STRINGSTRING
EDS75697.1 EDS75697.1 EDS75696.1 EDS75696.1 EDS74010.1 EDS74010.1 EDS74002.1 EDS74002.1 glyA glyA EDS75963.1 EDS75963.1 EDS75486.1 EDS75486.1 EDS73831.1 EDS73831.1 EDS75552.1 EDS75552.1 gpmI gpmI EDS75269.1 EDS75269.1 asd asd EDS75145.1 EDS75145.1 serC serC EDS75473.1 EDS75473.1 trpB trpB trpA trpA ilvA ilvA pdxB-3 pdxB-3 EDS73674.1 EDS73674.1 EDS74222.1 EDS74222.1 pdxB-2 pdxB-2 EDS74549.1 EDS74549.1 EDS74933.1 EDS74933.1 EDS75746.1 EDS75746.1 thrB thrB thrC thrC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EDS75697.1KEGG: aae:aq_1812 4.4e-67 thrA; homoserine dehydrogenase K00003; COG: COG0460 Homoserine dehydrogenase; Psort location: Cytoplasmic, score: 8.87. (384 aa)
EDS75696.1Amino acid kinase family; KEGG: sco:SCO3615 4.7e-70 ask, SC66T3.26c; putative aspartokinase K00928; COG: COG0527 Aspartokinases; Psort location: Cytoplasmic, score: 8.87; Belongs to the aspartokinase family. (412 aa)
EDS74010.1ACT domain protein; KEGG: sab:SAB1248 3.4e-17 lysC; aspartate kinase II K00928; COG: COG0527 Aspartokinases; Psort location: Cytoplasmic, score: 8.87. (156 aa)
EDS74002.1Transcriptional regulator, Spx/MgsR family; KEGG: fnu:FN0052 7.1e-28 arsenate reductase; COG: COG1393 Arsenate reductase and related proteins, glutaredoxin family; Psort location: Cytoplasmic, score: 8.87; Belongs to the ArsC family. (116 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
EDS75963.1Amino acid kinase family; KEGG: cac:CAC0278 4.7e-125 aspartate kinase K00928; COG: COG0527 Aspartokinases; Psort location: Cytoplasmic, score: 8.87; Belongs to the aspartokinase family. (452 aa)
EDS75486.1Transcriptional regulator, Spx/MgsR family; KEGG: lsl:LSL_1330 9.1e-35 arsC; arsenate reductase; COG: COG1393 Arsenate reductase and related proteins, glutaredoxin family; Psort location: Cytoplasmic, score: 8.87; Belongs to the ArsC family. (148 aa)
EDS73831.1CDP-alcohol phosphatidyltransferase; KEGG: cac:CAC0798 1.2e-27 phosphatidylserine synthase K00998; COG: COG1183 Phosphatidylserine synthase; Psort location: CytoplasmicMembrane, score: 10.00. (185 aa)
EDS75552.1Hypothetical protein; KEGG: mxa:MXAN_0764 3.3e-18 peptidase, M24 (methionyl aminopeptidase 1) family K01423; COG: NOG08884 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87. (410 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (505 aa)
EDS75269.1Hypothetical protein; Psort location: CytoplasmicMembrane, score: 9.75. (278 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa)
EDS75145.1Creatinase; KEGG: cpr:CPR_2506 5.8e-88 metallopeptidase, family M24 K01271; COG: COG0006 Xaa-Pro aminopeptidase; Psort location: Cytoplasmic, score: 8.87. (357 aa)
serCPhosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (361 aa)
EDS75473.1KEGG: bth:BT4678 3.0e-100 L-serine dehydratase K01752; COG: COG1760 L-serine deaminase; Psort location: Cytoplasmic, score: 8.87. (404 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (255 aa)
ilvAThreonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (400 aa)
pdxB-3KEGG: stl:stu1527 2.8e-104 serA; D-3-phosphoglycerate dehydrogenase K00058; COG: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Psort location: Cytoplasmic, score: 9.98; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (398 aa)
EDS73674.1DNA-binding helix-turn-helix protein; KEGG: mmo:MMOB3450 0.00011 dam; adenine-specific DNA methyltransferase K06223; COG: COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases); Psort location: Cytoplasmic, score: 8.87. (212 aa)
EDS74222.1Glycerate kinase; KEGG: sak:SAK_0918 1.7e-106 glycerate kinase K00865; COG: COG1929 Glycerate kinase; Psort location: Cytoplasmic, score: 8.87; Belongs to the glycerate kinase type-1 family. (396 aa)
pdxB-2KEGG: cff:CFF8240_1663 1.6e-67 hprA; glycerate dehydrogenase K00018; COG: COG1052 Lactate dehydrogenase and related dehydrogenases; Psort location: Cytoplasmic, score: 9.98; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (461 aa)
EDS74549.1Beta-eliminating lyase; KEGG: cac:CAC3420 7.4e-88 low specificity L-threonine aldolase K01620; COG: COG2008 Threonine aldolase. (355 aa)
EDS74933.1ACT domain protein; KEGG: nph:NP5006A 6.0e-08 purU; formyltetrahydrofolate deformylase K01433; COG: COG3830 ACT domain-containing protein; Psort location: Cytoplasmic, score: 8.87; Belongs to the UPF0237 family. (99 aa)
EDS75746.1Creatinase; KEGG: fnu:FN0453 5.4e-140 Xaa-Pro aminopeptidase K01262; COG: COG0006 Xaa-Pro aminopeptidase; Psort location: Cytoplasmic, score: 8.87. (583 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (297 aa)
thrCThreonine synthase; KEGG: cac:CAC0999 6.2e-123 thrC; threonine synthase K01733; COG: COG0498 Threonine synthase; Psort location: Cytoplasmic, score: 8.87. (494 aa)
Your Current Organism:
Clostridium spiroforme
NCBI taxonomy Id: 428126
Other names: Clostridium spiroforme ATCC 29900, [. spiroforme DSM 1552, [Clostridium] spiroforme DSM 1552
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