacterized protein.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.995
FNYG_04460	FNYG_03648	A0A2K0WJ16	A0A2K0WM29	RPOL9 domain-containing protein.	Uncharacterized protein.	0.994
FNYG_04460	FNYG_06458	A0A2K0WJ16	A0A2K0WD71	RPOL9 domain-containing protein.	Uncharacterized protein.	0.917
FNYG_04460	FNYG_06955	A0A2K0WJ16	A0A2K0WBF4	RPOL9 domain-containing protein.	Plus3 domain-containing protein.	0.923