(37 nodes) Mixed, incl. Tubulin, and Calponin repeat network (Anopheles darlingi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AND_009537	Chitinase; Belongs to the glycosyl hydrolase 18 family. (399 aa)
	AND_010679	Muscle-specific protein 20. (244 aa)
	AND_010540	Transcription factor IIB. (200 aa)
	AND_009265	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (364 aa)
	AND_009725	Transgelin; Belongs to the calponin family. (210 aa)
	AND_010074	Tektin. (430 aa)
	AND_009403	Nuclear lamin L1 alpha. (487 aa)
	AND_009817	Paramyosin. (519 aa)
	AND_009605	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
	AND_008606	Dynein heavy chain. (4667 aa)
	AND_008368	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (438 aa)
	AND_008429	Tubulin beta-4 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (445 aa)
	AND_007739	Calcium/calmodulin-dependent protein kinase type 1. (628 aa)
	AND_006967	DUF4812 domain-containing protein. (460 aa)
	AND_007319	Growth factor receptor-bound protein. (1318 aa)
	AND_007116	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
	AND_007072	EF-hand calcium-binding domain-containing protein 1. (220 aa)
	AND_004438	Tubulin beta-4 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (445 aa)
	AND_004388	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
	AND_005568	Uncharacterized protein. (805 aa)
	AND_005489	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (504 aa)
	AND_005362	Protofilament ribbon protein. (381 aa)
	AND_005030	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (483 aa)
	AND_002634	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
	AND_003217	EF-hand domain-containing family member C2. (762 aa)
	AND_002635	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (519 aa)
	AND_002216	Armc4. (763 aa)
	AND_002485	Transcription factor IIB. (265 aa)
	AND_002628	Kinectin. (438 aa)
	AND_000951	Uncharacterized protein. (260 aa)
	AND_000793	Putative actin-5c. (376 aa)
	AND_001633	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (437 aa)
	AND_002176	TPR_REGION domain-containing protein. (254 aa)
	AND_000590	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (169 aa)
	AND_001717	EF-hand domain-containing protein 1. (670 aa)
	AND_001049	Tektin A. (511 aa)
	AND_000538	Uncharacterized protein. (249 aa)

Your Current Organism:

Anopheles darlingi

NCBI taxonomy Id: 43151
Other names: A. darlingi, American malaria mosquito, Anopheles paulistensis, Nyssorhynchus darlingi

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AND_000538	AND_001633	W5JWL2	W5JTH0	Uncharacterized protein.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.950
AND_000538	AND_002176	W5JWL2	W5JTH5	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.626
AND_000538	AND_002634	W5JWL2	W5JMI3	Uncharacterized protein.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.950
AND_000538	AND_002635	W5JWL2	W5JQL0	Uncharacterized protein.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	0.950
AND_000538	AND_004388	W5JWL2	W5JID4	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.903
AND_000538	AND_004438	W5JWL2	W5JI84	Uncharacterized protein.	Tubulin beta-4 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	0.950
AND_000538	AND_005030	W5JWL2	W5JKF4	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.903
AND_000538	AND_005489	W5JWL2	W5JJ36	Uncharacterized protein.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.950
AND_000538	AND_007116	W5JWL2	W5JEA1	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.903
AND_000538	AND_007739	W5JWL2	W5JB49	Uncharacterized protein.	Calcium/calmodulin-dependent protein kinase type 1.	0.731
AND_000538	AND_008368	W5JWL2	W5J9F0	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.903
AND_000538	AND_008429	W5JWL2	W5JB20	Uncharacterized protein.	Tubulin beta-4 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	0.950
AND_000538	AND_008606	W5JWL2	W5J8T0	Uncharacterized protein.	Dynein heavy chain.	0.471
AND_000538	AND_009265	W5JWL2	W5J570	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.903
AND_000538	AND_009605	W5JWL2	W5J7G0	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.903
AND_000590	AND_000793	W5JTY1	W5JSR8	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.	Putative actin-5c.	0.822
AND_000590	AND_000951	W5JTY1	W5JS79	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.	Uncharacterized protein.	0.787
AND_000590	AND_001049	W5JTY1	W5JV24	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.	Tektin A.	0.459
AND_000590	AND_001633	W5JTY1	W5JTH0	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.695
AND_000590	AND_001717	W5JTY1	W5JUQ5	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.	EF-hand domain-containing protein 1.	0.661