(27 nodes) Nuclear DNA replication network (Fusarium nygamai)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FNYG_02256	Uncharacterized protein. (574 aa)
	FNYG_14443	Rtf2 domain-containing protein. (259 aa)
	FNYG_14359	DNA helicase; Belongs to the MCM family. (879 aa)
	FNYG_13555	WD_REPEATS_REGION domain-containing protein. (711 aa)
	FNYG_11831	Uncharacterized protein. (348 aa)
	FNYG_11716	ORC_WH_C domain-containing protein. (717 aa)
	FNYG_11592	DNA helicase; Belongs to the MCM family. (889 aa)
	FNYG_11209	DNA helicase; Belongs to the MCM family. (957 aa)
	FNYG_10754	CBFD_NFYB_HMF domain-containing protein. (177 aa)
	FNYG_10411	PHD-type domain-containing protein. (765 aa)
	FNYG_09701	DNA helicase; Belongs to the MCM family. (721 aa)
	FNYG_09224	DNA helicase; Belongs to the MCM family. (1006 aa)
	FNYG_09023	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa)
	FNYG_09024	Vezatin domain-containing protein. (617 aa)
	FNYG_09047	Cell division control protein; Belongs to the CDC6/cdc18 family. (603 aa)
	FNYG_08994	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (348 aa)
	FNYG_08509	Protein kinase domain-containing protein. (490 aa)
	FNYG_08297	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (656 aa)
	FNYG_07549	Uncharacterized protein. (379 aa)
	FNYG_04953	DNA ligase. (869 aa)
	FNYG_04984	DNA polymerase. (1453 aa)
	FNYG_04987	Uncharacterized protein. (312 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (814 aa)
	FNYG_02311	Uncharacterized protein. (577 aa)
	FNYG_00577	Uncharacterized protein. (853 aa)
	FNYG_00543	AAA_16 domain-containing protein. (472 aa)
	FNYG_00051	Uncharacterized protein. (697 aa)

Your Current Organism:

Fusarium nygamai

NCBI taxonomy Id: 42673
Other names: ATCC 58555, BBA 69862, CBS 749.97, DAOM 225148, F. nygamai, Gibberella nygamai, IMI 375354, NRRL 13448

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FNYG_00051	FNYG_09047	A0A2K0WWE9	A0A2K0W5K4	Uncharacterized protein.	Cell division control protein; Belongs to the CDC6/cdc18 family.	0.432
FNYG_00543	FNYG_00577	A0A2K0WVL4	A0A2K0WTA5	AAA_16 domain-containing protein.	Uncharacterized protein.	0.962
FNYG_00543	FNYG_02311	A0A2K0WVL4	A0A2K0WQY5	AAA_16 domain-containing protein.	Uncharacterized protein.	0.999
FNYG_00543	FNYG_04953	A0A2K0WVL4	A0A2K0WI13	AAA_16 domain-containing protein.	DNA ligase.	0.445
FNYG_00543	FNYG_04984	A0A2K0WVL4	A0A2K0WI57	AAA_16 domain-containing protein.	DNA polymerase.	0.725
FNYG_00543	FNYG_04987	A0A2K0WVL4	A0A2K0WI64	AAA_16 domain-containing protein.	Uncharacterized protein.	0.725
FNYG_00543	FNYG_07549	A0A2K0WVL4	A0A2K0WA49	AAA_16 domain-containing protein.	Uncharacterized protein.	0.998
FNYG_00543	FNYG_08509	A0A2K0WVL4	A0A2K0W7E6	AAA_16 domain-containing protein.	Protein kinase domain-containing protein.	0.945
FNYG_00543	FNYG_09023	A0A2K0WVL4	A0A2K0W5I5	AAA_16 domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.506
FNYG_00543	FNYG_09024	A0A2K0WVL4	A0A2K0W5J3	AAA_16 domain-containing protein.	Vezatin domain-containing protein.	0.506
FNYG_00543	FNYG_09047	A0A2K0WVL4	A0A2K0W5K4	AAA_16 domain-containing protein.	Cell division control protein; Belongs to the CDC6/cdc18 family.	0.997
FNYG_00543	FNYG_09224	A0A2K0WVL4	A0A2K0W4Z7	AAA_16 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.992
FNYG_00543	FNYG_09701	A0A2K0WVL4	A0A2K0W3U5	AAA_16 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.998
FNYG_00543	FNYG_10411	A0A2K0WVL4	A0A2K0W250	AAA_16 domain-containing protein.	PHD-type domain-containing protein.	0.999
FNYG_00543	FNYG_11209	A0A2K0WVL4	A0A2K0VZE9	AAA_16 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.995
FNYG_00543	FNYG_11592	A0A2K0WVL4	A0A2K0VYK3	AAA_16 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.997
FNYG_00543	FNYG_11716	A0A2K0WVL4	A0A2K0VY25	AAA_16 domain-containing protein.	ORC_WH_C domain-containing protein.	0.998
FNYG_00543	FNYG_14359	A0A2K0WVL4	A0A2K0UT41	AAA_16 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.996
FNYG_00543	MCM7	A0A2K0WVL4	A0A2K0WLC1	AAA_16 domain-containing protein.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.990
FNYG_00577	FNYG_00543	A0A2K0WTA5	A0A2K0WVL4	Uncharacterized protein.	AAA_16 domain-containing protein.	0.962