(52 nodes) Mixed, incl. Regulation of I-kappaB kinase/NF-kappaB signaling, and TAK1-dependent IKK and NF-kappa-B activation network (Anopheles darlingi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AND_010585	Sulfatase-modifying factor 1. (350 aa)
	AND_010020	RING-type domain-containing protein. (315 aa)
	AND_010432	Uncharacterized protein. (627 aa)
	AND_009872	Tak1; Belongs to the protein kinase superfamily. (385 aa)
	AND_010657	Myd88-like adapter protein. (451 aa)
	AND_010060	Toll; Belongs to the Toll-like receptor family. (1377 aa)
	AND_009884	TGF-beta activated kinase 1. (260 aa)
	AND_010256	Inhibitor of kappab kinase epsilon. (747 aa)
	AND_009927	TNF-receptor-associated factor 6. (381 aa)
	AND_009191	WD_REPEATS_REGION domain-containing protein. (75 aa)
	AND_009491	Uncharacterized protein. (564 aa)
	AND_008865	Leucine-rich transmembrane protein. (1066 aa)
	AND_008782	Death domain-containing protein. (260 aa)
	AND_006872	Uncharacterized protein. (888 aa)
	AND_006014	Caspase short class; Belongs to the peptidase C14A family. (281 aa)
	AND_007582	Ubiquitin conjugating enzyme 7 interacting protein. (1975 aa)
	AND_007510	Ubiquitin carboxyl-terminal hydrolase. (955 aa)
	AND_006159	RING-type domain-containing protein. (2999 aa)
	AND_005327	RBR-type E3 ubiquitin transferase. (773 aa)
	AND_006671	Zinc finger Ran-binding domain-containing protein 1. (801 aa)
	AND_006079	Protein cactus (TOLL pathway signalling). (381 aa)
	AND_006070	NHL repeat containing 2. (845 aa)
	AND_005408	Inhibitor of nuclear factor kappa B kinase beta subunit. (800 aa)
	AND_005744	Uncharacterized protein. (245 aa)
	AND_005684	CCHC NOA-type domain-containing protein. (541 aa)
	AND_003945	DUF4203 domain-containing protein. (366 aa)
	AND_003707	Uncharacterized protein. (315 aa)
	AND_003947	Caspase long class, Dredd; Belongs to the peptidase C14A family. (507 aa)
	AND_004636	Caspase short class; Belongs to the peptidase C14A family. (300 aa)
	AND_004577	Tak1 binding protein-1. (533 aa)
	AND_003708	Uncharacterized protein. (262 aa)
	AND_003269	Pellino. (634 aa)
	AND_004674	OTU domain-containing protein 7A. (961 aa)
	AND_004524	Ubiquitin carboxyl-terminal hydrolase. (701 aa)
	AND_002968	Uncharacterized protein. (674 aa)
	AND_003846	Serine/threonine protein kinase death domain protein, pelle. (512 aa)
	AND_003603	Uncharacterized protein; Belongs to the peptidase C14A family. (355 aa)
	AND_002697	Rel 2 protein, relish. (1180 aa)
	AND_002425	RING-type domain-containing protein. (337 aa)
	AND_003438	Rolling pebble. (1285 aa)
	AND_003247	Putative ubiquitin-conjugating enzyme e2-17 kDa ubiquitin-conjugating enzyme e2-17 kDa; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	AND_002432	Apoptosis 1 inhibitor. (447 aa)
	AND_001005	Uncharacterized protein. (433 aa)
	AND_001704	Uncharacterized protein. (1439 aa)
	AND_001681	Uncharacterized protein. (509 aa)
	AND_002192	Baculoviral IAP repeat-containing protein 3. (508 aa)
	AND_000593	RanBP2-type domain-containing protein. (1002 aa)
	AND_000474	Caspase short class; Belongs to the peptidase C14A family. (295 aa)
	AND_001685	RBR-type E3 ubiquitin transferase. (440 aa)
	AND_001495	Toll-like receptor; Belongs to the Toll-like receptor family. (1162 aa)
	AND_001392	Rel1/Dif/Dorsal. (636 aa)
	AND_000023	Uncharacterized protein. (495 aa)

Your Current Organism:

Anopheles darlingi

NCBI taxonomy Id: 43151
Other names: A. darlingi, American malaria mosquito, Anopheles paulistensis, Nyssorhynchus darlingi

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AND_000023	AND_000474	W5JX81	W5JU83	Uncharacterized protein.	Caspase short class; Belongs to the peptidase C14A family.	0.649
AND_000023	AND_000593	W5JX81	W5JTX6	Uncharacterized protein.	RanBP2-type domain-containing protein.	0.938
AND_000023	AND_001005	W5JX81	W5JSS0	Uncharacterized protein.	Uncharacterized protein.	0.906
AND_000023	AND_001392	W5JX81	W5JVH3	Uncharacterized protein.	Rel1/Dif/Dorsal.	0.510
AND_000023	AND_001495	W5JX81	W5JUT7	Uncharacterized protein.	Toll-like receptor; Belongs to the Toll-like receptor family.	0.627
AND_000023	AND_001681	W5JX81	W5JTB0	Uncharacterized protein.	Uncharacterized protein.	0.539
AND_000023	AND_001685	W5JX81	W5JU92	Uncharacterized protein.	RBR-type E3 ubiquitin transferase.	0.539
AND_000023	AND_002192	W5JX81	W5JTH2	Uncharacterized protein.	Baculoviral IAP repeat-containing protein 3.	0.845
AND_000023	AND_002425	W5JX81	W5JN43	Uncharacterized protein.	RING-type domain-containing protein.	0.845
AND_000023	AND_002432	W5JX81	W5JR61	Uncharacterized protein.	Apoptosis 1 inhibitor.	0.845
AND_000023	AND_002697	W5JX81	W5JN07	Uncharacterized protein.	Rel 2 protein, relish.	0.615
AND_000023	AND_002968	W5JX81	W5JLM0	Uncharacterized protein.	Uncharacterized protein.	0.844
AND_000023	AND_003247	W5JX81	W5JQ37	Uncharacterized protein.	Putative ubiquitin-conjugating enzyme e2-17 kDa ubiquitin-conjugating enzyme e2-17 kDa; Belongs to the ubiquitin-conjugating enzyme family.	0.826
AND_000023	AND_003269	W5JX81	W5JKS9	Uncharacterized protein.	Pellino.	0.693
AND_000023	AND_003438	W5JX81	W5JPW3	Uncharacterized protein.	Rolling pebble.	0.548
AND_000023	AND_003603	W5JX81	W5JMV4	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.649
AND_000023	AND_003707	W5JX81	W5JJJ2	Uncharacterized protein.	Uncharacterized protein.	0.510
AND_000023	AND_003708	W5JX81	W5JK96	Uncharacterized protein.	Uncharacterized protein.	0.510
AND_000023	AND_003846	W5JX81	W5JM72	Uncharacterized protein.	Serine/threonine protein kinase death domain protein, pelle.	0.902
AND_000023	AND_003945	W5JX81	W5JIW3	Uncharacterized protein.	DUF4203 domain-containing protein.	0.618